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| 1 | The bHLH Transcription Factor MYC3 Interacts with the Jasmonate ZIM-Domain Proteins to Mediate Jasmonate Response in Arabidopsis显示文摘Arabidopsis Jasmonate ZIM 域蛋白质(JAZ ) 充当复杂的 SCFCOI1 的底层镇压他们的下游地指向,它为调整 JA 的植物开发和防卫是必要的。bHLH 抄写因素 MYC2 被发现 JA 回答包括与 JAZ 交往并且调停 JA 禁止的根生长。这里,我们识别了直接由它的 N 终端区域的优点与 JAZ 交往了调整 JA 回答的另一 bHLH 抄写因素 MYC3。有 MYC3 的 overexpression 的转基因的植物在 JA 禁止的根延伸和幼苗开发展出了超敏性。交往 JAZ 模式和 MYC3 的导致 JA 的表示模式从 MYC2 的那些是可区分的。我们推测那 MYC3, MYC2 可以在 JA 回答的规定有冗余而且可区分的功能。 | Zhiwei Cheng Li Sun Tiancong Qi Bosen Zhang Wen Peng Yule Liu Daoxin Xie | 2011 | Molecular Plant2011，4，2： | 35 |
| 2 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 3 | A Deep Adaptive Learning Method for Rolling Bearing Fault Diagnosis Using Immunity显示文摘The extraction of rolling bearing fault features using traditional diagnostic methods is not sufficiently comprehensive and the features are often chosen subjectively and depend on human experience. In this paper, an improved deep convolutional process is used to extract a set of features adaptively. The hidden multi-layer feature of deep convolutional neural networks is also exploited to improve the extraction features. A deterministic detection of low-confidence samples is performed to ensure the reliability of the recognition results and to decrease the rate of false positives by evaluating the diagnosis of the deep convolutional neural network. To improve the efficiency of the continuous learning elements of the rolling bearing fault diagnosis, a clone learning strategy based on cloning and mutation operations is proposed. The experimental results show that the proposed deep convolutional neural network model can extract multiple rolling bearing fault features, improve classification and detection accuracy by reducing the false positive rate when diagnosing rolling bearing faults, and accelerate learning efficiency when using low-confidence rolling bearing fault samples. | Yuling Tian Xiangyu Liu | 2019 | Tsinghua Science and Technology2019，24，6： | 18 |
| 4 | Role of plant autophagy in stress response显示文摘Autophagy is a conserved pathway for the bulk degradation of cytoplasmic components in all eukaryotes.This process plays a critical role in the adaptation of plants to drastic changing environmental stresses such as starvation,oxidative stress,drought,salt,and pathogen invasion.This paper summarizes the current knowledge about the mechanism and roles of plant autophagy in various plant stress responses. | Shaojie Han Bingjie Yu Yan Wang Yule Liu | 2011 | Protein & Cell2011，2，10： | 15 |
| 5 | An eco-environmental friendly operation: An effective method to mitigate the harmful blooms in the tributary bays of Three Gorges Reservoir显示文摘Harmful algal blooms, which frequently occur in different tributaries, have become a serious water quality problem of the Three Gorges Reservoir (TGR) since its initial filling. A three-year monitoring campaign from 2008 to 2010 was conducted to identify the controlling factors of algal blooms and effective preventive measures. The following results were obtained: 1) Layered and bidirectional currents, called intrusive density currents, dominate the tributary bays of the TGR year round; 2) continuously increasing water level can make the intruding density current shift from the middle to the surface, and surface intrusive water can reduce the surface water temperature and break the stable stratification of the tributary; 3) the appearing or fading away of algal blooms is closely associated with fluctuations in the TGR water level. Thus, the water level fluctuation patterns of different 'tide-types' may prevent the occurrence of algal blooms in the spring and summer, and the 'stair-type' tides may control autumn blooms during the impounding period. These methods were feasible and effective throughout the actual TGR's operation in 2009 2011. These patterns formed an eco-environmentally friendly operation (EEFO) to mitigate algal blooms. As an in situ treatment with easier operation and less negative impact and loss, compared with chemical and filter-feeding fish methods, the EEFO is currently considered as the most feasible remedial measure to remit the eco-environmental problems at the Three Gorges Dam (TGD). | YANG ZhengJian LIU DeFu JI DaoBin XIAO ShangBin HUANG YuLing MA Jun | 2013 | Science China(Technological Sciences)2013，56，6： | 14 |
| 6 | The role of maize root size in phosphorus uptake and productivity of maize/faba bean and maize/wheat intercropping systems显示文摘Interspecific root/rhizosphere interactions affect phosphorus (P) uptake and the productivity of maize/faba bean and maize/wheat intercropping systems. The aim of these experiments was to determine whether manipulation of maize root growth could improve the productivity of the two intercropping systems. Two near isogenic maize hybrids (the larger-rooted T149 and smaller-rooted T222) were intercropped with faba bean and wheat, under conditions of high- and low-P availability. The larger-rooted T149 showed greater competitive ability than the smaller-rooted T222 in both maize/faba bean and maize/wheat intercropping systems. The higher competitive ability of T149 improved the productivity of the maize/faba bean intercropping system in P-sufficient conditions. In maize/wheat intercropping systems, root growth, shoot biomass, and P uptake of maize were inhibited by wheat, regardless of the P-supply. Compared with T222, the larger-rooted T149 suffered less in the intercropping systems. The total biomass of the maize/wheat intercropping system was higher for wheat/T149 than for wheat/T222 under low-P conditions. These data suggested that genetic improvement of maize root size could enhance maize growth and its ability to compete for P resources in maize/faba bean and maize/wheat intercropping systems. In addition, depending on the P availability, larger maize roots could increase the productivity of intercropping systems. | ZHANG YiKai CHEN FanJun LI Long CHEN YanHua LIU BingRan ZHOU YuLing YUAN LiXing ZHANG FuSuo MI GuoHua | 2012 | Science China(Life Sciences)2012，55，11： | 13 |
| 7 | Study on the velocity structure of the crust in Southwest Yunnan of the north-south seismic belt—Results from the Menghai-Gengma-Lushui deep seismic sounding profile显示文摘Southwest Yunnan, located in the southern segment of the north-south seismic belt, is one of the regions with strong tectonic movement and seismic activity in China. Study on the characteristics of tectonic setting and deep geophysical field in the region is an important issue in basic science. In 2013, we conducted a 600-km-long Menghai-Gengma-Lushui profile of deep seismic wide-angle reflection/refraction and high-resolution seismic refraction in Southwest Yunnan. In this paper, we use 6 groups of clear intracrustal P-wave phases picked from the seismic record sections of 11 shots to build a velocity structure model of basement and 2D crustal P-wave of the region by using finite difference inversion and ray travel time forward fitting technology. The results show that, from south to north, the crust gradually thickens along the profile and its basement shows a significant lateral heterogeneity. In the vicinity of the Nanting River fault, the basement structure shows the character of alternate depressions and uplifts, and the shallowest basement is about 1.0 km. In the vicinity of Tengchong and Lancang, the basement is about 5.0 km deep. The velocity of the middle and lower crust in the region generally increases with the increasing of depth. At the block boundary and beneath the fault tectonic belt, the velocity contours show apparent irregularity and the P-wave velocity changes sharply. In this region, the Moho gradually deepens from south to north with relatively large lateral undulations. The shallowest point of the Moho is located near Menghai at a depth of about 32.0 km. The deepest point of the Moho is located near Tengchong at a depth of about 40.5 km. Between Gengma and Yongde, the Moho shows significantly fast uplifting and depressing with an amplitude of about 4.0 km. Beneath the Nanting River fault, Longling-Ruili fault, Dayingjiang fault and Tengchong volcano, the basement velocity structure, 2D crustal P-wave velocity structure, distribution of average profile velocity and intracrustal interface spreading also show significant changes from the basement to the top of the Moho, indicating that the crustal velocity and medium physical properties beneath the fault tectonic belt are apparently different from the crustal materials on its both sides, which suggests that these faults should be in a certain scale and may extend to the lower crust or the top of the upper mantle. The earthquakes in the region mainly occurred at a depth of 10–20 km, and the seismic activity is related to the intracrustal medium velocity difference and fault belt distribution. The results can serve as the important data of the crust-mantle structure for the analysis of the deep tectonic setting, earthquake precise positioning, seismogenic structure modeling of the seismic activities in Southwest Yunnan, as well as the important reference for the evaluation of seismic hazard and the planning of earthquake disaster mitigation of this region. | WANG ShuaiJun LIU BaoJin ZHANG JianShi LIU BaoFeng DUAN YuLing SONG XiangHui DENG XiaoGuo MA CeJun ZANG YiRan | 2015 | Science China Earth Sciences2015，58，12： | 13 |
| 8 | Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma显示文摘Tumor-associated macrophages(TAMs)generally display an immunosuppressive M2 phenotype and promote tumor progression and metastasis,suggesting their potential value as a target in cancer immunotherapy.Chlorogenic acid(CHA)has been identified as a potent immunomodulator that promotes the polarization of TAMs from an M2 to an M1 phenotype.However,rapid clearance in vivo and low tumor accumulation have compromised the immunotherapeutic efficacy of CHA in clinical trials.In this study,mannosylated liposomes are developed for targeted delivery of CHA to TAMs.The immunoregulatory effects of CHA,along with the overall antitumor efficacy of CHA-encapsulated mannosylated liposomes,are investigated through in vitro and in vivo experiments.The prepared CHA-encapsulated mannosylated liposomes exhibit an ideal particle size,favorable stability,and preferential accumulation in tumors via the mannose receptor-mediated TAMs-targeting effects.Further,CHA-encapsulated mannosylated liposomes inhibit G422 glioma tumor growth by efficiently promoting the polarization of the pro-tumorigenic M2 phenotype to the anti-tumorigenic M1 phenotype.Overall,these findings indicate that CHA-encapsulated mannosylated liposomes have great potential to enhance the immunotherapeutic efficacy of CHA by inducing a shift from the M2 to the M1 phenotype. | Jun Ye Yanfang Yang Jing Jin Ming Ji Yue Gao Yu Feng Hongliang Wang Xiaoguang Chen Yuling Liu | 2020 | Bioactive Materials2020，5，3： | 9 |
| 9 | Effect of organic amine alkali and inorganic alkali on benzotriazole removal during post Cu-CMP cleaning显示文摘Benzotriazole(BTA), an anticorrosion agent of slurry, is the main organic pollutant remaining after CMP of multilayer copper wiring, and also the main removal object of post CMP cleaning. The adsorption of BTA onto the copper could form a dense Cu-BTA film, which makes the copper surface strongly passivated. According to this characteristic, quantitative analysis of BTA residue after cleaning is carried out by contact angle measurement and electrochemical measurement in this paper. A scanning electron microscope(SEM) with EDX was used to observe and analyze the BTA shape and elements. The efficiencies of organic alkali and inorganic alkali on the removal of BTA were studied. The corresponding reaction mechanism was also analyzed. The results show that the adsorption structure of Cu(I)-BTA cannot be destroyed in an alkaline environment with a pH less than 10; the effect of BTA removal by inorganic alkali is worse than that of the organic amine alkali with the coordination structure under the same pH environment; the FA/O Ⅱ chelating agent with the fraction of 200 ppm can effectively remove BTA residue on the surface of copper wafer. | Liu Yang Baimei Tan Yuling Liu Baohong Gao Yilin Liu Chunyu Han Qi Wang Siyu Tian | 2018 | Journal of Semiconductors2018，39，12： | 6 |
| 10 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 11 | Differential gene expression analysis of ‘Chili’ (Pyrus bretschneideri) fruit pericarp with two types of bagging treatments显示文摘Preharvest bagging is a simple,grower-friendly and safe physical protection technique commonly applied to many fruits,and the application of different fruit bags can have various effects.To explore the molecular mechanisms underlying the fruit quality effects of different bagging treatments,digital gene expression(DGE)profiling of bagged and unbagged‘Chili’(Pyrus bretschneideri Rehd.)pear pericarp during development was performed.Relative to unbagged fruit,a total of 3022 and 769 differentially expressed genes(DEGs)were detected in the polyethylene(PE)-bagged and non-woven fabric-bagged fruit,respectively.DEGs annotated as photosynthesis-antenna proteins and photosynthesis metabolism pathway were upregulated in non-woven fabric-bagged fruit but downregulated in the PE-bagged fruit.Non-woven fabric bagging inhibited lignin synthesis in‘Chili’pear pericarp by downregulating DEGs involved in phenylpropanoid biosynthesis;consequently,the fruit lenticels in non-woven fabric-bagged fruit were smaller than those in the other treatments.The results indicate that the non-woven fabric bagging method has a positive effect on the appearance of‘Chili’pear fruit but neither of the two bagging treatments is conducive to the accumulation of soluble sugar. | Yuling Wang Xinfu Zhang Ran Wang Yingxin Bai Chenglian Liu Yongbing Yuan Yingjie Yang Shaolan Yang | 2017 | Horticulture Research2017，4，1： | 6 |
| 12 | Graphene oxide as an antimicrobial agent can extenCthe vase life of cut flowers显示文摘"PlantNanOmics" is an emerging topic in agricultural research that explores thepotential effect of application of nanomaterials on plant growth. Graphene oxide(GO) has excellent properties due to its basal carbon plane and oxygen-containingfunctional groups. In the present work, the antimicrobial activity of GO wasexploited to extend the vase life and improve the quality of cut roses (cv. Carola).The results revealed that the cut roses cultivated in low doses of GO (0.1 mg/L)had longer vase life, larger diameter, and better water relations. Microbialcontaminations at the basal stem end is the most common reason for stemblockage that causes water stress and early wilting of cut flowers. GO wasfound to act as a germicide, effectively inhibiting the microbial growth atthe cut stem end and improving water uptake and water balance of cut roses.Therefore, GO can serve as a promising preservative to increase the ornamentalvalue of cut flowers. | Yijia He Lichao Qian Xu Liu Ruirui Hu Meirong Huang Yule Liu Guoqiang Chen Dusan Losic Hongwei Zhu | 2018 | Nano Research2018，11，11： | 6 |
| 13 | Optimization of Grouping Evacuation Strategy in High-rise Building Fires Based on Graph Theory and Computational Experiments显示文摘It is difficult to rescue people from outside, and emergency evacuation is still a main measure to decrease casualties in high-rise building fires. To improve evacuation efficiency, a valid and easily manipulated grouping evacuation strategy is proposed. Occupants escape in groups according to the shortest evacuation route is determined by graph theory. In order to evaluate and find the optimal grouping, computational experiments are performed to design and simulate the evacuation processes. A case study shown the application in detail and quantitative research conclusions is obtained. The thoughts and approaches of this study can be used to guide actual high-rise building evacuation processes in future. | Yuling Hu Xiwei Liu | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，6： | 5 |
| 14 | Distributed Finite-Time Integral Sliding-Mode Control for Multi-Agent Systems with Multiple Disturbances Based on Nonlinear Disturbance Observers显示文摘This paper proposes a finite-time consensus control algorithm based on nonlinear integral sliding-mode control for second-order multi-agent systems(MASs)with mismatched and matched disturbances.Firstly,a nonlinear finite-time disturbance observer is established to estimate the states and mismatched disturbances of the agent.Secondly,a dynamic integral sliding-mode(ISM)surface is designed by employing the estimates of mismatched disturbances.Then,based on the designed ISM and disturbance observer,the discontinuous or continuous campsite control protocols are respectively developed to guarantee the consensus for MASs in finite time with active anti-disturbance control.Finally,numerical simulation results illustrate the effectiveness of the proposed consensus control algorithm. | YANG Yize LIU Fan YANG Hongyong LI Yuling LIU Yuanshan | 2021 | Journal of Systems Science & Complexity2021，34，3： | 4 |
| 15 | High-Performance Solid-State Supercapacitors Fabricated by Pencil Drawing and Polypyrrole Depositing on Paper Substrate显示文摘A solid-state powerful supercapacitor(SC) is fabricated with a substrate of Xerox paper. Its current collector based on a foldable electronic circuit is developed by simply pencil drawing. Thin graphite sheets on paper provide effective channels for electron transmission with a low resistance of 95 X sq-1. The conductive organic material of polypyrrole coated on thin graphite sheets acts as the electrode material of the device. The as-fabricated SC exhibits a high specific capacitance of 52.9 F cm-3at a scan rate of 1 m V s-1. An energy storage unit fabricated by three full-charged series SCs can drive a commercial light-emitting diode robustly. This work demonstrated a simple, versatile and costeffective method for paper-based devices. | Jiayou Tao Wenzhen Ma Nishuang Liu Xiaoliang Ren Yuling Shi Jun Su Yihua Gao | 2015 | Nano-Micro Letters2015，7，3： | 4 |
| 16 | Structural and magnetic properties of Sm_2Fe_(17-x)Nb_x (x = 0-4) alloys prepared by HDDR processes and their nitrides显示文摘Sm2Fe17-xNbxNy (x = 0-4) powder was synthesized by HDDR treatment and nitrogenation. The effects of partial Nb substitution for Fe on the structural and magnetic properties of Sm2Fe17?xNbx alloys and their nitrides were investigated. It was seen that Sm2(Fe,Nb)17 phase exists in both annealed and HDDR-treated Sm2Fe17?xNbx alloys. However, its content is decreased with the increase in Nb substitution. In annealed alloys, Sm2(Fe,Nb)17 phase becomes unstable and will dissociate into SmFe2 and Fe-rich phases when x > 1.5. With HDDR-treatment, the Nb concentration in recombined Sm2(Fe,Nb)17 phase is decreased, and the content of Fe-rich phases is increased. Sm2Fe17?xNbx powder exhibits dendritic cracks and fine particles with a size of less than 300 nm. In nitrogenated alloys, N atoms mainly enter 2:17-type phase to form Sm2(Fe,Nb)17Ny. Partial Nb atoms in Sm2(Fe,Nb)17Ny phase will be released or excluded by nitrogen atoms. Fe-rich phases increase, and are followed by the amorphous Sm2(Fe,Nb)17Ny phase. Nb substitution for Fe with x = 0.5 and 1.0 in Sm2Fe17?xNbxNy powders increases the coercivity and remanence. But when x is greater than 2.0, Nb substitution will dete- riorate the magnetic properties. | SUN Jibing CUI Chunxiang ZHANG Ying LI lin GAO Jianxia LIU Yuling | 2006 | Rare Metals2006，25，2： | 4 |
| 17 | Effect of 1,2,4-triazole on galvanic corrosion between cobalt and copper in CMP based alkaline slurry显示文摘Cobalt has become a new type of barrier material with its unique advantages since the copper-interconnects in the great-large scale integrated circuits(GLSI)into 10 nm and below technical nodes,but cobalt and copper have severe galvanic corrosion during chemical–mechanical flattening.The effect of 1,2,4-triazole on Co/Cu galvanic corrosion in alkaline slurry and the control of rate selectivity of copper and cobalt were investigated in this work.The results of electrochemical experiments and polishing experiments had indicated that a certain concentration of 1,2,4-triazole could form a layer of insoluble and dense passive film on the surface of cobalt and copper,which reduced the corrosion potential difference between cobalt and copper.Meantime,the removal rate of cobalt and copper could be effectively controlled according to demand during the CMP process.When the study optimized slurry was composed of 0.5 wt%colloidal silica,0.1%vol.hydrogen peroxide,0.05 wt%FA/O,345 ppm1,2,4-triazole,cobalt had higher corrosion potential than copper and the galvanic corrosion could be reduced effectively when the corrosion potential difference between them decreased to 1 mV and the galvanic corrosion current density reached 0.02 nMeanwhile,the removal rate of Co was 62.396 nm/min,the removal rate of Cu was 47.328 nm/min,so that the removal rate ratio of cobalt and copper was 1.32:1,which was a good amendment to the dishing pits.The contact potential corrosion of Co/Cu was very weak,which could be better for meeting the requirements of the barrier CMP. | Lei Fu Yuling Liu Chenwei Wang Linan Han | 2018 | Journal of Semiconductors2018，39，4： | 4 |
| 18 | Tm-2^2 Confers Different Resistance Responses against Tobacco mosaic virus Dependent on Its Expression Level显示文摘Dear Editor, The innate immunity system of plants can be summarized into two clades.The former clade,where resistant processes are mediated by pattern recognition receptors,is termed pathogen-associated molecular patterns-triggered immunity and the latter is termed effector-triggered immunity (ETI),where R proteins play crucial roles. | Haili Zhang Jinping Zhao Shanshan Liu Da-Peng Zhang Yule Liu | 2013 | Molecular Plant2013，6，3： | 4 |
| 19 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 20 | Improving in vitro and in vivo corrosion resistance and biocompatibility of Mg-1Zn-1Sn alloys by microalloying with Sr显示文摘Magnesium(Mg)and its alloys have attracted attention as potential biodegradable materials in orthopedics due to their mechanical and physical properties,which are compatible with those of human bone.However,the effect of the mismatch between the rapid material degradation and fracture healing caused by the adverse effect of hydrogen(H2),which is generated during degradation,on surrounding bone tissue has severely restricted the application of Mg and its alloys.Thus,the development of new Mg alloys to achieve ideal degradation rates,H2 evolution and mechanical properties is necessary.Herein,a novel Mg-1Zn-1Sn-xSr(x=0,0.2,0.4,and 0.6 wt%)quaternary alloy was developed,and the microstructure,mechanical properties,corrosion behavior and biocompatibility in vitro/vivo were investigated.The results demonstrated that a minor amount of strontium(Sr)(0.2 wt%)enhanced the corrosion resistance and mechanical properties of Mg-1Zn-1Sn alloy through grain refinement and second phase strengthening.Simultaneously,due to the high hydrogen overpotential of tin(Sn),the H2 release of the alloys was significantly reduced.Furthermore,Sr-containing Mg-1Zn-1Sn-based alloys significantly enhanced the viability,adhesion and spreading of MC3T3-E1 cells in vitro due to their unique biological activity and the ability to spontaneously form a network structure layer with micro/nanotopography.A low corrosion rate and improved biocompatibility were also maintained in a rat subcutaneous implantation model.However,excessive Sr(>0.2 wt%)led to a microgalvanic reaction and accelerated corrosion and H2 evolution.Considering the corrosion resistance,H2 evolution,mechanical properties and biocompatibility in vitro and in vivo,Mg-1Zn-1Sn-0.2Sr alloy has tremendous potential for clinical applications. | Yafeng Wen Qingshan Liu Jingfeng Wang Qiming Yang Weikang Zhao Bo Qiao Yuling Li Dianming Jiang | 2021 | Bioactive Materials2021，6，12： | 3 |
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