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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | The effect of beta-elemene on alpha-tubulin polymerization in human hepatoma HepG2 cells显示文摘Objective:To investigate the impact of beta-elemene injection on the growth and alpha-tubule of human hepatocarcinoma HepG2 cells.Methods:Cell proliferation was assessed by MTT assay.Cell cycle distribution was detected by flow cytometry(FCM).The mRNA expression of alpha-tubulin was measured by RT-PCR.Western blot analysis was used to determine protein expression of alpha-tubulin and the polymerization of tubulin.Results:Beta-elemene injection inhibited HepG2 cells proliferation in a dose-and time-dependent manner;FCM analysis indicated beta-elemene injection induced cell cycle arrested at S phase.RT-PCR and westernblot analysis showed that beta-elemene injection down-regulated alpha-tublin at both mRNA and protein levels,presenting a dose-dependent manner.Moreover,beta-elemene injection reduced the polymerization of microtubules in a dose-dependent manner.Conclusions:Beta-elemene injection can inhibit the proliferation of hepatoma HepG2 cells and induce cell apoptosis,the mechanism might be partly related to the down-regulation of alpha-tubulin and inhibition of microtubular polymerization. | Jielin Zhang Yuqiu Mao Li Hou Xiaonan Cui | 2013 | Chinese Journal of Cancer Research2013，25，6： | 17 |
| 3 | Heterologous biosynthesis of natural product naringenin by co-culture engineering显示文摘Co-culture engineering is an emerging approach for microbial biosynthesis of a variety of biochemicals.In this study,E.coli-E.coli co-cultures were developed for heterologous biosynthesis of the natural product naringenin.The co-cultures were composed of two independent E.coli strains dedicated to functional expression of different portions of the biosynthetic pathway,respectively.The co-culture biosynthesis was optimized by investigating the effect of carbon source,E.coli strain selection,timing of IPTG induction and the inoculation ratio between the co-culture strains.Compared with the monoculture strategy,the utilization of the designed co-cultures significantly improved the naringenin production,largely due to the reduction of metabolic stress,employment of proper hosts for improving pathway enzyme activities,and flexible adjustment of the relative biosynthetic strength between the coculture strains.The findings of this study extend the applicability of co-culture engineering in complex natural product biosynthesis. | Vijaydev Ganesan Zhenghong Li Xiaonan Wang Haoran Zhang | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 13 |
| 4 | Hydrochemical characteristics and recharge sources of Lake Nuoertu in the Badain Jaran Desert显示文摘We present a case study of physical and chemical indicators and isotope characteristics of Lake Nuoertu,one of the largest and deepest lakes of the Badain Jaran Desert.We analyze the concentrations of eight ions,total dissolved solids,and stable isotope composition of the lake and groundwater,as well as radioactive isotope tritium concentration in groundwater.The results show that annual and seasonal variations of the physical and chemical characteristics of Lake Nuoertu water are significantly greater than those of groundwater.The lake is uniformly mixed in the horizontal and vertical directions,and the hydrochemical types of the lake at different depths are consistent for Na–Cl–CO3–(SO4).Stable isotope composition of the lake and groundwater at Nuoertu is distributed along the local evaporation line(EL)slope,which is less than the slope of the global meteoric water line.The comparatively small slope shows the characteristic strong evaporation in the study area.Lake water isotopes are mostly in the upper right corner of the EL,whereas groundwater is mostly in the lower left corner.The main recharge source of Nuoertu lake water is groundwater,in combination with lake water and groundwater level change.The age of tufa springs around Nuoertu is about75–80 a,which shows that the initial recharge source of the lake is a mix between modern and 1952 or older;however,further research is required. | Yue Wu Naiang Wang Liqiang Zhao Zhenyu Zhang Li Chen Ying Lu Xiaonan L Jinlong Chang | 2014 | Chinese Science Bulletin2014，59，9： | 12 |
| 5 | Effect of Laser Welding Process Parameters on Microstructure and Mechanical Properties on Butt Joint of New Hot-Rolled Nano-scale Precipitation-Strengthened Steel显示文摘A 4 kW fiber laser was chosen to weld the new hot-rolled nano-scale precipitation-strengthened steel with a thickness of 4.5 mm. The effect of laser power, defocusing distance, and welding speed on the welded joint appearance was examined, and the microstructure and mechanical properties on the typical butt joints were investigated. Results showed that increasing laser welding power may cause faster downward flow of molten metal to produce greater root humping. With the welding speed increasing, the average welding seam(WS) width decreased, and the average WS and heat-affected zone(HAZ) hardness increased. The microstructures of WS, fusion line, and coarse grain heat-affected zone were lath martensite, but the growth direction of the original austenite grain boundaries was significantly different. The microstructures of fine grain heat-affected zone were ferrite and martensite, and the microstructure of mixed grain heataffected zone contained ferrite, massive M/A island, and a small amount of martensite. The micro-hardness values of WS,HAZ, and base metal(BM) were 358, 302, and 265 HV, respectively. The butt joint fracture at the BM far from the WS and the welded joint tensile strength are observed to follow proportional relationship with hardness. | Min Zhang Xiaonan Wang Guangjiang Zhu Changjun Chen Jixin Hou Shunhu Zhang Hemin Jing | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 10 |
| 6 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 7 | ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-a-processing alteration显示文摘 | Ming Zhu Xiaonan Zhao Jia Chen Jiajia Xu Guangjing Hu Dongqing Guo Qin Li Xiaowei Zhang Catherine C.Y. Chang Baoliang Song Ying Xiong Tayuan Chang Boliang Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 7 |
| 8 | Constructing a high-density linkage map for Gossypium hirsutum × Gossypium barbadense and identifying QTLs for lint percentage显示文摘To introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, a high-density simple sequence repeat(SSR) genetic linkage map was developed from a BC1F1 population of Gossypium hirsutum×Gossypium barbadense. The map comprised 2,292 loci and covered 5115.16 centi Morgan(c M) of the cotton AD genome, with an average marker interval of 2.23 c M. Of the marker order for 1,577 common loci on this new map, 90.36% agrees well with the marker order on the D genome sequence genetic map. Compared with five published high-density SSR genetic maps, 53.14% of marker loci were newly discovered in this map. Twenty-six quantitative trait loci(QTLs) for lint percentage(LP) were identified on nine chromosomes. Nine stable or common QTLs could be used for marker-assisted selection. Fifty percent of the QTLs were from G. barbadense and increased LP by 1.07%–2.41%. These results indicated that the map could be used for screening chromosome substitution segments from G. barbadense in the Upland cotton background, identifying QTLs or genes from G. barbadense, and further developing the gene pyramiding effect for improving fiber yield and quality. | Yuzhen Shi Wentan Li Aiguo Li Ruihua Ge Baocai Zhang Junzhi Li Guangping Liu Junwen Li Aiying Liu Haihong Shang Juwu Gong Wankui Gong Zemao Yang Feiyü Tang Zhi Liu Weiping Zhu Jianxiong Jiang Xiaonan Yu Tao Wang Wei Wang Tingting Chen Kunbo Wang Zhengsheng Zhang Youlu Yuan | 2015 | Journal of Integrative Plant Biology2015，57，5： | 7 |
| 9 | Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer显示文摘地岬相当或相同的事物基因家庭成员 A (RhoA ) 作为肿瘤的一个批评管理者被识别了好攻击的行为。在 thisstudy,我们在位于有鳞的细胞 carcinomaof 舌头(TSCC ) 的生长,移植,和侵略下面的机制估计了 RhoA 的角色。TSCC 房间线 SCC-4 和 CAL27 击倒的稳定的 RhoA 用 Lentiviral transfection 被完成。房间移植,侵略,和房间增长上的 RhoA 弄空的 Theeffects 是坚定的。TSCC 房间线上的可能的位于决定 Galectin-3 (Gal-3 ) 的表示下面 mechanismof RhoA 弄空被也评估,在 vivo 的 -catenin, andmatrix metalloproteinase-9 (MMP-9 ) 。同时, TSCC 生长的内在的机制被 cyclin D1/2 的分析学习, p21 CIP1/WAF1 , 和 p27 Kip1 蛋白质层次。Immunohistochemical 评价被执行进一步证明 Gal-3 和 -catenin expression.We 的改变发现了那,在与在舌头的人的 TSCC 房间注射的老鼠, RhoA 层次与在正常纸巾的那些相比在主要肿瘤和 metastasizedlymph 节点是更高的。RhoA 的 Silencing 显著地减少了肿瘤生长, Gal-3 的 decreasedthe 层次, -catenin, MMP-9,和 cyclin D1/2,并且增加了 p21 CIP1/WAF1 和 p27 Kip1 。在 vitro, RhoA 击倒也导致了房间移植,侵略,和增长的抑制。我们的数据建议 RhoA 由通过分别地通过房间周期规定表明小径 andcell 增长的 Wnt/-catenin 调整房间移植和侵略在 TSCC 前进起 asignificant 作用。RhoA 可能是 TSCC 的一个新奇治疗学的目标。 | Guoxin Yan Ronghai Zou Zhenggang Chen Bing Fan Zhaoyan Wang Ying Wang Xiaonan Yin Dong Zhang Lei Tong Fang Yang Weina Jiang Wensheng Fu Jiwei Zheng Martin O. Bergo Martin Dalin Jiawei Zheng Shulan Chen Jianhua Zhou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 7 |
| 10 | Structural basis for nucleosome-mediated inhibition of cGAS activity显示文摘Activation of cyclic GMP-AMP synthase(cGAS)through sensing cytosolic double stranded DNA(dsDNA)plays a pivotal role in innate immunity against exogenous infection as well as cellular regulation under stress.Aberrant activation of cGAS induced by self-DNA is related to autoimmune diseases.cGAS accumulates at chromosomes during mitosis or spontaneously in the nucleus.Binding of cGAS to the nucleosome competitively attenuates the dsDNA-mediated cGAS activation,but the molecular mechanism of the attenuation is still poorly understood.Here,we report two cryo-electron microscopy structures of cGAS-nucleosome complexes.The structures reveal that cGAS interacts with the nucleosome as a monomer,forming 1:1 and 2:2 complexes,respectively.cGAS contacts the nucleosomal acidic patch formed by the H2A-H2B heterodimer through the dsDNA-binding site B in both complexes,and could interact with the DNA from the other symmetrically placed nucleosome via the dsDNA-binding site C in the 2:2 complex.The bound nucleosome inhibits the activation of cGAS through blocking the interaction of cGAS with ligand dsDNA and disrupting cGAS dimerization.R236A or R255A mutation of cGAS impairs the binding between cGAS and the nucleosome,and largely relieves the nucleosome-mediated inhibition of cGAS activity.Our study provides structural insights into the inhibition of cGAS activity by the nucleosome,and advances the understanding of the mechanism by which hosts avoid the autoimmune attack caused by cGAS. | Duanfang Cao Xiaonan Han Xiaoyi Fan Rui-Ming Xu Xinzheng Zhang | 2020 | Cell Research2020，30，12： | 6 |
| 11 | Profilin Regulates Apical Actin Polymerization to Control Polarized Pollen Tube Growth显示文摘花粉试管生长在 flowering 植物复制期间是必要的步,其生长取决于动态顶端的肌动朊细丝的一张人口。顶端的肌动朊细丝被认为涉及泡熔化的规定并且在花粉试管指向。然而,在花粉试管调整顶端的肌动朊结构的构造的分子的机制仍然保持大部分不清楚。这里,我们在花粉试管在顶端的膜在肌动朊聚合的规定作为一个重要播放器识别 profilin。profilin 的 Downregulation 减少了在花粉试管的细丝状的肌动朊的数量和顶端的肌动朊细丝的导致的组织的破坏。肌动朊动力学的直接可视化表明在顶端的膜发源的肌动朊细丝的延伸在 profilin 异种花粉试管减少了。仅仅在有约束力的 poly-L-proline 是有缺点的变异的 profilin 部分在 profilin 异种花粉试管救肌动朊聚合缺点,尽管它充分救肌动朊周转显型。我们建议 profilin 在花粉试管尖端控制肌动朊结构的构造,大概由在顶端的膜赞成调停 formin 的肌动朊聚合。 | Xiaonan Liu Xiaolu Qu Yuxiang Jiang Ming Chang Ruihui Zhang Youjun Wu Ying Fu Shanjin Huang | 2015 | Molecular Plant2015，8，12： | 6 |
| 12 | A New Species of the Genus Tylototriton(Amphibia: Urodela: Salamandridae) from the Southern Dabie Mountains in Anhui Province显示文摘A new species of the genus Tylototriton is described,from Yuexi county,Anhui province,in the south of the Dabie Mountains.It is based on morphological and molecular analysis.The new species is identified as belonging to the Tylototriton asperrimus group and shares a number of similarities with T.wenxianensis,T.broadoridgus and T.dabienicus.The diagnostic characteristics of the new species are as follows: the head length is greater than the width of the head; bony ridges on the head are prominent and necked-in; the distal digit ends,ventral digits,peripheral area of the cloaca and the tail's lower edge are orange.The result from the molecular analysis of the genus Tylototriton(including the type specimen of the new species) based on three mitochondrial genes(ND1,ND2 and CYTB) indicated that the new species was close to T.wenxianensis,T.dabienicus,and T.broadoridgus,but formed an independent clade.This result was consistent with the morphological analysis above,which supports the theory that the population distributed in the south of the Dabie Mountains,namely in from Yuexi county,Anhui province,represented a distinct species,Tylototriton anhuiensis sp.nov. | Lifu QIAN Xiaonan SUN Jiaqi LI Weibo GUO Tao PAN Xing KANG Hui WANG Jianping JIANG Jun WU Baowei ZHANG | 2017 | Asian Herpetological Research2017，18，3： | 6 |
| 13 | Protein expression and fucosylated glycans of the serum haptoglobin-β subunit in hepatitis B virus-based liver diseases显示文摘Glycosylation,调整 glycoproteins 的配置和功能,是最重要的 translational 以后修正。学习是在 glycan 和浆液 haptoglobin- 子单元(Hp-) 的蛋白质部分观察微分模式的这的目的与肝炎 B 从病人净化了病毒(HBV ) 感染,肝肝硬化(LC ) ,或 hepatocellular 癌(HCC ) 。2-D 胶化电气泳动和多路的 proteomics 染色技术被采用调查 Hp- glycan 水平是否与蛋白质水平成正比。Multi-lectin 污点,高效的液体层析(HPLC ) ,和西方的污点分析被执行识别 Hp- 份量上的 glycoform。我们的实验证明到 Hp- 的 glycosylated 形式的全部的浆液 Hp- 的比率与不同的肝疾病在病人之中变化了。全部的 Hp- 蛋白质表示水平比 LC 在 HCC 是高得多的,当 fucosylated Hp- 的一个增长比例也在 HBV 和健康控制与那相比在 LC 和 HCC 病人被观察时。微分 fucosylation 被 HPLC 和反人的 SialylLewis X 抗体进一步作为路易斯十世结构识别。在结论, Hp- glycan 和全部的蛋白质表示的异常引申可以是为早 hepatocarcinogenesis 的有希望的 biomarker。 | Hong Shu Shu Zhang Xiaonan Kang Shan Li Xue Qin Chun Sun Haojie Lu Yinkun Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 6 |
| 14 | Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital显示文摘Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.Methods:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively included.The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease.Patient information was collected from hospital records.Results:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were malignant.Compared to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as benign.In 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR wild-type.Prior to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]nodules.Usage of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary nodules.Currently,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules. | Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye | 2020 | Cancer Biology & Medicine2020，17，1： | 5 |
| 15 | Assessing the impacts of ecological-living-productive land changes on eco-environmental quality in Xining City on Qinghai-Tibet Plateau, China显示文摘The Ecological-living-productive land(ELPL)classification system was proposed in an effort to steer China's land pattern to an ecological-centered path,with the development model shifting from a single function into more integrated multifunction land use.The focus is coordinating the man-land contradictions and developing an intensive,efficient and sustainable land use policy in an increasingly tense relationship between humans and nature.Driven by socioeconomic change and rapid population growth,many cities are undergoing urban sprawl,which involves the consumption of cropland and ecological land and threatens the ecological balance.This paper aims to quantitatively analyze the critical effects of ELPL changes on eco-environmental quality according to land use classification based on leading function of ecology,living and production from 1990 to 2015 with a case study of Xining City.Also,four future land use scenarios were simulated for 2030 using the Future Land Use Simulation(FLUS)model that couples human and natural effects.Our results show a decrease in productive land(PL)and an increase in ecological land(EL)and living land(LL)in Xining City.Forestry ecological land(FEL)covered the top largest proportion;agriculture productive land(APL)showed the greatest reduction and urban and rural living land(U-RLL)presented a dramatic increase.The eco-environmental quality improved in 1990-2010,mainly affected by the conversion of APL to FEL and GEL.However,the encroachment of U-RLL into APL,other ecological land(OEL)and FEL was the main contributor to the decline in eco-environmental quality in 2010-2015 as well as the primary reason for the increase area of lower-quality.The Harmonious Development(HD)-Scenario,characterized by a rational allocation of LL and PL and a better eco-environment,would have implications for planning and monitoring future management of ELPL,and may represent a valuable reference for local policy-makers. | ZiYi Gao HaiFeng Zhang XiaoNan Yang ZhiYuan Song | 2019 | Research in Cold and Arid Regions2019，11，3： | 5 |
| 16 | Phase 1 studies comparing safety, tolerability, pharmacokinetics and pharmacodynamics of HLX01(a rituximab biosimilar) to reference rituximab in Chinese patients with CD20-positive B-cell lymphoma显示文摘Objective: This study aimed to compare the pharmacokinetic, pharmacodynamic and safety profiles of HLX01(a rituximab biosimilar) and reference rituximab sourced from China(Mab Thera?;rituximab-CN).Methods: Here we report the results of two phase 1 studies. In the phase 1 a, open-label, dose-escalation study(NCT03218072, CTR20140400), eligible patients received 250, 375 and 500 mg/m^(2) HLX01 sequentially at 7-day intervals, after confirming no dose-limiting toxicity(DLT). In the phase 1 b, double-blind study(NCT02584920,CTR20140764), eligible patients were given a single dose of 375 mg/m^(2) HLX01 or rituximab-CN. The primary endpoints included safety and tolerability parameters for the phase 1 a and the area under the plasma concentrationtime curve from time zero to day 91(AUC0-91 d) for the phase 1 b study. Equivalence was concluded if 90%confidence interval(90% CI) for the geometric least squares mean ratio(GLSMR) fell in the pre-specified equivalence criteria(80%-125%).Results: Between June 20, 2014 and January 5, 2015, 12 patients were enrolled in the phase 1 a study. The pharmacokinetics of HLX01 showed dose proportionality and accumulation to steady state. HLX01 was well tolerated, with no serious adverse events(AEs), discontinuations or DLTs. Between November 8, 2014 and August13, 2015, 87 eligible patients were enrolled in the phase 1 b study, including 43 who received HLX01 and 44 who were treated with rituximab-CN. The equivalence endpoint was met with GLSMR for AUC0-91 d being 89.6%(90% CI: 80.4%-99.8%). AEs, anti-drug antibodies, and CD19+ and CD20+ B lymphocyte counts were similar between the HLX01 and rituximab-CN treatment groups.Conclusions: Treatment with HLX01 was safe and well tolerated in Chinese patients with B-cell lymphoma.HLX01 and rituximab-CN have similar pharmacokinetic, pharmacodynamic and safety profiles. | Yuankai Shi Qingyuan Zhang Xiaohong Han Yan Qin Xiaoyan Ke Hang Su Li Liu Jinxiang Fu Jie Jin Jifeng Feng Xiaonan Hong Xiaohong Zhang Depei Wu Bin Jiang Xiaodong Dong | 2021 | Chinese Journal of Cancer Research2021，33，3： | 5 |
| 17 | Wide river or narrow river:Future river training strategy for Lower Yellow River under global change显示文摘The choice of a river training strategy is extremely important for the Lower Yellow River(LYR). Currently,the wide-river training strategy applies in the training of the LYR. However, remarkable changes in the hydrological processes in the Yellow River basin, as well as immediate pressure from socio-economic development in the Yellow River basin, make it necessary to consider if there is a possibility to change the river training strategy from wide-river training to narrow-river training. This research investigates the impacts of different river training strategies on the LYR through numerical simulations. A onedimensional(1-D) model was used to simulate the fluvial processes for the future 50 years and a threedimensional(3-D) model was applied to study typical floods. The study focused on river morphology, the results show that if the present decreasing trend in both water discharge and sediment load persists, the deposition rate in the LYR will further decrease no matter what strategy is applied. Especially, narrowriver training can achieve the aim to increase the sediment transport capacity in the LYR compared with wide-river training. However, if the incoming water and sediment load recovers to the mean level of the last century, main channel shrinkage due to sedimentation inevitably occurs for both wide-river and narrow-river training. Most importantly, this study shows that narrow-river training reduces the deposition amount over the whole LYR, but it provides little help in alleviating the development of the'suspended river'. Instead, narrow-river training can cause aggradation in the transitional reach where the river pattern changes from highly wandering to meandering, further worsening the 'hump deposition' there. Because of uncertainty regarding future changes in hydrological processes in the Yellow River basin, and the lack of feasible engineering measures to mitigate 'suspended river' and'hump deposition' problems in the LYR, caution should be exercised with respect to changes in the river training strategy for the LYR. | Xiaonan Li Deyu Zhong Y.Joseph Zhang Yanjun Wang Yongqiang Wang Hongwu Zhang | 2018 | International Journal of Sediment Research2018，33，3： | 5 |
| 18 | Receiver-channel based adaptive blind equalization approach for GPS dynamic multipath mitigation显示文摘Aiming at mitigating multipath effect in dynamic global positioning system (GPS) satellite navigation applications, an approach based on channel blind equalization and real-time recursive least square (RLS) algorithm is proposed, which is an application of the wireless communication channel equalization theory to GPS receiver tracking loops. The blind equalization mechanism builds upon the detection of the correlation distortion due to multipath channels; therefore an increase in the number of correlator channels is required compared with conventional GPS receivers. An adaptive estimator based on the real-time RLS algorithm is designed for dynamic estimation of multipath channel response. Then, the code and carrier phase receiver tracking errors are compensated by removing the estimated multipath components from the correlators' outputs. To demonstrate the capabilities of the proposed approach, this technique is integrated into a GPS software receiver connected to a navigation satellite signal simulator, thus simulations under controlled dynamic multipath scenarios can be carried out. Simulation results show that in a dynamic and fairly severe multipath environment, the proposed approach achieves simultaneously instantaneous accurate multipath channel estimation and significant multipath tracking errors reduction in both code delay and carrier phase. | Zhao Yun Xue Xiaonan Zhang Tingfei | 2013 | Chinese Journal of Aeronautics2013，26，2： | 5 |
| 19 | A Novel Single-Phase Five-Level Transformer-less Photovoltaic (PV) Inverter显示文摘Multilevel inverters are preferred solutions for photovoltaic(PV)applications because of lower total harmonic distortion(THD),lower switching stress and lower electromagnetic interference(EMI).In order to reduce the leakage current in the single-phase low-power PV inverters,a five-level transformer-less inverter is proposed in this paper.A total of eleven switches are required,while six of them only withstand a quarter of the dc-bus voltage,so the costs for them are low.Another four switches are turned on or off at the power line cycle,the switching losses for them are ignored.In addition,the flying-capacitors(FCs)voltages are only a quarter of the dc-bus voltage,and they are balanced at the switching frequency,which further reduces the system investment.The experimental results based on a 1 kW prototype show that the proposed modulation strategy can balance the FCs voltages at Vdc/4 very well.And the leakage current can be reduced to about 27 mA under both active and reactive operations,which satisfies the VDE 0126-1-1 standard. | Xiaonan Zhu Hongliang Wang Wenyuan Zhang Hanzhe Wang Xiaojun Deng Xiumei Yue | 2020 | CES Transactions on Electrical Machines and Systems2020，4，4： | 5 |
| 20 | Si/C particles on graphene sheet as stable anode for lithium-ion batteries显示文摘Silicon is considered as one of the most promising anodes for Li-ion batteries(LIBs), but it is limited for commercial applications by the critical issue of large volume expansion during the lithiation. In this work, the structure of silicon/carbon(Si/C) particles on graphene sheets(Si/C–G) was obtained to solve the issue by using the void space of Si/C particles and graphene. Si/C–G material was from Si/PDA-GO that silicon particles was coated by polydopamine(PDA) and reacted with oxide graphene(GO). The Si/C–G material have good cycling performance as the stability of the structure during the lithiation/dislithiation.The Si/C–G anode materials exhibited high reversible capacity of 1910.5 mA h g^(-1) and 1196.1 mA h g^(-1) after 700 cycles at 357.9 m A g^(-1), and have good rate property of 507.2 mA h g^(-1) at high current density,showing significantly improved commercial viability of silicon electrodes in high-energy-density LIBs. | Jian Han Xiaonan Tang Shaofan Ge Ying Shi Chengzhi Zhang Feng Li Shuo Bai | 2021 | Journal of Materials Science & Technology2021，，21： | 4 |
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