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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem cell line显示文摘AIM: To investigate the photodynamic inhibitory effects of Elsinochrome A (EA), Hypocrellin A (HA) and Hypocrellin B (HB) on human colorectal carcinoma Hce-8693 cells and rhesus monkey embryonic stem R366.4 cells, via inducing apoptosis.METHODS: EA, HA and HB were extracted from metabolites of Hypomyces (Fr) Tul.Sp. R366.4 cells or Hce8693 cells were cultured with different concentrations of EA, HA or HB respectively, irradiated and incubated with fresh medium for 2 h. Cell cycle analysis was performed by flow cytometry (FCM). Data were expressed as means ±SD and analysis of variance and Student' t-test for individual comparisons.RESULTS: The photodynamic bioactivity of EA was first reported in this study. After irradiation for 5 min, 6 min, 10 min or 20 min, photoactivated EA at lower concentrations,which were 10-7 Mol/L, 10-6 Mol/L, 10-5 Mol/L respectively,had no cytotoxic effects on R366.4 ES ceils. Whereas, all of the three perylenequinones could induce apoptosis with a dose-dependent manner when Hce-8693 cells were incubated with photoactivated EA, HA and HB respectively. When Hce-8693 cells were incubated with EA at 10-6 Mol/L and irradiated 5 lin, 6 min, 10 min and 20 min respectively,the rates of EA-induced apoptosis were 0, 0, 13.4 % and 40.5 %. While the rates of HA-induced apoptosis were 29.5 %, 32.0 %, 40.2 % and 22.6 %. And the rates of HBinduced apoptosis were 0, 0, 0 and 13.7 % respectively.Meanwhile, after 10-5 Mol/L treatment, the rates of EA-induced apoptosis were 32.7 %, 19.3 %, 26.4 % and 52.7 %, the rates of HA-induced apoptosis were 47.2 %, 39.1%, 45.2% and 56.6 %, and the rates of HB-induced apoptosis were 0, 0, 20.0 % and 13.9 % respectively.CONCLUSION: EA, HA and HB have significant anti-cancer activity. The order of photodynamic inhibitory effects on tumor cells would be approximately HA>EA>HB. The molecular mechanisms of apoptosis may not be induced by reactive oxygen species and are worth further investigation. | LanMa HongTai CongLi YuZhang Ze-HuaWang Wei-ZhiJi | 2003 | World Journal of Gastroenterology2003，9，3： | 14 |
| 3 | The emergence, development and regional differences of mixed farming of rice and millet in the upper and middle Huai River Valley, China显示文摘Mixed farming of rice and millet is one of the basic agricultural modes in the upper and middle Huai River Valley(HRV). According to the latest data, this agricultural mode appeared during the middle and late Peiligang Culture(7.8–7.0 ka BP) in the upper HRV, and then became a common subsistence economy in the end of the Neolithic(5.0–4.0 ka BP) in both the upper and middle HRV. However, it is still not clear how this mixed farming developed in the upper HRV after its occurrence, nor are the regional differences in the development of mixed farming between the upper and middle HRV during the Neolithic completely understood. In this paper, flotation and starch analyses were conducted on samples from eight archaeological sites in the upper and middle HRV. The results indicate that the mixed farming of rice and millet first appeared in the later phase of the middle Neolithic in the regions of the Peiligang Culture, then developed quite rapidly in the late Neolithic(6.8–5.0 ka BP), finally becoming the main subsistence economy at the end of the Neolithic in the upper HRV. However, there are obvious differences in the emergence and development of agriculture between the middle and upper HRV. Rice farming was the only agricultural system during the middle Neolithic, lasting until the end of the Neolithic, when mixed farming appeared in the middle HRV. Furthermore, although mixed farming appeared in both the upper and middle HRV during the end of the Neolithic, the roles of rice, foxtail millet and broomcorn millet in the subsistence economy were not the same. In general, millet was more widely cultivated than rice in the upper HRV, but rice occupied the same or a slightly more prominent position in the middle HRV at the end of the Neolithic. These results are significant for understanding the process of agricultural development and transformation, as well as human adaptation to climatic and cultural variability duringthe Neolithic. | YANG YuZhang CHENG ZhiJie LI WeiYa YAO Ling LI ZhanYang LUO WuHong YUAN ZengJian ZHANG Juan ZHANG JuZhong | 2016 | Science China Earth Sciences2016，59，9： | 11 |
| 4 | Plant food sources and stone tools' function at the site of Shunshanji based on starch grain analysis显示文摘The upper-middle Huai River valley(HRV) is located in the transition zone in the middle of eastern China. Previous studies have shown that the past populations in the upper HRV obtained plant food through gathering and cultivation of both rice and millet during the middle Neolithic. However, for the middle HRV it is not very clear what methods were used by humans to obtain plant food in that time. In this paper, starch grain analysis was carried out on 17 stone tools and 29 cauldron pottery sherds unearthed at Shunshanji(8.5–7.0 kyr BP), which is known as the earliest Neolithic site in the middle HRV excavated so far. Here, ancient starches from Coix lacryma-jobi, Triticeae, Oryza sativa, Trichosanthes kirilowii and one unidentified specie were recovered. This study contributes to the limited knowledge of food strategies as observed in the middle HRV. It demonstrates that both gathering and cultivation of rice took place during the middle-Neolithic. Among the identified species, Coix lacryma-jobi appears to have been the main plant food at Shunshanji. Moreover, it is clear that Oryza sativa was not consumed as much as other plant species according to the occurrence frequency of different starch grains. Starch grains were also found on the used surfaces of grinding stone implements as well as pestles, which means that these stone tools were used for food processing. In addition, axes from Shunshanji may also have been used for food processing as well as wood working because starches were also found on the edge of axes. Information about subsistence strategies and tool use at Shunshanji will also be helpful to understanding the utilization of plants and agricultural development in the middle HRV during the early-middle Neolithic period. | YANG YuZhang LI WeiYa YAO Ling CHENG ZhiJie LUO WuHong ZHANG JuZhong LIN LiuGen GAN HuiYuan YAN Long | 2016 | Science China Earth Sciences2016，59，8： | 9 |
| 5 | Impedance Modeling and Stability Analysis of PV Grid-connected Inverter Systems Considering Frequency Coupling显示文摘Impedance analysis is an effective method to analyze the oscillation issue associated with grid-connected photovoltaic systems.However,the existing impedance modeling of a gridconnected photovoltaic inverter usually only considers the effect of a single perturbation frequency,ignoring the coupling frequency response between the internal control loops of a grid-connected inverter,which severely affects the accuracy of the stability analysis.Hence,a method of impedance modeling and stability analysis for grid-connected photovoltaic inverters considering cross-coupling frequency is proposed in this paper.First,the generation mechanism of frequency coupling in gridconnected photovoltaic inverters,and the relationship between the coupling frequency and perturbation frequency are analyzed.Secondly,a sequence impedance model of grid-connected photovoltaic systems considering the coupling frequency is established by using the harmonic linearization method.The impact of DC bus voltage control strategy on frequency coupling characteristics of a grid-connected photovoltaic system is evaluated,and the impact of a coupling frequency term on system stability is quantitatively analyzed.Finally,the advantages of the proposed method are verified by several simulations.The results show that the proposed impedance model can accurately predict the potential resonance points of the system,and the coupling frequency characteristics will become much stronger with smaller DC bus capacitance or larger bandwidth of the DC bus controller. | Shaojian Song Ze Wei Yuzhang Lin Bin Liu Hui Liu | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 8 |
| 6 | Dynamic State Estimation for Integrated Electricity-gas Systems Based on Kalman Filter显示文摘In recent years, integrated electricity-gas systems(IEGSs) have attracted widespread attention. The unifiedscheduling and control of the IEGS depends on high-precisionoperating data. To this end, it is necessary to establish anappropriate state estimation (SE) model for IEGS to filter theraw measured data. Considering that power systems and naturalgas systems have different time scales and sampling periods, thispaper proposes a dynamic state estimation (DSE) method basedon a Kalman filter that can consider the dynamic characteristicsof natural gas pipelines. First, the standardized state transitionequations for the gas system are developed by applying the finitedifference method to the partial differential equations (PDEs) ofthe gas system;then the DSE model for IEGS is formulatedbased on a Kalman filter;also, the measurements from theelectricity system and the gas system with different samplingperiods are fused to ensure the observability of DSE by using theinterpolation method. The IEEE 39-bus electricity system and the18-nodes Belgium gas system are integrated as the test systems.Simulation results verify the proposed method’s accuracy andcalculation efficiency. | Yanbo Chen Yuan Yao Yuzhang Lin Xiaonan Yang | 2022 | CSEE Journal of Power and Energy Systems2022，8，1： | 7 |
| 7 | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China显示文摘We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. | E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen BingyinSi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 6 |
| 8 | Data-driven Robust State Estimation Through Off-line Learning and On-line Matching显示文摘To overcome the shortcomings of model-driven state estimation methods, this paper proposes a data-driven robust state estimation (DDSE) method through off-line learning and on-line matching. At the off-line learning stage, a linear regression equation is presented by clustering historical data from supervisory control and data acquisition (SCADA), which provides a guarantee for solving the over-learning problem of the existing DDSE methods;then a novel robust state estimation method that can be transformed into quadratic programming (QP) models is proposed to obtain the mapping relationship between the measurements and the state variables (MRBMS). The proposed QP models can well solve the problem of collinearity in historical data. Furthermore, the off-line learning stage is greatly accelerated from three aspects including reducing historical categories, constructing tree retrieval structure for known topologies, and using sensitivity analysis when solving QP models. At the on-line matching stage, by quickly matching the current snapshot with the historical ones, the corresponding MRBMS can be obtained, and then the estimation values of the state variables can be obtained. Simulations demonstrate that the proposed DDSE method has obvious advantages in terms of suppressing over-learning problems, dealing with collinearity problems, robustness, and computation efficiency. | Yanbo Chen Hao Chen Yang Jiao Jin Ma Yuzhang Lin | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 6 |
| 9 | Aggregation-induced Emission-active Hyperbranched Poly (tetrahydropyrimidine)s Synthesized from Multicomponent Tandem Polymerization显示文摘Hyperbranched polymer with highly branched three-dimensional topological structure, a large number of end groups, and multifaceted functionalities have gained much attention, while polymers with aggregation-induced emission(AIE) properties become a group of popular luminescent materials recently. The design and synthesis of AIE-active hyperbranched polymers, which combine the advantages of these two types of materials, are attractive but challenging. In this work, four hyperbranched poly(tetrahydropyrimidine)s were synthesized from the metal-free room temperature multicomponent tandem polymerization of diester group-activated internal alkyne,polyfunctional aromatic amines, and formaldehyde in methanol under the catalysis of acetic acid. Through different monomer combination and controlling the monomer loading order, hyperbranched polymers with various topological structures as well as sequences of different functional groups in the polymer backbone were obtained with high molecular weights(up to 3.0 × 10~4 g/mol) in high yields(up to 98%). The hyperbranched poly(tetrahydropyrimidine) emitted faintly in solution, while its luminescence was notably enhanced in the aggregated state, suggesting its typical aggregation-induced emission property. It is anticipated that the multicomponent polymerization may provide a synthetic platform for the construction of hyperbranched polyheterocycles with diverse structures and functionalities. | Yuzhang Huang Ping Chen Bo Wei Rongrong Hu Ben Zhong Tang | 2019 | Chinese Journal of Polymer Science2019，37，4： | 6 |
| 10 | Hepatitis B Virus X Protein-Induced Aberrant Epigenetic Modifications Contributing to Human Hepatocellular Carcinoma Pathogenesis显示文摘 | Yi Tian Weibing Yang Jianxun Song Yuzhang Wu Bing Ni | 2013 | Molecular and Cellular Biology2013，，15： | 6 |
| 11 | Fiber-Optic Surface Plasmon Resonance Sensor With Multi-Alternating Metal Layers for Biological Measurement显示文摘 | Yanjie WANG Shengwei MENG Yuzhang LIANG Lixia LI Wei PENG | 2013 | Photonic Sensors2013，3，3： | 5 |
| 12 | Determination of erodible particles on cultivated soils by wind tunnel simulation显示文摘The erodible particle size distribution, diameter range and separate content of three soils from semi-arid regions of China were determined at different wind velocities through wind tunnel simulation and dry sieving. It was demonstrated that soil erodibility by wind depends not only on the intrinsic soil properties, but also on the extrinsic erosion effect of the erosive winds. It was supposed that there existed general consistency in the mechanics of wind erosion on different soils. | Lianyou Liu Jianhua Wang Xiaoyan Li Yuzhang Liu Wanquan Ta Haimei Peng | 1998 | Chinese Science Bulletin1998，43，19： | 4 |
| 13 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 14 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 15 | Quantitative detection of common deletion of mitochondrial DNA in hepatocellular carcinoma and hepatocellular nodular hyperplasia显示文摘AIM: To study the deletion of mitochondiral DNA in hepatocellular carcinoma and hepatocellular nodular hyperplasia and its significance in the development of cancer. METHODS: Deleted mtDNA (CD-mtDNA) and wild type mtDNA (WT-mtDNA) were quantitatively analyzed by using real-time PCR in 27 hepatocellular carcinomas (HCC) and corresponding noncancerous liver tissues and 27 hepatocellular nodular hyperplasiae (HNH). RESULTS: A novel CD (4 981 bp) was detected in 85% (23/27) and 83%(22/27) of HCC and HNH tumor tissues, respectively, which were significantly higher than that in paired noncancerous liver tissues (57%, 15/27) (P<0.05). The CD/WT-mtDNA ratio in HCC tumors was 0.00092 (median, interquartile range, 0.0001202-0.00105), which was significantly higher than that in paired noncancerous liver tissues (median, 0.000, quartile range, 0-0) (P=0.002, Mann-Whitney Test), and was 25 of times of that in HNH tissues (median, 0.0000374, quartile range, 0-0.0004225) (P=0.002, Mann-Whitney test). CONCLUSION: CD-mtDNA mutation plays an important role in the development and progression of HCC. | Jian-YongShao Hong-YiGao Yu-HongLi YuZhang You-YongLu Yi-XinZeng | 2004 | World Journal of Gastroenterology2004，10，11： | 4 |
| 16 | Optical detection of Prorocentrum donghaiense blooms based on multispectral reflectance显示文摘Prorocentrum donghaiense is one of the most common red tide causative dinoflagellates in the Changjiang(Yangtze)River Estuary and the adjacent area of the East China Sea.It causes large-scale blooms in late spring and early summer that lead to widespread ecologic and economic damage.A means for distinguishing dinoflagellate blooms from diatom(Skeletonema costatum)blooms is desired.On the basis of measurements of remote sensing reflectance[Rrs(λ)]and inherent optical parameters,the potential of using a multispectral approach is assessed for discriminating the algal blooms due to P.donghaiense from those due to S.costatum.The behavior of two reflectance ratios[R1=Rrs(560)/Rrs(532)and R2=Rrs(708)/Rrs(665)],suggests that differentiation of P.donghaiense blooms from diatom bloom types is possible from the current band setup of ocean color sensors.It is found that there are two reflectance ratio regimes that indicate a bloom is dominated by P.donghaiense:(1)R1>1.55 and R2<1.0 or(2)R1>1.75 and R21.0.Various sensitivity analyses are conducted to investigate the effects of the variation in varying levels of chlorophyll concentration and colored dissolved organic matter(CDOM)as well as changes in the backscattering ratio(bbp/bp)on the efficacy of this multispectral approach.Results indicate that the intensity and inherent optical properties of the algal species explain much of the behavior of the two ratios.Although backscattering influences the amplitude of Rrs(λ),especially in the 530 and 560 nm bands,the discrimination between P.donghaiense and diatoms is not significantly affected by the variation of bbp/bp.Since aCDOM(440)in coastal areas of the ECS is typically lower than 1.0 m 1in most situations,the presence of CDOM does not interfere with this discrimination,even as SCDOM varies from 0.01 to 0.026 nm 1.Despite all of these effects,the discrimination of P.donghaiense blooms from diatom blooms based on multispectral measurements of Rrs(λ)is feasible. | TAO Bangyi PAN Delu MAO Zhihua SHEN Yuzhang ZHU Qiankun CHEN Jianyu | 2013 | Acta Oceanologica Sinica2013，32，10： | 3 |
| 17 | Identification of ten serum microRNAs from a genome‐wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis显示文摘 | XiChen ZhibinHu WenjingWang YiBa LijiaMa ChunniZhang ChengWang ZhijiRen YangZhao SijiaWu RuiZhuang YixinZhang HengHu ChazhenLiu LinXu JunWang HongbingShen JunfengZhang KeZen Chen‐YuZhang | 2012 | Int J Cancer2012，，7： | 3 |
| 18 | 面瘫针刺疗效的量化描述手段研究显示文摘在目前国内外中西医人体生物、经络系统生物电信息理论基础上,特别是在University of North Carolina at Greensboro[美]博士研究生Yuzhang Han所建立的人工智能深度学习建模及相关概率与数理统计分析计算理论与技术支持下,提出了周围性面瘫患者面部有无明显严重症状侧相关穴位静电位分布的离散/聚拢与平衡/失衡状态以及动态平衡状态的概念。结合临床试验结果建立起以这些概念为基础的数学计算结果为指标来描述及判断面瘫病态及治愈状态的手段并获得初步实验结果。从上述三个概念的角度分析了电针治疗面瘫过程中的生理状态变化过程的静电特性表现。运用人工智能-深度学习神经网络数学方法初步证实了上述两侧静电位分布状况与面瘫治愈状态二元判断指标之间数学关系的存在,并给出了描述模型的结构。从而为面瘫治愈的量化描述与量化评估手段研究提供切实可行的途径,并为中医经穴学说的电子-物理-数学量化性研究手段提供可行性的参照。 | 李文明 陈修明 梁利宇 毕晓艳 丛滔 Yuzhang Han 韩建国 | 2019 | 中医临床研究2019，11，14： | 2 |
| 19 | Reconstruction clipping of ruptured anterior circulation aneurysms via supraorbital lateral keyhole approach显示文摘Background:Intracranial aneurysm(IA)is a serious disease.Analyze and review the cases of anterior circulation ruptured IA by supraorbital lateral keyhole approach,and summarize the experiences of this approach.Methods:Retrospective analysis of 16 cases of ruptured anterior circulation IA in our department from January 2019 to June 2020,CT angiography(CTA)was performed before operation.Analyzing the IA’s parameters by 3D-CT reconstruction.The IA was clipped by supraorbital lateral keyhole approach combined with the 3D-skull reconstruction.Extraventricular drainage was performed before craniotomy.Intraoperative neurophysiological monitoring was performed during the operation.After operation,fluorescein angiography and vascular ultrasound were performed to check the clipping effect.Intracranial pressure monitor was performed postoperatively.CTA was reexamined one week after operation.The modified Rankin Scale(MRS)was performed 6 months after operation.Results:There were 7 males(43.8%)and 9 females(56.2%),and the average age is 52.31±11.12 years old.Among them,11 patients(68.8%)were anterior communicating artery aneurysms and 5(31.2%)were middle cerebral artery aneurysms.All patients were out of hospital within 10 days without any death,without cerebral infarction,cerebrospinal fluid leakage and neurological impairments.About mRS score,after 6 months follow-up,8 cases(50%)had 0 point,4 cases(25%)had 1 point,and 4 cases(25%)had 2 points.Conclusions:For ruptured anterior circulation IA,the supraorbital lateral keyhole approach combined with ventricular drainage,intraoperative electrophysiological monitoring,and intraoperative vascular ultrasound is a safe and minimally invasive treatment.The application of reconstruction clipping can reconstruct the diameter of parent vessel and reduce the recurrence rate of IA. | Yuzhang Wu Yan Zhao Shengping Yu Fan Li Shifei Cai Chao Peng Zhen Wang Yifan Yang Bangyue Wang Xinyu Yang | 2022 | Chinese Neurosurgical Journal2022，8，2： | 2 |
| 20 | The trajectory parameters analysis of saltating sand grains driven by wind显示文摘The study of trajectory parameters of saltating sand grains is of great importance to forming the kinematic theory of wind-sand current. By establishing the simplified theoretical pattern and probing into the relationship between lift-off angle (α) and landing angle (β), relationship between the ratio of saltation length ( L) to maximum height (H) and lift-off angle as | Xueyong Zou Qingzhen Hao Chunlai Zhang Bao Yang Yuzhang Liu Guangrong Dong Shaoxiang Zhou | 1999 | Chinese Science Bulletin1999，44，18： | 2 |
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