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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | The Z-scheme g-C_(3)N_(4)/3DOM-WO_(3) photocatalysts with enhanced activity for CO_(2) photoreduction into CO显示文摘The catalytic performance of light-derived CO_(2)reduction with H_(2)O is strongly dependent on the sepa-ration efficiency of photogenerated carriers.Herein,the direct Z-scheme catalysts(g-C_(3)N_(4)/3DOM-WO_(3))of graphitic carbon nitride(g-C_(3)N_(4))nanosheets decorated three-dimensional ordered macroporous WO_(3)(3DOM-WO_(3))were successfully fabricated by using the in-situ colloidal crystal template method.The slow light effect of 3DOM-WO_(3)photonic crystals expands the absorption of visible light and improves the uti-lization of light energy.The Z-scheme structure of g-C_(3)N_(4)/3DOM-WO_(3)catalysts is able to upgrade the separation efficiency of photogenerated electron-hole pairs.The g-C_(3)N_(4)/3DOM-WO_(3)photocatalyst,whose formation rate of CO product is 48.7μmol g^(−1)h^(−1),exhibits the excellent catalytic activity for CO_(2)reduc-tion.The transfer pathway of stimulated electrons over the g-C_(3)N_(4)/3DOM-WO_(3)photocatalyst is proposed and discussed.The present approach provides unique insights into the rational development of high-performance photochemical systems for efficient CO_(2)reduction into valuable carbon-containing chemicals and energy fuels. | Zhiling Tang Chujun Wang Wenjie He Yuechang Wei Zhen Zhao Jian Liu | 2022 | Chinese Chemical Letters2022，33，2： | 3 |
| 3 | WiFi CSI Gesture Recognition Based on Parallel LSTM-FCN Deep Space-Time Neural Network显示文摘In this study,we developed a system based on deep space–time neural networks for gesture recognition.When users change or the number of gesture categories increases,the accuracy of gesture recognition decreases considerably because most gesture recognition systems cannot accommodate both user differentiation and gesture diversity.To overcome the limitations of existing methods,we designed a onedimensional parallel long short-term memory–fully convolutional network(LSTM–FCN)model to extract gesture features of different dimensions.LSTM can learn complex time dynamic information,whereas FCN can predict gestures efficiently by extracting the deep,abstract features of gestures in the spatial dimension.In the experiment,50 types of gestures of five users were collected and evaluated.The experimental results demonstrate the effectiveness of this system and robustness to various gestures and individual changes.Statistical analysis of the recognition results indicated that an average accuracy of approximately 98.9% was achieved. | Zhiling Tang Qianqian Liu Minjie Wu Wenjing Chen Jingwen Huang | 2021 | China Communications2021，18，3： | 2 |
| 4 | Z-scheme heterojunction of SnS_(2)-decorated 3DOM-SrTiO_(3) for selectively photocatalytic CO_(2) reduction into CH4显示文摘The rapid recombination of photoinduced electron-hole pairs as well as the deficiency of high-energy carriers restricted the redox ability and products selectivity.Herein,the heterojunction of SnS_(2)-deco rated three-dimensional ordered macropores(3DOM)-SrTiO_(3) catalysts were in-situ constructed to provide transmit channel for high-energy electron transmission.The suitable band edges of SnS_(2) and SrTiO_(3) contribute to the Z-scheme transfer of photogenerated carrier.The 3DOM structure of SrTiO_(3)-based catalyst possesses the slow light effect for enhancing light adsorption efficiency,and the surface alkalis strontium is benefit to the boosting adsorption for CO_(2).The in-situ introduced SnS_(2) decorated on the macroporous wall surface of 3DOM-SrTiO_(3) altered the primary product from CO to CH4.The Z-scheme electron transfer from SnS_(2) combining with the holes in SrTiO_(3) occurred under full spectrum photoexcitation,which improved the excitation and utilization of photogene rated electrons for C02 multi-electrons reduction.As a result,(SnS_(2))3/3 DOM-SrTiO_(3) catalyst exhibits higher activity for photocatalytic CO_(2) reduction to CH4 compared with single SnS_(2) or 3 DOM-SrTiO_(3),i.e.,its yield and selectivity of CH4 are 12.5μmol g^(-1) h^(-1) and 74.9%,re spectively.The present work proposed the theoretical foundation of Z-scheme heterojunction construction for enhancing photocatalytic activity and selectivity for CO_(2) conversion. | Wenjie He Xingxing Wu Yifei Li Jing Xiong Zhiling Tang Yuechang Wei Zhen Zhao Xiao Zhang Jian Liu | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 5 | Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics显示文摘Effective cancer treatment puts high demands for cancer theranostics.For cancer diagnostics,optical coherence tomography(OCT)technology(including photothermal optical coherence tomography(PT-OCT))has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes(such as temperature change for PT-OCT).In this report,redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent.Briefly,black phosphorus quantum dots(BPQDs)are incorporated into cysteine-based poly-(disulfide amide)(Cys-PDSA)to form stable and biodegradable nanoagent.The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles(NPs)as a novel contrast agent for high-resolution PT-OCT bioimaging.The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo.And the obtained NPs exhibit excellent near-infrared(NIR)photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform,with very low chemo drug dosage and side effects.Both of the polymer and BPQD are degradable,indicating this platform is a rare PT-OCT agent that is completely biodegradable.Overall,our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy. | Haolin Chen Zhiming Liu Bo Wei Jun Huang Xinru You Jingyang Zhang Zhiling Yuan Zhilie Tang Zhouyi Guo Jun Wu | 2021 | Bioactive Materials2021，6，3： | 1 |
| 6 | In situ spectral imaging of marker proteins in gastric cancer with near-infrared and visible quantum dots probes显示文摘 | Yue He Hao Xu Chuang Chen Jun Peng Hongwu Tang Zhiling Zhang Yan Li Daiwen Pang | 2011 | Talanta2011，，1： | 1 |
| 7 | Variable valence Mo^(5+)/Mo^(6+)ionic bridge in hollow spherical g-C_(3)N_(4)/Bi_(2)MoO_(6) catalysts for promoting selective visible light-driven CO_(2)photoreduction into CO显示文摘Herein,the catalysts of ultrathin g-C_(3)N_(4)surface-modified hollow spherical Bi2MoO6(g-C_(3)N_(4)/Bi2MoO6,abbreviated as CN/BMO)were fabricated by the co-solvothermal method.The variable valence Mo^(5+)/Mo^(6+)ionic bridge in CN/BMO catalysts can boost the rapid transfer of photogenerated electrons from Bi2MoO6to g-C_(3)N_(4).And the synergy effect of g-C_(3)N_(4)and Bi2MoO6components remarkably enhance CO_(2)adsorption capability.CN/BMO-2 catalyst has the best performances for visible light-driven CO_(2)reduction compared with single Bi2MoO6and g-C_(3)N_(4),i.e.,its amount and selectivity of CO product are 139.50μmol g-1and 96.88%for 9 h,respectively.Based on the results of characterizations and density functional theory calculation,the photocatalytic mechanism for CO_(2)reduction is proposed.The high-efficient separation efficiency of photogenerated electron-hole pairs,induced by variable valence Mo^(5+)/Mo^(6+)ionic bridge,can boost the rate-limiting steps(COOH*-to-CO*and CO*desorption)of selective visible light-driven CO_(2)conversion into CO.It inspires the establishment of efficient photocatalysts for CO_(2)conversion. | Wenjie He Yuechang Wei Jing Xiong Zhiling Tang Yingli Wang Xiong Wang Hui Xu Xiao Zhang Xiaolin Yu Zhen Zhao Jian Liu | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 8 | Role of endothelial cells in the regulation of mechanical microenvironment on tumor progression显示文摘Majority of cancer patients die from cancer metastases.The physical stimulation produced by microenvironment regulates invasive behavior of cancer cells.Blood vessel is one of the“pathways”for cancer to metastasize,in which tumor cells need to cross the endothelial barrier for intravasation and extravasation.Tumor vessels are arranged in untraditional hierarchies and characterized with rupture,bend,swell and high permeability that are beneficial to intravasation of cancer cell.Abnormal vessels are accompanied with uneven blood flow,increased compression and interstitial fluid pressure.Meanwhile,excessive proliferation of tumor leads to low oxygen pressure in solid tumor.The aberrant tumor mechanical microenvironment changes the biochemical and mechanical signal transduction of endothelial cells and participates in tumor progression.Many current researches focus on how chemical signals regulate endothelial cell function while the role of physical cues is unclear.In this review,the role of endothelial cells in the regulation of shear stress,intercellular force,extracellular matrix and pressure on tumor progression is summarized. | Changling Wei Mei Tang Zhiling Xu Li Yang Yonggang Lv | 2021 | Acta Mechanica Sinica2021，37，2： | 0 |
| 9 | Seasonal and treatment-process variations in invertebrates in drinking water treatment plants显示文摘Problems associated with excessive propagation and leakage of invertebrates in drinking water have received increasing attention in recent years.We performed a monthly survey of invertebrate abundance and taxa in the effluent of each treatment stage in a drinking water treatment plant between May 2015 and April 2016 and analyzed seasonal and treatment-process variations in invertebrates.The results showed that invertebrate abundances in raw water,effluent of the biological activated carbon(BAC)filter,and finished water significantly correlated with water temperature,whereas no correlation was observed between water temperature and invertebrate abundance in the effluents of the sedimentation tank and sand filter.The dominant taxa in the effluent of each treatment stage were rotifers,nematodes,and crustaceans.The sedimentation tank could efficiently remove invertebrates with an annual average removal rate of 92%.The propagation and leakage of invertebrates occurred in the sand and BAC filters but more seriously in the latter.The average reproduction rate in the BAC filter was 268.8%with rotifers as the taxon that leaked the most.Invertebrate survival and reproduction were also observed in the chlorine-disinfected clean water reservoir with an average reproduction rate of 41.9%.Owing to differences in chlorine resistance,the reproduction ability of the dominant taxa was in the order nematodes>crustaceans>rotifers.The proportion of endogenous invertebrates gradually increased along the treatment process.The average proportion of endogenous invertebrates in the finished water was higher than 79.0%.Our findings suggested that waterworks should pay more attention to endogenous invertebrate growth. | Zhiling Wu Xianchun Tang Hongbin Chen | 2021 | Frontiers of Environmental Science & Engineering2021，15，4： | 0 |
| 10 | Ordered macroporous structured TiO_(2)-based photocatalysts for CO_(2)reduction:A review显示文摘Herein,we review the significant of ordered macroporous(OM)TiO_(2)-based catalysts for boosting pho-tocatalytic CO_(2)reduction.Based on the need to improve the three key factors of photogenerated charge separation eficiency,solar energy utilization and CO_(2)adsorption rate during the conversion of CO_(2)to H_(2)O,we summarized five modification measures:including doping ions into OM TiO_(2),introducing sec-ond semiconductor coupling and noble metal nanoparticles for fabricating multiple Z-scheme heterojunc-tions,constructing hierarchical pore and carbon-loaded OM TiO_(2)materials,which effectively enhance the absorption rate of visible light,the separation rate of electrons-hole pairs and the selection of multiple active sites.The OM structured TiO_(2)-based photocatalysts solve the single or multiple key factors for en-hancing photocatalytic performances during CO_(2)conversion.The catalytic mechanism and pathways of OM structured TiO_(2)-based photocatalysts for CO_(2)reduction are discussed and summarized.It provides new insights on the development of high-efficient catalyst for photocatalytic CO_(2)conversion to solar fu-els. | Yifei Li Yuechang Wei Wenjie He Zhiling Tang Jing Xiong Zhen Zhao | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 11 | The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells显示文摘In this study,we established cell models for Parkinson's disease using rotenone.An RNA interference vector targeting Parkin-associated endothelin receptor-like receptor(Pael-R) was transfected into the model cells.The results of reverse-transcription polymerase chain reaction and western blot analysis showed that Pael-R expression was decreased after RNA interference compared with the control group(no treatment) and the model group(rotenone treatment),while the rate of apoptosis and survival of dopaminergic cells did not differ significantly between groups,as detected by flow cytometry and an MTT assay.These experimental findings indicate that the Pael-R gene has no role in the changes in rotenone-induced Parkinson's disease model cells. | Ting Zou Xiangqi Tang Zhiling Huang Niangui Xu Zhiping Hu | 2014 | Neural Regeneration Research2014，9，4： | 0 |
| 12 | Microbial-driven ectopic uranium extraction with net electrical energy production显示文摘The extraction of uranium (U) from U-bearing wastewater is of paramount importance for mitigating negative environmental impacts and recovering U resources. Microbial reduction of soluble hexavalent uranium (U(VI)) to insoluble tetravalent uranium (U(IV)) holds immense potential for this purpose, but its practical application has been impeded by the challenges associated with managing U-bacterial mixtures and the biotoxicity of U. To address these challenges, we present a novel spontaneous microbial electrochemical (SMEC) method that spatially decoupled the microbial oxidation reaction and the U(VI) reduction reaction. Our results demonstrated stable and efficient U extraction with net electrical energy production, which was achieved with both synthetic and real wastewater. U(VI) removal occurred via diffusion-controlled U(VI)-to-U(IV) reduction-precipitation at the cathode, and the UIVO_(2) deposited on the surface of the cathode contributed to the stability and durability of the abiotic U(VI) reduction. Metagenomic sequencing revealed the formation of efficient electroactive communities on the anodic biofilm and enrichment of the key functional genes and metabolic pathways involved in electron transfer, energy metabolism, the TCA cycle, and acetate metabolism, which indicated the ectopic reduction of U(VI) at the cathode. Our study represents a significant advancement in the cost-effective recovery of U from U(VI)-bearing wastewater and may open a new avenue for sustainable uranium extraction. | Xin Tang Yin Ye Chunlin Wang Bingqian Wang Zemin Qin Cui Li Yanlong Chen Yuheng Wang Zhiling Li Miao Lv Aijie Wang Fan Chen | 2024 | Frontiers of Environmental Science & Engineering2024，18，1： | 0 |
| 13 | Analysis and design of handover in multicell cooperation networks: a field trial显示文摘Cooperative communication networks have been studied and analyzed for many years for enhancing system performance,capacity,and reducing interference with the least focus on handover in cooperative communication scenarios.This paper focuses on trial field testing system for evaluating the proposed handover scheme called slide handover(HO).An automatic power allocation technique is coupled with slide HO scheme and its performance is also evaluated under cooperative networks.Our proposed scheme has achieved 100%successful HO executions in our field trial system.Block error rate(BLER)and slide HO are tested and analyzed in this trial system,and it is shown that the capacity of cooperative networks in these trials implementation has improved and maintained the expected quality of service.BLER below1%is noted at different testing locations which occasionally reached to 10%.Real-time video streaming performance is tested at different trial locations,and uniform streaming performance is noted at all different locations including during the HO process.This implies the improved HO delay of the proposed slide HO as compared to traditional HO techniques. | Xiaofeng Tao Dezhuang Wu Waheed Ur Rehman Yue Yin Zhiling Tang | 2014 | Chinese Science Bulletin2014，59，17： | 0 |
| 14 | The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China显示文摘Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely understood.In this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were investigated.Chemical material industry was the dominant contributor to VOCs of fugitive emission in comparison with other industries.The OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control strategies.Acetaldehyde,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be targeted.Health risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human health.OVOCs were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human health.Our findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources. | Zhiling Liang Yunjiang Yu Bingbing Sun Qian Yao Xihua Lin Yongsheng Wang Jianping Zhang Yingzi Li Xuefeng Wang Zhengzheng Tang Shexia Ma | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 15 | CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease显示文摘Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's disease.FIFO-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy metabolism.However,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea r.Therefore,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of PD.We found that CHCHD2 protected mitochondria from developing MPP^(+)-induced dysfunction.Under normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase assembly.In addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and F1FO-ATPase.Three weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this model.These findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function. | Xiang Chen Yuwan Lin Zhiling Zhang Yuting Tang Panghai Ye Wei Dai Wenlong Zhang Hanqun Liu Guoyou Peng Shuxuan Huang Jiewen Qiu Wenyuan Guo Xiaoqin Zhu Zhuohua Wu Yaoyun Kuang Pingyi Xu Miaomiao Zhou | 2024 | Neural Regeneration Research2024，19，1： | 0 |
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