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| 1 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 2 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 3 | A Review on Binderless Tungsten Carbide: Development and Application显示文摘WC-Co alloys have enjoyed great practical significance owing to their excellent properties during the past decades.Despite the advantages,however,recently there have been concerns about the challenges associated with the use of Co,i.e.price instability,toxicity and properties degeneration,which necessitates the fabrication of binderless tungsten carbide(BTC).On the other hand,BTC or BTC composites,none of them,to date has been commercialized and produced on an industrial scale,but only used to a limited extent for specialized applications,such as mechanical seals undergoing high burthen as well as high temperature electrical contacts.There are two challenges in developing BTC:fully densifying the sintered body together with achieving a high toughness.Thus,this review applies towards comprehensively summarize the current knowledge of sintering behavior,microstructure,and mechanical properties of BTC,highlighting the densification improving strategies as well as toughening methods,so as to provide reference for those who would like to enhance the performance of BTC with better reliability advancing them to further wide applications and prepare the material in a way that is environment friendly,harmless to human health and low in production cost.This paper shows that the fabrication of highly dense and high-performance BTC is economically and technically feasible.The properties of BTC can be tailored by judiciously selecting the chemical composition coupled with taking into careful account the effects of processing techniques and parameters. | Jialin Sun Jun Zhao Zhifu Huang Ke Yan Xuehui Shen Jiandong Xing Yimin Gao Yongxin Jian Hejie Yang Bo Li | 2020 | Nano-Micro Letters2020，12，1： | 8 |
| 4 | Roles of fishing and climate change in long-term fish species succession and population dynamics in the outer Beibu Gulf,South China Sea显示文摘A prevailing,controversial hypothesis is that fishing pressure has played a greater role than climatic and environmental drivers,in changing fish species succession and biomass fluctuation in the South China Sea(SCS).Based on otter trawl survey data from 1959 to 2010 in the outer Beibu Gulf(OBG),northern SCS,large seasonal and interannual variation is reported for fish species composition,the proportional abundances of dominant taxa,and fish biomass.Generalized additive models are developed to quantify relationships between fish biomass and the external factors of fishing pressure and climate change.Fishing pressure proved to be the main driver of sharp declines in demersal fish stocks,with high-value species being replaced by low-value ones over time.Abrupt decreases in fish biomass during the years of 1993 and 1998 correspond to El Nino events,with climate change possibly the main driver of proportional representation of pelagic species in fisheries trawl catch.The need to differentiate impacts of fishing and environmental drivers on fish species with different life history strategies is stressed to better understand fish community dynamics. | Xuehui Wang Yongsong Qiu Feiyan Du Weida Liu Dianrong Sun Xiao Chen Weiwen Yuan Yong Chen | 2019 | Acta Oceanologica Sinica2019，38，10： | 6 |
| 5 | Zn–Ca–Al mixed oxide as efficient catalyst for synthesis of propylene carbonate from urea and 1,2-propylene glycol显示文摘A series of Zn–Ca–Al oxides with different CaO and ZnO contents have been prepared and evaluated in the synthesis of propylene carbonate(PC) from 1,2-propylene glycol(PG) and urea in a batch reactor. The effect of catalyst composition, basicity and reaction process parameters such as temperature, catalyst dose, molar ratio of PG to urea, purge gas flow and reaction time has been studied to find suitable reaction conditions for the PC synthesis. The PC selectivity and yield under the desired conditions could reach 98.4% and 90.8%, respectively. The best performing catalyst also exhibited a good reusability without appreciable loss in the PC selectivity and yield after five consecutive reaction runs. In addition, a stepwise reaction pathway involving a 2-hydroxypropyl carbamate intermediate was proposed for the urea alcoholysis to PC in the presence of Zn–Ca–Al catalysts, according to the time dependences of reaction intermediates and products. | Sen Liu Suhong Sun Xuehui Tian Peiyong Sun Shenghong Zhang Zhilong Yao | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 4 |
| 6 | Genome-wide identification of agronomically important genes in outcrossing crops using OutcrossSeq显示文摘Many important crops(e.g.,tuber,root,and tree crops)are cross-pollinating.For these crops,no inbred lines are available for genetic study and breeding because they are self-incompatible,clonally propagated,or have a long generation time,making the identification of agronomically important genes difficult,particularly in crops with a complex autopolyploid genome.In this study,we developed a method,OutcrossSeq,for mapping agronomically important loci in outcrossing crops based on whole-genome low-coverage resequencing of a large genetic population,and designed three computation algorithms in OutcrossSeq for different types of outcrossing populations.We applied OutcrossSeq to a tuberous root crop(sweet potato,autopolyploid),a tree crop(walnut tree,highly heterozygous diploid),and hybrid crops(double-cross populations)to generate high-density genotype maps for the outcrossing populations,which enable precise identification of genomic loci underlying important agronomic traits.Candidate causative genes at these loci were detected based on functional clues.Taken together,our results indicate that OutcrossSeq is a robust and powerful method for identifying agronomically important genes in heterozygous species,including polyploids,in a cost-efficient way.The OutcrossSeq software and its instruction manual are available for downloading at www.xhhuanglab.cn/tool/OutcrossSeq.html. | Mengjiao Chen Weijuan Fan Feiyang Ji Hua Hua Jie Liu Mengxiao Yan Qingguo Ma Jiongjiong Fan Qin Wang Shufeng Zhang Guiling Liu Zhe Sun Changgeng Tian Fengling Zhao Jianli Zheng Qi Zhang Jiaxin Chen Jie Qiu Xin Wei Ziru Chen Peng Zhang Dong Pei Jun Yang Xuehui Huang | 2021 | Molecular Plant2021，14，4： | 4 |
| 7 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 8 | Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma显示文摘 | Tongsen Zheng Xuehui Hong Jiabei Wang Tiemin Pei Yingjian Liang Dalong Yin Ruipeng Song Xuan Song Zhaoyang Lu Shuyi Qi Jiaren Liu Boshi Sun Changming Xie Shangha Pan Yuejin Li Xiaohe Luo Shuai Li Xiang Fang Nishant Bhatta Hongchi Jiang Lianxin Liu | 2014 | Hepatology2014，，： | 2 |
| 9 | Activation tagging, an efficient tool for functional analysis of the rice genome显示文摘 | Shuyan Wan Jinxia Wu Zhiguo Zhang Xuehui Sun Yaci Lv Ci Gao Yingda Ning Jun Ma Yupeng Guo Qian Zhang Xia Zheng Caiying Zhang Zhiying Ma Tiegang Lu | 2009 | Plant Molecular Biology (-)2009，，1： | 1 |
| 10 | 显示文摘 | Sun Yongjiang Wang Li Jiang Xuehui | 2013 | Journal of In- organic Materials2013，28，2： | 1 |
| 11 | Splitting Regularities of Thin Ferrofluid Layer Manipulated by Vertical Magnetic Field显示文摘The regular distribution of micro-droplets splitting from thin ferrofluid layer is systematic experimentally investigated, as the layer is placed in a vertical magnetic field. In this work, the field is applied in an instant manner and a slow manner, respectively; the field strength is linear increased. With instantly raising the field, it is observed that the ferrofluid layer is split into several regularly distributed micro-droplets, and that the number of micro-droplets is linear to the magnetic field strength and the thickness of the liquid layers. When the field is slowly increased, a liquid ring together with several micro-droplets appears from the ferrofluid layer splitting. A spatial drift of the micro-droplets is also observed in the process of increasing the magnetic field. Our results are useful for manipulating the splitting regularities of ferrofluid layers by magnetic field, which may be used in non-contact segmentation, and magnetically manipulated drug carriers for targeting the therapy, etc. | 陈芳 SUN Cheng LI Xuehui ZHOU Qianru YAN Zhaoqiang 李军 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 1 |
| 12 | Synthesis and properties of ionic, rigid-Rod, and thermally stable polyimides containing bipyridinium triflates 显示文摘 | Sun Xuehui Yang Yukun Lu Fengcai | 1998 | Macromolecules1998，31，13： | 1 |
| 13 | Synthesis of soluble polyimides containing bipyridinium dihydrogen phosphate and p-toluenesulfonate and effect of anions on properties of polyimides 显示文摘 | Sun Xuehui Yang Yukun Lu Fengcai | 1999 | Polymer1999，40，2： | 1 |
| 14 | Simultaneous determination of diaUyl trisulilde and dially disulfide in rat blood by gas chromatography with electron-capture detection显示文摘 | Sun Xuehui Guo Tao He Jin | 2006 | Pharmazie2006，61，12： | 1 |
| 15 | Endogenous biosynthesis of docosahexaenoic acid(DHA)regulates fish oocyte maturation by promoting pregnenolone production显示文摘Omega-3 polyunsaturated fatty acids(n-3 PUFAs),particularly docosahexaenoic acid(22:6n-3,DHA),play crucial roles in the reproductive health of vertebrates,including humans.Nevertheless,the underlying mechanism related to this phenomenon remains largely unknown.In this study,we employed two zebrafish genetic models,i.e.,elovl2^(-/-)mutant as an endogenous DHAdeficient model and fat1(omega-3 desaturase encoding gene)transgenic zebrafish as an endogenous DHA-rich model,to investigate the effects of DHA on oocyte maturation and quality.Results show that the elovl2^(-/-)mutants had much lower fecundity and poorer oocyte quality than the wild-type controls,while the fat1 zebrafish had higher fecundity and better oocyte quality than wildtype controls.DHA deficiency in elovl2^(-/-)embryos led to defects in egg activation,poor microtubule stability,and reduced pregnenolone levels.Further study revealed that DHA promoted pregnenolone synthesis by enhancing transcription of cyp11a1,which encodes the cholesterol side-chain cleavage enzyme,thereby stabilizing microtubule assembly during oogenesis.In turn,the hypothalamic-pituitary-gonadal axis was enhanced by DHA.In conclusion,using two unique genetic models,our findings demonstrate that endogenously synthesized DHA promotes oocyte maturation and quality by promoting pregnenolone production via transcriptional regulation of cyp11a1. | Yi Li Xuehui Li Ding Ye Ru Zhang Chengjie Liu Mudan He Houpeng Wang Wei Hu Yonghua Sun | 2024 | Zoological Research2024，45，1： | 0 |
| 16 | SYNTHESIS AND FINE STRUCTURE-PROPERTY RELATIONSHIPS OF ION-CONTAINING BIOMEDICAL POLYETHERURETHANES显示文摘SYNTHESISANDFINESTRUCTURE-PROPERTYRELATIONSHIPSOFION-CONTAININGBIOMEDICALPOLYETHERURETHANESSYNTHESISANDFINESTRUCTURE-PROPERTY... | Chen Huiying Feng Shiqing Sun Xuehui(Department of Chemistry, Peking University, Beijing 100871,China) | 1996 | Chinese Journal of Biomedical Engineering(English Edition)1996，5，2： | 0 |
| 17 | A reference-grade genome assembly for Astragalus mongholicus and insights into the biosynthesis and high accumulation of triterpenoids and flavonoids in its roots显示文摘Astragalus membranaceus var.mongholicus(AMM),a member of the Leguminosae,is one of the most important medicinal plants worldwide.The dried roots of AMM have a wide range of pharmacological effects and are a traditional Chinese medicine.Here,we report the first chromosome-level reference genome of AMM,comprising nine pseudochromosomes with a total size of 1.47 Gb and 27868 protein-encoding genes.Comparative genomic analysis reveals that AMM has not experienced an independent wholegenome duplication(WGD)event after the WGD event shared by the Papilionoideae species.Analysis of long terminal repeat retrotransposons suggests a recent burst of these elements at approximately 0.13 million years ago,which may explain the large size of the AMM genome.Multiple gene families involved in the biosynthesis of triterpenoids and flavonoids were expanded,and our data indicate that tandemduplication has been the main driver for expansion of these families.Among the expanded families,the phenylalanine ammonia-lyase gene family was primarily expressed in the roots of AMM,suggesting their roles in the biosynthesis of phenylpropanoid compounds.The functional versatility of 2,3-oxidosqualene cyclase genes in cluster Ⅲ may play a critical role in the diversification of triterpenoids in AMM.Our findings provide novel insights into triterpenoid and flavonoid biosynthesis and can facilitate future research on the genetics and medical applications of AMM. | Yi Chen Ting Fang He Su Sifei Duan Ruirui Ma Ping Wang Lin Wu Wenbin Sun Qichen Hu Meixia Zhao Lianjun Sun Xuehui Dong | 2023 | Plant Communications2023，4，2： | 0 |
| 18 | Research on the Characteristics of Anomalies in ELF Electromagnetic Observations in Yunnan Province显示文摘Located in an earthquake-prone region,the geological structures in Yunnan Province are complex. Taking into account that Tonghai county is located in the intersection of Xiaojiang fault and Honghe fault, an ACF-4M ELF electromagnetic instrument was installed at the Tonghai seismic station,which has produced continuous reliable data. The author collected the data and information for the year 2009 and 2010,and performed analysis on the variation characteristics of both geomagnetic fields and electrical resistivity. The result shows that the 1Hz and 39Hz electromagnetic power spectra are 0. 2 to 1. 4 orders of magnitude higher than the normal values immediately before many earthquakes. The anomalies are represented by the abrupt changes of the electric and magnetic field power spectra in earthquake and aftershock sequences,and the amplitude of change is related to the size of earthquake magnitude and epicentral distance. The electrical resistivity also obviously changes. Therefore, further research on the anomalous characteristics of ELF electromagnetic data will be meaningful to the future use of this instrument in earthquake prediction. | Sun Weihuai Tang Ji Zhang Ping Yang Xuehui | 2013 | Earthquake Research in China2013，27，2： | 0 |
| 19 | Causal Association of Cardiac Function by Magnetic Resonance Imaging with Frailty Index:A Mendelian Randomization Study显示文摘Owing to the susceptibility of conventional observational studies to confounding factors and reverse causation,the causal association between cardiac function and frailty is unclear.We aimed to investigate whether cardiac function has causal effects on frailty.In this study,a two-sample Mendelian randomization(MR)study was conducted using genetic variants associated with cardiac function assessed by magnetic resonance imaging phenotypes as instrumental variables.Genetic variants asso-ciated with cardiac function by magnetic resonance imaging(including seven cardiac function phenotypes)and the frailty index(FI)were obtained from two large genome-wide association studies.MR estimates from each genetic instrument were combined using inverse variance weighted(IVW),weighted median,and MR‒Egger regression methods.We found that the increase in genetically determined stroke volume(beta-0.13,95%CI-0.16 to-0.10,p=1.39E-6),rather than other cardiac phenotypes,was associated with lower FI in MR analysis of IVW after Bonferroni correction.Sensitivity analyses examining potential bias caused by pleiotropy or reverse causality revealed similar findings(e.g.,intercept[SE],-0.008[0.011],p=0.47 by MR‒Egger intercept test).The leave-one-out analysis indicated that the association was not driven by single nucleotide polymorphisms.No evidence of heterogeneity was found among the genetic variants(e.g.,MR‒Egger:Q statistic=14.4,p=0.156).In conclusion,we provided evidence that improved cardiac function could contribute to reducing FI.These findings support the hypothesis that enhancing cardiac function could be an effective prevention strategy for frailty. | Hui Zhang Meng Hao Zixin Hu Yi Li Xiaoxi Hu Xiaoyan Jiang Zuyun Liu Xuehui Sun Xiaofeng Wang | 2022 | Phenomics2022，2，6： | 0 |
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