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| 1 | Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2显示文摘Medical treatment has progressed significantly over the past decade towards achieving and maintaining clinical remission in patients with refractory ulcerative colitis(UC). Proposed mediators of inflammation in UC include pro-inflammatory cytokines such as tumor necrosis factor-α(TNF-α) and interleukin-2, and the cellsurface adhesive molecule integrin α4β7. Conventional therapeutics for active UC include 5-aminosalicylic acid, corticosteroids and purine analogues(azathioprine and 6-mercaptopurine). Patients who fail to respond to conventional therapy are treated with agents such as the calicineurin inhibitors cyclosporine and tacrolimus, the TNF-α inhibitors infliximab or adalimumab, or a neutralizing antibody(vedolizumab) directed against integrin α4β7. These therapeutic agents are of benefit for patients with refractory UC, but are not universally effective. Our recent research on TNF-α shedding demonstrated that inhibition of annexin(ANX) A2 may be a new therapeutic strategy for the prevention of TNF-α shedding during inflammatory bowel disease(IBD) inflammation. In this review, we provide an overview of therapeutic treatments that are effective and currently available for UC patients, as well as some that are likely to be available in the near future. We also propose the potential of ANX A2 as a new molecular target for IBD treatment. | Satoshi Tanida Tsutomu Mizoshita Keiji Ozeki Takahito Katano Hiromi Kataoka Takeshi Kamiya Takashi Joh | 2015 | World Journal of Gastroenterology2015，21，29： | 4 |
| 2 | Incomplete transformations of Pb to pyromorphite by phosphate-induced immobilization investigated by X-ray absorption fine structure (XAFS) spectroscopy显示文摘 | Yohey Hashimoto Masaki Takaoka Kazuyuki Oshita Hajime Tanida | 2009 | Chemosphere2009，，5： | 2 |
| 3 | Diagnostic utility of small-caliber and conventional endoscopes for gastric cancer and analysis of endoscopic false-negative gastric cancers显示文摘AIM: To analyze the diagnostic utility of a small-caliber endoscope(SC-E) and clinicopathological features of false-negative gastric cancers(FN-GCs). METHODS: A total of 21638 esophagogastroduodenoscopy(EGD) gastric cancer(GC) screening examinations were analyzed. Secondary endoscopic examinations(n = 3352) were excluded because most secondary examinations tended to be included in the conventional endoscopy(C-E) group. Detection rates of GCs and FN-GCs were compared between SC-E and C-E groups. FN-GC was defined as GC performed with EGD within the past 3 years without GC detection. Macroscopic types, histopathological characteristics and locations of FN-GCs were compared with firstly foundgastric cancers(FF-GCs) in detail. RESULTS: SC-E cases(n = 6657) and C-E cases(n = 11644), a total of 18301 cases, were analyzed. GCs were detected in 16(0.24%) SC-E cases and 40 C-E(0.34%) cases(P = 0.23) and there were 4 FN-GCs(0.06%) in SC-E and 13(0.11%) in C-E(P = 0.27), with no significant difference. FN-GCs/GCs ratio between SC-E and C-E groups was not significantly different(P = 0.75). The comparison of endoscopic macroscopic types of FN-GCs tended to be a less advanced type(P = 0.02). Histopathologically, 70.6% of FN-GCs were differentiated and 29.4% undifferentiated type. On the other hand, 43.0% of FF-GCs were differentiated and 53.8% undifferentiated type, so FN-GCs tended to be more differentiated type(P = 0.048). CONCLUSION: The diagnostic utility of SC-E for the detection of GCs and FN-GCs was not inferior to that of C-E. Careful observation for superficially depressed type lesions in the upper lesser curvature region is needed to decrease FN-GCs. | Hiromi Kataoka Kiyoshi Mizuno Noriyuki Hayashi Mamoru Tanaka Hirotaka Nishiwaki Masahide Ebi Tsutomu Mizoshita Yoshinori Mori Eiji Kubota Satoshi Tanida Takeshi Kamiya Takashi Joh | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 2 |
| 4 | LC3 conjugation system in mammalian autophagy显示文摘 | Isei Tanida Takashi Ueno Eiki Kominami | 2004 | International Journal of Biochemistry and Cell Biology2004，，12： | 2 |
| 5 | Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats显示文摘 | Tanida M Yamatodani A Akira Niijima | 2007 | Neuroscience Letters2007，413，： | 1 |
| 6 | A complicated case of tacrolimus- induced rapid remission after cesarean section in the early third trimester for refi:actory severe ulcerative colitis flaring in the initial period of gestation 显示文摘 | Mizushima T Tanida S Mizoshita T | 2011 | Case Rep Gastroenterol2011，5，1： | 1 |
| 7 | CA 125/MUC 16 interacts with Src family kinases,and over-expression of its C-terminal fragment in human epithelial cancer ceils reduces cell-cell adhesion显示文摘 | Akita K Tanaka M Tanida S | 2013 | Eur J Cell Biol2013，92，89： | 1 |
| 8 | Fluorescence resonance energy transfer-based molecular logic circuit using a DNA scaffold显示文摘 | Nishimura T Ogura Y Tanida J | | 0，，23： | 1 |
| 9 | Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy显示文摘 | Tanida I Minematsu IN Ueno T | 2005 | Autophagy2005，1，2： | 1 |
| 10 | TAN-999 and TAN -1 030A, new indolocarbazo1e alkaloids with macrophage-activating properties显示文摘 | Tanida S Takizawa M Takahashi T | 1989 | J Antibiot1989，42，11： | 1 |
| 11 | Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis显示文摘 | Murata K Yoshitomi H Tanida S | | 0，，： | 1 |
| 12 | Calculation of iron loss in rotating machines by direct consideration of eddy currents in electrical steel sheets 显示文摘 | YAMAZAKI K TANIDA M SATOMI H | 2011 | Electrical Engineering in Japan2011，176，3： | 1 |
| 13 | LC3 conjugation system in mammalian autophagy显示文摘 | Tanida I Ueno T Kominami E | 2004 | Int J Biochem Cell Biol2004，36，12： | 1 |
| 14 | IL 8 promot, es cell proliferation and migration through metalloproteinase cleavageproHB-EgFinhumancoloncarcinomacells显示文摘 | Itoh Y Joh T Tanida S | 2005 | Cytokine2005，29，： | 1 |
| 15 | A lysosomal proteinase,the late-infantile neuronal ceroid lipofuscinosis gene (CLN2)product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase显示文摘 | EZAKI J TANIDA L KANEHAGI N | 1999 | J Neurochem1999，72，： | 1 |
| 16 | Recombinant adenovirus expression wild-type p53 is antiangiogenic:a proposed mechanism for bystander effect显示文摘 | Nishizaki M Fujiwara T Tanida T | 1999 | Clin Cancer Res1999，5，5： | 1 |
| 17 | Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteo- arthritis显示文摘 | Murata K Yoshitomi H Tanida S | 2010 | Arthritis Res Ther2010，12，： | 1 |
| 18 | Leptin injection into white adipose tissue elevates renal sympathetic nerve activity dose-dependently through the afferent nerves pathway in rats显示文摘 | Tanida M Iwashida S Ootsuka Y | 2000 | Neurosci Lett2000，293，： | 1 |
| 19 | Helicobacter pyloriand gastriccancer 显示文摘 | Tanida N Sakagami T Nakamura Y | 1996 | Nih Geka Gakkai Zasshi1996，97，4： | 1 |
| 20 | HsAtg4B/HsApg4B/antophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-assoeiated protein light chain3 and GABAA receptor-associated protein-phosphalipid conjugates 显示文摘 | Tanida I Sou YS Ezaki J | 2004 | J Biol Chem2004，279，36： | 1 |
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