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| 1 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 2 | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China显示文摘We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. | E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen BingyinSi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 6 |
| 3 | Gene Identification and Expression Analysis of 86,136 Expressed Sequence Tags(EST)from the Rice Genome显示文摘Expressed Sequence Tag(EST)analysis has pioneered genome-wide gene discovery and expression profiling.In order to establish a gene expression index in the rice cultivar indica,we sequenced and analyzed 86,136 ESTs from nine rice cDNA libraries from the super hybrid cultivar LYP9 and its parental cultivars.We assembled these ESTs into 13,232 contigs and leave 8,976 singletons.Overall,7,497 sequences were found similar to the existing sequences in GenBank and 14,711 are novel.These sequences are classified by molecular function,biological process and pathways according to the Gene Ontology.We compared our sequenced ESTs with the publicly available 95,000 ESTs from japonica,and found little sequence variation,despite the large difference between genome sequences,We then assembled the combined 173,000 rice ESTs for further analysis.Using the pooled ESTs,we compared gene expression in metabolism pathway between rice and Arabidopsis according to KEGG.We further profiled gene expression patterns in different tissues,developmental stages,and in a conditional sterile mutant,after checking the libraries are comparable by means of sequence coverage.We also identified some possible library specific genes and a number of enzymes and transcription factors that contribute to rice development. | YanZhou JiabinTang MichaelG.Walker XiuqingZhang JunWang SongnianHu HuayongXu SigiLiu HuanmingYang JunYu JianWang YajunDeng JianhaiDong LinYe LiLin JunLi XuegangWang HaoHu YibinPan WeiLin WeiTian JingLiu LipingWei | 2003 | Genomics, Proteomics & Bioinformatics2003，1，1： | 4 |
| 4 | A sulfur dioxide polymer prodrug showing combined effect with doxorubicin in combating subcutaneous and metastatic melanoma显示文摘Melanoma,as the most aggressive and treatment-resistant skin malignancy,is responsible for about 80%of all skin cancer mortalities.Prone to invade into the dermis and form distant metastases significantly reduce the patient survival rate.Therefore,early treatment of the melanoma in situ or timely blocking the deterioration of metastases is critical.In this study,a sulfur dioxide(SO_(2))polymer prodrug was designed as both an intracellular glutathione(GSH)-responsive SO_(2) generator and a carrier of doxorubicin(DOX),and used for the treatment of subcutaneous and metastatic melanoma.Firstly,chemical conjugation of 4-N-(2,4-dinitrobenzenesulfonyl)-imino-1-butyric acid(DIBA)onto the side chains of methoxy poly(ethylene glycol)grafted dextran(mPEG-g-Dex)resulted in the synthesis of the amphiphilic polymer prodrug of SO_(2),mPEG-g-Dex(DIBA).The obtained mPEG-g-Dex(DIBA)could self-assemble into stable micellar nanoparticles and exhibited a glutathione-responsive SO_(2) release behavior.Subsequently,DOX was encapsulated into the core of mPEG-g-Dex(DIBA)micelles to form DOX-loaded nanoparticles(PDDN-DOX).The formed PDDN-DOX could be internalized by B16F10 cells and synchronously release DOX and SO_(2) into the tumor cells.As a result,PDDN-DOX exerted synergistic anti-tumor effects in B16F10 melanoma cells because of the oxidative damage properties of SO_(2) and toxic effects of DOX.Furthermore,in vivo experiments verified that PDDN-DOX had great potential for the treatment of subcutaneous and metastasis melanoma.Collectively,our present work demonstrates that the combination of SO_(2)-based gas therapy and chemotherapeutics offers a new avenue for inhibiting melanoma progression and metastases. | Lin An Peng Zhang Wei Shen Xuan Yi Weitian Yin Rihua Jiang Chunsheng Xiao | 2021 | Bioactive Materials2021，6，5： | 3 |
| 5 | Guest Editorial: Special Issue on Internet of Things显示文摘Internet of Things(IoT)is a new paradigm that the ubiquitous smart objects,such as devices,vehicles,buildings,etc.,interact and exchange data through emerging wireless technology with the intention of improving people’s quality of lives in variety areas,such as transportation,manufacturing industry,health care industry,etc:Besides benefits,this | Zhipeng Cai Anu Bourgeois Weitian Tong | 2017 | Tsinghua Science and Technology2017，22，4： | 2 |
| 6 | Accelerated slice encoding for metal aartifact correction显示文摘 | Hargreaves BA Weitian Chen Lu W | 2010 | Magnetic Resonance in Medicine2010，31，4： | 1 |
| 7 | From China’s Heavy Precipitation in 2020 to a “Glocal” Hydrometeorological Solution for Flood Risk Prediction显示文摘The prolonged mei-yu/baiu system with anomalous precipitation in the year 2020 has swollen many rivers and lakes,caused flash flooding,urban flooding and landslides,and consistently wreaked havoc across large swathes of China,particularly in the Yangtze River basin.Significant precipitation and flooding anomalies have already been seen in magnitude and extension so far this year,which have been exerting much higher pressure on emergency responses in flood control and mitigation than in other years,even though a rainy season with multiple ongoing serious flood events in different provinces is not that uncommon in China.Instead of delving into the causes of the uniqueness of this year’s extreme precipitation-flooding situation,which certainly warrants in-depth exploration,in this article we provide a short view toward a more general hydrometeorological solution to this annual nationwide problem.A“glocal”(global to local)hydrometeorological solution for floods(GHS-F)is considered to be critical for better preparedness,mitigation,and management of different types of significant precipitation-caused flooding,which happen extensively almost every year in many countries such as China,India and the United States.Such a GHS-F model is necessary from both scientific and operational perspectives,with the strength in providing spatially consistent flood definitions and spatially distributed flood risk classification considering the heterogeneity in vulnerability and resilience across the entire domain.Priorities in the development of such a GHS-F are suggested,emphasizing the user’s requirements and needs according to practical experiences with various flood response agencies. | Huan WU Xiaomeng LI Guy J.-P.SCHUMANN Lorenzo ALFIERI Yun CHEN Hui XU Zhifang WU Hong LU Yamin HU Qiang ZHU Zhijun HUANG Weitian CHEN Ying HU | 2021 | Advances in Atmospheric Sciences2021，38，1： | 1 |
| 8 | Electrochemically Grown Ultrathin Platinum Nanosheet Electrodes with Ultralow Loadings for Energy-Saving and Industrial-Level Hydrogen Evolution显示文摘Nanostructured catalyst-integrated electrodes with remarkably reduced catalyst loadings,high catalyst utilization and facile fabrication are urgently needed to enable cost-effective,green hydrogen production via proton exchange membrane electrolyzer cells(PEMECs).Herein,benefitting from a thin seeding layer,bottom-up grown ultrathin Pt nanosheets(Pt-NSs)were first deposited on thin Ti substrates for PEMECs via a fast,template-and surfactant-free electrochemical growth process at room temperature,showing highly uniform Pt surface coverage with ultralow loadings and vertically well-aligned nanosheet morphologies.Combined with an anode-only Nafion 117 catalyst-coated membrane(CCM),the Pt-NS electrode with an ultralow loading of 0.015 mgPt cm−2 demonstrates superior cell performance to the commercial CCM(3.0 mgPt cm^(−2)),achieving 99.5%catalyst savings and more than 237-fold higher catalyst utilization.The remarkable performance with high catalyst utilization is mainly due to the vertically well-aligned ultrathin nanosheets with good surface coverage exposing abundant active sites for the electrochemical reaction.Overall,this study not only paves a new way for optimizing the catalyst uniformity and surface coverage with ultralow loadings but also provides new insights into nanostructured electrode design and facile fabrication for highly efficient and low-cost PEMECs and other energy storage/conversion devices. | Lei Ding Zhiqiang Xie Shule Yu Weitian Wang Alexander Y.Terekhov Brian K.Canfield Christopher B.Capuano Alex Keane Kathy Ayers David A.Cullen Feng-Yuan Zhang | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 9 | Actuator fault diagnosis for uncertain linear systems using a high-order slidingmode robust differentiator显示文摘 | CHEN Weitian SAIF M | 2008 | International Journal of Robust and Nonlinear Control2008，18，6： | 1 |
| 10 | Sufficient conditions on fuzzy logic controllers as universal approximators显示文摘 | | 2001 | IEEE Transaction on Systems Man and Cybernetics-Part B:Cybernetics2001，31，2： | 1 |
| 11 | Modified differential evolution strategy for antenna array pattern synthesis显示文摘 | Li Xin Li Weitian Shi Xiaowei | 2013 | Progress in Electromagnetics Research2013，137，2： | 1 |
| 12 | Microarray analy- sis of two single-nucleotide polymorphisms of transforming growth factor alpha in patients with nonsyndromic cleft of north china显示文摘 | Wei Xu Weitian Han Yongping Lu | 2014 | CPCJ2014，51，4： | 1 |
| 13 | Linear and nonlinear optical properties of Ag nanocluster BaTiO2 composite films显示文摘 | Yang Guang Wang Weitian Zhou Yueliang | 2008 | Appl Phys Lett2008，81，21： | 1 |
| 14 | A primal-dual interior point algorithm for solving bilevel programming problem显示文摘 | WENG Weitian Wen U P | | 0，，： | 1 |
| 15 | Nonlinear optical properties of Fe/BaTiO3 composite thin films prepared by two-target pulsed laser deposition 显示文摘 | Wang Weitian Yang Guang Chen Zhenghao | 2003 | J Opt Soc Am B2003，20，6： | 1 |
| 16 | A Local and Global Search Combined Particle Swarm Optimization Algorithm and Its Convergence Analysis 显示文摘 | LI N Weitian LIAN Zhigang | | Mathematical Problems in Engi- neering0，211，14： | 1 |
| 17 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 18 | Z -scan determination of the large third - order optical nonlinearity of Rh: BaTiO3 thin films deposition on MgO substrates 显示文摘 | Guang Yang Weitian Wang Lei Yan | 2002 | Optics Communication2002，209，： | 1 |
| 19 | Iron nanoparticles in amorphous BaTiO3 thin films with large third - order optical nonlinearity 显示文摘 | Weitian Wang Guang Yang Zhenghao chen | 2002 | Journal of Applied Physics2002，92，12： | 1 |
| 20 | Study of the styrene–acrylic emulsion modified by hydroxyl-phosphate ester and its stoving varnish显示文摘 | Zeqin Zhong Qian Yu Huang Yao Weitian Wu Weiliang Feng Lin Yu Zhenyang Xu | 2013 | Progress in Organic Coatings2013，，5： | 1 |
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