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| 1 | A new interpretation of the tectonic setting and age of meta-basic volcanics in the Ondor Sum Group, Inner Mongolia显示文摘The Ondor Sum Group in the central Inner Mongolia is mainly composed of meta-basic volcanics intercalated with ferruginous quartzite and quartz schist,and has been interpreted as slices of oceanic crust or an ophiolite suite of the Early Paleozoic or much older ages.This paper presents new LA-ICP-MS zircon U-Pb dating and geochemical data for the meta-basic volcanics.The results show that zircons in the meta-basic volcanics were derived from complicated sources,most of which may be captured by basic magma from the country rocks or other sources.They yield a large age range from the Late Archean to Early Mesozoic with the youngest age group between 246 and 261 Ma,constraining the protolith of the meta-basic volcanics formed in the Late Permian to Early Triassic.The meta-basic volcanics have an affinity to E-MORB in geochemistry,and also a similarity toward OIB,representing a tectonic setting of limited intra-continental ocean basin.This limited basin might have been related to the continuous extension of the area since the Early Permian and finally closed in the Early Mesozoic. | CHU Hang ZHANG JinRui WEI ChunJing WANG HuiChu REN YunWei | 2013 | Chinese Science Bulletin2013，58，28： | 25 |
| 2 | Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis显示文摘AIM To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction(DCQD) in the liver of rats with severe acute pancreatitis(SAP) based on an herbal recipe tissue pharmacology hypothesis.METHODS Healthy male Sprague-Dawley rats were randomly divided into a sham operation group(SOG); a model group(MG); and low-, median- and high-dose treatment groups(LDG, MDG, and HDG, respectively). Different dosages(6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP. The tissue concentrations of aloeemodin, rhein, emodin, chrysophanol, honokiol, rheo chrysophanol, magnolol, hesperidin, naringenin and naringin in the liver of the treated rats were detected by high-performance liquid chromatography tandem mass spectrometry. Alanine transaminase(ALT) and aspartate transaminase(AST) in serum, inflammatory mediators in the liver and pathological scores were evaluated.RESULTS The major components of DCQD were detected in the liver, and their concentrations increased dosedependently. The high dose of DCQD showed a maximal effect in ameliorating the pathological damages, decreasing the pro-inflammatory mediators tumor necrosis factor-α and interleukin(IL)-6 and increasing anti-inflammatory mediators IL-4 and IL-10 in the liver. The pathological scores in the pancreas for the MG were significantly higher than those for the SOG(P < 0.05). DCQD could reduce the pathological scores in the pancreas and liver of the rats with SAP, especially in the HDG. Compared to the SOG, the ALT and AST levels in serum were higher in the MG(P < 0.05), while there was no statistical difference in the MG and HDG.CONCLUSION DCQD could alleviate liver damage by altering the inflammatory response in rats with SAP based on the liver distribution of its components. | Yu-Mei Zhang Hong-Yu Ren Xian-Lin Zhao Juan Li Jun-Yi Li Fu-Sheng Wu Hang Su Wen-Fu Tang | 2017 | World Journal of Gastroenterology2017，23，8： | 26 |
| 3 | Endostatin inhibits hypertrophic scarring in a rabbit ear model显示文摘Objective:The present study was designed to use an in vivo rabbit ear scar model to investigate the efficacy of systemic administration of endostatin in inhibiting scar formation.Methods:Eight male New Zealand white rabbits were randomly assigned to two groups.Scar model was established by making six full skin defect wounds in each ear.For the intervention group,intraperitoneal injection of endostatin was performed each day after the wound healed(about 15 d post wounding).For the control group,equal volume of saline was injected.Thickness of scars in each group was measured by sliding caliper and the scar microcirculatory perfusion was assessed by laser Doppler flowmetry on Days 15,21,28,and 35 post wounding.Rabbits were euthanatized and their scars were harvested for histological and proteomic analyses on Day 35 post wounding.Results:Macroscopically,scars of the control group were thicker than those of the intervention group.Significant differences between the two groups were observed on Days 21 and 35(p<0.05).Scar thickness,measured by scar elevation index(SEI) at Day 35 post wounding,was significantly reduced in the intervention group(1.09±0.19) compared with the controls(1.36±0.28).Microvessel density(MVD) observed in the intervention group(1.73±0.94) was significantly lower than that of the control group(5.63±1.78) on Day 35.The distribution of collagen fibers in scars treated with endostatin was relatively regular,while collagen fibers in untreated controls were thicker and showed disordered alignment.Western blot analysis showed that the expressions of type I collagen and Bcl-2 were depressed by injection of endostatin.Conclusions:Our results from the rabbit ear hypertrophic scar model indicate that systemic application of endostatin could inhibit local hypertrophic scar formation,possibly through reducing scar vascularization and angiogenesis.Our results indicated that endostatin may promote the apoptosis of endothelial cells and block their release of platelet-derived growth factor(PDGF) and fibroblast growth factor(FGF),thereby controlling collagen production by fibroblasts.Blood vessel-targeted treatment may be a promising strategy for scar therapy. | Hai-tao REN Hang HU Yuan LI Hong-fei JIANG Xin-lei HU Chun-mao HAN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，3： | 17 |
| 4 | Hierarchical Dragonfly Wing: Microstructure-Biomechanical Behavior Relations显示文摘 | Yinglong Chen Xishu Wang Huaihui Ren Hang Yin Su Jia | 2012 | Journal of Bionic Engineering2012，9，2： | 13 |
| 5 | Platelet count combined with right liver volume and spleen volume measured by magnetic resonance imaging for identifying cirrhosis and esophageal varices显示文摘AIM: To determine whether the combination of platelet count(PLT) with spleen volume parameters and right liver volume(RV) measured by magnetic resonance imaging(MRI) could predict the Child-Pugh class of liver cirrhosis and esophageal varices(EV).METHODS: Two hundred and five cirrhotic patients with hepatitis B and 40 healthy volunteers underwent abdominal triphasic-enhancement MRI and laboratory examination of PLT in 109/L. Cirrhotic patients underwent endoscopy for detecting EV. Spleen maximal width(W), thickness(T) and length(L) in mm together with spleen volume(SV) and RV in mm3 were measured by MRI, and spleen volume index(SI) in mm3 was obtained by W × T × L. SV/PLT, SI/PLT and RV × PLT/SV(RVPS) were calculated and statistically analyzed to assess cirrhosis and EV.RESULTS: SV/PLT(r = 0.676) and SI/PLT(r = 0.707) increased, and PLT(r =-0.626) and RVPS(r =-0.802) decreased with the progress of Child-Pugh class(P < 0.001 for all). All parameters could determine the presence of cirrhosis, distinguish between each class of Child-Pugh class, and identify the presence of EV [the areas under the curve(AUCs) = 0.661-0.973]. A m o n g p a ra m e t e r s, R V P S c o u l d b e s t d e t e r m i n e presence and each class of cirrhosis with AUCs of 0.973 and 0.740-0.853, respectively; and SV/PLT could best identify EV with an AUC of 0.782.CONCLUSION: The combination of PLT with SV and RV could predict Child-Pugh class of liver cirrhosis and identify the presence of esophageal varices. | Xiao-Li Chen Tian-Wu Chen Xiao-Ming Zhang Zhen-Lin Li Nan-Lin Zeng Ping Zhou Hang Li Jing Ren Guo-Hui Xu Jia-Ni Hu | 2015 | World Journal of Gastroenterology2015，21，35： | 10 |
| 6 | Protein A immunoadsorption combined with rituximab in highly sensitized kidney transplant recipients显示文摘背景高度敏化的病人的数字正在升起,并且促进感受性能导致肾移植学习试图调查 immunoadsorption 在肾 transplants.Methods 的高度敏化的接受者与 rituximab ( RTX )相结合的蛋白质的安全和功效的在场的 failure.The 七个高度敏化的接受者生活相关肾移植( 4 个男人和 3 个女人, 42.5 岁(范围 33-51 )的平均数)是有这联合的 pretreated 。人的白血球抗原(HLA ) 失配数字是 2-5。班 1 的面板反应抗体(PRA ) 在 2 种情况中高,班的在 1 种情况中高。所有病人是有 immunoadsorption 2-10 时间的 pretreated。免疫球蛋白和 PRA 变化在吸收前后被监视。当 PRA 或免疫球蛋白层次在或下面正常的 levels.Immunosuppressive 药是如果在操作前的 3-5 天,和 RTX (375 mg/m^2 ) 的一剂量在操作的日子与 polyclonal 抗体被灌输时,操作被进行。手术后的 creatinine (Cr ) , creatinine 清理率(Ccr ) , PRA 比率,和免疫球蛋白变化都是 monitored.Results 没有推迟的接枝功能, 7 个病人有好恢复。尖锐拒绝在手术后的天发生在 3 种情况中 8, 10,和 14 分别地。Banff 07 活体检视等级是在 1 种情况中的 la,在 2 cases.Successful 回复的 lla C4d0 在给 methylprednisolone 或 antithymocyte 免疫球蛋白 + cyclophosphamide 以后被完成。所有病人与正常肾的功能被解除,意味着班 1 PRA 是 14% ,吝啬的类 PRA 是 35% 。PRA 在与 RTX 相结合的 immunoadsorption 能安全地减少的 3 cases.Conclusion 蛋白质是完全否定的体液的拒绝在的出现高度敏化肾移植接受者。 | YIN Hang HU Xiao-peng LI Xiao-bei LIU Hang WANG Wei REN Liang WANG Yong ZHANG Xiao-dong | 2009 | Chinese Medical Journal2009，，22： | 9 |
| 7 | Assessment of different biomarkers provides valuable diagnostic standards in the evaluation of the risk of acute rejection显示文摘尖锐拒绝(AR ) 是为长期的拒绝在的一个强壮的风险因素肾移植接受者。AR 事件的精确、及时的诊断为疾病控制和预后是很重要的。因此,客观地评估了病人的有免疫力的地位在移植以后的治疗的地里是必要的。这纵的研究在外部血 mononuclear 房间( PBMC )和活体检视在 sera ,CD4+ T 房间的细胞内部的腺苷 triphosphate ( iATP )版本水平,和 granzyme B/perforin 表示调查了五 biomarkers ,人的白血球抗原( HLA ) -G5 和 sCD30 水平的实用性,总共肾的移植的 84 个案例的检测 AR 和 biomarkers 的决定。数据证明接受者与临床或证明的活体检视拒绝显著地增加了 CD4+ T 房间的 iATP 版本水平,并且提高了 sCD30,但是与稳定的接枝功能与个人相比在 sera 降低了 HLA-G5 水平。granzyme B 和 perforin 的表示层次也在 PBMC 和 AR 病人的接枝活体检视被提高。一起拿,我们鉴别 HLA-G5 的 sCD30, iATP, granzyme B, perforin,和 downregulation 的 upregulation 能提供珍贵诊断标准在 AR 的风险识别那些接受者。并且 iATP 可以比为预言接枝拒绝事件的其它是更好的 biomarker。 | Jin Zheng Xiaoming Ding Xiaohui Tian Zhankui Jin Xiaoming Pan Hang Yan Xinshun Feng Jun Hou Heli Xiang Li Ren Puxun Tian Wujun Xue | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 8 |
| 8 | Research on the carbon isotopic composition of organic matter from Lake Chenghai and Caohai Lake sediments显示文摘The carbon isotopic composition of organic matter from lake sediments has been extensively used to infer variations in productivity. In this paper, based on the study of the contents and δ13C values of organic matter in different types of lakes, it has been found that δ13C values of organic matter have different responses to lake productivity in different lakes. As to the lakes dominated by aqutic macrophytes such as Lake Caohai, organic matter becomes enriched in 13C with increasing productivity. As to the lakes dominated by aquatic algae such as Lake Chenghai, δ13C values of organic matter decrease with increasing productivity, and the degradation of aquatic algae is the main factor leading to the decrease of δ13C values of organic matter with increasing productivity. Therefore, we should be cautious to use the carbon isotopic composition of organic matter to deduce lake productivity. | ZHU Zhengjie CHEN Jing'an ZENG Yan LI Hang YAN Hui REN Shicong | 2011 | Chinese Journal Of Geochemistry2011，30，1： | 7 |
| 9 | Factors affecting the long-term renal allograft survival显示文摘在过去的十年的背景, cadaveric 的一个年接枝幸存肾的 allografts 显著地被改进了,但是他们的长期的幸存没保留步。在一年以后幸存的肾的 allografts 的摩擦率仍然保持几乎未改变。为迟了的接枝损失的原因是多重的。这研究的目的是分析在我们回顾地分析了的肾 transplantation.Methods 以后影响接枝的长期的幸存的预兆的因素在我们在1991年1月和2000年1月之间的医院里被对待的 524 个肾移植病人,包括生活了的 254 个病人有正常接枝功能(长幸存组)的超过 10 年,和其肾的接枝不到 10 年(控制组)幸存的 270 个盒子。明确地,我们分析了可以潜在地由 univariate 和逻辑模型 multivariate 分析影响接枝幸存指出分析显示出的独立风险 factors.Results Univariate 的 10 个因素没有重要差别在接受者的年龄或性存在,分离时间, lymphotoxin 层次,或在二之间的冷局部缺血时间组织。然而,推迟的接枝功能的比率和尖锐拒绝,和在长幸存的病人的尿酸层次组织是比在控制组(P 0.01 ) 的那些显著地低的。而且,我们发现在在移植和为在长幸存组以内的病人的施主接受者的 histocompatibility 抗原匹配以后的一年的 cyclosporin A 的集中比在控制组(P 0.01 ) 的那些显著地高。而且, multivariate 分析证明这四个因素是影响推迟的接枝功能和尖锐拒绝,在在移植以后的一年的 cyclosporin A 的集中,和尿酸铺平的浆液的比率是的耐心的 survival.Conclusions 的独立风险因素影响肾的接枝的长期的幸存的很重要的因素。 | WANG Wei LI Xiao-bei YIN Hang YANG Xiao-yong LIU Hang REN Liang HU Xiao-peng WANG Yong ZHANG Xiao-dong | 2011 | Chinese Medical Journal2011，，8： | 7 |
| 10 | Constitutive Modeling and Hot Deformation Behavior of Duplex Structured Mg–Li–Al–Sr Alloy显示文摘Hot deformation behavior of an as-extruded duplex structured Mg–9Li–3Al–2.5Sr alloy is investigated via hot compression tests conducted at 200–350 °C with strain rate of 0.001–1 s-1.The flow behavior of Mg–9Li–3Al–2.5Sr alloy can be described accurately by hyperbolic sine constitutive equation and the average activation energy for deformation is calculated as 143.5 k J/mol.Based on a dynamic materials model,the processing maps of Mg–9Li–3Al–2.5Sr alloy which describe the variation of power dissipation efficiency are constructed as a function of temperature and strain rate.The processing maps exhibit an area of discontinuous dynamic recrystallization occurring at 280–300 °C with strain rate of 0.001–0.01 s-1,which corresponds to the optimum hot working conditions. | Yan hang Xiaodong Peng Fengjuan Ren Haiming Wen Junfei Su Weidong xie | 2016 | Journal of Materials Science & Technology2016，32，12： | 6 |
| 11 | Size-dependent elastic properties of thin films: surface anisotropy and surface bonding显示文摘Surface eigenstress and eigendisplacement models were used to investigate the surface stress,surface relaxation and surface elasticity of thin films with different surface orientations.Molecular dynamics simulations and first-principles calculations were conducted on face-centered cubic Au films with the focus on relaxation induced nonlinear initial deformation.The simulation results verify the theoretical predictions of the size dependency of surface energy density and surface stress,and the nonlinear scaling law of the size-dependent Young’s modulus of thin films.The mechanism of the size-dependent behaviors was further explored at the atomic bonding level with the charge density field.The Au atomic bonding at surfaces is enhanced compared to its interior counterpart and therefore the nominal Young’s modulus of the Au thin films is larger when the film thickness is smaller. | ZHOU XiaoYe REN Hang HUANG BaoLing ZHANG TongYi | 2014 | Science China(Technological Sciences)2014，57，4： | 5 |
| 12 | A novel design of 3D carbon host for stable lithium metal anode显示文摘Rational design of porous conductive hosts with high electrical conductivity,large surface area,and adequate interior space is desirable to suppressing dendritic lithium growth and accommodating large volume change of lithium metal anode during the Li plating/stripping process.However,due to the conductive nature of the conductive hosts,Li is easily deposited directly on the top of the hosts,which hinders it from fully functioning.To circumvent the issue,in this study,we designed a novel porous carbon host with a gradient-pore-size structure based on one-dimensional(1D)carbon with different diameters.With this kind of host,stable cycling with high and stable Coulombic efficiency of~98%is achieved at 0.5 mA cm^(−2) with an areal capacity of 1 mAh cm^(−2) over 320 cycles.In contrast,the normal three-dimensional(3D)carbon nanotube host presents a moss-like Li morphology with wildly fluctuating Coulombic efficiency after 100 cycles.The results reveal that the unique gradient-pore-size structure of the 3D conductive host greatly improves the performance of lithium metal batteries. | Hang Liu Jie Di Ping Wang Rui Gao Han Tian Pengfei Ren Qingxi Yuan Wanxia Huang Ruiping Liu Qiang Liu Ming Feng | 2022 | Carbon Energy2022，4，4： | 5 |
| 13 | A retrospective comparison of the efficacy and safety in kidney transplant recipients with basiliximab and anti-thymocyte globulin显示文摘 | WANG Wei YIN Hang LI Xiao-bei HU Xiao-peng YANG Xiao-yong LIU Hang REN Liang WANG Yong ZHANG Xiao-dong | 2012 | Chinese Medical Journal2012，，6： | 5 |
| 14 | Fabrication of BiOBr-silicone aerogel photocatalyst in an aqueous system with degradation performance by sol-gel method显示文摘It is a challenge to endow the material with the ability to pollutants degradation while maintaining the oil/water separation performance. Herein, the mixed dispersion of BiOBr photocatalyst and silicone sol was adsorbed in melamine foam. Superhydrophobic BiOBr-silicone aerogel(WCA=154°) was obtained through the transfer melamine foam to an autoclave and reaction at 80℃ for 20 h. The prepared superhydrophobic BiOBr-silicone aerogel can effectively remove the water soluble pollutants which remain within the water phase after oil/water separation. The band gap of the superhydrophobic BiOBr-silicone aerogel was calculated to be 2.71 eV, which shows sensitivity to visible light(458 nm). Through mechanism analysis, it is found that the VB position of BiOBr is at 1.07 eV and the position of CB is at-1.64 eV. Finally, we prepared a superhydrophobic BiOBr-silicone aerogel(5 cm×5 cm×3 cm) for the verification of the large scale preparation. | GE Bo REN GuiNa YANG Hang YANG JingJing PU XiPeng LI WenZhi JIN ChuanYu ZHANG ZhaoZhu | 2020 | Science China(Technological Sciences)2020，63，5： | 4 |
| 15 | Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet显示文摘BACKGROUND Obesity worsens inflammatory organ injury in acute pancreatitis(AP), but there is no effective preventive strategy. Sheng-jiang powder(SJP) has been shown to alleviate multiple-organ inflammatory injury in rats with high-fat diet-induced obesity. Hence, SJP is supposed to have an effect on multiple-organ inflammatory injury in AP in rats fed a high-fat diet.AIM To explore how obesity may contribute to aggravating inflammatory organ injury in AP in rats and observe the effect of SJP on multiple-organ inflammatory injury in AP in rats fed a high-fat diet.METHODS Rats were randomly assigned to a control group(CG), an obese group(OG), and an SJP treatment group(SG), with eight rats per group. The rats in the OG and SG were fed a high-fat diet. From the third week, the rats in the SG were given oral doses of SJP(5 g/kg of body weight). After 12 wk, AP was induced in the three groups. Serum amylase level, body weight, Lee's index, serum biochemistry parameters, and serum inflammatory cytokine and tissue cytokine levels were assessed, and the tissue histopathological scores were evaluated and compared.RESULTS Compared with the CG, serum triglyceride, total cholesterol, interleukin-6, and interleukin-10 levels were significantly higher in the OG, and serum high-density lipoprotein cholesterol level was significantly lower in the OG. Moreover,enhanced oxidative damage was observed in the pancreas, heart, spleen, lung,intestine, liver, and kidney. Evidence of an imbalanced antioxidant defense system, especially in the pancreas, spleen, and intestine, was observed in the obese AP rats. Compared with the OG, serum high-density lipoprotein cholesterol, interleukin-10, and superoxide dismutase expression levels in the pancreas, spleen, and intestine were increased in the SG. Additionally, SJP intervention led to a decrease in the following parameters: body weight; Lee's index; serum triglyceride levels; serum total cholesterol levels; malondialdehyde expression levels in the pancreas, heart, spleen, lung, and liver; myeloperoxidase expression levels in the lung; and pathological scores in the liver.CONCLUSION Obesity may aggravate the inflammatory reaction and pathological multipleorgan injury in AP rats, and SJP may alleviate multiple-organ inflammatory injury in AP in rats fed a high-fat diet. | Yi-Fan Miao Hong-Xin Kang Juan Li Yu-Mei Zhang Hong-Yu Ren Lv Zhu Huan Chen Ling Yuan Hang Su Mei-Hua Wan Wen-Fu Tang | 2019 | World Journal of Gastroenterology2019，25，6： | 4 |
| 16 | Activating PPARy Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia显示文摘The present study aimed to explore the molecular mechanisms underlying the increase of nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1(NQO1)and y-glutamylcysteine synthetase(γ-GCS)in brain tissues after intracerebral hemorrhage(ICH).The microglial cells obtained from newborn rats were cultured and then randomly divided into the normal control group(NC group),model control group(MC group),rosiglitazone(RSG)intervention group(RSG group),retinoic-acid intervention group(RSG+RA group),and sulfbraphane group(RSG+SF group).The expression levels of NQO1,γ-GCS,and nuclear factor E2-related factor 2(Nrf2)were measured by real-time polymerase chain reaction(RT-PCR)and Western blotting,respectively.The results showed that the levels of NQO1,γ-GCS and Nrf2 were significantly increased in the MC group and the RSG group as compared with those in the NC group(P<0.01).They were found to be markedly decreased in the RSG+RA group and increased in the RSG+SF group when compared with those in the MC group or the RSG group(P<0.01).The RSG+SF group displayed the highest levels of NQO1,γ-GCS,and Nrf2 among the five groups.In conclusion,a medium dose of RSG increased the anti-oxidative ability of thrombinactivated microglia by increasing the expression of NQO1 and γ-GCS.The molecular mechanisms underlying the increase of NQO1 and γ-GCS in thrombin-activated microglia may be associated with the activation of Nrf2. | Hang HANG Li-kun WANG Si-ying REN An-jun SONG Guo-feng WU | 2020 | Current Medical Science2020，40，1： | 4 |
| 17 | Neuroendocrine characteristics of induced pluripotent stem cells from polycystic ovary syndrome women显示文摘Dear Editor, Polycystic ovary syn drome (PCOS) is a comm on female reproductive endocrinopathy that afflicts up to 10%-15% of women in reproductive age worldwide (Nestler, 2016). Women with PCOS exhibit hyperandrogenism, intermittent/ absent menstrual cycles, and polycystic ovaries on ultrasound (Rotterdam, 2004). The pathophysiology of PCOS extends beyond infertility and hirsutism to hypothalamic neuroendocrine dysfunotion (Goodarzi et al., 2011). Most wome n with PCOS exhibit in creased luteinizing horm one (LH) levels, resulting from high-frequency gonadotropin-releasing hormone (GnRH) secretion (Cimino et al., 2016). Pren ata I testostero ne (T) treatment in sheep results in disrupted steroid feedback on gonadotropin release, which in creases pituitary sen sitivity to GnRH and subseque ntly leads to LH hypersecretion (Sullivan and Moenter, 2004;Cardoso et al., 2016). A recent study shows that GnRHdependent LH pulsatility and secretion are elevated by anti- Mullerian hormone (AMH) in PCOS disease. The increased prenatal AMH reprograms fetus and induces PCOS in adults (Tata et al., 2018). Furthermore, the androgen receptor (AR) plays a role in hyperandrogenism and ovarian folliculoge esis in PCOS (Wang et al., 2015;Abbott, 2017). However, the disease mechanism behind PCOS remains unclear, and current management focuses on treating the symptoms but not the mechanism (Chen et al., 2016;Shi et al., 2018). A further understanding of this disease is necessary to uncover the pathology of PCOS and develop new potential therapeutic avenues and drugs. | Zheying Min Yue Zhao Jing Hang Yun Ren Tao Tan Yong Fan Yang Yu | 2019 | Protein & Cell2019，10，7： | 4 |
| 18 | Changes in biochemical parameters on the first day after kidney transplantation: risk factors for nosocomial infection?显示文摘在早移植以后的时期的背景医院的感染是为肾移植的一个坚韧的问题。很少报告在肾移植探索了在生物化学的参数和医院的感染之间的关系。这回顾的研究被执行在肾移植的早时期描述医院的感染的特征并且在生物化学的参数和他们的改变决定风险因素。在北京 Chao-Yang 医院里从 2001 年 1 月经历了他们的第一肾移植到 2009 年 3 月的方法病人被招募,医院的传染事件为这研究是镇定的。性,年龄,施主类型,推迟的接枝函数(DGF ) 和象浆液那样的生物化学的参数白天 0 上的尿酸,类脂化合物文件和白朊(在移植前) 并且白天 1 (在移植以后的 24 个小时) 并且他们的变化为医院的感染与逻辑回归模型一起被分析。405 个病人(315 个男人和 90 个女人) 全部的结果 A 涉及这研究。有 80 个病人,经历 113 个感染事件,微生物的 105 紧张是 indentified。在 univariate 分析,在 DGF 有重要差别,白天 0 上的白朊,白天 1 上的脂蛋白(a)( Lp (a)),在低密度脂蛋白胆固醇的变化( LDL-C ,白天1天 0 )并且在尿酸变化(白天1天 0 )在医院的感染病人和 noninfectious 病人之间( P < 0.05 )。在 multivariate 分析,在尿酸变化(白天 1 天 0 )( 离开 5.139, 95% Cl 1.176-22.465, P < 0.05 ) ,在 LDL-C 的变化(白天 1 天 0 ){ OR4.179, 95% Cl 1.375-12.703, P < 0.05 ) 并且 DGF (吗?14.409, 95% Cl 1.603-129.522, P < 0.05 ) 在肾移植为医院的感染作为独立风险因素被识别。在肾移植的早手术后的时期的结论很医院的感染是细菌的,特别与克否定的细菌。最普通的感染地点是呼吸的道,尿道和外科的地点。DGF, LDL-C 的减少和尿酸的增加能为医院的感染增加风险。 | YANG Yi REN Liang ZHANG Yong LIU Hang CAO Bin ZHANG Xiao-dong | 2010 | Chinese Medical Journal2010，，5： | 4 |
| 19 | Investigation of Portevin–Le Chatelier effect in rolled α-phase Mg-Li alloy during tensile and compressive deformation显示文摘Avoiding the Portevin-Le Chatelier(PLC)effect is very important concern for wrought Mg-Li alloys.In this study,the special PLC effect was found in rolled Mg-5Li-3Al-2Zn(LAZ532)alloy during tensile and compressive deformation.By observing microstructure evolution of the alloy during tensile and compressive deformation,it was found that prismaticand pyramidalslips were activated during tensile deformation,resulting in plenty of dislocation accumulation.In the deformation process after compressive yielding,the deformations in coarse grains and fine grains were dominated by{1012}extension twinning and grain boundary slip,respectively.Based on experimental result analysis,the sudden appearance of PLC effect in the later stage of axial tensile deformation(along rolled direction)was caused by interaction between solute atoms and dislocations.In the process of axial compressive deformation(along rolled direction),PLC effect presented the complex and changeable phenomenon of appeared-disappeared-appeared,which was mainly caused by the continuous nucleation of twin in the material,the activation of grain boundary slip and the shear deformation of twin,respectively. | Xiaoqiang Li Chunlong Cheng Qichi Le Lei Bao Peipeng Jin Ping Wang Liang Ren Hang Wang Xiong Zhou Chenglu Hu | 2020 | Journal of Materials Science & Technology2020，52，17： | 3 |
| 20 | Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis显示文摘Depression is a serious public-health issue.Recent reports have suggested higher susceptibility to viral infections in depressive patients.However,how depression affects antiviral innate immune signaling remains unknown.Here,we revealed a reduction in expression of Abelson helper integration site 1(AHI1)in the peripheral blood mononuclear cells(PBMCs)and macrophages from the patients with major depressive disorder(MDD),which leads to attenuated antiviral immune response.We found that depression-related arginine vasopressin(AVP)induces reduction of AHI1 in macrophages.Further studies demonstrated that AHI1 is a critical stabilizer of basal type-I-interferon(IFN-I)signaling.Mechanistically,AHI1 recruits OTUD1 to deubiquitinate and stabilize Tyk2,while AHI1 reduction downregulates Tyk2 and IFN-I signaling activity in macrophages from both MDD patients and depression model mice.Interestingly,we identified a clinical analgesic meptazinol that effectively stimulates AHI1 expression,thus enhancing IFN-I antiviral defense in depression model mice.Our study promotes the understanding of the signaling mechanisms of depression-mediated antiviral immune dysfunction,and reveals meptazinol as an enhancer of antiviral innate immunity in depressive patients. | Hong-Guang Zhang Bin Wang Yong Yang Xuan Liu Junjie Wang Ning Xin Shifeng Li Ying Miao Qiuyu Wu Tingting Guo Yukang Yuan Yibo Zuo Xiangjie Chen Tengfei Ren Chunsheng Dong Jun Wang Hang Ruan Miao Sun Xingshun Xu Hui Zheng | 2022 | Cell Research2022，32，10： | 3 |
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