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| 1 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 2 | Structural and magnetic properties of Sm_2Fe_(17-x)Nb_x (x = 0-4) alloys prepared by HDDR processes and their nitrides显示文摘Sm2Fe17-xNbxNy (x = 0-4) powder was synthesized by HDDR treatment and nitrogenation. The effects of partial Nb substitution for Fe on the structural and magnetic properties of Sm2Fe17?xNbx alloys and their nitrides were investigated. It was seen that Sm2(Fe,Nb)17 phase exists in both annealed and HDDR-treated Sm2Fe17?xNbx alloys. However, its content is decreased with the increase in Nb substitution. In annealed alloys, Sm2(Fe,Nb)17 phase becomes unstable and will dissociate into SmFe2 and Fe-rich phases when x > 1.5. With HDDR-treatment, the Nb concentration in recombined Sm2(Fe,Nb)17 phase is decreased, and the content of Fe-rich phases is increased. Sm2Fe17?xNbx powder exhibits dendritic cracks and fine particles with a size of less than 300 nm. In nitrogenated alloys, N atoms mainly enter 2:17-type phase to form Sm2(Fe,Nb)17Ny. Partial Nb atoms in Sm2(Fe,Nb)17Ny phase will be released or excluded by nitrogen atoms. Fe-rich phases increase, and are followed by the amorphous Sm2(Fe,Nb)17Ny phase. Nb substitution for Fe with x = 0.5 and 1.0 in Sm2Fe17?xNbxNy powders increases the coercivity and remanence. But when x is greater than 2.0, Nb substitution will dete- riorate the magnetic properties. | SUN Jibing CUI Chunxiang ZHANG Ying LI lin GAO Jianxia LIU Yuling | 2006 | Rare Metals2006，25，2： | 4 |
| 3 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 4 | Effects of 2, 4-Dichlorophenoxy Acetic Acid andLight on Growth of Gerbera (Gerbera jamesoniicv. Daxueju) Callus显示文摘This study was conducted to determine effects of 2,4-dichlorophenoxy acetic acid(2,4-D) and light on growth of gerbera(Gerbera jamesonii cv. Daxueju) callus. Callus was induced from both petiole and leaf explants of gerbera on Murashige and Skoog medium supplemented with 3% sucrose and various concentrations of 2,4-D and placed under light and dark. Callus induction percentage, callus size and callus fresh and dry weights were efficiently higher when using petiole as explant. MS medium supplemented with 1.5 mg/L 2,4-D showed the highest callus induction percentage of 96.70%. Callus induced under light had larger weight mass. It was indicated that 1.5 mg/L 2,4-D and light could promote growth of gerbera callus from petiole explant. | Esther Mabafokeng MOHLAKOLA Chunzhen CHENG Yuling LIN Rongfang GUO Kyaw Thu MIN Yukun CHEN Zhongxiong LAI | 2017 | Agricultural Science & Technology2017，18，3： | 2 |
| 5 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 6 | Effects of Si and its content on the scale formation on hot- rolled steel strips 显示文摘 | YANG Yuling YANG Chenghsien LIN Szuning | 2008 | Materials Chemistry and Physics2008，112，2： | 1 |
| 7 | Incorporation of Lysine-Containing Copolymer with Polyurethane Affording Biomaterial with Specific Adsorption of Plasminogen显示文摘新奇 biomaterial 通过包含离氨酸的共聚物的物理加入基于聚氨酯(PU ) 被准备改进它的 hemocompatibility 和 plasminogen 的表面识别。包含离氨酸的共聚物经由 2-ethylhexyl methacrylate ( EHMA )的 copolymerization 被综合, oligo (乙烯乙二醇)甲基醚 methacrylate ( OEGMA )和 6-tert-butoxycarbonyl amino-2-( 2-methyl-acryloylamino ) -hexanoic 酸tert丁基酉旨( Lys (P)麻省),在共聚物在离氨酸残余上由 COOH 和 -NH2 组的 deprotection 列在后面。共聚物的作文能被改变单体调整喂比率。三个部件贡献分别地与 PU,到 nonspecific 蛋白质吸附的抵抗和 plasminogen 的特定的绑定改进相容性。向 plasminogen 的有约束力的能力在共聚物与离氨酸内容增加了。这条途径与改进 hemocompatibility 和特定的 biomolecules 的表面识别为新奇 biomaterials 的产生说明一个简单方法。 | Haichao Xu Yafei Luan Zhaoqiang Wu Xinming Li Yuling Yuan Xiaoli Liu Lin Yuan Dan Li Hong Chen | 2014 | Chinese Journal of Chemistry2014，32，1： | 1 |
| 8 | Environmental behavior, human health effect, and pollution control of heavy metal(loid)s toward full life cycle processes显示文摘Heavy metal(loid)s(HMs)have caused serious environmental pollution and health risks.Although the past few years have witnessed the achievements of studies on environmental behavior of HMs,the related toxicity mechanisms,and pollution control,their relationship remains a mystery.Researchers generally focused on one topic independently without comprehensive considerations due to the knowledge gap between environmental science and human health.Indeed,the full life cycle control of HMs is crucial and should be reconsidered with the combination of the occurrence,transport,and fate of HMs in the environment.Therefore,we started by reviewing the environmental behaviors of HMs which are affected by a variety of natural factors as well as their physicochemical properties.Furthermore,the related toxicity mechanisms were discussed according to exposure route,toxicity mechanism,and adverse consequences.In addition,the current state-of-the-art of available technologies for pollution control of HMs wastewater and solid wastes were summarized.Finally,based on the research trend,we proposed that advanced in-operando characterizations will help us better understand the fundamental reaction mechanisms,and big data analysis approaches will aid in establishing the prediction model for risk management. | Haoyu Deng Yuling Tu Han Wang Ziyi Wang Yanyu Li Liyuan Chai Wenchao Zhang Zhang Lin | 2022 | Eco-Environment & Health2022，1，4： | 1 |
| 9 | Establishment and application of a fluorescent polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) method for identifying porcine, eaprine, and bovine meats显示文摘 | SUN Yuling LIN C S | 2003 | Journal of Agricultural and Food Chemistry2003，51，7： | 1 |
| 10 | Cloning and Characterization of a Tyrosine Aminotransferase( TAT)Gene in Gerbera hybrida显示文摘In our previous study,a gene predicted to encode a Tyrosine aminotransferase( TAT) was found to be significantly up-regulated in root rot diseased Gerbera by transcriptome sequencing. To confirm the genes and investigate the function,we cloned the gene by RT-PCR and then conduct bioinformatic analyses. In this study,a 1 537 bp long c DNA sequence of this gene( named as Gh TAT) was firstly cloned,which contained a coding region of 1 233 bp,which was predicted to encode a protein of 410 amino acids. Bioinformatic analysis showed that the Gh TAT was a stable hydrophobic protein without signal peptide. Subcellular location prediction result indicated that this protein located in chloroplast,which is the biosynthesis position of tyrosine and the derived products of tyrosine biosynthesis pathway. Moreover,typical Tyrosine aminotransferase domain was found in this protein,indicating that it is a TAT. According to the TAT-based phylogenetic analysis and similarity analysis,the closest relationship and highest similarity was found between Gh TAT and Halianthus annuus TAT,which again verified the TAT property of Gh TAT. Tyrosine aminotransferase( TAT) is the first enzyme in tyrosine biosynthesis pathway,whose products include many antioxidant substances such as tocopherols and tocotrienols. The up-regulation of Gh TAT in root rot diseased gerbera suggests that it may play an important role in response to the root rot pathogen infection. In addition,60 phosphorylation sites( accounting for 14. 6%) were found in this protein,suggesting that the expression of this protein and its encoding gene were greatly influenced by the phosphorylation reactions. | Nigarish MUNIR Min Kyaw THU Muhammad Azher NAWAZ Yuling LIN Chunzhen CHENG Zhongxiong LAI | 2018 | Asian Agricultural Research2018，10，2： | 1 |
| 11 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 12 | Motion adaptive interpolation with horizontal motion detection for de-interlacing显示文摘 | Lin Shyhfeng Chang Yuling Chen Lianggee | 2003 | IEEE J Consumer Electronics2003，49，4： | 1 |
| 13 | Performance and Mechanisms of Fluoride Removal from Groundwater by Lanthanum-aluminum-loaded Hydrothermal Palygorskite Composite显示文摘 | ZHANG Shengyu | 2015 | Chemical Research in Chinese Universities2015，31，1： | 1 |
| 14 | 显示文摘 | Wei Yuling Yang Jing-Chiang Lin Yongyang | 2008 | Marine Pollution Bulletin2008，57，： | 1 |
| 15 | in-situ thermoreversible gelation of block and star copolymers of poly(ethylene glycol) and poly(N-Iisopropylacrylamide) of varying architectures 显示文摘 | Lin Haihui Cheng Yuling | 2001 | Macromolecules2001，34，11： | 1 |
| 16 | Core(Au)-shell(Ag)structure nitrogen dots for the recognition of nitroaniline isomers by surface-enhanced Raman scattering显示文摘In this work, we report a facile synthesis method for NDs-Au@AgNPs surface-enhanced Raman scattering(SERS) substrate using Au seeds prepared by nitrogen-rich quantum dots(NDs). As a new member of quantum-dots family, NDs are rich in nitrogen and oxygen-containing functional groups and therefore can be used as an efficient reducing and stabilizing agent for the synthesis of AuNPs. The NDs-Au@AgNPs with core-shell structures was synthesized by seed-mediated growth method in presence of NDs-AuNPs seeds and exhibited high SERS activity with a high SERS enhancement factor of 10~7. The NDs-Au@AgNPs SERS substrate was effectively used for the recognition and detection of isomers of meta, ortho and para nitroanilines, while commercial SERS substrate cannot. In addition, the possible adsorption behavior was further studied, which is of great significance for the related work about differentiation of isomers and the mechanism of SERS enhancement. | Jiani Yang Ling Xia Zhenhua Lin Zhijiao Tang Gongke Li Yuling Hu | 2019 | Chinese Chemical Letters2019，30，3： | 1 |
| 17 | 1,3-β-glucan Quantification by a Fluorescence Microassay and Analysis of Distribution in Foods显示文摘 | Yuan-Tin Ko Yuling Lin | 2004 | Journal of Agriculture and Food Chemistry2004，52，： | 1 |
| 18 | Effects of Lycium barbarum extract on production and immunomodulatory activity of the extra- cellular polysaccharopeptides from submerged fermentation culture of Coriolus versicolor 显示文摘 | Lin F Yulee Y K Yu H C | 2008 | Food Chem2008，，2： | 1 |
| 19 | 1, 3-β-Glucan quantification by a fluorescence microassay and analysis of its distribution in foods显示文摘 | KO Yuantih LIN Yuling | 2004 | J Agric Food Chem2004，52，11： | 1 |
| 20 | A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging显示文摘Osteosarcoma is the most common primary malignant tumor of bone,particularly among children and adolescents.Advances in imaging,surgical techniques,and implants have dramatically reduced the need for amputation in the past three decades.Recently,in vivo fluorescence imaging in the second near-infrared window(NIR-II,1,000–1,700 nm)shows impressive advantages of deeper tissue penetration and higher spatial resolution,which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma.To the best of our knowledge,this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model. | Jiacheng Lin Qianqian Li Xiaodong Zeng Ziyang Chen Qihang Ding Yang Li Hui Zhou Xianli Meng Deliang Chen Zixin Deng Xuechuan Hong Yuling Xiao | 2020 | Science China Chemistry2020，63，6： | 1 |
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