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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Dynamic soft sensor development based on Gaussian mixture regression for fermentation processes显示文摘The dynamic soft sensor based on a single Gaussian process regression(GPR) model has been developed in fermentation processes.However,limitations of single regression models,for multiphase/multimode fermentation processes,may result in large prediction errors and complexity of the soft sensor.Therefore,a dynamic soft sensor based on Gaussian mixture regression(GMR) was proposed to overcome the problems.Two structure parameters,the number of Gaussian components and the order of the model,are crucial to the soft sensor model.To achieve a simple and effective soft sensor,an iterative strategy was proposed to optimize the two structure parameters synchronously.For the aim of comparisons,the proposed dynamic GMR soft sensor and the existing dynamic GPR soft sensor were both investigated to estimate biomass concentration in a Penicillin simulation process and an industrial Erythromycin fermentation process.Results show that the proposed dynamic GMR soft sensor has higher prediction accuracy and is more suitable for dynamic multiphase/multimode fermentation processes. | Congli Mei Yong Su Guohai Liu Yuhan Ding Zhiling Liao | 2017 | Chinese Journal of Chemical Engineering2017，25，1： | 8 |
| 3 | Isolation, characterization and functional analysis of a cdc48 homologue from tobacco BY-2 cells显示文摘分裂酵母 Schizosaccharomyces pombe 被用来从可以在房间周期规定起作用的烟草 BY-2 房间识别基因。编码对酵母 CDC48 相应的蛋白质的 cDNA 被孤立,基因被指定为 NtCDC48。cDNA 包含为二个 twical ATPase 模块包括的 808 氨基酸的预言的蛋白质编码的一个开的读物框架(一 245-374 并且一 518-646 ) 。NtCDC48in 烟草 BY-2 房间的 Overexpression 在有丝分裂的索引以及到传播有丝分裂的锭子的形成导致了增加。NtCDC48-GFP 熔化蛋白质还通过 G1 无所不在地被散布到 M 阶段的家他们细胞的本地化与房间周期前进一起定期改变了的潜水艇。这些结果显示 NtCDC48 可以在 BY-2 房间在房间周期的规定起一个重要作用。 | CHEN Zhiling Yu Yi LIU Lina XIA Guixian | 2007 | Progress in Natural Science:Materials International2007，17，2： | 6 |
| 4 | Synthesis of chain-like MoS_2 nanoparticles in W/O reverse microemulsion and application in photocatalysis显示文摘Chain-like MoS2assemblies consisting of hexagonal MoS2nanoparticles(20-60 nm) have been successfully synthesized in a Triton X-100/cyclohexane/hexanol/water W/O reverse microemulsion in the presence of(NH 4)2MoS 4 as the molybdenum source and NH2OH·HCl as the reducing agent.The products were characterized by X-ray powder diffraction(XRD),transmission electron microscopy(TEM) and UV-vis diffuse reflectance absorption spectra.The influence of synthetic parameters such as acidity,water/oil ratio(0),aging time and annealing temperature on the formation of MoS2assemblies was investigated.TEM analysis showed that these synthetic factors played important roles in controlling the size of MoS2nanoparticles and the length of the chain-like MoS2assemblies.XRD analysis indicated that the well-crystallized MoS2nanoparticles could be obtained by annealing the precursors at 700 C for2h under a flow of N2atmosphere.In addition,the as-prepared chain-like MoS2nanoparticles exhibited excellent photocatalytic H2activity in Ru(bpy) 3 2+-MoS2-H2A three-component molecular systems under visible light irradiation. | LIU MeiYing LI XiaoQian XU ZhiLing LI BoNa CHEN LinLin SHAN NanNan | 2012 | Chinese Science Bulletin2012，57，30： | 6 |
| 5 | Optimal capacity planning of combined renewable energy source-pumped storage and seawater desalination systems显示文摘As water scarcity is becoming a growing threat to human development, finding effective solutions has become an urgent need. To make better use of water resources, seawater desalination and storage systems using renewable energy sources(RES) are designed and implemented around the world. In this paper, an optimal capacity planning method for RES-pumped storage-seawater desalination(RES-PS-D) system is introduced. The configuration of the RES-PS-D system is clarified first, after which a cost-benefit analysis is performed using all cost and benefit components. A function for determining maximum economic benefits of the RES-PS-D system is then established, and the constraints are proposed based on various limitations. The mixed-integer linear programming algorithm is applied to solve the optimal function. A case study is introduced to validate the feasibility and effectiveness of the method. The conclusion shows that the strategy is suitable for solving the configuration optimization problem, and finally both merits and defects of the method are discussed. | Boyu Liu Bowen Zhou Dongsheng Yang Zhile Yang Mingjian Cui | 2019 | Global Energy Interconnection2019，2，4： | 4 |
| 6 | The Z-scheme g-C_(3)N_(4)/3DOM-WO_(3) photocatalysts with enhanced activity for CO_(2) photoreduction into CO显示文摘The catalytic performance of light-derived CO_(2)reduction with H_(2)O is strongly dependent on the sepa-ration efficiency of photogenerated carriers.Herein,the direct Z-scheme catalysts(g-C_(3)N_(4)/3DOM-WO_(3))of graphitic carbon nitride(g-C_(3)N_(4))nanosheets decorated three-dimensional ordered macroporous WO_(3)(3DOM-WO_(3))were successfully fabricated by using the in-situ colloidal crystal template method.The slow light effect of 3DOM-WO_(3)photonic crystals expands the absorption of visible light and improves the uti-lization of light energy.The Z-scheme structure of g-C_(3)N_(4)/3DOM-WO_(3)catalysts is able to upgrade the separation efficiency of photogenerated electron-hole pairs.The g-C_(3)N_(4)/3DOM-WO_(3)photocatalyst,whose formation rate of CO product is 48.7μmol g^(−1)h^(−1),exhibits the excellent catalytic activity for CO_(2)reduc-tion.The transfer pathway of stimulated electrons over the g-C_(3)N_(4)/3DOM-WO_(3)photocatalyst is proposed and discussed.The present approach provides unique insights into the rational development of high-performance photochemical systems for efficient CO_(2)reduction into valuable carbon-containing chemicals and energy fuels. | Zhiling Tang Chujun Wang Wenjie He Yuechang Wei Zhen Zhao Jian Liu | 2022 | Chinese Chemical Letters2022，33，2： | 3 |
| 7 | Atacamite and Nantokite in Kaerqueka Copper Deposit of Qimantag Area:Evidence for Cenozoic Climate Evolution of the Qaidam Basin显示文摘Using a mineralogy method to reflect climate evolution is a new approach to research Cenozoic environmental progression of the Qaidam Basin. In this paper, we present the chemical composition and crystallographic parameter of atacamite, nantokite, and tenorite in cryptocrystalline aggregates from the Kaerqueka copper deposit of Qimantag metallogenic belt by means of electron microprobe and in-situ X-ray diffraction analyses. Atacamite and nantokite occur in an intimate intergrowth as the secondary precipitation of chalcopyrite and bornite filling in the interstitial space of andradite in the Kaerqueka copper deposit, with an average composition of Cl: 12.38 wt.%, Cu: 63.76 wt.%, O: 21.46 wt.%. X-ray microdiffraction shows that the intergrowth contains nantokite with a cubic unit cell a=5.403(2) ? and atacamite with an orthorhombic unit cell a=6.030(3), b=6.883(2), c=9.114(1) ?. XRD quantitative calculation shows that the nanometric aggregate contains 36.07 wt.% tenorite, 18.41 wt.% atacamite, and 45.52 wt.% nantokite. The presence of nantokite and atacamite requires saline solutions for their formation and hyper-arid climate conditions for their preservation. Combined with the data of salt lakes and the pollen sequence of western China, we suggest that during the uplift of the Tibetan Plateau and the retreat of the Paratethys, saline water was forced to the surface through a basal fracture zone. In the hyper-arid climate of the Qaidam Basin, the recharge of groundwater by direct precipitation is negligible, and groundwater is derived from inflow from the salt lakes. Thus, atacamite is preserved. In addition, spertiniite in the edge and fractures of atacamite and nantokite may represent wetter climate after the formation of atacamite and nantokite. | Liwen Yi Xiangping Gu Anhuai Lu Xiangyu Li Dexian Zhang Zhiling Wang Jianping Liu Shuai Li Zhengxiang Shu Cui Yu Hongyan Zuo Can Shen | 2017 | Journal of Earth Science2017，28，3： | 3 |
| 8 | Monolithic superaligned carbon nanotube composite with integrated rewriting, actuating and sensing multifunctions显示文摘Multifunctionality has become a mainstream trend in the development of smart clothing and flexible wearable devices.Nevertheless,it remains a grand challenge to realize multiple functions,such as sensing,actuating and information displaying,in one single multifunctional material.Here,we present one multifunctional integration strategy by employing monolithic superaligned carbon nanotube(SACNT)composite,which can leverage three different functions through fascinating features of SACNT.Firstly,by using thermochromic dye as a color-memorizing component and SACNT as a photothermal converter,the composite film can be utilized as a flexible rewritable medium.It demonstrates excellent rewriting performances(reversibility>500 times).Secondly,the composite can be tailored to fabricate an actuator,when its length direction is along the SACNT alignment.The actuator shows a bending-morphing when illuminated by near-infrared light.The morphing is attributed to a large difference in volume change between the SACNT and polymer when the SACNT absorbs the optical energy and heats the composite.Thirdly,owing to the unique anisotropy of SACNT,the composite is easily to be stretched in the direction perpendicular to the SACNT alignment,accompanied by a change in electrical resistance.Therefore,the composite is able to be used as a strain sensor.Finally,we fabricate two smart wearable devices to demonstrate the applications,which realize the functions of human-motion detection(sensing)and rewritable information display(rewriting)simultaneously.This multifunctional SACNT composite is expected to have potential applications in the next-generation wearable devices,smart clothing and so on. | Peidi Zhou Wei Zhang Luzhuo Chen Jian Lin Zhiling Luo Changhong Liu Kaili Jiang | 2021 | Nano Research2021，14，7： | 2 |
| 9 | Boron doped graphdiyne:A metal-free peroxidase mimetic nanozyme for antibacterial application显示文摘The abuse of conventional antibiotics leads to increasing bacterial resistance.Nanozyme is a new kind of ultra-efficient and safe nanomaterial with intrinsic enzyme-like activities,showing remarkable potential as a next generation nanobactericide.Graphdiyne(GDY)is a burgeoning two-dimensional(2D)carbon allotrope with intriguing physicochemical properties,holding a great promise as a metal-free nanozyme.In this study,a boron doped GDY nanosheet(B-GDY)was constructed to simulate the performance of peroxidase(POD).By promoting the decomposition of H_(2)O_(2) to produce reactive oxygen species(ROS),the bactericidal efficacies against both Gram-positive and Gram-negative bacteria were substantially enhanced attributed to the extremely high catalytic activity of B-GDY.In-depth density functional theory(DFT)calculations illuminate that doping of boron can introduce more active B-defect sites as well as lower Gibbs free energy during the H_(2)O_(2) decomposition reaction.Notably,B-GDY contributes to significant wound healing and excellent biocompatibility,reducing the biological burden.The design of this nanozyme opens a new avenue for the development of alternative antibiotics. | Xuelong Bi Qiang Bai Lina Wang Fanglin Du Manhong Liu William W.Yu Siheng Li Jiaqiang Li Zhiling Zhu Ning Sui Jin Zhang | 2022 | Nano Research2022，15，2： | 2 |
| 10 | WiFi CSI Gesture Recognition Based on Parallel LSTM-FCN Deep Space-Time Neural Network显示文摘In this study,we developed a system based on deep space–time neural networks for gesture recognition.When users change or the number of gesture categories increases,the accuracy of gesture recognition decreases considerably because most gesture recognition systems cannot accommodate both user differentiation and gesture diversity.To overcome the limitations of existing methods,we designed a onedimensional parallel long short-term memory–fully convolutional network(LSTM–FCN)model to extract gesture features of different dimensions.LSTM can learn complex time dynamic information,whereas FCN can predict gestures efficiently by extracting the deep,abstract features of gestures in the spatial dimension.In the experiment,50 types of gestures of five users were collected and evaluated.The experimental results demonstrate the effectiveness of this system and robustness to various gestures and individual changes.Statistical analysis of the recognition results indicated that an average accuracy of approximately 98.9% was achieved. | Zhiling Tang Qianqian Liu Minjie Wu Wenjing Chen Jingwen Huang | 2021 | China Communications2021，18，3： | 2 |
| 11 | Major and Trace Elements of Magnetite from the Qimantag Metallogenic Belt: Insights into Evolution of Ore–forming Fluids显示文摘Magnetite, as a genetic indicator of ores, has been studied in various deposits in the world. In this paper, we present textural and compositional data of magnetite from the Qimantag metallogenic belt of the Kunlun Orogenic Belt in China, to provide a better understanding of the formation mechanism and genesis of the metallogenic belt and to shed light on analytical protocols for the in situ chemical analysis of magnetite. Magnetite samples from various occurrences, including the ore–related granitoid pluton, mineralised endoskarn and vein–type iron ores hosted in marine carbonate intruded by the pluton, were examined using scanning electron microscopy and analysed for major and trace elements using electron microprobe and laser ablation–inductively coupled plasma–mass spectrometry. The field and microscope observation reveals that early–stage magnetite from the Hutouya and Kendekeke deposits occurs as massive or banded assemblages, whereas late–stage magnetite is disseminated or scattered in the ores. Early–stage magnetite contains high contents of Ti, V, Ga, Al and low in Mg and Mn. In contrast, late–stage magnetite is high in Mg, Mn and low in Ti, V, Ga, Al. Most magnetite grains from the Qimantag metallogenic belt deposits except the Kendekeke deposit plot in the ' Skarn ' field in the Ca+Al+Mn vs Ti+V diagram, far from typical magmatic Fe deposits such as the Damiao and Panzhihua deposits. According to the(Mg O+Mn O)–Ti O2–Al2O3 diagram, magnetite grains from the Kaerqueka and Galingge deposits and the No.7 ore body of the Hutouya deposit show typical characteristics of skarn magnetite, whereas magnetite grains from the Kendekeke deposit and the No.2 ore body of the Hutouya deposit show continuous elemental variation from magmatic type to skarn type. This compositional contrast indicates that chemical composition of magnetite is largely controlled by the compositions of magmatic fluids and host rocks of the ores that have reacted with the fluids. Moreover, a combination of petrography and magnetite geochemistry indicates that the formation of those ore deposits in the Qimantag metallogenic belt involved a magmatic–hydrothermal process. | YI Liwen GU Xiangping LU Anhuai LIU Jianping LEI Hao WANG Zhiling CUI Yu ZUO Hongyan SHEN Can | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 2 |
| 12 | Efficacy of radical cystectomy plus adjuvant intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced bladder cancer显示文摘 | Jiang Lijuan Zhang Zhiling Dong Pei Li Yonghong Yao Kai Liu Zhuowei Han Hui Qin Zike Yao Min Zhou Fangjian | 2014 | Chinese Medical Journal2014，，7： | 2 |
| 13 | Z-scheme heterojunction of SnS_(2)-decorated 3DOM-SrTiO_(3) for selectively photocatalytic CO_(2) reduction into CH4显示文摘The rapid recombination of photoinduced electron-hole pairs as well as the deficiency of high-energy carriers restricted the redox ability and products selectivity.Herein,the heterojunction of SnS_(2)-deco rated three-dimensional ordered macropores(3DOM)-SrTiO_(3) catalysts were in-situ constructed to provide transmit channel for high-energy electron transmission.The suitable band edges of SnS_(2) and SrTiO_(3) contribute to the Z-scheme transfer of photogenerated carrier.The 3DOM structure of SrTiO_(3)-based catalyst possesses the slow light effect for enhancing light adsorption efficiency,and the surface alkalis strontium is benefit to the boosting adsorption for CO_(2).The in-situ introduced SnS_(2) decorated on the macroporous wall surface of 3DOM-SrTiO_(3) altered the primary product from CO to CH4.The Z-scheme electron transfer from SnS_(2) combining with the holes in SrTiO_(3) occurred under full spectrum photoexcitation,which improved the excitation and utilization of photogene rated electrons for C02 multi-electrons reduction.As a result,(SnS_(2))3/3 DOM-SrTiO_(3) catalyst exhibits higher activity for photocatalytic CO_(2) reduction to CH4 compared with single SnS_(2) or 3 DOM-SrTiO_(3),i.e.,its yield and selectivity of CH4 are 12.5μmol g^(-1) h^(-1) and 74.9%,re spectively.The present work proposed the theoretical foundation of Z-scheme heterojunction construction for enhancing photocatalytic activity and selectivity for CO_(2) conversion. | Wenjie He Xingxing Wu Yifei Li Jing Xiong Zhiling Tang Yuechang Wei Zhen Zhao Xiao Zhang Jian Liu | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 14 | Construction of CdSe/ZnS quantum dot microarray in a microfluidic chip显示文摘Microarray technology has been proved to be greatly helpful for biomedical and biological diagnosis. And the evaluation of its biological applications lies in the detection sensitivity, which requires high intensity and stability of the signal. Recently, several nanomaterials, especially semiconductor nanomaterials, due to their excellent fluorescence properties, have been widely used to construct microarrays for biosensors. Here, we presented an approach for constructing CdSe/ZnS quantum dot (QD) microarray in microfluidic channels on a glass slide by photolithography. The conditions for immobilizing stable and uniform QD microarray on the glass slide were optimized. Several types of QD microarrays with different emission wavelengths and modified groups were constructed using silanization and lithography technology. Based on the fluorescence quenching effect of Cu2+ on QDs, the microfluidic chip with QD microarray was applied for the determination of Cu2+. 1 nmol/L Cu2+ could be detected by this method. | LIU HongWei JING YingYing YU Xu PANG DaiWen ZHANG ZhiLing | 2012 | Science China Chemistry2012，55，4： | 2 |
| 15 | An improved ileal conduit surgery for bladder cancer with fewer complications显示文摘Background:Radical cystectomy and urinary diversion remains the standard surgical treatment for patients with muscle-invasive or high-risk or recurrent non-muscle-invasive bladder cancer.Although this approach prolongs patient survival remarkably,there are postoperative complications associated with urinary diversion.This study aimed to assess the efficacy of modified ileal conduit surgery for reducing early and late stoma-and ureteroileal anastomo-sis-related complications,as compared with conventional ileal conduit urinary diversion.Methods:We retrospectively evaluated the clinical data of bladder cancer patients treated with radical cystectomy and ileal conduit urinary diversion at Sun Yat-sen University Cancer Center between January 1,2000 and June 30,2016.Ileal conduit was created by the conventional or a modified technique.The clinicopathologic features of the conventional and the modified ileal conduit groups were compared using the t test and the Chi square test.Multivari-able logistic regression analysis and multivariable Cox regression analysis were performed to determine the odds of developing stoma-and ureteroileal anastomosis-related complications in the two groups.Results:145 and 100 patients underwent the modified and conventional ileal conduit surgery,respectively.The two groups were comparable with regard to clinicopathologic features.The rate of stoma-related complications was significantly lower in the modified ileal conduit group than in the conventional ileal conduit group(0.7%vs.17.0%,P<0.001).No late stoma-related complications were seen in the modified ileal conduit group,but were seen in 13(13.0%)patients in the conventional ileal conduit group.The rate of ureteroileal anastomosis-related complications was significantly lower in the modified ileal conduit group than in the conventional ileal conduit group(4.8%vs.15.0%,P=0.001).In multivariable analyses,the modified ileal conduit group was significantly less likely to develop stoma-(odds ratio[OR]=0.024,95%confidence interval[CI]0.003-0.235;P=0.001)or ureteroileal anastomosis-related complications(OR=0.141,95%CI 0.042-0.476;P=0.002)than the conventional ileal conduit group.Conclusions:Our modified surgical technique for ileal conduit urinary diversion may be effective for reducing early and late complications related to the stoma and the ureteroileal anastomosis.Prospective randomized clinical trials are needed to confirm our results. | Zhiyong Li Zhuowei Liu Kai Yao Zike Qin Hui Han Yonghong Li Pei Dong Yunlin Ye Yanjun Wang Zhiming Wu Zhiling Zhang Fangjian Zhou | 2019 | Cancer Communications2019，39，1： | 2 |
| 16 | Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics显示文摘Effective cancer treatment puts high demands for cancer theranostics.For cancer diagnostics,optical coherence tomography(OCT)technology(including photothermal optical coherence tomography(PT-OCT))has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes(such as temperature change for PT-OCT).In this report,redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent.Briefly,black phosphorus quantum dots(BPQDs)are incorporated into cysteine-based poly-(disulfide amide)(Cys-PDSA)to form stable and biodegradable nanoagent.The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles(NPs)as a novel contrast agent for high-resolution PT-OCT bioimaging.The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo.And the obtained NPs exhibit excellent near-infrared(NIR)photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform,with very low chemo drug dosage and side effects.Both of the polymer and BPQD are degradable,indicating this platform is a rare PT-OCT agent that is completely biodegradable.Overall,our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy. | Haolin Chen Zhiming Liu Bo Wei Jun Huang Xinru You Jingyang Zhang Zhiling Yuan Zhilie Tang Zhouyi Guo Jun Wu | 2021 | Bioactive Materials2021，6，3： | 1 |
| 17 | CmNF-YB8 affects drought resistance in chrysanthemum by altering stomatal status and leaf cuticle thickness显示文摘Drought is a major abiotic stress that limits plant growth and development.Adaptive mechanisms have evolved to mitigate drought stress,including the capacity to adjust water loss rate and to modify the morphology and structure of the epidermis.Here,we show that the expression of CmNF-YB8,encoding a nuclear factor Y(NF-Y)B-type subunit,is lower under drought conditions in chrysanthemum(Chrysanthemum morifolium).Transgenicchrysanthemumlinesinwhich transcript levels of CmNF-YB8 were reduced by RNA interference(CmNF-YB8-RNAi)exhibited enhanced drought resistance relative to control lines,whereas lines overexpressing CmNF-YB8(CmNF-YB8-OX)were less tolerant to drought.Compared to wild type(WT),CmNF-YB8-RNAi plants showed reduced stomatal opening and a thicker epidermal cuticle that correlated with their water loss rate.We also identified genes involved in stomatal adjustment(CBLinteracting protein kinase 6,CmCIPK6)and cuticle biosynthesis(CmSHN3)that are more highly expressed in CmNF-YB8-RNAi lines than in WT,CmCIPK6 being a direct downstream target of CmNF-YB8.Virus-induced gene silencing of CmCIPK6 or CmSHN3 in the CmNFYB8-RNAi background abolished the effects of CmNF-YB8-RNAi on stomatal closure and cuticle deposition,respectively.CmNF-YB8 thus regulates CmCIPK6 and CmSHN3 expression to alter stomatal movement and cuticle thickness in the leaf epidermis,thereby affecting drought resistance. | Tianle Wang Qian Wei Zhiling Wang Wenwen Liu Xin Zhao Chao Ma Junping Gao Yanjie Xu Bo Hong | 2022 | Journal of Integrative Plant Biology2022，64，3： | 1 |
| 18 | Untangling the increasing elevation of cropland in China from 1980 to 2020显示文摘The redistribution of cropland to areas of higher elevation in China has long affected agricultural development and could seriously threaten national food security.However,there is currently little research reported on this phenomenon,which may limit the improvement of cropland protection policies.To fill this gap,we analyzed the spatiotemporal characteristics and driving mechanisms of increased cropland elevation in China during the period 1980-2020.The average cropland elevation in China increased by 17.38 m from 1980 to 2020.The gravity center of the cropland area and average cropland elevation in China moved to the northwest by 81.00 km and 51.47 km,respectively.The amount of newly added cropland in eastern China was less than that in occupied regions;however,the average elevation of newly added cropland was greater than that of occupied cropland,though the opposite phenomenon was observed in western China.Slope,temperature,land-use intensity,population,economic density,and distance to main roads were the main factors affecting the redistribution of cropland to areas of higher elevation.The effects of these major driving factors exhibited significant spatial and temporal variations in China.This study has important implications for improving existing cropland protection policies and developing more effective cropland management systems in China. | Wanxu Chen Liyan Yang Jie Zeng Jintao Yuan Tianci Gu Zhiling Liu | 2023 | Geography and Sustainability2023，4，4： | 1 |
| 19 | The activation and differential signalling of the growth hormone receptor induced by pGH or anti-idiotypic monoclonal antibodies in primary rat hepatocytes显示文摘 | Wei Li Hainan Lan Huimin Liu Zhiling Fu Yanhong Yang Weiwei Han Feng Guo Yu Liu Hui Zhang Jingsheng Liu Xin Zheng | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
| 20 | Nonuniform Bulk Second-order Optical Nonlinearity in PbO/B2O3 Glass显示文摘 | Xu Zhiling Liu Liying Fei Yue | 2000 | Applied Physics Letters2000，77，1： | 1 |
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