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| 1 | Artificial and bioartificial liver support:A review of perfusion treatment for hepatic failure patients显示文摘Liver transplantation and blood purification therapy,including plasmapheresis,hemodiafiltration,and bioartificial liver support,are the available treatments for patients with severe hepatic failure.Bioartificial liver support,in which living liver tissue is used to support hepatic function,has been anticipated as an effective treatment for hepatic failure.The two mainstream systems developed for bioartificial liver support are extracorporeal whole liver perfusion(ECLP)and bioreactor systems.Comparing various types of bioartificial liver in view of function,safety,and operability,we concluded that the best efficacy can be provided by the ECLP system.Moreover,in our subsequent experiments comparing ECLP and apheresis therapy,ECLP offers more ammonia metabolism than HD and HF.In addition,ECLP can compensate amino acid imbalance and can secret bile.A controversial point with ECLP is the procedure is labor intensive,resulting in high costs.However,ECLP has the potential to reduce elevated serum ammonia levels of hepatic coma patients in a short duration.When these problems are solved,bioartificial liver support,especially ECLP,can be adopted as an option in ordinary clinical therapy to treat patients with hepatic failure. | Katsutoshi Naruse Masatoshi Makuuchi | 2007 | World Journal of Gastroenterology2007，13，10： | 23 |
| 2 | Using sorbents to control heavy metals and particulate matter emission during solid fuel combustion显示文摘Some of the heavy metals in coal and wastes vaporize during combustion, concentrate in fine particulates, and emit with the flue gas into the atmosphere, to produce adverse effect on environment and health. This study first investigates the fate of the heavy metal species, especially Pb, Cd and Cr, known as semi-volatile, in various flue gases, especially in the presence of HCl and SO2, by chemical equilibrium calculation, in which, Si and Ca were proposed as base sorbent materials to capture Pb, Cd and Cr. Then Si-and Ca-based compounds as well as waste materials used as sorbents were optimized to capture the heavy metals. Finally, the optimal sorbent was tested in actual burning of dried sewage sludge as solid fuel, to evaluate the effectiveness of the sorbent. Calculated results show that Cl increases the volatility of most heavy metals, while SO2 enhances formation of condensed phases. Among the sorbents tested, kaolin appears most efficient to capture Pb and Cd. For sludge combustion with kaolin addition, both Pb and Cd were shifted from sub-micron to macro-sized particles, and accompanied by considerable decrease of 0.1 m particles. | Hong Yao Ichiro Naruse | 2009 | Particuology2009，7，6： | 18 |
| 3 | Hepatitis B virus reactivation with a rituximab-containing regimen显示文摘Rituximab is currently used not only in the treatment of B-cell lymphoma but also for various other diseases, including autoimmune diseases, post-transplant graft vs host disease, and rejection following kidney transplants. Due to rituximab's widespread use, great progress has been made regarding research into complications that arise from its use, one of the most serious being the reactivation of hepatitis B virus(HBV), and efforts continue to establish guidelines for preventive treatment against this occurrence. This report discusses preventive measures against rituximab-induced HBV reactivation and future objectives. | Yutaka Tsutsumi Yoshiya Yamamoto Shinichi Ito Hiroyuki Ohigashi Souichi Shiratori Hirohito Naruse Takanori Teshima | 2015 | World Journal of Hepatology2015，7，21： | 5 |
| 4 | Recent progress in tar removal by char and the applications:A comprehensive analysis显示文摘Tar catalytic removal by char is a promising technology for gasification process because of its porous structure,good catalytic activity,low cost,and easy to treatment after deactivation.To provide comprehensive information on the tar catalytic removal by char,this study focuses on the ongoing efforts and advances from fundamental researches to the industrial applications.The tar removal efficiency by char much depends on reaction conditions and char property,such as char origin,porous structure,the functional group on char surface,carbon structure,and AAEM components.The typical reaction kinetics,reaction mechanism,and the deactivation,will be introduced.Then,for the different gasification processes,the potential or typical applications of tar removal by char are discussed and compared.Finally,a comprehensive analysis and improvement in scaling up,commercializing tar removal technologies and integrating the gasification process,are also evaluated and analyzed in this review. | Xi Zeng Yasuaki Ueki Ryo Yoshiie Ichiro Naruse Fang Wang Zhennan Han Guangwen Xu | 2020 | Carbon Resources Conversion2020，3，1： | 5 |
| 5 | The susceptibility of T5-TG12 of theCFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province,China显示文摘Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders.In the present study,we investigated the role of CFTR variations,poly-T,TG-repeats,and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province,China.A total of 72 bronchial asthma patients,68 chronic bronchitis patients,and 117 healthy subjects were included in this study.The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism(RFLP).We found that the frequency of T5-TG12-V470 in chronic bronchitis patients was 0.07%,which was notably higher than that in healthy subjects(0.01%) and bronchial asthma patients(0.04%).Thus,the presence of the T5-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions,such as chronic bronchitis. | Ping Wang Satoru Naruse Hong Yin Zhongfang Yu Tianqu Zhuang Wei Ding Yanmin Wu Muxin Wei | 2012 | The Journal of Biomedical Research2012，26，6： | 4 |
| 6 | PACAP对豚鼠离体胆囊平滑肌的作用显示文摘目的探讨 VIP 族神经肽PACAP 对胆囊运动的影响。方法将豚鼠胆囊制备成1.2mm×10mm 的平滑肌条标本4条,固定在组织浴槽中,并连接等张换能器。以 pH7.4的 Krebs-Ringer缓冲液灌流,温度37℃,并通与95% O_2和5% CO_2。胆囊条对神经肽的效应,用ACh 作标准化处理。结果 VIP 对胆囊条有浓度依赖性的舒张作用;PACAP 则呈现出浓度依赖性收缩反应,PACAP38的作用弱于 PACAP27。结论 PACAP 和 VIP 在对离体胆囊运动的作用方面,呈相反的效应。 | 魏睦新 Satoru Naruse 尾崎毅 轩原清史 安藤英治 Victor Wray | 1996 | 新消化病学杂志1996，4，5： | 3 |
| 7 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal显示文摘 | Kazuichi Okazaki Shigeyuki Kawa Terumi Kamisawa Satoru Naruse Shigeki Tanaka Isao Nishimori Hirotaka Ohara Tetsuhide Ito Seiki Kiriyama Kazuro Inui Tooru Shimosegawa Masaru Koizumi Koichi Suda Keiko Shiratori Koji Yamaguchi Taketo Yamaguchi Masanori Sugiy | 2006 | Journal of Gastroenterology2006，，7： | 3 |
| 8 | High-Density Lipoprotein Cholesterol and Risk of Stroke in Japanese Men and Women: The Oyabe Study显示文摘 | Yoshiyuki Soyama Katsuyuki Miura Yuko Morikawa Muneko Nishijo Yumiko Nakanishi Yuchi Naruse Sadanobu Kagamimori Hideaki Nakagawa | 2003 | Stroke: Journal of the American Heart Association2003，，4： | 2 |
| 9 | Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms显示文摘 | Sakai Kiyoshi Yamamoto Akihito Matsubara Kohki Nakamura Shoko Naruse Mami Yamagata Mari Sakamoto Kazuma Tauchi Ryoji Wakao Norimitsu Imagama Shiro Hibi Hideharu Kadomatsu Kenji Ishiguro Naoki Ueda Minoru | 2012 | Journal of Clinical Investigation2012，，1： | 2 |
| 10 | Role of heme oxygenase carbon monoxide system in genetically hypertensive rats 显示文摘 | Seki T Naruse M Naruse K | 1997 | Biochem Biophys Res Commun1997，241，2： | 2 |
| 11 | 胰管细胞HCO_3^-分泌:囊性纤维化跨膜电导调节体和SLC26转运体(英文)显示文摘胰管细胞以至少6倍浓度差逆向分泌HCO_3^-(人体浓度约140 mmol/L)。HCO_3^-跨顶膜转运的可能机制包括SLC26阴离子转运体的Cl^--HCO_3^-交换和囊性纤维化跨膜电导调节体(cystic fibrosis transmembrane conductance regulator,CFTR)对HCO_3^-的传导扩散。SLC26家族成员介导上皮顶膜Cl^--HCO_3^-交换,胰管中检测到SLC26A6和SLC26A3。共表达研究揭示,鼠类slc26a6和slc26a3通过slc26的STAS结构域与CFTR的R结构域相互作用,导致活性互相增强。研究显示这些交换体是产电的:slc26a6介导ICl^--2HCO_3^-交换,slc26a3介导2Cl^--1HCO_3^-交换。近期slc26a6-/-小鼠离体胰管研究显示,slc26a6介导大部分Cl^-依赖的HCO_3^-跨顶膜分泌,与slc26a6的产电性一致。然而,因为人体能分泌非常高浓度的HCO3^-,SLC26A6在胰管HCO_3^-分泌中的作用并不十分清楚。SLC26A6的作用只能在与人类似能分泌约140 mmol/L HCO_3^-的物种,如豚鼠中研究。现有的豚鼠研究数据显示,像slc26a6介导的ICl^--2HCO_3^-交换不可能完成这种高浓度差的HCO_3^-分泌。另一方面,CFTR的HCO_3^-电导性可以在理论上支持HCO_3^-逆向分泌。所以,在豚鼠和人胰腺HCO_3^-的分泌中,CFTR可能比SLC26A6发挥更大作用。 | ISHIGURO Hiroshi STEWARD Martin NARUSE Satoru | 2007 | 生理学报2007，59，4： | 2 |
| 12 | Molecular cloning and characterization of DMRT genes from the medaka Oryzias latipes and the platyfish Xiphophorus maculatus显示文摘 | Mariko Kondo Alexander Froschauer Akiko Kitano Indrajit Nanda Ute Hornung Jean-Nicolas Volff Shuichi Asakawa Hiroshi Mitani Kiyoshi Naruse Minoru Tanaka Michael Schmid Nobuyoshi Shimizu Manfred Schartl Akihiro Shima | 2002 | Gene2002，，2： | 2 |
| 13 | The revised Japanese clinical diagnostic criteria for chronic pancreatitis显示文摘 | Tooru Shimosegawa Keisho Kataoka Terumi Kamisawa Hiroyuki Miyakawa Hirotaka Ohara Tetsuhide Ito Satoru Naruse Naohiro Sata Koichi Suda Morihisa Hirota Yoshifumi Takeyama Keiko Shiratori Takashi Hatori Makoto Otsuki Yutaka Atomi Kentaro Sugano Masao Tanaka | 2010 | Journal of Gastroenterology2010，，6： | 2 |
| 14 | Possible key residues that determine left gastric artery blood flow response to PACAP in dogs显示文摘AIM:To determine the effect of pituitary adenylate cy-clase-activating polypeptide (PACAP) on left gastric artery (LGA) flow and to unveil the structural or functional important sites that may be critical for discrimination of different receptor subtypes. METHODS: Peptides, including PACAP-27, PACAP-38, amino acid substituted PACAP-27 and C-terminus truncated analogues PACAP (27-38), were synthesized by a simultaneous multiple solid-phase peptide synthesizer. Flow probes of an ultrasound transit-time blood flowmeter were placed around the LGA of beagle dogs. Whenpeptides were infused intravenously, the blood flow was measured.RESULTS: [Ala4, Val5]-PACAP-27 caused a concentration-dependent vasodepressor action which was similar to that caused by PACAP-27. The LGA blood flow response to [Ala4, Val5]-PACAP-27 was significantly higher than that to PACAP-27, which was similar to that to vasoactive intestinal polypeptide (VIP) at the same dose. [Ala6]-PACAP-27 did not increase the peak LGA ? ow. [Gly8]-PACAP-27 showed a similar activity to VIP. [Asn24, Ser25, Ile26]-PACAP-27 did not change the activity of peptides at all doses. CONCLUSION: NH2 terminus is more important to biological activity of peptides and specifi c receptor recognition than COOH-terminus. | Mu-Xin Wei Ping Hu Ping Wang Satoru Naruse Kiyoshi Nokihara Victor Wray Tsuyoshi Ozaki | 2010 | World Journal of Gastroenterology2010，16，38： | 2 |
| 15 | Nationwide epidemiological survey of chronic pancreatitis in Japan显示文摘 | Yingsong Lin Akiko Tamakoshi Seiki Matsuno Kazunori Takeda Tetsuo Hayakawa Motoji Kitagawa Satoru Naruse Takashi Kawamura Kenji Wakai Rie Aoki Masayo Kojima Yoshiyuki Ohno | 2000 | Journal of Gastroenterology2000，，2： | 2 |
| 16 | Homeostasis model assessment of insulin resistance and the risk of cardiovascular events in middle-aged non-diabetic Japanese men显示文摘 | K. Nakamura M. Sakurai K. Miura Y. Morikawa M. Ishizaki K. Yoshita T. Kido Y. Naruse H. Nakagawa | 2010 | Diabetologia2010，，9： | 2 |
| 17 | Early Repolarization Is an Independent Predictor of Occurrences of Ventricular Fibrillation in the Very Early Phase of Acute Myocardial Infarction显示文摘 | Yoshihisa Naruse Hiroshi Tada Yoshie Harimura Mayu Hayashi Yuichi Noguchi Akira Sato Kentaro Yoshida Yukio Sekiguchi Kazutaka Aonuma | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，3： | 2 |
| 18 | Transcatheter arterial embolization for the treatment of liver metastases in a patient with malignant pheochromoeytoma显示文摘 | Watanabe D Tanabe A Naruse M el al | 2006 | Endocr J2006，53，： | 1 |
| 19 | Aldosterone breakthrough during angiotensin Ⅱ receptor antagonist therapy in stroke-prone spontaneously hypertensive rats 显示文摘 | Naruse M Tanabe A Sato A | 2002 | Hypertension2002，40，1： | 1 |
| 20 | Discrimination between different types of white matter edema with diffusionweighted MR imaging 显示文摘 | Naruse S Horikawa Y | 1993 | J Magn Reson Imaging1993，3，： | 1 |
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