|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 2 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 3 | Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis显示文摘AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis. | Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 4 | Plasma Brain Natriuretic Peptide Levels Increase in Proportion to the Extent of Right Ventricular Dysfunction in Pulmonary Hypertension显示文摘 | Noritoshi Nagaya Toshio Nishikimi Yoshiaki Okano Masaaki Uematsu Toru Satoh Shingo Kyotani Sachio Kuribayashi Seiki Hamada Mikio Kakishita Norifumi Nakanishi Makoto Takamiya Takeyoshi Kunieda Hisayuki Matsuo Kenji Kangawa | 1998 | Journal of the American College of Cardiology1998，，1： | 2 |
| 5 | Contrast-enhanced sonography of pancreatic carcinoma: correlations with pathological findings显示文摘 | Kazushi Numata Yutaka Ozawa Noritoshi Kobayashi Toru Kubota Hiroshi Shimada Akinori Nozawa Yukio Nakatani Kazuya Sugimori Kenichi Matsuo Toshio Imada Katsuaki Tanaka | 2005 | Journal of Gastroenterology2005，，6： | 2 |
| 6 | Undifferentiated spindle-cell carcinoma of the gallbladder: an immunohistochemical study显示文摘 | Kensuke Kubota Yukio Kakuta Shunji Kawamura Yasunobu Abe Masahiko Inamori Harunobu Kawamura Hiroyuki Kirikoshi Noritoshi Kobayashi Satoru Saito Atushi Nakajima | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，5： | 2 |
| 7 | The growth factor midkine regulates the renin-angiotensin system in mice显示文摘 | Hobo Akinori Yuzawa Yukio Kosugi Tomoki Kato Noritoshi Asai Naoto Sato Waichi Maruyama Shoichi Ito Yasuhiko Kobori Hiroyuki Ikematsu Shinya Nishiyama Akira Matsuo Seiichi Kadomatsu Kenji | 2009 | Journal of Clinical Investigation2009，，6： | 2 |
| 8 | Hybrid cell - gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells 显示文摘 | Noritoshi N Kenji K Munetake K | 2003 | Circulation2003，108，10： | 1 |
| 9 | Hemodynamic , Renal, and Hormonal Effects of Adrenomedullin Infusion in Patients with Congestive Heart Failure显示文摘 | MD Tora Satoh MD Toshio Nishikimi MD | 2000 | Circulation2000，101，： | 1 |
| 10 | Factors affecting both the numbers of the pinewood nematode,Bursaphelenchus xylophilus(Nematoda:Aphelenchoididae),carried by the Japanese pine sawyer,Monochamus alternatus(Coleoptera:Cerambycidae) and the nematode's life history显示文摘 | Noritoshi Maehara Kazuyoshi Futai | 1996 | Appl Entomol Zool1996，31，3： | 1 |
| 11 | Factors affecting the numbers of Bursaphelenchus xylophilus(Nematoda:Aphelenchoididae) carried by several species of beetles显示文摘 | Noritoshi Maehara Kazuyoshi Futai | 2002 | Nematology2002，4，5： | 1 |
| 12 | Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy显示文摘 | Noritoshi N Kenji K Takefumi I | 2005 | American Heart Association2005，112，8： | 1 |
| 13 | Applicability of recycling materials to cavity filling materials 显示文摘 | SAKAMOTO AKIO YAMADA NORITOSHI IWAKI KEISUKE | 2005 | Journal of the Society of Materials Science2005，54，11： | 1 |
| 14 | Serum uric acid levels correlate with the severity and the mortality of primary pulmonary hypertension显示文摘 | Noritoshi N Masaki K Toru S | 1999 | Am J Respir and Crit Care Med1999，160，2： | 1 |
| 15 | Treatment of domestic wastewater mixed with crushed garbage and garbage washing water by advanced gappei -shori johkaso显示文摘 | Sankai Toshihiro Ding Guoji Emori Noritoshi | 1997 | Wat Sci Tech1997，36，12： | 1 |
| 16 | Development of strong wind warning system显示文摘 | Makoto S Noritoshi K | 2003 | Japan Railway Engineering2003，43，1： | 1 |
| 17 | Isolation and characterization of a thermophilic bacterium, Geobacillus thermocatenulatus, degrading nylon 12 and nylon 66 显示文摘 | Tomita Kosuke Ikeda Noritoshi Ayumi Ueno | 2003 | Biotechnology Letters2003，25，： | 1 |
| 18 | EDM of micro-rods by self-drilled holes显示文摘 | Minoru Yamazaki Takemi Suzuki Noritoshi Mori Masanori Kunieda | 2004 | Journal of Materials Processing Technology2004，149，13： | 1 |
| 19 | Study of a strong wind warning system显示文摘 | Noritoshi K Makoto S | 2003 | JR EAST Technical Review2003，，2： | 1 |
| 20 | SJES14121200095083显示文摘 | Sonia A. Melo Hikaru Sugimoto Joyce T. O’Connell Noritoshi Kato Alberto Villanueva August Vidal Le Qiu Edward Vitkin Lev T. Perelman Carlos A. Melo Anthony Lucci Cristina Ivan George A. Calin Raghu Kalluri | 2014 | Cancer Cell2014，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员