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| 1 | Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy,and tumor-targeting S.typhimurium A1-R is superior to first-line chemotherapy显示文摘Cancer of unknown primary(CUP)is a recalcitrant disease with poor prognosis because it lacks standard first-line therapy.CUP consists of diverse malignancy groups,making personalized precision therapy essential.The present study aimed to identify an effective therapy for a CUP patient using a patient-derived orthotopic xenograft(PDOX)model.This paper reports the usefulness of the PDOX model to precisely identify effective and ineffective chemotherapy and to compare the efficacy of S.typhimurium A1-R with first-line chemotherapy using the CUP PDOX model.The present study is the first to use a CUP PDOX model,which was able to precisely distinguish the chemotherapeutic course.We found that a carboplatinum(CAR)-based regimen was effective for this CUP patient.We also demonstrated that S.typhimurium A1-R was more effective against the CUP tumor than first-line chemotherapy.Our results indicate that S.typhimurium A1-R has clinical potential for CUP,a resistant disease that requires effective therapy. | Kentaro Miyake Tasuku Kiyuna Masuyo Miyake Kei Kawaguchi Sang Nam Yoon Zhiying Zhang Kentaro Igarashi Sahar Razmjooei Sintawat Wangsiricharoen Takashi Murakami Yunfeng Li Scott D.Nelson Tara A.Russell Arun S.Singh Yukihiko Hiroshima Masashi Momiyama Ryusei Matsuyama Takashi Chishima Shree Ram Singh Itaru Endo Fritz C.Eilber Robert M.Hoffman | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 2 | increased expression of cyclooxygenase-2 in local lesions of endometriosis patients显示文摘 | Chishima F hayakawa S Sugita K | 2002 | Am J Repro Immunol2002，48，： | 1 |
| 3 | Shape memory effect in gamma reversible reaction epsilon transformation in Fe-30Mn-1Si alloy single crystals显示文摘 | Sato A Chishima E Soma K | 1982 | Acta Metallurgica1982，30，6： | 1 |
| 4 | Increased expression of cyclooxygenase -2 in local lesions of endometriosis patients显示文摘 | Chishima F Hayakawa S Sugita K | 2002 | Am J Reprod Immunol2002，48，1： | 1 |
| 5 | Orientation and composition dependencies of shape memory effect in Fe-Mn-Si alloys显示文摘 | SATO A CHISHIMA E YAMAJI Y | 1984 | Acta Metall1984，23，： | 1 |
| 6 | Ovarian Burkitt′s lymphoma diagnosed by a combination of clinical fea-tures,morphology,immunophenotype,and molecular fin-dings and successfully managed with surgery and chemo-therapy显示文摘 | Chishima F Hayakawa S Ohta Y | 2006 | Int J Gynecol Cancer2006，，161： | 1 |
| 7 | Increased expression of cyclooxygenase 22 in local lesionsof endometriosis patients显示文摘 | Chishima F Hayakawa S Sugita K | 2002 | Am J Reprod Immunol2002，48，1： | 1 |
| 8 | Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression显示文摘 | Chishima T Miyagi Y Wang X | 1997 | Cancer Res1997，57，10： | 1 |
| 9 | increased in local lesions of endometriosis patients 显示文摘 | Chishima F hayakawa S Sugita K expression of cyclooxygenase-2 | 2002 | Am J Repro Immunol2002，48，： | 1 |
| 10 | Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients显示文摘 | Chishima F Hayakawa S Sugita K | 2002 | Am J Reprod Immunol2002，48，1： | 1 |
| 11 | Increased expression of cyclooxygenase22 in local lesionsof endometriosis patients显示文摘 | Chishima F Hayakawa S Sugita K | 2002 | Am J Reprod Immunol2002，2，2： | 1 |
| 12 | Expression of inducible microsomal prostaglandin E synthase in local le- sions of endometriosis patients 显示文摘 | Chishima F Hayakawa S Yamamoto T | 2007 | Am J Reprod Immu- nol2007，57，： | 1 |
| 13 | Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression显示文摘 | Chishima T Miyagi Y Wang X | 1997 | Cancer Res1997，57，10： | 1 |
| 14 | Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression显示文摘 | Chishima T Miyagi Y Wang X | 1997 | Cancer Res1997，57，10： | 1 |
| 15 | The effect of IgG (AT1-AA) from preeclampsia sera on the production of sEng and various kinds of eytokines from human primary trophoblast cells显示文摘 | Koabayshi Y Yamamoto T Chishima F | 2015 | Pregnancy Hyper- tens2015，5，1： | 1 |
| 16 | Governing step of metastasis visualized in vitro 显示文摘 | Chishima T Yang M Miyagi Y | 1997 | Proc Natl Acad Sci USA1997，94，11： | 1 |
| 17 | Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression显示文摘 | Chishima T Miyagi Y Wang X E | 1997 | Cancer Res1997，57，： | 1 |
| 18 | Increase expression of cyclooxygenase-2 in local lesions of endometriosis patients显示文摘 | CHISHIMA F HAYAKAWA S SUGITA K | 2002 | Rep Immunology2002，48，： | 1 |
| 19 | Ovarian Burkitt's lymphoma diagnosed by a combination of clinical features,morphology, immunophenotype, and molecular findings and successfully managed with surgery and chemotherapy 显示文摘 | Chishima F Hayakawa S Ohta Y | 2006 | Int J Gynecol Cancer2006，161，： | 1 |
| 20 | Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients显示文摘 | Chishima F Hayakawa S Sugita K | 2002 | Am 1 Reprod Immunol2002，48，1： | 1 |
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