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| 1 | HLA-A Gene Polymorphism Defined by High-Resolution Sequence-Based Typing in 161 Northern Chinese Han People显示文摘Human leukocyte antigen(HLA)system is the most polymorphic region known in the human genome.In the present study,we analyzed for the first time the HLA-A gene polymorphisms defined by the high-resolution typing methods-sequence-based typing(SBT)in 161 Northern Chinese Han people. A total of 74 different HLA-A gene types and 36 alleles were detected. The most frequent alleles were A 110101(GF=0.2360),A 24020101(GF=0.1646),and A 020101(GF=0.1553);followed by A 3303(GF=0.1180),A3001(GF=0.0590),and A310102(GF=0.0404).The frequencies of following alleles,A0203,A0205,A0206,A0207,A030101,A2423,A2601,A3201,and A3301,are all higher than 0.0093. The homozygous alleles include A020101,A110101,A24020101 and A310102.Heterozygosity(H),polymorphism information content (PIC),discrimination power(DP)and probability of paternity exclusion(PPE)of HLA-A in the samples were calculated and their values were 0.8705,0.8491,0.6014,and 0.9475,respectively. Han population,especially the allele subtypes character,will be of great interest for clinical transplantation, disease-associated study and forensic identification. Implementation of high-resolution typing methods allows a significantly wider spectrum of HLA variation including rare alleles. This rpectrum will further be extensively utilized in many fields. | ChunxiaYan RuilinWang JingxiangLi YajunDeng DongyingWu HongboZhang HongxingZhang LidongWang ChunrongZhang HaiyanSun XiuqingZhang JianWang HuanmingYang ShengbinLi | 2003 | Genomics, Proteomics & Bioinformatics2003，1，4： | 13 |
| 2 | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China显示文摘We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. | E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen BingyinSi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 6 |
| 3 | Polymorphism Profile of Nine Short Tandem Repeat Loci in the Han Chinese显示文摘Nine short tandem repeat (STR) markers (D3S1358, VWA, FGA, THO1, TPOX,CSFIPO, D5S818, D13S317, and D7S820) and a sex-identification marker (Amel-ogenin locus) were amplified with multiplex PCR and were genotyped with afour-color fluorescence method in samples from 174 unrelated Han individuals inNorth China. The allele frequencies, genotype frequencies, heterozygosity, prob-ability of discrimination powers, probability of paternity exclusion and Hardy-Weinberg equilibrium expectations were determined. The results demonstratedthat the genotypes at all these STR loci in Han population conform to Hardy-Weinberg equilibrium expectations. The combined discrimination power (DP) was1.05 × 10-10 within nine STR loci analyzed and the probability of paternity exclusion(EPP) was 0.9998. The results indicate that these nine STR loci and the Amelo-genin locus are useful markers for human identification, paternity and maternitytesting and sex determination in forensic sciences. | ShuangdingLi ChunxiaYan YajunDeng RuilinWang JianWang HuanmingYan ShengbinLi | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 0 |
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