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| 1 | Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy显示文摘AIM To compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor(PPI)-based therapies to treat Helicobacter pylori(H. pylori).METHODS We retrospectively analysed data from first-line(vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d)(n = 1353) and second-line(vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d)(n = 261) eradication treatments for H. pylori- positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at Hattori Clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related factors.RESULTS After the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9%(95%CI: 84.9%-90.5%), 71.6%(95%CI: 67.5%-75.5%), 62.9%(95%CI: 52.0%-72.9%), and 57.3%(95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs(P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group(P = 0.34), whereas it decreased the rates in the PPI groups(P = 0.013). The incidence of adverse events in the vonop-razan group was not different from the PPI group(P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based therapy.CONCLUSION Vonoprazan might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events. | Kouichi Sakurai Hiroko Suda Yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro Hattori | 2017 | World Journal of Gastroenterology2017，23，4： | 16 |
| 2 | Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts显示文摘以前的研究显示了那脂肪的多糖(LPS ) 在匾的 fromGram 否定的细菌导致前列腺素 E_2 (PGE_2 ) 的版本,它在吸烟的 periodontitis,和那棵烟草支持牙槽的骨头再吞可能是为 periodontitis 的发展和严厉的一个重要风险因素。我们在碱性磷酸酶(ALPase ) 上决定了烟碱 andLPS 的效果活动, PGE_2 生产,和表示 ofcyclooxygenase (COX-1, COX-2 ) , PGE_2 受体 Ep1-4,和在人的 osteoblastic Saos-2 房间的巨噬细胞殖民地刺激因素(M-CSF ) 。房间与 10 ~ 是有教养的(-3) M 烟碱面对 0, 1,或 10 μ g /ml LPS,或与 LPS 独自一个。ALPase 活动独自在与烟碱或 LPS 有教养的房间减少了,并且在与烟碱和 LPS 有教养的那些进一步减少了,而 PGE_2 生产显著地在前者增加了并且在后者进一步增加了。由自己,烟碱没影响 COX-1, COX-2,任何 PGE_2 受体,或 M-CSF 的表示,但是烟碱和 LPS 什么时候是现在, COX-2 的表示, Ep3, Ep4,和 M-CSF,显著地增加。10 ~ 的同时的增加(-4) M 消炎痛在 ALPase 活动, PGE_2 生产,和 M-CSF 表示消除了烟碱和 LPS 的效果。proteinkinase A 的 Phosphorylation 在与烟碱和 LPS 有教养的房间高。这些结果建议 LPS 由造骨细胞的 COX-2 表示的增加提高导致烟碱的 PGE_2 的生产, thatnicotine-LPS-induced PGE_2 首先在 autocrine orparacnne 模式与造骨细胞 Ep4 受体交往,并且 nicotine-LPS-induced PGE_2 然后减少 ALPase 活动和 increasesM-CSF 表示。 | Maiko SHOJI Natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI Masao MAENO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 9 |
| 3 | Adaptive design of an X-ray magnetic circular dichroism spectroscopy experiment with Gaussian process modelling显示文摘Spectroscopy is a widely used experimental technique,and enhancing its efficiency can have a strong impact on materials research.We propose an adaptive design for spectroscopy experiments that uses a machine learning technique to improve efficiency.We examined X-ray magnetic circular dichroism(XMCD)spectroscopy for the applicability of a machine learning technique to spectroscopy.An XMCD spectrum was predicted by Gaussian process modelling with learning of an experimental spectrum using a limited number of observed data points.Adaptive sampling of data points with maximum variance of the predicted spectrum successfully reduced the total data points for the evaluation of magnetic moments while providing the required accuracy.The present method reduces the time and cost for XMCD spectroscopy and has potential applicability to various spectroscopies. | Tetsuro Ueno Hideitsu Hino Ai Hashimoto Yasuo Takeichi Masahiro Sawada Kanta Ono | 2018 | npj Computational Materials2018，，1： | 4 |
| 4 | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori -related gastritis显示文摘 | Takeichi Yoshida Jun Kato Takao Maekita Satoshi Yamashita Shotaro Enomoto Takayuki Ando Tohru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Toshikazu Ushijima Masao Ichinose | 2013 | Gastric Cancer2013，，4： | 3 |
| 5 | Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver显示文摘AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury. | Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi Izumi Takeyoshi Yukihiro Inomata Koichi Tanaka Eiji Kobayashi | 2009 | World Journal of Gastroenterology2009，15，45： | 3 |
| 6 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 7 | Multi-modal Gesture Recognition using Integrated Model of Motion, Audio and Video显示文摘Gesture recognition is used in many practical applications such as human-robot interaction, medical rehabilitation and sign language. With increasing motion sensor development, multiple data sources have become available, which leads to the rise of multi-modal gesture recognition. Since our previous approach to gesture recognition depends on a unimodal system, it is difficult to classify similar motion patterns. In order to solve this problem, a novel approach which integrates motion, audio and video models is proposed by using dataset captured by Kinect. The proposed system can recognize observed gestures by using three models. Recognition results of three models are integrated by using the proposed framework and the output becomes the final result. The motion and audio models are learned by using Hidden Markov Model. Random Forest which is the video classifier is used to learn the video model. In the experiments to test the performances of the proposed system, the motion and audio models most suitable for gesture recognition are chosen by varying feature vectors and learning methods. Additionally, the unimodal and multi-modal models are compared with respect to recognition accuracy. All the experiments are conducted on dataset provided by the competition organizer of MMGRC, which is a workshop for Multi-Modal Gesture Recognition Challenge. The comparison results show that the multi-modal model composed of three models scores the highest recognition rate. This improvement of recognition accuracy means that the complementary relationship among three models improves the accuracy of gesture recognition. The proposed system provides the application technology to understand human actions of daily life more precisely. | GOUTSU Yusuke KOBAYASHI Takaki OBARA Junya KUSAJIMA Ikuo TAKEICHI Kazunari TAKANO Wataru NAKAMURA Yoshihiko | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 3 |
| 8 | Solution structure of the epithelial cadherin domain responsible for selective cell adhesion显示文摘 | Overduin M Harvey TS Bagby S Tong KI Yau P Takeichi M Ikura M | | 0，，： | 2 |
| 9 | 楼梯间内人流合并特性研究(英文)显示文摘探讨了楼梯间内人流合并的影响以及随着人员密度的变化,合流方向和楼梯间与大厅之间门开启与关闭状态对人流合并难易程度的影响。研究结果表明:(1)人员密度小时合流较容易;(2)如果加入人流与楼梯内人员疏散方向相同时,人流合并较容易;(3)门处于开启状态时,合流较容易。如果门处于关闭状态,人员的疏散速度将降低30%。 | NAOHIRO TAKEICHI YOSHIYUKI YOSHIDA TOMONORI SANO TAKESHI KIMURA HITOSHI WATANABE YOSHIFUMI OHMIYA5 | 2007 | 消防科学与技术2007，26，4： | 2 |
| 10 | Cadherin cell adhesion receptors as a morphogentic regulator显示文摘 | Takeichi M | 1991 | Science1991，251，： | 1 |
| 11 | Drosophila Synapse Formation:Regulation by Transmembrane Protein with Leu-Rich Repeats,CAPRICIOUS显示文摘 | Shishido E Takeichi M Nose A | 1998 | Science1998，280，5372： | 1 |
| 12 | 'Hybrid hydrogen storacle vessel', a novel high-pressure hydrogen storacle vessel combined with hydrogen storage material显示文摘 | Nobuhiko Takeichi Hiroshi Senoh Tomoyuki Yokota | 2003 | International Journal of Hydrogen Energy2003，28，： | 1 |
| 13 | Performance improvement of polybenzoxazine by alloying with polyimide: effect of preparation method on the properties 显示文摘 | Takeichi T Yong Guo Rimdusit S | 2005 | Polyme r2005，46，13： | 1 |
| 14 | High-Molecular-Weight AB- Type Benzoxazines as New Precursors for High-Performance Thermosets显示文摘 | Tarek Agag Tstomu Takeichi | 2007 | Journal of Polymer Science Part A: Polymer Chemistry2007，45，： | 1 |
| 15 | Developmental Defects in Mouse Embryos Lacking N-Cadherin显示文摘 | Glenn L. Radice Helen Rayburn Hiroaki Matsunami Karen A. Knudsen Masatoshi Takeichi Richard O. Hynes | 1997 | Developmental Biology1997，，1： | 1 |
| 16 | Cadherins in cancer: implications for invasion and metastasis显示文摘 | Takeichi M | 1993 | Curr Opin Cell Biol1993，5，5： | 1 |
| 17 | Cadherins in cancer:implications for invasion and metastasis显示文摘 | Takeichi M | | 0，，05： | 1 |
| 18 | Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome显示文摘 | Petrol G Nanda A Howden J Takeichi T McMillan J R Aristodemou S | 2014 | Am J Hum Genet2014，95，： | 1 |
| 19 | Cadherin cell adhesion receptors asa morphogenetic regulator显示文摘 | Takeichi M | 1991 | Science1991，251，5000： | 1 |
| 20 | Morphogenetic roles of classic cadherins 显示文摘 | Takeichi M | 1995 | Curr Opin Cell Biol1995，7，5： | 1 |
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