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| 1 | L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia显示文摘 | Peilon Lu | 2013 | Cell Research2013，23，5： | 23 |
| 2 | The role of maize root size in phosphorus uptake and productivity of maize/faba bean and maize/wheat intercropping systems显示文摘Interspecific root/rhizosphere interactions affect phosphorus (P) uptake and the productivity of maize/faba bean and maize/wheat intercropping systems. The aim of these experiments was to determine whether manipulation of maize root growth could improve the productivity of the two intercropping systems. Two near isogenic maize hybrids (the larger-rooted T149 and smaller-rooted T222) were intercropped with faba bean and wheat, under conditions of high- and low-P availability. The larger-rooted T149 showed greater competitive ability than the smaller-rooted T222 in both maize/faba bean and maize/wheat intercropping systems. The higher competitive ability of T149 improved the productivity of the maize/faba bean intercropping system in P-sufficient conditions. In maize/wheat intercropping systems, root growth, shoot biomass, and P uptake of maize were inhibited by wheat, regardless of the P-supply. Compared with T222, the larger-rooted T149 suffered less in the intercropping systems. The total biomass of the maize/wheat intercropping system was higher for wheat/T149 than for wheat/T222 under low-P conditions. These data suggested that genetic improvement of maize root size could enhance maize growth and its ability to compete for P resources in maize/faba bean and maize/wheat intercropping systems. In addition, depending on the P availability, larger maize roots could increase the productivity of intercropping systems. | ZHANG YiKai CHEN FanJun LI Long CHEN YanHua LIU BingRan ZHOU YuLing YUAN LiXing ZHANG FuSuo MI GuoHua | 2012 | Science China(Life Sciences)2012，55，11： | 13 |
| 3 | Spatial correlation analysis of sea-bottom backscattering显示文摘The principle of the spatial correlation characteristics of sea-bottom backscattering was expounded.The Kirchhoff model is introduced to simulate sea-bottom backscattering and the spatial correlation is calculated.Some sediment characteristic parameters,such as the ratio of sediment mass density to water mass density,the ratio of sediment sound speed to water sound speed,the attenuation coefficient of sound waves,the strength and exponent of seabottom interface roughness spectrum,are considered while simulating and their influences on spatial correlation are analyzed.By establishing the expressions of the sediment characteristic parameters with the logarithmic sediment grain size,the variation tendency of the spatial correlation versus the logarithmic sediment grain size is obtained.The width of the major lobe of the spatial correlation function narrows as the logarithmic sediment grain size increases.The comparisons between simulated data and in-situ data collected in October 2007 have proven that their spatial correlation function waveforms agree well under the same sediment characteristics. | KUAI Duojie WANG Changhong FENG Lei WANG Yuling QIU Wei YI Huiqin CHEN Long | 2012 | Chinese Journal of Acoustics2012，31，3： | 9 |
| 4 | Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma显示文摘Tumor-associated macrophages(TAMs)generally display an immunosuppressive M2 phenotype and promote tumor progression and metastasis,suggesting their potential value as a target in cancer immunotherapy.Chlorogenic acid(CHA)has been identified as a potent immunomodulator that promotes the polarization of TAMs from an M2 to an M1 phenotype.However,rapid clearance in vivo and low tumor accumulation have compromised the immunotherapeutic efficacy of CHA in clinical trials.In this study,mannosylated liposomes are developed for targeted delivery of CHA to TAMs.The immunoregulatory effects of CHA,along with the overall antitumor efficacy of CHA-encapsulated mannosylated liposomes,are investigated through in vitro and in vivo experiments.The prepared CHA-encapsulated mannosylated liposomes exhibit an ideal particle size,favorable stability,and preferential accumulation in tumors via the mannose receptor-mediated TAMs-targeting effects.Further,CHA-encapsulated mannosylated liposomes inhibit G422 glioma tumor growth by efficiently promoting the polarization of the pro-tumorigenic M2 phenotype to the anti-tumorigenic M1 phenotype.Overall,these findings indicate that CHA-encapsulated mannosylated liposomes have great potential to enhance the immunotherapeutic efficacy of CHA by inducing a shift from the M2 to the M1 phenotype. | Jun Ye Yanfang Yang Jing Jin Ming Ji Yue Gao Yu Feng Hongliang Wang Xiaoguang Chen Yuling Liu | 2020 | Bioactive Materials2020，5，3： | 9 |
| 5 | Graphene oxide as an antimicrobial agent can extenCthe vase life of cut flowers显示文摘"PlantNanOmics" is an emerging topic in agricultural research that explores thepotential effect of application of nanomaterials on plant growth. Graphene oxide(GO) has excellent properties due to its basal carbon plane and oxygen-containingfunctional groups. In the present work, the antimicrobial activity of GO wasexploited to extend the vase life and improve the quality of cut roses (cv. Carola).The results revealed that the cut roses cultivated in low doses of GO (0.1 mg/L)had longer vase life, larger diameter, and better water relations. Microbialcontaminations at the basal stem end is the most common reason for stemblockage that causes water stress and early wilting of cut flowers. GO wasfound to act as a germicide, effectively inhibiting the microbial growth atthe cut stem end and improving water uptake and water balance of cut roses.Therefore, GO can serve as a promising preservative to increase the ornamentalvalue of cut flowers. | Yijia He Lichao Qian Xu Liu Ruirui Hu Meirong Huang Yule Liu Guoqiang Chen Dusan Losic Hongwei Zhu | 2018 | Nano Research2018，11，11： | 6 |
| 6 | Synthesis and characterization of yttrium hydroxide and oxide microtubes显示文摘有六角形的阶段 Y 的六角形的微试管(哦)3 被一个灵巧的 solvothermal 方法成功地经由一条水晶转变线路当表面活化剂或模板不在时为 12 h 在 160 ° C 综合。扫描电子显微镜学(SEM ) 结果证明准备六角形的微试管与 50 100 nm, ∼1 μ m 的一条外部直径,并且长度在十测微计上面去的墙厚度。立方的阶段 Y 2 O 3 微试管在 Y 的热处理以后被获得(哦)3 在为 4 h 的 700 ° C 的微试管。Eu 3+-doped Y 2 有在 610 nm 的强壮的红排放的微试管也是的 O 3 准备了,他们的光致发光(PL ) 性质被学习。为微试管的形成的可能的机制简短被讨论。 | WANG Shijin ZHONG Shengliang WEN Zubiao WANG Yuling WANG Shangping CHEN Jianjun XU Rong LUO Longfei | 2009 | Rare Metals2009，28，5： | 5 |
| 7 | EBV-Induced Human CD8^+ NKT Cells Synergise CD4^+ NKT Cells Suppressing EBV-Associated Tumours upon Induction of Thl-Bias显示文摘 | Wei Xiao Li Li Rui Zhou Ruijing Xiao Yujuan Wang Xiang Ji Mengjun Wu Lan Wang Wei Huang Xiaoling Zheng Xinti Tan Lang Chen Tao Xiong Jie Xiong Youxin Jin Jinquan Tan Yuling He | 2009 | Cellular & Molecular Immunology2009，6，5： | 5 |
| 8 | Solenites (Czekanowskiales) from the Late Mesozoic Jehol Biota of Southeastern Jilin,China and its Paleoclimatic Implications显示文摘Situated at the easternmost area of the Late Mesozoic Jehol Biota, China, abundant fossils, including invertebrates, vertebrates and plants, were collected from the Early Cretaceous Yingzuilazi Formation of the Baishan Basin, southeastern Jilin. The faunal remains from this formation distinctly belong to the Early Cretaceous Lycoptera–Ephemeropsis–Eosestheria assemblage of the Jehol Biota. Based on the gross leaf morphology and epidermal structures, two new species and one indeterminate species of genus Solenites(Czekanowskiales), S. baishanensis sp. nov., S. gracilis sp. nov. and S. sp. are described in this paper. This is the first fossil plant of Czekanowskiales reported from this new fossil locality of the easternmost area of the Late Mesozoic Jehol Biota, China. The new discovery contributes to improve our knowledge for understanding of leaf morphology, epidermal characters and diversity of this genus during the Early Cretaceous time, and extends geologic and geographic distribution of Solenites in northern China and Eurasia. Along with consideration of associated plant and faunal assemblages and sedimentology, we suggest that the regional climate was warm and moderately humid with seasonal temperature and precipitation variations in warm–temperate zone during the Early Cretaceous. | LI Yunfeng SUN Chunlin LI Tao NA Yuling CHEN Yuejun XING Dehe | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 5 |
| 9 | Synthesis and assessment of attractiveness and mating disruption efficacy of sex pheromone microcapsules for the diamondback moth, Plutella xylostella (L.)显示文摘Microcapsules of sex pheromone of the diamondback moth (DBM), Plutella xylostella (Lepidoptera: Plutellidae) were synthesized through complex coacervation using gelatin and gum arabic as wall-forming materials. The encapsulated pheromone released from these microcapsules into the air was monitored over six weeks in the field. Results of a field trial show that the attractiveness of microcapsules was superior to that of rubber septa loaded with the same amount of pheromone. The mating disruption efficiency of the pheromone treatment was estimated through comparing numbers of moths captured in pheromone-baited traps placed in pheromone treatment fields and pesticide treatment fields. The estimated mating disruption efficiency of the pheromone treatments ranged from 76.94% to 98.67% during the season. This study shows that pheromone microcapsules might provide a new method for P. xylostella control. | CHEN ZengLiang FANG YuLing ZHANG ZhongNing | 2007 | Chinese Science Bulletin2007，52，10： | 5 |
| 10 | Decrease in the Ki67 index during neoadjuvant chemotherapy predicts favorable relapse-free survival in patients with locally advanced breast cancer显示文摘Objective: The purpose of this study was to explore the optimal cutoffs of the three parameters of Ki67 during NAC for predicting patient prognosis and investigate whether the optimal cutoffs of the Ki67 values were associated with relapse-free survival(RFS) or breast cancer-specific survival(BCSS).Methods: A total of 92 patients with locally advanced breast cancer(LABC), who had residual disease after NAC were retrospectively investigated.The optimal cutoff values of the Ki67 parameters were assessed by the online algorithm Cutoff Finder.Kaplan-Meier analysis, the log-rank test and Cox regression analysis were carried out to analyze survival.Results: The optimal cutoff values for the postsurgical Ki67 level and the decrease in the Ki67 level during NAC were defined as 25% and 12.5%, respectively.According to the univariate survival analysis, a higher Ki67 level in residual disease was associated with poor RFS(P = 0.004) and BCSS(P = 0.014).In addition, a Ki67 expression decrease > 12.5% during NAC was related to favorable RFS(P = 0.007), but was not related to BCSS(P = 0.452).Cox regression analysis showed that the Ki67 expression decrease(> 12.5% vs.≤ 12.5%) and histological grade(grade 3 vs.grade 1-2) were the independent factors associated with RFS(P =0.020 and P = 0.023, respectively), with HR values of 0.353(95% CI: 0.147-0.850) and 3.422(95% CI: 1.188-9.858), respectively.Conclusions: The Ki67 decrease was one of the independent factors associated with RFS in LABC patients with residual disease after receiving NAC. | Chunfa Chen Yuling Zhang Ziyi Huang Jundong Wu Wenhe Huang Guojun Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 11 | Facile Synthesis of Mo2C Nanocrystals Embedded in Nanopo- rous Carbon Network for Efficient Hydrogen Evolution显示文摘为综合探索灵巧、容易可伸缩的方法地球丰富、划算、有效的氢进化反应(她的) electrocatalysts 作为一个干净、持续的精力搬运人为氢的大量生产是必要的。我们这里报导简单策略生产瞬间 2 在碳网络嵌入的 C nanocrystals (瞬间 2 C@C ) 由铵 molybdate 和 polyvinylpyrrolidone (PVP ) 的直接热分解。PVP 能有效地被用作单身的来源形成碳化物和碳网络,这被发现。有 PVP 的转变金属的长聚合物链和协调能力使形成连接的多孔的碳网络和分散得好的瞬间 2 在几纳米的 C nanocrystals。PVP 的碳化不仅在原处有效地阻止瞬间 2 C nanocrystals 在他们的形成期间,而且提供传导性的多孔的矩阵。作为结果,瞬间 2 C@C 合成展览为她的优异 electrocatalytic 性能,能从很多的小瞬间 2 | Yuyun Chen Yun Zhang Yuling Ma Tang Tang Zhihui Dai Jinsong Hu Lijun Wan | 2017 | Chinese Journal of Chemistry2017，35，6： | 4 |
| 12 | Simultaneous determination of three curcuminoids in Curcuma longa L.by high performance liquid chromatography coupled with electrochemical detection显示文摘A novel method for analysis of three active components curcumin,demethoxycurcumin and bisdemethoxycurcumin in Curcuma longa L.was developed by HPLC coupled with electrochemical detection.Three curcuminoids were well separated on a C_(18) column and detected with high sensitivity.A mobile phase containing acetonilrile and 10 mM Na_2HPO_4-H_3PO_4(pH 5.0)(50:50.v/v) was used.Good linearity was obtained in the range of 0.208-41.6,0.197-39.4,and 0.227-114 μM for curcumin.demethoxycurcumin and bisdemethoxycurcumin respectively.The limit of detection reached up to 10^(-8) M.which was lower than that by UV detection.The relative standard deviations(RSDs) ranged from 1.06% to 1.88% for intra-day precision and from 4.30% to 5.79% for inter-day precision,respectively.The proposed method has been applied in real herb sample and recoveries ranging from 86.3% to 111% were obtained. | Yuling Long Wenpeng Zhang Fang Wang Zilin Chen | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 4 |
| 13 | Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression显示文摘 | Xiaofei Wang Haiping Tang Yuling Chen Binghuan Chi Shiyu Wang Yang Lv Di WU Renshan Ge Haiteng Deng | 2016 | Protein & Cell2016，7，4： | 3 |
| 14 | Experimental investigations on the fluid flow mechanism in porous media of enhanced oil recovery by alkli/surfactant/polymer flooding显示文摘The fluid flow mechanism in porous media of enhanced oil recovery by Alkli/ Surfactant/ Polymer (ASP) flooding is investigated by measuring production performance, pressure distribution and saturation distribution through installing differential pressure transducers and saturation measuring probes in a physical model of vertical heterogeneous reservoir. The fluid flow variation in porous media is the main reason of enhanced oil recovery of ASP flooding. The pressure field and saturation field are nonlinearly coupled together and the interaction between them results in the fluid flow variation in the reservoir. In a vertical heterogeneous reservoir, the ASP agents initially flow in the high permeability layer, and fluid changes the flow direction toward the low and the middle permeability layers because the resistance in the high permeability layer is increased under the physical and chemical action of adsorption, retention and emulsion. ASP flooding displaces out not only the residual oil in the high permeability layer, but also the remaining oil in the low and the middle permeability layers by increasing swept volume and displacing efficiency. | WANG Jialu SHEN Pingping CHEN Yongzhong ZHANG Zubo JIA Xu TIAN Yuling | 2005 | Science China(Technological Sciences)2005，48，4： | 3 |
| 15 | Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold显示文摘Critical oral-maxillofacial bone defects,damaged by trauma and tumors,not only affect the physiological functions and mental health of patients but are also highly challenging to reconstruct.Personalized biomaterials customized by 3D printing technology have the potential to match oralmaxillofacial bone repair and regeneration requirements.Laponite(LAP)nanosilicates have been added to biomaterials to achieve biofunctional modification owing to their excellent biocompatibility and bioactivity.Herein,porous nanosilicate-functionalized polycaprolactone(PCL/LAP)was fabricated by 3D printing technology,and its bioactivities in bone regeneration were investigated in vitro and in vivo.In vitro experiments demonstrated that PCL/LAP exhibited good cytocompatibility and enhanced the viability of bone marrow mesenchymal stem cells(BMSCs).PCL/LAP functioned to stimulate osteogenic differentiation of BMSCs at the mRNA and protein levels and elevated angiogenic gene expression and cytokine secretion.Moreover,BMSCs cultured on PCL/LAP promoted the angiogenesis potential of endothelial cells by angiogenic cytokine secretion.Then,PCL/LAP scaffolds were implanted into the calvarial defect model.Toxicological safety of PCL/LAP was confirmed,and significant enhancement of vascularized bone formation was observed.Taken together,3D-printed PCL/LAP scaffolds with brilliant osteogenesis to enhance bone regeneration could be envisaged as an outstanding bone substitute for a promising change in oral-maxillofacial bone defect reconstruction. | Xiongcheng Xu Long Xiao Yanmei Xu Jin Zhuo Xue Yang Li Li Nianqi Xiao Jing Tao Quan Zhong Yanfen Li Yuling Chen Zhibin Du Kai Luo | 2021 | Regenerative Biomaterials2021，8，6： | 3 |
| 16 | Connectivity of wireless sensor networks for plant growth in greenhouse显示文摘Wireless sensor networks have been applied in farmland and greenhouse.However,poor connectivity always results in a lot of nodes isolation in the network in a scenario.For this reason,the network connectivity is worth considering to improve its quality,especially when the collected data cannot be sent to the data center because of the obstacles such as the growth of crop plants and weeds.Therefore,how to reduce the effect of crop growth on network connectivity,and enable the reliable transmission of field information,are the key problems to be resolved.To solve these problems,the method which adds long distance routing nodes to the WSN to reduce the deterioration of WSN connectivity during the growth of plants was proposed.To verify this method,the network connectivity of the deployed WSN was represented by the rank of connection matrix based on the graph theory.Consequently,the rank with value of 1 indicates a fully connected network.Moreover,the smaller value of rank means the better connectedness.In addition,the network simulator NS2 simulation results showed that the addition of long-distance backup routing nodes can improve the network connectivity.Furthermore,in experiments,using ZigBee-based wireless sensor network,a remote monitoring system in greenhouse was established,which can obtain environmental information for crops,e.g.temperature,humidity,light intensity and other environmental parameters as well as the wireless link quality especially.Experimental results showed adding of long-distance backup routing nodes can guarantee network connectivity in the region where received signal strength indication(RSSI)was poor,i.e.RSSI value was less than−100 dBm,and the energy was low.In conclusion,this method was essential to improve the connectivity of WSN,and the optimized method still needs further research. | Chen Yang Shi Yuling Wang Zhongyi Huang Lan | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 3 |
| 17 | Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration显示文摘Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition.Herein,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo.The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency.Furthermore,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement.It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in vitro.In the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in vivo.Altogether,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment. | Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen Ruichao Cao Zongchao Liu Yuling Li Jie Hao | 2022 | Bioactive Materials2022，7，6： | 2 |
| 18 | Rotavirus VP7 epitope chimeric proteins elicit cross-immunoreactivity in guinea pigs显示文摘VP7 of group A rotavirus(RVA) contains major neutralizing epitopes. Using the antigenic protein VP6 as the vector, chimeric proteins carrying foreign epitopes have been shown to possess good immunoreactivity and immunogenicity. In the present study, using modified VP6 as the vector,three chimeric proteins carrying epitopes derived from VP7 of RVA were constructed. The results showed that the chimeric proteins reacted with anti-VP6 and with SA11 and Wa virus strains.Antibodies from guinea pigs inoculated with the chimeric proteins recognized VP6 and VP7 of RVA and protected mammalian cells from SA11 and Wa infection in vitro. The neutralizing activities of the antibodies against the chimeric proteins were significantly higher than those against the vector protein VP6 F. Thus, development of chimeric vaccines carrying VP7 epitopes using VP6 as a vector could be a promising alternative to enhance immunization against RVAs. | Bingxin Zhao Xiaoxia Pan Yumei Teng Wenyue Xia Jing Wang Yuling Wen Yuanding Chen | 2015 | Virologica Sinica2015，30，5： | 2 |
| 19 | Effects of 2, 4-Dichlorophenoxy Acetic Acid andLight on Growth of Gerbera (Gerbera jamesoniicv. Daxueju) Callus显示文摘This study was conducted to determine effects of 2,4-dichlorophenoxy acetic acid(2,4-D) and light on growth of gerbera(Gerbera jamesonii cv. Daxueju) callus. Callus was induced from both petiole and leaf explants of gerbera on Murashige and Skoog medium supplemented with 3% sucrose and various concentrations of 2,4-D and placed under light and dark. Callus induction percentage, callus size and callus fresh and dry weights were efficiently higher when using petiole as explant. MS medium supplemented with 1.5 mg/L 2,4-D showed the highest callus induction percentage of 96.70%. Callus induced under light had larger weight mass. It was indicated that 1.5 mg/L 2,4-D and light could promote growth of gerbera callus from petiole explant. | Esther Mabafokeng MOHLAKOLA Chunzhen CHENG Yuling LIN Rongfang GUO Kyaw Thu MIN Yukun CHEN Zhongxiong LAI | 2017 | Agricultural Science & Technology2017，18，3： | 2 |
| 20 | RNA modifications:importance in immune cell biology and related diseases显示文摘RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years.Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells,including development,differentiation,activation,migration,and polarization,thereby modulating the immune responses and are involved in some immune related diseases.In this review,we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications,including N6-methyladenosine(m^(6)A),5-methylcytosine(m^(5)C),N1-methyladenosine(m1 A),N7-methylguanosine(m^(7)G),N4-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,and adenosine-to-inosine(A-to-I)RNA editing,and summarize their critical roles in immune cell biology.Via regulating the biological processes of immune cells,RNA modifications can participate in the pathogenesis of immune related diseases,such as cancers,infection,inflammatory and autoimmune diseases.We further highlight the challenges and future directions based on the existing knowledge.All in all,this review will provide helpful knowledge as well as novel ideas for the researchers in this area. | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 2 |
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