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| 1 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 2 | Deforming TC6 titanium alloys at ultrahigh strain rates during multiple laser shock peening显示文摘 | Liucheng Zhou Yinghong Li Weifeng He Guangyu He Xiangfan Nie Donglin Chen Zhilin Lai Zhibin An | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 3 | Mitigating thermal runaway hazard of high-energy lithium-ion batteries by poison agent显示文摘Lithium-ion batteries with high-energy density are extensively commercialized in long-range electric vehicles. However, they are poor in thermal stability and pose fire or explosion, which has attracted the global attention. This study describes a new route to mitigate the battery thermal runaway(TR) hazard by poison agents. First, the self-destructive cell is built using the embedded poison layer. Then, the poisoning mechanism and paths are experimentally investigated at the material, electrode, and cell levels. Finally, the proposed route is verified by TR tests. The results show the TR hazard can be significantly reduced in the self-destructive cell based on a new reaction sequence regulation. Specifically, the maximum temperature of the self-destructive cell is more than 300℃ lower than that of the normal cell during TR. The drop in maximum temperature can reduce total heat release and the probability of TR propagation in the battery system, significantly improving battery safety. | Xin Lai Zheng Meng Fangnan Zhang Yong Peng Weifeng Zhang Lei Sun Li Wang Fei Gao Jie Sheng Shufa Su Yuejiu Zheng Xuning Feng | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 4 | 建立具有体内胚内和胚外发育潜能的多能干细胞显示文摘文章简介在已知的体外培养的干细胞类型当中,多能干细胞具有最高的发育潜能,能够形成构成成年个体的所有细胞类型。但是,多能干细胞很难在体内发育过程中形成胚外的胎盘组织。 | Yang Yang Bei Liu Jun Xu Jinlin Wang Jun Wu Cheng Shi Yaxing Xu Jiebin Dong Chengyan Wang Weifeng Lai Jialiang Zhu Liang Xiong Dicong Zhu Xiang Li Weifeng Yang Takayoshi Yamauchi Atsushi Sugawara Zhongwei Li Fangyuan Sun Xiangyun Li Chen Li Aibin He Yaqin Du Ting Wang Chaoran Zhao Haibo Li Xiaochun Chi Hongquan Zhang Yifang Liu Cheng Li Shuguang Duo Ming Yin 沈浣 Juan Carlos Izpisua Belmonte 邓宏魁 | 2018 | 科学新闻2018，0，4： | 0 |
| 5 | 在成纤维细胞中通过一个化学小分子诱导的类XEN状态实现直接重编程显示文摘文章简介直接谱系重编程已经成为了一种具备应用前景的制备目的细胞类型的新方法。在通过化学小分子将小鼠成纤维细胞诱导为多能干细胞形成的过程中。 | Xiang Li Defang Liu Yantao Ma Xiaomin Du Junzhan Jing Lipeng Wang Bingqing Xie Da Sun Shaoqiang Sun Xueqin Jin Xu Zhang Ting Zhao Jingyang Guan Zexuan Yi Weifeng Lai Ping Zheng Zhuo Huang Yanzhong Chang 柴真 Jun Xu 邓宏魁 | 2018 | 科学新闻2018，0，4： | 0 |
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