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| 1 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021,11,12: | 23 |
| 2 | Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1显示文摘Bone regeneration remains a great clinical challenge. Low intensity near-infrared(NIR) light showed strong potential to promote tissue regeneration, offering a promising strategy for bone defect regeneration. However, the effect and underlying mechanism of NIR on bone regeneration remain unclear. We demonstrated that bone regeneration in the rat skull defect model was significantly accelerated with low-intensity NIR stimulation. In vitro studies showed that NIR stimulation could promote the osteoblast differentiation in bone mesenchymal stem cells(BMSCs) and MC3T3-E1 cells, which was associated with increased ubiquitination of the core circadian clock protein Cryptochrome 1(CRY1) in the nucleus. We found that the reduction of CRY1 induced by NIR light activated the bone morphogenetic protein(BMP) signaling pathways, promoting SMAD1/5/9 phosphorylation and increasing the expression levels of Runx2 and Osterix. NIR light treatment may act through sodium voltage-gated channel Scn4a, which may be a potential responder of NIR light to accelerate bone regeneration. Together, these findings suggest that low-intensity NIR light may promote in situ bone regeneration in a CRY1-dependent manner, providing a novel, efficient and non-invasive strategy to promote bone regeneration for clinical bone defects. | Jinfeng Peng Jiajia Zhao Qingming Tang Jinyu Wang Wencheng Song Xiaofeng Lu Xiaofei Huang Guangjin Chen Wenhao Zheng Luoying Zhang Yunyun Han Chunze Yan Qian Wan Lili Chen | 2022 | International Journal of Oral Science2022,14,4: | 2 |
| 3 | SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation显示文摘The nucleocapsid(N)protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation,which enables its incorporation into stress granules(SGs)of host cells.However,whether SG invasion by N protein occurs in the scenario of SARS-CoV-2 infection is unknow,neither do we know its con-sequence.Here,we used SARS-CoV-2 to infect mam-malian cells and observed the incorporation of N protein into SGs,which resulted in markedly impaired self-dis-assembly but stimulated cell cellular clearance of SGs.NMR experiments further showed that N protein binds to the SG-related amyloid proteins via non-specific tran-sient interactions,which not only expedites the phase transition of these proteins to aberrant amyloid aggre-gation in vitro,but also promotes the aggregation of FUS with ALS-associated P525L mutation in cells.In addition,we found that ACE2 is not necessary for the infection of SARS-CoV-2 to mammalian cells.Our work indicates that SARS-CoV-2 infection can impair the dis-assembly of host SGs and promote the aggregation of SG-related amyloid proteins,which may lead to an increased risk of neurodegeneration. | Yichen Li Shuaiyao Lu Jinge Gu Wencheng Xia Shengnan Zhang Shenqing Zhang Yan Wang Chong Zhang Yunpeng Sun Jian Lei Cong Liu Zhaoming Su Juntao Yang Xiaozhong Peng Dan Li | 2022 | Protein & Cell2022,13,8: | 1 |
| 4 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021,16,6: | 1 |
| 5 | Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders显示文摘Dear Editor,Protein amyloid aggregation is a histological hallmark of neurodegenerative diseases(NDs).1,2 In synucleinopathies including Parkinson’s disease(PD),Parkinson’s disease dementia(PDD),dementia with Lewy body and multiple system atrophy,αsynuclein(α-syn)is commonly characterized to form amyloid aggregates presenting distinct pathological activities in diseased brains.3,4 Structural characterization ofα-syn amyloid fibrils formed in different diseases could provide mechanistic understanding of heterogeneousα-syn pathologies. | Yun Fan Qinyue Zhao Wencheng Xia Youqi Tao Wenbo Yu Mingjia Chen Yiqi Liu Jue Zhao Yan Shen Yunpeng Sun Chenfang Si Shenqing Zhang Yaoyang Zhang Wensheng Li Cong Liu Jian Wang Dan Li | 2022 | Cell Research2022,32,6: | 1 |
| 6 | Super-resolution imaging and real-time tracking lysosome in living cells by a fluorescent probe显示文摘Lysosomes function as important organelles within cells and their movement associates with diverse biological events, hence the real-time tracking of lysosomal movement is of great significance. However, since most ly so some fluorescent probes suffer from relatively unsatisfactory photo stability,tracking lysosomal movement in real-time remains challenging. Here,we report that a naphthalimide-based fluorescent compound,namely NIMS,is a quite promising probe for ly so some imaging. The visualizing mechanism lies in the selective accumulation of NIMS in lysosomes via a protonation reaction, followed by the fluorescence enhancement due to the interactions of NIMS with proteins. Owing to its high selectivity and good photo stability, NIMS was successfully applied to capture super-resolution fluorescence images of lysosomes. More importantly, real-time tracking of ly so some movement in a single living cell by NIMS was realized with a confocal laser scanning microscope. Surprisingly,even in normal culture conditions, around 2/3 of the captured lysosomes were observed to move within 5 min, indicative of the highly dynamic features of lysosomes. Thus, this probe may facilitate the understanding of the ly so some dynamics in physiologicalor pathological conditions. | Wencheng Zhu Xujun Zheng Yan Huang Zhiyun Lu Hua Ai | 2018 | Science China Chemistry2018,61,4: | 1 |
| 7 | Site-specific fabrication of gold nanocluster-based fluorescence photoswitch enabled by the dual roles of albumin proteins显示文摘Fluorescence photoswitch is becoming increasingly desirable for many applications,but its controllable fabrication still remains challenging yet.In this paper,a new strategy is proposed to fabricate fluorescence photoswitch by harnessing dual roles of albumin proteins as both photochrome carriers and biotemplates of fluorophore.As an example,we demonstrated the successful fabrication of a fluorescence photoswitch by incorporating both the photochromic diarylethene dye(CMTE)and red-emitting fluorescent gold nanoclusters(AuNCs)into the specific domains of bovine serum albumin(BSA)in a highly controllable manner.Detailed spectral and photophysical characterisation showed that CMTE well-retains the photochromic properties within the CMTE–BSA–AuNC construct,although its photoconversion rate is slightly retarded.Different from previously reported photoswitches,the fluorescence of the present system is mainly modulated via the inner filter effect(IFE)mechanism,which exhibits high switching efficiency with an on-off ratio up to 90%,reversible fluorescence response and good antifatigue performance.This work provides a new,generable albumin protein-assisted strategy of fabricating advanced fluorescence photoswitch,which can find wide applications in biological,optical and information fields. | Wencheng Zhong Xiaojian Yan Shaohua Qu Li Shang | 2023 | Aggregate2023,4,1: | 0 |
| 8 | Feature extraction and learning approaches for cancellable biometrics:A survey显示文摘Biometric recognition is a widely used technology for user authentication.In the application of this technology,biometric security and recognition accuracy are two important issues that should be considered.In terms of biometric security,cancellable biometrics is an effective technique for protecting biometric data.Regarding recognition accuracy,feature representation plays a significant role in the performance and reliability of cancellable biometric systems.How to design good feature representations for cancellable biometrics is a challenging topic that has attracted a great deal of attention from the computer vision community,especially from researchers of cancellable biometrics.Feature extraction and learning in cancellable biometrics is to find suitable feature representations with a view to achieving satisfactory recognition performance,while the privacy of biometric data is protected.This survey informs the progress,trend and challenges of feature extraction and learning for cancellable biometrics,thus shedding light on the latest developments and future research of this area. | Wencheng Yang Song Wang Jiankun Hu Xiaohui Tao Yan Li | 2024 | CAAI Transactions on Intelligence Technology2024,9,1: | 0 |
| 9 | Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing显示文摘In this work,novel antibacterial cellulose diacetate/poly(ethylenimine)/hyaluronic acid(CDA/PEI/HA)composite three-dimension(3D)scaffolds were prepared through electrospinning and post-processing.Firstly,CDA/PEI 2D composite nanofiber membranes were prepared by electrospinning,and then the CDA/PEI/HA 3D composite scaffolds were fabricated by post-processing and freeze-drying of CDA/PEI membranes.In particular,HA was added to improve the biocompatibility of composite scaffolds.Compared with CDA/PEI scaffolds,CDA/PEI/HA composite scaffolds showed higher water absorbing rate,higher water retention rate and higher mechanical strength.Moreover,CDA/PEI/HA composite scaffolds with abundant positive charge were benefit for improving antibacterial activity.CDA/PEI/HA scaffolds with biology function of HA were benefit for improving hemocompatibility and cell proliferation of CDA/PEI scaffolds.In summary,antibacterial CDA/PEI/HA scaffolds could protect wound from bacterial infection,improve cellular behavior and accelerate wound healing.Thus,CDA/PEI/HA scaffolds could be potential application for wound dressing. | Wencheng Liang Mingli Jiang Junyong Zhang Xiaoming Dou Yan Zhou Yun Jiang Li Zhao Meidong Lang | 2021 | Journal of Materials Science & Technology2021,,30: | 0 |
| 10 | 小分子化合物诱导人胃上皮细胞直接转化为内胚层多潜能祖细胞显示文摘内胚层干/祖细胞是肝脏、胰腺、小肠等内脏器官的共同起源,在再生医学的基础研究和临床应用中具有广阔的应用前景。因此,寻找一种安全高效的获取内胚层干/祖细胞的方式将具有极其重要的意义。 | 王韫芳 Jinhua Qin Shuyong Wang Wencheng Zhang Jialei Duan Jing Zhang Xin Wang Fang Yan Mingyang Chang Xiaofang Liu Bo Feng Jiang Liu 裴雪涛 | 2017 | 科学新闻2017,19,4: | 0 |
| 11 | Characteristics and Clinical Implication of UGT1A1 Heterozygous Mutation in Tumor显示文摘Background:The literature recommends that reduced dosage of CPT-11 should be applied in patients with UGT1 A1 homozygous mutations,but the impact of UGT1 A1 heterozygous mutations on the adverse reactions of CPT-11 is still not fully clear.Methods:A total of 107 patients with UGT1 A1 heterozygous mutation or wild-type,who were treated with CPT-11 from January 2018 to September 2021 in Peking University Third Hospital,were retrospectively enrolled.The adverse reaction spectra of patients with UGT1 A1*6 and UGT1 A1*28 mutations were analyzed.Adverse reactions were evaluated according to National Cancer Institute Common Terminology Criteria for Adverse Events(NCI-CTCAE) 5.0.The efficacy was evaluated according to Response Evaluation Criteria in Solid Tumors(RECIST) 1.1.The genotypes of UGT1 A1*6 and UGT1 A1*28 were detected by digital fluorescence molecular hybridization.Results:There were 43 patients with UGT1 A1*6 heterozygous mutation,26 patients with UGT1 A1*28 heterozygous mutation,8 patients with UGT1 A1*6 and UGT1 A1*28 double heterozygous mutations,61 patients with heterozygous mutation at any gene locus of UGT1 A1*6 and UGT1 A1*28.Logistic regression analysis showed that the presence or absence of vomiting(P=0.013) and mucositis(P=0.005) was significantly correlated with heterozygous mutation of UGT1 A1*28,and the severity of vomiting(P<0.001) and neutropenia(P=0.021) were significantly correlated with heterozygous mutation of UGT1 A1*6.In colorectal cancer,UGT1 A1*6 was significantly correlated to diarrhea(P=0.005),and the other adverse reactions spectrum was similar to that of the whole patient cohort,and efficacy and prognosis were similar between patients with different genotypes and patients treated with reduced CPT-11 dosage or not.Conclusion:In clinical use,heterozygous mutations of UGT1 A1*6 and UGT1 A1*28 are related to the risk and severity of vomiting,diarrhea,neutropenia and mucositis in patients with Pan-tumor and colorectal cancer post CPT-11 therpy.In colorectal cancer,UGT1 A1*6 is significantly related to diarrhea post CPT-11 use,efficacy and prognosis is not affected by various genotypes or CPT-11 dosage reduction. | Qian LI Tao SUN Hua ZHANG Wei LIU Yu XIAO Hongqi SUN Wencheng YIN Yanhong YAO Yangchun GU Yan'e LIU Fumei YI Qiqi WANG Jinyu YU Baoshan CAO Li LIANG | 2022 | 中国肺癌杂志2022,25,3: | 0 |
| 12 | Thermally tunable GeSi electro-absorption modulator with a wide effective operating wavelength range显示文摘We demonstrate a GeSi electro-absorption modulator with on-chip thermal tuning for the first time,to the best of our knowledge.Theoretical simulation proves that the device temperature can be tuned and the effective operating wavelength range can be broadened.When the heater power is 4.63 mW,the temperature of the waveguide increases by about 27 K and the theoretical operating wavelength range is broadened by 23.7 nm.The experimental results show that the optical transmission line shifted to the longer wavelength by 4.8 nm by every 1 mW heater power.The effective static operating wavelength range of the device is increased from 34.4 nm to 60.1 nm,which means it is broadened by 25.7 nm.The band edge shift coefficient of 0.76 nm/K is obtained by temperature simulation and linear fitting of the measured data.The device has a 3 dB EO bandwidth of 89 GHz at 3 V reverse bias,and the eye diagram measurement shows a data rate of 80 Gbit/s for non-return-to-zero on–off keying modulation and 100 Gbit/s for 4 pulse amplitude modulation in the 1526.8 nm to 1613.2 nm wavelength range as the heater power increases from 0 mW to 10.1 mW. | YUFEI LIU JIALIANG SUN XINYU LI SHUXIAO WANG WENCHENG YUE YAN CAI MINGBIN YU | 2023 | Photonics Research2023,11,8: | 0 |
| 13 | Preparation of green cellulose diacetate-based antibacterial wound dressings for wound healing显示文摘Managing wounds is a growing universal problem and developing effective wound dressings to staunch bleeding and protect wounds from bacterial infections is an increasingly serious challenge.In this work,a remolding electrospinning nanofiber three-dimensional structure wound dressing(CCP)was prepared with superhydrophilicity,high water absorption and absorbing capacity,excellent hemostatic capacity and antibacterial ability,and biocompatibility to promote wound healing.Polyhexamethylene guanidine hydrochloride(PHMG)was grafted to cellulose diacetate(CDA)wound dressing surface through an amide reaction.A water contact angle analysis demonstrated that CCP wound dressing could be beneficial to promote wound exudate management effectively with rapid absorption of water within 0.2 s.In vitro hemo-and cytocompatibility assay showed that a CCP wound dressing had no significant hemotoxicity or cytoxicity.Specifically,CCP wound dressings could be beneficial to accelerate wound hemostasis and further reduce mortality caused by uncontrolled bleeding.Furthermore,CCP wound dressings have an excellent antibacterial ability,which could be beneficial to inhibit wound inflammatory over-reaction and promote normal wound healing.Combined together,the prepared wound dressing in this research effort is expected to have high-potential in clinical applications. | Chuang XIAO Ge ZHANG Wencheng LIANG Zhaochuang WANG Qiaohui LU Weibin SHI Yan ZHOU Yong GUAN Meidong LANG | 2022 | Frontiers of Materials Science2022,16,2: | 0 |
| 14 | Semen extracellular vesicles mediate vertical transmission of subgroup J avian leukosis virus显示文摘Subgroup J avian leukosis virus(ALV-J) is a highly oncogenic retrovirus that has been devastating the global poultry industry since the late 1990s. The major infection model of ALV-J is vertical transmission, which is responsible for the congenital infection of progeny from generation to generation. Increasing evidence has suggested that extracellular vesicles(EVs) derived from virus-infected cells or biological fluids have been thought to be vehicles of transmission for viruses. However, the role of EVs in infection and transmission of ALV-J remains obscure. In the present study, semen extracellular vesicles(SE) were isolated and purified from ALV-J-infected rooster seminal plasma(SE-ALV-J), which was shown to contain ALV-J genomic RNA and partial viral proteins, as determined by RNA sequencing, reverse transcription-quantitative PCR and Western blotting. Furthermore, SE-ALV-J was proved to be able to transmit ALV-J infection to host cells and establish productive infection.More importantly, artificial insemination experiments showed that SE-ALV-J transmitted ALV-J infection to SPF hens, and subsequently mediated vertical transmission of ALV-J from the SPF hens to the progeny chicks. Taken together, the results of the present study suggested that ALV-J utilized host semen extracellular vesicles as a novel means for vertical transmission, enhancing our understanding on mechanisms underlying ALV-J transmission. | Liqin Liao Weiguo Chen Xiangyu Zhang Huanmin Zhang Aijun Li Yiming Yan Zi Xie Hongxing Li Wencheng Lin Jingyun Ma Xinheng Zhang Qingmei Xie | 2022 | Virologica Sinica2022,37,2: | 0 |
| 15 | Phytochemistry,bioactivities,and future prospects of Callicarpa nudiflora:A review显示文摘This work was supported by Hainan Province Science and Technology Special Fund of China(No.ZDKJ2021034)and the Hainan Province Natural Science Foundation of China(No.822RC697). | Yan Ma Licheng Guo Wencheng Hou Jinsheng Zhuo Mingming Zhao Yangyang Liu | 2022 | Medicinal Plant Biology2022,1,1: | 0 |
| 16 | Response of tomato growth to continuous elevated CO_(2)concentration 2 under controlled environment显示文摘CO_(2)fumigation has been extensively used in greenhouses cultivation to enhance crop yield.The effects under the precise level of elevated CO_(2)(e[CO_(2)])on crop morphology,yield,and fruit quality remain largely elusive yet.To explore the response of plant growth to the continuous RCPs(Representative Concentration Pathways)projected CO_(2)concentration[CO_(2)],tomato(Hezuo 908)plants were grown under ambient CO_(2)(a[CO_(2)],462μmol/mol)and e[CO_(2)](550,700,850 and 1000μmol/mol):named as EC550,EC_(700),EC_(850),and EC_(1000),respectively,under uniform environmental condition for two planting seasons.Collective growth of tomato plants(plant height,stem diameter,and leaf area index)was significantly enhanced under EC_(700)and showed a slightly negative response under EC_(850).The optimum yield was stimulated under EC_(700)by 74.05%and 55.91%,while maximum total dry weight(DW_(t))was enhanced under EC_(1000)by 58.23%and 39.78%during autumn-winter and spring-summer planting seasons,respectively,as compared to a[CO_(2)].The greatest yield and least DWt stimulated under EC_(700)for both seasons indicated that EC_(700)improved the ability of the tomato plants to translocate carbohydrates to fruits.Optimum water use efficiency related to yield(WUE_(y))was enhanced by 55.91-210.87%under EC_(700)compared to a[CO_(2)].The titratable acid(TA)was improved by 19.94%(EC_(700)),29.17%(EC_(850)),and 97.92%(EC_(1000)),and the lycopene(Lp)was increased by 2.22%(EC_(700))and reduced by 2.28%(EC_(1000)).Thus,the overall optimum impact on tomato growth was explored under EC_(700).Super e[CO_(2)]did not positively influence the tomato growth process and yield under adequate water and fertilizer conditions.The present study results are beneficial for greenhouse crop production and might be used as a reference to validate the climate change influence modeling. | Muhammad Akhlaq Chuan Zhang Haofang Yan Mingxiong Ou Wencheng Zhang Shaowei Liang Rana Muhammad Adnan Ikram | 2022 | International Journal of Agricultural and Biological Engineering2022,15,6: | 0 |