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| 1 | L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia显示文摘 | Peilon Lu | 2013 | Cell Research2013，23，5： | 23 |
| 2 | High-Performance Solid-State Supercapacitors Fabricated by Pencil Drawing and Polypyrrole Depositing on Paper Substrate显示文摘A solid-state powerful supercapacitor(SC) is fabricated with a substrate of Xerox paper. Its current collector based on a foldable electronic circuit is developed by simply pencil drawing. Thin graphite sheets on paper provide effective channels for electron transmission with a low resistance of 95 X sq-1. The conductive organic material of polypyrrole coated on thin graphite sheets acts as the electrode material of the device. The as-fabricated SC exhibits a high specific capacitance of 52.9 F cm-3at a scan rate of 1 m V s-1. An energy storage unit fabricated by three full-charged series SCs can drive a commercial light-emitting diode robustly. This work demonstrated a simple, versatile and costeffective method for paper-based devices. | Jiayou Tao Wenzhen Ma Nishuang Liu Xiaoliang Ren Yuling Shi Jun Su Yihua Gao | 2015 | Nano-Micro Letters2015，7，3： | 4 |
| 3 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 4 | Connectivity of wireless sensor networks for plant growth in greenhouse显示文摘Wireless sensor networks have been applied in farmland and greenhouse.However,poor connectivity always results in a lot of nodes isolation in the network in a scenario.For this reason,the network connectivity is worth considering to improve its quality,especially when the collected data cannot be sent to the data center because of the obstacles such as the growth of crop plants and weeds.Therefore,how to reduce the effect of crop growth on network connectivity,and enable the reliable transmission of field information,are the key problems to be resolved.To solve these problems,the method which adds long distance routing nodes to the WSN to reduce the deterioration of WSN connectivity during the growth of plants was proposed.To verify this method,the network connectivity of the deployed WSN was represented by the rank of connection matrix based on the graph theory.Consequently,the rank with value of 1 indicates a fully connected network.Moreover,the smaller value of rank means the better connectedness.In addition,the network simulator NS2 simulation results showed that the addition of long-distance backup routing nodes can improve the network connectivity.Furthermore,in experiments,using ZigBee-based wireless sensor network,a remote monitoring system in greenhouse was established,which can obtain environmental information for crops,e.g.temperature,humidity,light intensity and other environmental parameters as well as the wireless link quality especially.Experimental results showed adding of long-distance backup routing nodes can guarantee network connectivity in the region where received signal strength indication(RSSI)was poor,i.e.RSSI value was less than−100 dBm,and the energy was low.In conclusion,this method was essential to improve the connectivity of WSN,and the optimized method still needs further research. | Chen Yang Shi Yuling Wang Zhongyi Huang Lan | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 3 |
| 5 | RNA modifications:importance in immune cell biology and related diseases显示文摘RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years.Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells,including development,differentiation,activation,migration,and polarization,thereby modulating the immune responses and are involved in some immune related diseases.In this review,we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications,including N6-methyladenosine(m^(6)A),5-methylcytosine(m^(5)C),N1-methyladenosine(m1 A),N7-methylguanosine(m^(7)G),N4-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,and adenosine-to-inosine(A-to-I)RNA editing,and summarize their critical roles in immune cell biology.Via regulating the biological processes of immune cells,RNA modifications can participate in the pathogenesis of immune related diseases,such as cancers,infection,inflammatory and autoimmune diseases.We further highlight the challenges and future directions based on the existing knowledge.All in all,this review will provide helpful knowledge as well as novel ideas for the researchers in this area. | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 2 |
| 6 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 7 | Research on the countermeasure for development of container rail-sea intermodal transportation in EastChina region显示文摘 | YE YULING SHI LIMIN | 2010 | Shanghai railway science & technology2010，，5： | 1 |
| 8 | A web-based monitoring system as a measurement tool in greenhouses using wireless sensor networks 显示文摘 | Shi Yuling Wang Zhongyi Liu Xu | 2011 | IFIP Advances in Information and Communication Technology2011，346，3： | 1 |
| 9 | A Note On Multinomialmaximum likelihood estimation under Ordered restriction and the EMalgorithm显示文摘 | Yuling Li Wei Gao and Ning-Zhong Shi | 2007 | Metrika(2007)66:105-1142007，，2007： | 1 |
| 10 | Variable Selection via Generalized SELO-Penalized Cox Regression Models显示文摘The seamless-L_0(SELO) penalty is a smooth function that very closely resembles the L_0 penalty, which has been demonstrated theoretically and practically to be effective in nonconvex penalization for variable selection. In this paper, the authors first generalize the SELO penalty to a class of penalties retaining good features of SELO, and then develop variable selection and parameter estimation in Cox models using the proposed generalized SELO(GSELO) penalized log partial likelihood(PPL) approach. The authors show that the GSELO-PPL procedure possesses the oracle property with a diverging number of predictors under certain mild, interpretable regularity conditions. The entire path of GSELO-PPL estimates can be efficiently computed through a smoothing quasi-Newton(SQN) with continuation algorithm. The authors propose a consistent modified BIC(MBIC) tuning parameter selector for GSELO-PPL, and show that under some regularity conditions, the GSELOPPL-MBIC procedure consistently identifies the true model. Simulation studies and real data analysis are conducted to evaluate the finite sample performance of the proposed method. | SHI Yueyong XU Deyi CAO Yongxiu JIAO Yuling | 2019 | Journal of Systems Science & Complexity2019，32，2： | 1 |
| 11 | AUXIN RESPONSE FACTOR 3 integrates the functions of AGAMOUS and APETALA 2 in floral meristem determinacy显示文摘 | Xigang Liu Thanh Theresa Dinh Dongming Li Bihai Shi Yongpeng Li Xiuwei Cao Lin Guo Yanyun Pan Yuling Jiao Xuemei Chen | 2014 | Plant J2014，，4： | 1 |
| 12 | Recent progress and future perspectives of flexible metal‐air batteries显示文摘With the rapid development of wearable and intelligent flexible electronic devices(FEDs),the demand for flexible energy storage/conversion devices(ESCDs)has also increased.Rechargeable flexible metal‐air batteries(MABs)are expected to be one of the most ideal ESCDs due to their high theoretical energy density,cost advantage,and strong deformation adaptability.With the improvement of the device design,material assemblies,and manufacturing technology,the research on the electrochemical performance of flexible MABs has made significant progress.However,achieving the high mechanical flexibility,high safety,and wearable comfortability required by FEDs while maintaining the high performance of flexible MABs are still a daunting challenge.In this review,flexible Zn‐air and Li‐air batteries are mainly exemplified to describe the most recent progress and challenges of flexible MABs.We start with an overview of the structure and configuration of the flexible MABs and discuss their impact on battery performance and function.Then it focuses on the research progress of flexible metal anodes,gel polymer electrolytes,and air cathodes.Finally,the main challenges and future research perspectives involving flexible MABs for FEDs are proposed. | Tingzhen Li Xinwen Peng Peng Cui Ge Shi Wu Yang Zehong Chen Yongfa Huang Yongkang Chen Jinyuan Peng Ren Zou Xiaoyan Zeng Jian Yu Jianyun Gan Zhiyuan Mu Yuling Chen Jiaming Zeng Juan Liu Yunyi Yang Yujia Wei Jun Lu | 2021 | SmartMat2021，2，4： | 1 |
| 13 | Application of Otopoint Detection to Qualitative Diagnosis of Tumour显示文摘ApplicationofOtopointDetectiontoQualitativeDiagnosisofTumour￥ShiYuling;LiuXun;ZhaoTie;YanXiankai(LaboratoryofWuhanGeneralHosp... | Shi Yuling Liu Xun Zhao Tie Yan Xiankai(Laboratory of Wuhan General Hospital of Guangzhou Military Region 430070) | 1995 | 中国针灸1995，15，S2： | 0 |
| 14 | The Study on the Sports Injuries and Psychological Stress of Chinese Elite Players显示文摘 | Daling Shi Yuling Song Xinjian Luo Aicui Hu Jie Tao | 2014 | International English Education Research2014，，2： | 0 |
| 15 | Long-term follow-up of endoscopic papillectomy and the value of preventive pancreatic stent placement(with videos)显示文摘Background:Early-stage ampullary adenomas have only been reported in a small case series on endoscopic management.Hence,this study aimed to evaluate the long-term outcomes of early ampullary adenoma with endoscopic management and identify the risk factors for acute pancreatitis after endoscopic papillectomy(EP).Methods:In this study,115 patients who underwent EP at Changhai Hospital(Shanghai,China)between January 2012 and December 2018 were retrospectively analysed.Endoscopy was performed at 1,3,6,and 12months after EP.Data were statistically analysed using the t-test or the Mann–Whitney U test.Results:A total of 107 patients were included in this study and the follow-up period was 75643 months.The average age of the 107 patients was 54.6 years and the average tumor size was 17mm.The average age of the patients(53.7610.7 years vs 55.2610.5 years,P=0.482),minimum tumor size(13 vs 19mm,P=0.063),and complete resection rate(84.78%vs 85.25%,P=0.947)did not differ significantly between the stent placement and non-stent placement groups.Post-EP acute pancreatitis rates in the non-stent placement and stent placement groups were 11.48%and 4.35%,respectively.The risk of post-EP acute pancreatitis was significantly associated with the preoperative carcinoembryonic antigen level in univariate analysis,but not in multivariate analysis.The risk of post-EP acute pancreatitis was not significantly associated with the placement of the pancreatic stent in either univariate or multivariate analysis.Moreover,delayed proximal pancreatic duct stenosis was not noted in either group during long-term follow-up.Conclusions:EP is a satisfactory option for treating adenomas of the ampulla of the duodenum. | Yuling Wang Xiaoqing Zhang Zhenhua Yang Teng Wang Dongqing Zhu Jie Gao Ping-Ping Zhang Peiqin Wang Xingang Shi | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 16 | Effect of Ti additions on microstructure and mechanical properties of Cu-Cr-Zr alloy显示文摘Ti additions in Cu–Cr–Zr alloys are useful for achieving high mechanical properties.In this work,the influence of Ti contents(0.25 wt%,0.6 wt%,and 1.02 wt%)on the microstructure,mechanical,and electrical properties of Cu–Cr–Zr alloys has been investigated experimentally,along with thermodynamic and kinetic calculations.The electrical conductivity decreased but the hardness/strength increased with increasing Ti content.The lower electrical conductivity is due to increased electron scattering through the solution of more Ti atoms in the Cu matrix.As for the higher hardness/strength,it is mainly owing to higher dislocation density and finer FCC-Cr precipitates.Furthermore,a model considering the size distributions of precipitates is adopted to calculate precipitation strengthening quantitatively.The calculated yield strengths are consistent with the experimental ones for the alloys.The thermodynamic and kinetic calculations reveal that increasing Ti content can facilitate the nucleation of FCC-Cr but enhance its activation energy,hence hindering the growth process.The present work study can provide an effective strategy for producing copper alloys with expected performance. | Chenying Shi Muzhi Ma Biaobiao Yang Yuling Liu Yushen Huang Yong Du | 2023 | Journal of Materials Science & Technology2023，，32： | 0 |
| 17 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 18 | Generation of pigs with humanized type Ⅱ collagen by precise human COL2A1 gene knock-in显示文摘Osteoarthritis(OA)is the most common chronic disease,characterized by progressive cartilage breakdown,subchondral bone sclerosis,and aberrant bone outgrowth(Yucesoy et al.,2015;Hussain et al.,2016).OA is one of the leading causes of cartilage damage.Patients with severe cartilage damage require transplantation of articular cartilage to improve their quality of life.Type Ⅱ collagen is a major component of articular cartilage and intervertebral discs and plays an important role in the structure and strength of connective tissues that support muscles and joints(Byers,1994). | Ting Lan Yuling Zheng Yangyang Suo Yuhui Wei Hui Shi Quanmei Yan Zhenpeng Zhuang Huangyao Chen Quanjun Zhang Nana Fan Yu Zhao Zhen Ouyang Chengdan Lai Zhaoming Liu Jizeng Zhou Chengcheng Tang Nam-Hyung Kim Qingjian Zou Xiaomin Wang | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 19 | MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin显示文摘Mesoporous silica cocoon materials(MSNCs) and MgO doped mesoporous silica cocoons(MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin(IMC) was selected as a model drug and loaded into carriers. All materials and the drug-loaded samples were characterized by nitrogen adsorption, FTIR spectroscopy, transmission electron microscopy(TEM), powder X-Ray diffraction(XRD) and differential scanning calorimetry(DSC). The effect of the Mg/Si molar ratio on the kinetics and equilibrium of IMC adsorption on MgO-MSNCs was thoroughly examined, and it was found that the increase in the Mg/Si molar ratio resulted in an increasing IMC adsorption rate due to the increased affinity between alkaline MgO-MSNCs and weak acid IMC. The adsorption kinetics fitted a pseudo second-order model well. The Freundlich isotherm showed a better fit, indicating that the coverage of IMC on the surface of MgO-MSNCs was heterogeneous. The maximum adsorption capacity of adsorbent was calculated by the Langmuir isotherm equation. The Temkin equation provided further support that the IMC adsorption on MgO-MSNCs was dominated by a chemisorption process. MgO-MSNCs also have the advantage of allowing an adjustment of the drug release rate of weak acid drug. The cytotoxicity assay indicated good biocompatibility of MgO-MSNCs. Our research on MgO-MSNCs carriers demonstrated their potential therapeutic benefit for safe and effective management of IMC adsorption and in vitro release. | Xin Zheng Shuang Feng Xiudan Wang Zhenning Shi Yuling Mao Qinfu Zhao Siling Wang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 0 |
| 20 | Bone morphogenetic protein-7 induced bone marrow stromal cells differentiate into neuron-like cells显示文摘Bone morphogenetic protein-7 is widely accepted as an inducer for bone marrow stem cells differ-entiating into osteoblasts and chondrocytes. Whether bone marrow stromal cells differentiate into neuron-like cells remains unclear. The current study examined the presence of positive cells for in-termediate filament protein and microtubule associated protein-2 in the cytoplasm of bone marrow stromal cells induced by bone morphogenetic protein-7 under an inverted microscope, while no expression of glial fibrillary acidic protein was found. Reverse transcription PCR electrophoresis also revealed a positive target band for intermediate filament protein and microtubule-associated protein 2 mRNA. These results confirmed that bone morphogenetic protein-7 induces rat bone marrow stromal cells differentiating into neuron-like cells. | Kuanxin Li Yuling Zhang Weishan Wang Bin He Jianhua Sun Jinbo Dong Chenhui Shi | 2011 | Neural Regeneration Research2011，6，22： | 0 |
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