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| 1 | Rice Functional Genomics Research: Past Decade and Future显示文摘瑞斯(Oryza sativa ) 是为世界范围的超过 35 亿个人的主要主食食物庄稼。在米饭理解复杂农学的特点的规章的机制为全球食物安全是批评的。瑞斯也是为单子叶植物的 genomics 研究的模型植物。由于功能的 genomic 技术的快速的发展,控制重要农学的特点的超过 2000 基因被克隆,并且他们的分子的生物机制也是部分描绘了。这里,我们简短在米饭考察进展功能的 genomics 研究在过去的 10 年期间包括功能的 genomics 平台的一篇摘要,基因 ? 并且调整重要农学的特点的分子的规章的网络,并且 ? 为基因鉴定的最新发达的工具。在功能的 genomics 研究做的这些成就将极大地便于发展 ? 绿超级米饭。我们也讨论未来挑战和米饭的前景功能的 genomics 研究。 | Yan Li Jinghua Xiaot Lingling Chen Xuehui Huang Zhukuan Cheng Bin Han Qifa Zhang Changyin Wu | 2018 | Molecular Plant2018，11，3： | 14 |
| 2 | Exploring the molecular basis of heterosis for plant breeding显示文摘Since approximate a century ago, many hybrid crops have been continually developed by crossing two inbred varieties. Owing to heterosis(hybrid vigor) in plants, these hybrids often have superior agricultural performances in yield or disease resistance succeeding their inbred parental lines. Several classical hypotheses have been proposed to explain the genetic causes of heterosis. During recent years, many new genetics and genomics strategies have been developed and used for the identifications of heterotic genes in plants. Heterotic effects of the heterotic loci and molecular functions of the heterotic genes are being investigated in many plants such as rice, maize, sorghum, Arabidopsis and tomato.More and more data and knowledge coming from the molecular studies of heterotic loci and genes will serve as a valuable resource for hybrid breeding by molecular design in future. This review aims to address recent advances in our understanding of the genetic and molecular mechanisms of heterosis in plants. The remaining scientific questions on the molecular basis of heterosis and the potential applications in breeding are also proposed and discussed. | Jie Liu Mengjie Li Qi Zhang Xin Wei Xuehui Huang | 2020 | Journal of Integrative Plant Biology2020，62，3： | 13 |
| 3 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 4 | Petrogenesis and tectonic implications of early Paleozoic granitoids in East Kunlun belt: Evidences from geochronology, geochemistry and isotopes显示文摘The East Kunlun Orogenic Belt(EKOB) provides an important link to reconstruct the evolution of the Proto-Tethys and Paleo-Tethys realm. The EKOB is marked by widespread Early Paleozoic magmatism.Here we report the petrology, bulk geochemistry, zircon Ue Pb dating and, Lue Hf and SreN d isotopic data of the Early Paleozoic granitic rocks in Zhiyu area of the southern EKOB. Based on the zircon U-Pb dating, these granitoids, consisting of diorite, granodiorite and monzogranite, were formed during 450 -430 Ma the Late Ordovician to Middle Silurian. The diorite and granodiorite are high Sr/Y ratio as adakitic affinities, and the monzogranite belongs to highly fractionated I-type. Their(^(87)Sr/^(86)Sr)ivalues range from 0.7059 to 0.7085, εNd(t) values from -1.6 to -6.0 and the zircon εHf(t) values show large variations from +9.1 to -8.6 with Hf model ages(T_(DM2)) about 848 Ma and 1970 Ma. The large variations of whole-rock Nd and zircon Hf isotopes demonstrate strong isotopic heterogeneity of the source regions which probably resulted from multi-phase underplating of mantle-derived magmas. Geochemical and isotopic studies proved that the diorite and granodiorite had been derived from partial melting of heterogeneous crustal source with variable contributions from ancient continental crust and juvenile components, and the monzogranites were representing fractional crystallization and crustal contamination for arc magma. The Early Paleozoic adakitic rocks and high-K calc-alkaline granitoids in the southern EKOB were likely emplaced in a continental marginal arc setting possibly linked to the southwards subduction of the Paleo Kunlun Ocean and the magma generation is linked to partial melting of thickened continental crust induced by underplating of mantle-derived magmas. | Guochen Dong Mingfei Luo Xuanxue Mo Zhidan Zhao Liangqiong Dong Xuehui Yu Xin Wang Xiaowei Li Xiongfei Huang Yanbin Liu | 2018 | Geoscience Frontiers2018，9，5： | 10 |
| 5 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 6 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 7 | MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate-1显示文摘 | Li Yang Huang Qiming Shi Xuehui Jin Xiang Shen Li Xu Xiaolin Wei Wenbin | 2014 | Chinese Medical Journal2014，，8： | 9 |
| 8 | A Review on Binderless Tungsten Carbide: Development and Application显示文摘WC-Co alloys have enjoyed great practical significance owing to their excellent properties during the past decades.Despite the advantages,however,recently there have been concerns about the challenges associated with the use of Co,i.e.price instability,toxicity and properties degeneration,which necessitates the fabrication of binderless tungsten carbide(BTC).On the other hand,BTC or BTC composites,none of them,to date has been commercialized and produced on an industrial scale,but only used to a limited extent for specialized applications,such as mechanical seals undergoing high burthen as well as high temperature electrical contacts.There are two challenges in developing BTC:fully densifying the sintered body together with achieving a high toughness.Thus,this review applies towards comprehensively summarize the current knowledge of sintering behavior,microstructure,and mechanical properties of BTC,highlighting the densification improving strategies as well as toughening methods,so as to provide reference for those who would like to enhance the performance of BTC with better reliability advancing them to further wide applications and prepare the material in a way that is environment friendly,harmless to human health and low in production cost.This paper shows that the fabrication of highly dense and high-performance BTC is economically and technically feasible.The properties of BTC can be tailored by judiciously selecting the chemical composition coupled with taking into careful account the effects of processing techniques and parameters. | Jialin Sun Jun Zhao Zhifu Huang Ke Yan Xuehui Shen Jiandong Xing Yimin Gao Yongxin Jian Hejie Yang Bo Li | 2020 | Nano-Micro Letters2020，12，1： | 8 |
| 9 | Intravitreal ranibizumab therapy versus photodynamic therapy for idiopathic choroidal neovascularization: a comparative study on visual acuity, retinal and choroidal thickness显示文摘 | Shi Xuehui Wei Wenbin Zhang Cong | 2014 | Chinese Medical Journal2014，，12： | 8 |
| 10 | Dissecting the Genetic Basis of Grain Shape and Chalkiness Traits in Hybrid Rice Using Multiple Collaborative Populations显示文摘 | Junyi Gong Jiashun Miao Yan Zhao Qiang Zhao Qi Feng Qilin Zhan Benyi Cheng Junhui Xia Xuehui Huang Shihua Yang Bin Han | 2017 | Molecular Plant2017，10，10： | 8 |
| 11 | A high-quality genome sequence of alkaligrass provides insights into halophyte stress tolerance显示文摘Alkaligrass(Puccinellia tenuiflora) is a monocotyledonous halophytic forage grass widely distributed in Northern China. It belongs to the Gramineae family and shares a close phylogenetic relationship with the cereal crops, wheat and barley. Here, we present a high-quality chromosome-level genome sequence of alkaligrass assembled from Illumina, Pac Bio and 10× Genomics reads combined with genome-wide chromosome conformation capture(Hi-C) data. The ~1.50 Gb assembled alkaligrass genome encodes 38,387 protein-coding genes, and 54.9% of the assembly are transposable elements, with long terminal repeats being the most abundant. Comparative genomic analysis coupled with stress-treated transcriptome profiling uncovers a set of unique saline-and alkaline-responsive genes in alkaligrass. The high-quality genome assembly and the identified stress related genes in alkaligrass provide an important resource for evolutionary genomic studies in Gramineae and facilitate further understanding of molecular mechanisms underlying stress tolerance in monocotyledonous halophytes. The alkaligrass genome data is freely available at http://gffzz284c18d2de364501h5kqbww6nufc06fwx.ffgz.tsg.suse.edu.cn/data/alkaligrass.html. | Wenting Zhang Jie Liu Yongxue Zhang Jie Qiu Ying Li Baojiang Zheng Fenhong Hu Shaojun Dai Xuehui Huang | 2020 | Science China(Life Sciences)2020，63，9： | 8 |
| 12 | Effect of polycarboxylate-type superplasticizer on the paste fluidity based on the water film thickness of flocs显示文摘The excess water film theory and the properties of flocs are integrated to examine the effect of the polycarboxylate-type superplasticizer on the paste fluidity.The theory states that excess water can surround the flocs rather than the particles and that the cell consists of a floc and a superficial water film.Experiments on limestone powder pastes were conducted to verify the theory.The superplasticizer dosage(sp%)and the water–powder ratio by volume(Vw/Vp)were systematically varied.A sedimentation balance method was used to measure the size distribution of the flocs in the limestone powder pastes.The water film thickness(WFT)of flocs was then calculated and shown to determine the paste fluidity.Based on this WFT of flocs,the effect of the sp on the paste fluidity was determined and then compared with the effect of water. | WU Qiong AN XueHui LIU ChunNa | 2014 | Science China(Technological Sciences)2014，57，8： | 7 |
| 13 | Estimation of Storage and Density of Organic Carbon in Peatlands of China显示文摘Based on the results of the National Survey of Peat Resources(1983-1985) and the investigation results on the peatlands of China,the storage and density of the organic carbon in the peatlands of China were estimated.The total organic carbon storage(OCS) of the peatlands in China,including bare peatlands and buried peatlands,are 1.503 × 109 t,unevenly distributed over 30 provincial level administrative units and 16 climatic zones.Peatland organic carbon storage(POCS) in Sichuan(6.45 × 108 t) and Yunnan provinces(2.91 × 108 t) is the highest,accounting for 62.29% of the total POCS.Humid zone of plateau has the highest POCS of 7.14 × 108 t,especially in the Zoigê Plateau,where the POCS is 6.30 × 108 t,accounting for 41.92% of the total POCS of China.The organic carbon density(OCD) of the peatlands in China mostly ranges from 80 kg/m3 to 140 kg/m3,and the range of the maximum is 270-360 kg/m3,and the minimum is less than 80 kg/m3.Divided by the Yanshan Mountain,Taihang Mountains and Hengduan Mountains,the peatland oganic carbon density(POCD) is lower on the northwestern side than that on the southeastern side.Jiangxi Province has the highest POCD due to the ancient buried peatlands.The OCD of the bare peatlands is mostly in the range of 60-150 kg/m3,and that of the buried peatlands is more than 100 kg/m3.In the bare peatlands,the OCD generally increases from the surface layer to the below surface layer,and then decreases with the depth.Although the peatlands area in China is small,the OCS per unit area is far higher than the other soil types,so peatlands protection can effectively mitigate climate change. | LIU Zigang WANG Ming MA Xuehui | 2012 | Chinese Geographical Science2012，22，6： | 7 |
| 14 | ^(40)Ar/^(39)Ar dating for Cenozoic kamafugite from western Qinling in Gansu Province显示文摘40Ar/39Ar ages were determined for 6 phlogopite samples from a kamafugite pipe occurring in western Qinling, yielding a time span of 22 to 23 Ma for kamafugite eruption. Together with known geochronological data for the Qinghai-Tibet Plateau (QTP) and its peripheral regions, it is concluded that these Cenozoic potassic-ultrapotassic volcanic rocks are products of post-collisional volcanism. The age of the Cenozoic volcanic rocks in western Qinling partly overlaps that of potassic volcanics from the Gandise belt, reflecting the northward migration of the post-collisional volcanism in QTP. The age data not only confirm the temporal and spatial migration of post-collisional volcanism in QTP, but also provide geochronological constraints on the geodynamic set- ting at depth and the regimes of the tectonic evolution since Neogene in western Qinling regions. | YU Xuehui ZHAO Zhidan ZHOU Su MO Xuanxue ZHU Deqing WANG Yonglei | 2006 | Chinese Science Bulletin2006，51，13： | 7 |
| 15 | Effects of surfactants on graphene oxide nanoparticles transport in saturated porous media显示文摘Transport behaviors of graphene oxide nanoparticles(GONPs) in saturated porous media were examined as a function of the presence and concentration of anionic surfactant(SDBS)and non-ionic surfactant(Triton X-100) under different ionic strength(IS). The results showed that the GONPs were retained obviously in the sand columns at both IS of 50 and200 mmol/L, and they were more mobile at lower IS. The presence and concentration of surfactants could enhance the GONP transport, particularly as observed at higher IS. It was interesting to see that the GONP transport was surfactant type dependent, and SDBS was more effective to facilitate GONP transport than Triton X-100 in our experimental conditions. The advection–dispersion–retention numerical modeling followed this trend and depicted the difference quantitatively. Derjaguin–Landau–Verwey–Overbeek(DLVO)interaction calculations also were performed to interpret these effects, indicating that secondary minimum deposition was critical in this study. | Wei Fan Xuehui Jiang Ying Lu Mingxin Huo Shanshan Lin Zhi Geng | 2015 | Journal of Environmental Sciences2015，27，9： | 6 |
| 16 | Roles of fishing and climate change in long-term fish species succession and population dynamics in the outer Beibu Gulf,South China Sea显示文摘A prevailing,controversial hypothesis is that fishing pressure has played a greater role than climatic and environmental drivers,in changing fish species succession and biomass fluctuation in the South China Sea(SCS).Based on otter trawl survey data from 1959 to 2010 in the outer Beibu Gulf(OBG),northern SCS,large seasonal and interannual variation is reported for fish species composition,the proportional abundances of dominant taxa,and fish biomass.Generalized additive models are developed to quantify relationships between fish biomass and the external factors of fishing pressure and climate change.Fishing pressure proved to be the main driver of sharp declines in demersal fish stocks,with high-value species being replaced by low-value ones over time.Abrupt decreases in fish biomass during the years of 1993 and 1998 correspond to El Nino events,with climate change possibly the main driver of proportional representation of pelagic species in fisheries trawl catch.The need to differentiate impacts of fishing and environmental drivers on fish species with different life history strategies is stressed to better understand fish community dynamics. | Xuehui Wang Yongsong Qiu Feiyan Du Weida Liu Dianrong Sun Xiao Chen Weiwen Yuan Yong Chen | 2019 | Acta Oceanologica Sinica2019，38，10： | 6 |
| 17 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 18 | Magnetite-Fluorite Rock:A New Rock Type of Hot Water Sedimentation显示文摘新类型热水沉积岩石磁铁矿荧石岩石在 Changshan 县的 Bamianshan 在在岩石身体和阶层之间的接触地区的扁平的部分作为伪层发生,浙江省,中国。主要矿物质集合是 fluorite+magnetite+cassiterite。岩石显示出典型把压成薄片的结构和明显的马赛克质地。它的形成温度在 123 潲数瑲敩之间吗? | XU Shaokang XIA Xuehui YUAN Congjian WANG Bingquan YAN Fei YAN Shengxian ZHENG Xingquan | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 6 |
| 19 | Nb_5N_6 thin film on silicon and silicon oxide: A good material for terahertz detection显示文摘Voltage responsivity of bolometer will benefit from high temperature coefficient of resistance (TCR) of the material. The Nb5N6 thin solid films we proposed in this paper have high TCR, compared with the commonly-used materials such as Nb and Bi. The films were sputtered on Si(100), SiO2/Si(100), SiO2 substrates by using radio frequency (rf) magnetron sputtering. The deposition conditions have been optimized to get high TCR. The highest TCR is over 0.91% K-1 at 300 K and up to 4.5% K -1―7% K-1 at 78 K, which is good enough to be used in terahertz detection and thermometer fabrication in the range from 78 K to 300 K. | LU XueHui HE Ning KANG Lin CHEN Jian JIN BiaoBing WU PeiHeng | 2009 | Chinese Science Bulletin2009，54，18： | 5 |
| 20 | Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses显示文摘Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. | Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie Guohui Nie Xiyun Yan Minmin Liang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
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