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| 1 | Fever as the only manifestation of hypersensitivity reactions associated with oxaliplatin in a patient with colorectal cancer Oxaliplatin-induced hypersensitivity reaction显示文摘Hypersensitivity reactions (HSR) to oxaliplatin in patients with colorectal cancer include facial ushing, erythema, pruritis, fever, tachycardia, dyspnea, tongue swelling, rash/hives, headache, chills, weakness, vomiting, burning sensations, dizziness, and edema. We report a patient with fever as the sole manifestation of initial HSR, review the literature and discuss the management of HSR. A 57-year-old female with T3N2M0 rectal adenocarcinoma received modified FOLFOX-6. She tolerated the first 8 cycles without any toxicities except grade 1 peripheral neuropathy and nausea. During 9th and 10th infusions, she developed fever to a maximum of 38.3℃ with stable hemodynamic status despite medications. During 11th infusion, she developed grade 3 HSR consisting of symptomatic bronchospasm, hypotension, nausea, vomiting, cough, and fever. On examination, she was pale, cyanotic, with a temperature of 38.8℃, BP dropped to 95/43 mm Hg, pulse of 116/min and O2 saturation of 88%-91%. She was hospitalized for management and recovered in 24 h. Fever alone is not a usual symptom of oxaliplatin HSR. It may be indicative that the patient may develop serious reactions subsequently, as did our patient who developed hypotension with the third challenge. Treatment and prevention consists of slowing the infusion rate, use of steroids and antagonists of Type 1 and 2 histamine receptor antagonists, whereas desensitization could help to provide the small number of patients who experience severe HSR with the ability to further receive an effective therapy for their colorectal cancer. | M Wasif Saif Shailja Roy Leslie Ledbetter Jennifer Madison Kostas Syrigos | 2007 | World Journal of Gastroenterology2007，13，39： | 4 |
| 2 | Secondary pancreatic involvement by a diffuse large B-cell lymphoma presenting as acute pancreatitis显示文摘Diffuse large B-cell lymphoma is the most common type of non-Hodgkin's lymphoma. More than 50% of patients have some site of extra-nodal involvement at diagnosis, including the gastrointestinal tract and bone marrow. However, a diffuse large B-cell lymphoma presenting as acute pancreatitis is rare. A 57-year-old female presented with abdominal pain and matted lymph nodes in her axilla. She was admitted with a diagnosis of acute pancreatitis. Abdominal computed tomography (CT) scan showed diffusely enlarged pancreas due to infiltrative neoplasm and peripancreatic lymphadenopathy. Biopsy of the axillary mass revealed a large B-cell lymphoma. The patient was classified as stage Ⅳ, based on the Ann Arbor Classification, and as having a high-risk lymphoma, based on the International Prognostic Index. She was started on chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone). Within a week after chemotherapy, the patient’s abdominal pain resolved. Follow-up CT scan of the abdomen revealed a marked decrease in the size of the pancreas and peripancreatic lymphadenopathy. A literature search revealed only seven cases of primary involvement of the pancreas in B-cell lymphoma presenting as acute pancreatitis. However, only one case of secondary pancreatic involvement by B-cell lymphoma presenting as acute pancreatitis has been published. Our case appears to be the second report of such a manifestation. Both cases responded well to chemotherapy. | M Wasif Saif Sapna Khubchandani Marek Walczak | 2007 | World Journal of Gastroenterology2007，13，36： | 4 |
| 3 | 乳汁免疫和猪流行性腹泻病毒病疫苗:历史和现状(译文)显示文摘由于肠道病毒感染导致仔猪在发病率、死亡率和生产能力丧失方面的影响,每年给养猪者带来数百万美元的损失。2013—2014年间,猪流行性腹泻病毒(PEDV)病的暴发给美国养猪业带来了9亿~18亿美元的经济损失。被动乳汁免疫被认为是保护新生哺乳仔猪免受PED等肠道疾病危害的最有希望和有效的方法。通过乳汁免疫被动保护哺乳仔猪的效果依赖于病原特异性IgA浆细胞转运至乳腺的数量和乳汁中分泌型IgA的积累程度,这种免疫途径被定义为'肠-乳腺-sIgA轴'。由于胎盘的不可穿透性,新生仔猪处于无免疫球蛋白的状态,对很多的传染性病原体极易感。它们仅依靠来源于母源的初乳和乳汁抗体获得被动保护。先前开发的关于猪传染性胃肠炎病毒(TGEV)病的活疫苗和灭活疫苗,提供了对母源性免疫和仔猪被动保护机制的理解。在这篇文章中,综述了猪传染性胃肠炎病毒诱导乳汁免疫的研究进展,并指出对当前养猪业正努力控制的猪流行性腹泻病毒感染和相关疫苗的研究方向。同时研究和鉴别出影响乳汁免疫和'肠-乳腺-sIgA轴'的各种因素,有助于改善妊娠母猪预防猪流行性腹泻病毒感染以及改进其它肠道病原用疫苗方案,从而达到提升整个猪群的免疫力、猪群健康和企业生产力的目的。 | Langel Stephanie N Paim Francine Chimelo Lager Kelly M Vlasova Anastasia N Saif Linda J 吕茂杰 | 2017 | 养猪2017，，1： | 3 |
| 4 | Rotavirus as a cause of diarrhea in pigs 显示文摘 | Bohl E H Kohler E M Saif L J | 1978 | J Am Vet Med Assoc1978，172，： | 1 |
| 5 | Actuator fault diagnosis for uncertain linear systems using a high-order sliding-mode robust differentiator显示文摘 | CHEN W SAIF M | 2008 | International Journal Robust Nonlinear Control2008，18，4： | 1 |
| 6 | Strain gradient effect in nanoscale thin films显示文摘 | Haque M A Saif M T A | 2003 | Acta Materialia2003，51，： | 1 |
| 7 | In-situ tensile testing of nano-scale specimens in SEM and TEM 显示文摘 | HAQUE M A SAIF T A | 2002 | Experimental Mechanics2002，42，1： | 1 |
| 8 | Comparison between antigen capture ELISA and conventional methods used for titration of infectious bursal disease virus显示文摘 | HASSAN M K SAIF Y M SHAWKY S | 1996 | Avian Dis1996，40，3： | 1 |
| 9 | ^18F-FDG positron emission tomography CT (FDG PET-CT) in the management of pancreatic cancer: initial experience in 12 patients 显示文摘 | SAIF M W CORNFELD D MODARRESIFAR H | 2008 | J Gastrointestin Liver Dis2008，17，2： | 1 |
| 10 | Molecular differentation of transmissible gastroenteritis virus and porcine respiratory coronavirus strains显示文摘 | Kwon H M Saif J | 1995 | Adv Exp Med Biol1995，380，： | 1 |
| 11 | Radiation recall phenomenon secondary to capecitabine:possible role of thymidine phosphorylase显示文摘 | Saif MW Black G Johnson M | 2006 | Cancer Chemother Pharmacol2006，58，6： | 1 |
| 12 | A state observer for nonlinear systems 显示文摘 | BUSAWON K K SAIF M | 1999 | IEEE Transactions on Automatic Control1999，44，11： | 1 |
| 13 | Oct4 + stem/progenitor swine lung epithelial ceils are targets for influenza virus replication显示文摘 | Khatri M Goyal SM Saif YM | 2012 | J Virol2012，86，12： | 1 |
| 14 | Field isolates of transmissible gastroenteritis virus differ at the molecular level from the Miller and Purdue virulent and attenuated strains and from porcine respiratory coronaviruses显示文摘 | Saif L J Jackwood D J | 1998 | J Vet Med Sci1998，60，5： | 1 |
| 15 | Role of anticoagulation in the management of pancreatic cancer显示文摘 | Sohail M A Saif M W | 2009 | J Pancreas2009，10，2： | 1 |
| 16 | Robust quantized approach to fuzzy networked control systems显示文摘 | Mahmoud M S Saif A W A | | 0，，1： | 1 |
| 17 | Field isolates of transmissible gastroenteritis virus differ at the molecular level from the Miller and Purdue virulent and attenuated strains and from porcine respiratory coronaviruses显示文摘 | Kwon H M Saif L J Jackwood D J | 1998 | Journal of Veterinary Medical Science1998，60，5： | 1 |
| 18 | Pancreatic cancer:updates on translational research and future applications显示文摘 | Sarris E G Syrigos K N Saif M W | 2013 | Journal of the pancreas2013，14，2： | 1 |
| 19 | Egg yolk IgY antibodies:a therapeutic intervention against group a rotavirus in calves显示文摘 | VEGA C BOK M SAIF L | 2015 | Research in Veterinary Science2015，103，： | 1 |
| 20 | Titanium dioxide nano- material doped with trivalent lanthanide ions of Tb, Eu and Sin: Preparation, characterization and potential applications显示文摘 | Saif Mona Bdel-Mottaleb M S A | 2007 | Inorganica Chimiea Acta2007，360，9： | 1 |
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