|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Genome Sequence of Novel SARS-CoV Isolates: the Genotype, GD-Ins29, Leads to a Hypothesis of Viral Transmission in South China显示文摘We report a complete genomic sequence of rare isolates (minor genotype) of theSARS-CoV from SARS patients in Guangdong, China, where the first few casesemerged. The most striking discovery from the isolate is an extra 29-nucleotidesequence located at the nucleotide positions between 27,863 and 27,864 (referredto the complete sequence of B J01) within an overlapped region composed of BGI-PUP5 (BGI-postulated uncharacterized protein 5) and BGI-PUP6 upstream ofthe N (nucleocapsid) protein. The discovery of this minor genotype, GD-Ins29,suggests a significant genetic event and differentiates it from the previously re-ported genotype, the dominant form among all sequenced SARS-CoV isolates. A17-nt segment of this extra sequence is identical to a segment of the same size intwo human mRNA sequences that may interfere with viral genome replication andtranscription in the cytosol of the infected cells. It provides a new avenue for theexploration of the virus-host interaction in viral evolution, host pathogenesis, andvaccine development. | E‘deQin XiongleiHe WeiTian YongLiu WeiLi JieWen BingyinSi YongwuHu WenmingPeng LinTaug TaoJiang JianpingShi JiaJia YuZhang JiaYe Cui’eWang YujunHan JingqiangWang BaochangFan QingfaWu GuohuiChang WuchunCao ZuyuanXu RuifuYang JmgWang ManYu YanLi JingXu JunZhou YajumDeng XiaoyuLi JianfeiHu CaipingWang ChunxiaYan QingrunZhang JingyueBao GuoqingLi HaiqingZhang YilinZhang HuiZhao XiaoweiZhang ShuangliLi XiaoJieCheng XiuqingZhang BinLiu ChangqingZeng HuanmingYang WeijunChen LinFang ChangfengLi MengLei DaweiLi WeiTong XiangjunTian JianWang BoZhang SonggangLi XuehaiTan SiqiLiu WeiDong JunWang GaneKa-ShuWong JunYu QingyuZhu | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 6 |
| 2 | The Structure Analysis and Antigenicity Study of the N Protein of SARS-CoV显示文摘The Coronaviridae family is characterized by a nucleocapsid that is composed of thegenome RNA molecule in combination with the nucleoprotein (N protein) withina virion. The most striking physiochemical feature of the N protein of SARS-CoVis that it is a typical basic protein with a high predicted pI and high hydrophilicity,which is consistent with its function of binding to the ribophosphate backbone ofthe RNA molecule. The predicted high extent of phosphorylation of the N proteinon multiple candidate phosphorylation sites demonstrates that it would be relatedto important functions, such as RNA-binding and localization to the nucleolus ofhost cells. Subsequent study shows that there is an SR-rich region in the N proteinand this region might be involved in the protein-protein interaction. The abundantantigenic sites predicted in the N protein, as well as experimental evidence withsynthesized polypeptides, indicate that the N protein is one of the major antigensof the SARS-CoV. Compared with other viral structural proteins, the low variationrate of the N protein with regards to its size suggests its importance to the survivalof the virus. | JingqiangWang JiaJi JiaYe XiaoqianZhao JieWen WeiLi JianfeiHu DaweiLi MinSun HaipanZeng YongwuHu XiangjunTian XuehaiTan NingzhiXu ChangqingZeng JianWang ShengliBi HuanmingYang | 2003 | Genomics, Proteomics & Bioinformatics2003，1，2： | 3 |
| 3 | Analysis on appendicitis of 2000 patients in clinical anatomy显示文摘 | JianCao BinMeng BoZhang YingquanLi RuiWang MingzhiCheng WeiTao JunHu BoLiang DishengMeng DaweiLi YongLuo GeyangXu | 2004 | 中国组织化学与细胞化学杂志2004，13，3： | 0 |
| 4 | Clinical analysis on injuries by drugs low subcutaneous veins显示文摘 | RuiWang BinMeng MingzhiChen BoLiang DaweiLi ZengweiWang YongshengZhang | 2004 | 中国组织化学与细胞化学杂志2004，13，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员