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| 1 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 6 |
| 2 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 3 | A Novel Approach to the Prevention of Postoperative Delirium in the Elderly After Gastrointestinal Surgery显示文摘 | Ken-ichiro Aizawa Toshio Kanai Yoshiro Saikawa Tsukasa Takabayashi Yukio Kawano Naoto Miyazawa Tetsuya Yamamoto | 2002 | Surgery Today2002，，4： | 2 |
| 4 | High-reliability zircon separation for hunting the oldest material on Earth: An automatic zircon separator with image-processing/microtweezers-manipulating system and double-step dating显示文摘Despite the recent development in radiometric dating of numerous zircons by LA-ICPMS, mineral separation still remains a major obstacle, particularly in the search for the oldest material on Earth. To improve the efficiency in zircon separation by an order of magnitude, we have designed/developed a new machine-an automatic zircon separator(AZS). This is designed particularly for automatic pick-up of100 μm-sized zircon grains out of a heavy mineral fraction after conventional separation procedures. The AZS operates in three modes:(1) image processing to choose targeted individual zircon grains out of all heavy minerals spread on a tray,(2) automatic capturing of the individual zircon grains with microtweezers, and(3) placing them one-by-one in a coordinated alignment on a receiving tray. The automatic capturing was designed/created for continuous mineral selecting without human presence for many hours. This software also enables the registration of each separated zircon grain for dating, by recording digital photo-image, optical(color) indices, and coordinates on a receiving tray. We developed two new approaches for the dating; i.e.(1) direct dating of zircons selected by LA-ICPMS without conventional resin-mounting/polishing,(2) high speed U-Pb dating, combined with conventional sample preparation procedures using the new equipment with multiple-ion counting detectors(LA-MIC-ICPMS).With the first approach, Pb-Pb ages obtained from the surface of a mineral were crosschecked with the interior of the same grain after resin-mounting/polishing. With the second approach, the amount of time required for dating one zircon grain is ca. 20 s, and a sample throughput of >150 grains per hour can be achieved with sufficient precision(ca. 0.5%).We tested the practical efficiency of the AZS, by analyzing an Archean Jack Hills conglomerate in Western Australia with the known oldest(>4.3 Ga) zircon on Earth. Preliminary results are positive; we were able to obtain more than 194 zircons that are over 4.0 Ga out of ca. 3800 checked grains, and 9 grains were over 4300 Ma with the oldest at 4371 ± 7 Ma. This separation system by AZS, combined with the new approaches, guarantees much higher yield in the hunt for old zircons. | Yukio Isozaki Shinji Yamamoto Shuhei Sakata Hideyuki Obayashi Takafumi Hirata Ken-ichi Obori Toshinori Maebayashi Satoshi Takeshima Toshikazu Ebisuzaki Shigenori Maruyama | 2018 | Geoscience Frontiers2018，9，4： | 1 |
| 5 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 6 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 7 | A transparent metal: Nb-doped antatase TiO2显示文摘 | FURUBAYASHI YUTAKA HITOSUGI TARO YAMAMOTO YUKIO | 2005 | ApplPhys Lett2005，86，25： | 1 |
| 8 | Forced Oscillations of a Rotating Shaft with Nonlinear Spring Characteristics and Internal Damping (1/2 Order Subharmonic Oscilla- tions and Entrainment) 显示文摘 | Yukio Ishida Toshio Yamamoto | 1993 | Nonlinear Dynamics1993，4，5： | 1 |
| 9 | Nonlinear forced Oscillations Caused by Quadratic Nonlinearity in a Rotating Shaft System 显示文摘 | Yukio Ishida T Ikeda Toshio Yamamoto | 1990 | Journal of Vibration and Acoustics1990，112，3： | 1 |
| 10 | Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population显示文摘 | Fumihiko Takeuchi Masato Isono Tomohiro Katsuya Ken Yamamoto Mitsuhiro Yokota Takao Sugiyama Toru Nabika Akihiro Fujioka Keizo Ohnaka Hiroyuki Asano Yukio Yamori Shuhei Yamaguchi Shotai Kobayashi Ryoichi Takayanagi Toshio Ogihara Norihiro Kato | 2010 | Circulation2010，，21： | 1 |
| 11 | Current state of domino transplantation in Japan in terms of surgical procedures and de novo amyloid neuropathy显示文摘 | Katsuhiro Asonuma Yuki Ohya Kaori Isono Takayuki Takeichi Hidekazu Yamamoto Kwang-Jong Lee Kenji Okumura Yukio Ando Yukihiro Inomata | 2012 | Amyloid2012，，1： | 1 |
| 12 | Variability in Measuring the Ki-67 Labeling Index in Patients With Breast Cancer显示文摘 | Shinya Yamamoto Takashi Chishima Yuka Mastubara Shouko Adachi Fumi Harada Youko Toda Hitoshi Arioka Naoki Hasegawa Yukio Kakuta Kentaro Sakamaki | 2014 | Clinical Breast Cancer2014，，： | 1 |
| 13 | Bufalin inhibits endothelial cell proliferation and angiogenesis in vitro显示文摘 | Duck Yoon Lee Masako Yasuda Toshinori Yamamoto Takemi Yoshida Yukio Kuroiwa | 1996 | Life Sciences1996，，2： | 1 |
| 14 | Fecal pancreatic elastase: a reproducible marker for severe exocrine pancreatic insufficiency显示文摘 | Satoru Naruse Hiroshi Ishiguro Shigeru B.H. Ko Toshiyuki Yoshikawa Takeshi Yamamoto Akiko Yamamoto Sachiko Futakuchi Hidemi Goto Yukio Saito Susumu Takahashi | 2006 | Journal of Gastroenterology2006，，9： | 1 |
| 15 | Surgical design and outcome of duodenum-preserving pancreatic head resection for benign or low-grade malignant tumors显示文摘 | Akihiko Horiguchi Shuichi Miyakawa Shin Ishihara Masahiro Ito Yukio Asano Koichi Furusawa Tomohiro Shimizu Toshiyuki Yamamoto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，6： | 1 |
| 16 | Accuracy of High-Resolution Magnetic Resonance Imaging in Preoperative Staging of Rectal Cancer显示文摘 | Takayuki Akasu MD Gen Iinuma MD Masashi Takawa MD Seiichiro Yamamoto MD Yukio Muramatsu MD Noriyuki Moriyama MD | 2009 | Annals of Surgical Oncology2009，，10： | 1 |
| 17 | Influence of Helicobacter pylori infection on development of stress-induced gastric mucosal injury显示文摘 | Noriyasu Yamamoto Takashi Sakagami Yoshihiro Fukuda Hiromasa Koizuka Kazutoshi Hori Yukio Sawada Yutaka Hikasa Noritoshi Tanida Takashi Shimoyama | 2000 | Journal of Gastroenterology2000，，5： | 1 |
| 18 | Effects of blue and red light on unrolling of rice leaves显示文摘 | Hideo Sasakawa Yukio Yamamoto | 1980 | Planta1980，，5： | 1 |
| 19 | Functional computed tomography imaging of tumor-induced angiogenesis: preliminary results of new tracer kinetic modeling using a computer discretization approach显示文摘 | Katsuhiko Kaneoya Takuya Ueda Hiroshi Suito Youhei Nanazawa Junichi Tamaru Kouichi Isobe Yukio Naya Toyofusa Tobe Ken Motoori Seiji Yamamoto Geoffrey D. Rubin Manabu Minami Hisao Ito | 2008 | Radiation Medicine2008，，4： | 1 |
| 20 | Radiofrequency Ablation of Liver Tumors in Combination with Local OK-432 Injection Prolongs Survival and Suppresses Distant Tumor Growth in the Rabbit Model with Intra- and Extrahepatic VX2 Tumors显示文摘 | Ken Kageyama Akira Yamamoto Tomohisa Okuma Shinichi Hamamoto Toru Takeshita Yukimasa Sakai Norifumi Nishida Toshiyuki Matsuoka Yukio Miki | 2013 | CardioVascular and Interventional Radiology2013，，5： | 1 |
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