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| 1 | 附睾炎:基于临床和基础研究的总结启示显示文摘急性附睾炎在泌尿外科门诊的病人中有共同的临床表现。大多数情况下,性传播疾病或者泌尿系的感染都会引起病原菌的感染,并通过泌尿生殖道逆行引发急性附睾炎。虽然保守治疗可能对大多数患者有效并能根除病原菌,但有研究表明这类患者中少精子症甚至无精子症患者升高至40%。为了探讨引起这种现象和随后对精子功能损伤的潜在原因,我们建立了附睾炎的动物模型。研究数据表明附睾管里聚集着异常表达的免疫细胞、免疫调节基因以及病原菌敏感分子。我们推测在附睾头部存在一个耐药微环境,而炎症反应常发生在附睾尾部。这与附睾在不需要降低自身抵抗上行感染能力的前提下,当精子从睾丸中射出后,保护其不受新产生的抗精子抗体损害的观点相一致。然而,严重的炎症反应,特别是在附睾尾部,也可能迁延引发附睾结构和功能的损害。通过对动物模型临床观察研究,我们更好地理解附睾的免疫微环境,附睾炎的易感因素以及合理的治疗,在此基础上减轻附睾炎对附睾的损害,降低这类人群不育的发生率。 | Vera Michel Adrian Pilatz Mark P Hedger Andreas Meinhardt | 2015 | Asian Journal of Andrology2015，17，5： | 16 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 4 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 5 | A review of rescue regimens after clarithromycin-containing triple therapy failure (for Helicobacter pylori eradication)显示文摘 | Alicia C Marin Adrian G McNicholl Javier P Gisbert | 2013 | Expert Opinion on Pharmacotherapy2013，，7： | 2 |
| 6 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 7 | Biodegradation and bioconversion of cellulose wastes using bacterial and fungal cells immobilized in radiopolymerized hydrogels显示文摘 | Peter M Zarnea G Adrian P | 1999 | Re2 sources Conservation and Recycling1999，27，5： | 1 |
| 8 | Some Recent Designs and Developments of Screen-Printed Carbon Electrochemical Sensors/Biosensors for Biomedical,Environmental,and Industrial Analyses显示文摘 | John P H Adrian C Kevin C H | 2004 | Analytical Lett2004，37，5： | 1 |
| 9 | New gene cassettes for trimethoprim resistance, dfr13 ,and Streptomycin-Spectinomytin resistance, aadA4,inserled on a class 1 integron 显示文摘 | ADRIAN P V THOMSON C J KLUGMAN K P | 2000 | Antimicrob Agents Cheroother2000，44，2： | 1 |
| 10 | Biodegradation and bioconversion of cellulose wastes using bacterial and fungal cells immobilized in radiopolymerized hydrogels 显示文摘 | Peter M Zarnea G Adrian P | 1999 | Resources Conservation and Recycling1999，27，5： | 1 |
| 11 | Generation of DNA profiles from fabrics without DNA extraction 显示文摘 | Adrian L Vera P Yuvaneswari C S | 2010 | Forensic Sci Int(Genetics)2010，4，： | 1 |
| 12 | Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries显示文摘 | Minond D Adrian SA Subramaniam P | 2009 | Bioorganic & Med Chemist2009，17，14： | 1 |
| 13 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 14 | Resources conservation and recycling biodegradatiun and bioconversion of cellulose wastes using bacterial and fungal 显示文摘 | Peter M G Zarmea P Adrian | 1999 | Cells Immobilized in Radiopolymerized Hydrogels1999，27，4： | 1 |
| 15 | Tumor necrosis factor stimulates amylin secretion but inhibits insulin from islet β-cells by independent pathways显示文摘 | Ding X Z Flatt P R Adrian T E | 1996 | Regulatory Peptides1996，64，3： | 1 |
| 16 | Si/Si1-xGex/Si low-loss waveguides fabricated using selective epitaxial growth显示文摘 | ADRIAN Vonsovici SOUREN P VESCAN L | 2001 | Proceeding of SPIE2001，，4293： | 1 |
| 17 | Security in Wireless Sensor Networks显示文摘 | Adrian P John S David W | 2004 | Communication ACM2004，47，4： | 1 |
| 18 | Islet amyloid polypeptide in patients with pancreatic cancer and diabetes显示文摘 | POUR P M WESTERMARK P ADRIAN TE | 1994 | N Engl J Med1994，330，5： | 1 |
| 19 | Highly Ef- ficient Cu( In, Ga)Se2 Solar Cells Grown on Flexible Pol- ymer Films 显示文摘 | ADRIAN C STEPHAN B FABIAN P | 2011 | NATURE MATERIALS2011，10，11： | 1 |
| 20 | The role of emotion in explaining consumer satisfaction and future behavioural intention 显示文摘 | MARTIN D SUSAN H ADRIAN P | 2008 | Journal of Services Marketing2008，22，3： | 1 |
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