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| 1 | Some evidence of drying trend over northern China from 1951 to 2004显示文摘The surface wetness index, Palmer drought sererity index and the retrieval of soil moisture over China were calculated using monthly precipitation and monthly mean surface air temperature. Based on the contrast analysis of the variation of the above three indices and precipitation, the dry/wet spatio-temporal pattern of northern China in the last 54 years was revealed, and the evidence of drying trend over northern China was analyzed, especially. The results show the following four facts: (1) The drying trend is the main characteristic of the eastern part of Northwest China and the central part of North China since the 1980s and it was enhanced in the last 15 years mainly due to the precipitation decrease and the temperature increase; (2) During the last 54 years, there was only one dry/wet shift at the interdecadal scale occurring in the eastern part of Northwest China and the central part of North China in the late 1970s, which was related to 1977/1978 global abrupt change, whereas there were three shifts in Northeast China, one was in the mid 1990s and the other two were in 1965 and 1983, respectively; (3) Unlike the variation trend of other subregions of northern China, the western part of Northwest China is currently located in a relatively wetting period, which is weak-ened due to the temperature increase; (4) The extreme drought frequency is obviously increasing in the eastern part of Northwest China, the central part of North China and Northeast China since the 1980s, which is closely related to the precipitation decrease and temperature increase in these subregions. | MA Zhuguo1,2 & FU Congbin1,2 1. Key Laboratory of Regional Climate-Environment for Temperate East Asia, Chinese Academy of Sciences, Beijing 100029, China 2. START Regional Center for Temperate East Asia, Institute of Atmos-pheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2006 | Chinese Science Bulletin2006，51，23： | 63 |
| 2 | Chemical characteristics of PM_(2.5) during a typical haze episode in Guangzhou显示文摘The chemical characteristics(water-soluble ions and carbonaceous species) of PM2.5 in Guangzhou were measured during a typical haze episode.Most of the chemical species in PM2.5 showed significant difference between normal and haze days.The highest contributors to PM2.5 were organic carbon(OC),nitrate,and sulfate in haze days and were OC,sulfate,and elemental carbon(EC) in normal days.The concentrations of secondary species such as,NO3-,SO42-,and NH4+ in haze days were 6.5,3.9,and 5.3 times higher than those in normal days,respectively,while primary species(EC,Ca2+,K+) show similar increase from normal to haze days by a factor about 2.2-2.4.OC/EC ratio ranged from 2.8 to 6.2 with an average of 4.7 and the estimation on a minimum OC/EC ratio showed that SOC(secondary organic carbon) accounted more than 36.6% for the total organic carbon in haze days.The significantly increase in the secondary species(SOC,NO3-,SO42-,and NH4+),especially in NO3-,caused the worst air quality in this region.Simultaneously,the result illustrated that the serious air pollution in haze episodes was strongly correlated with the meteorological conditions.During the sampling periods,air pollution and visibility had a good relationship with the air mass transport distance;the shorter air masses transport distance,the worse air quality and visibility in Guangzhou,indicating the strong domination of local sources contributing to haze formation.High concentration of the secondary aerosol in haze episodes was likely due to the higher oxidation rates of sulfur and nitrogen species. | TAN Jihua DUAN Jingchun HE Kebin MA Yongliang DUAN Fengkui CHEN Yuan FU Jiamo | 2009 | Journal of Environmental Sciences2009，21，6： | 71 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | Trends of foodborne diseases in China: lessons from laboratory- based surveillance since 2011显示文摘Foodborne 疾病是世界范围的最重要的公共健康问题之一。中国在食物链的所有方面面对各种各样、崭新的挑战。从从 2013 ~ 2016 的基于实验室的 foodborne 疾病监视系统的数据,以及不同区域和年龄,能在与多样的特征检测的病原体的模式与差别一起被发现。Vibrio parahaemolyticus 是在中国的传染腹泻的领先的原因,特别在在沿海的区域的成年人之中。沙门氏菌是为实质的社会经济的负担负责的严肃、广泛地分布式的病原体。Shigella 主要在 5 年下面在孩子之中与开发更少的区域在西北中国和内陆省(河南省) 被识别。从从 2011 ~ 2016 报导系统的 foodborne 疾病爆发的数据证明有毒的动物和为大多数死亡负责的植物因素在在西南区域的遥远的区域是有毒的蘑菇(54.7%) 。引起了报导的大多数案例(42.3%) 的生物危险被归因于 V。parahaemolyticus, foodborne 爆发的领先的原因。在这评论,我们在中国总结最近的监视途径到 foodborne 疾病并且在发达国家把结果与那些作比较。 | Jikai Liu Li Bai Weiwei Li Haihong Han Ping Fu Xiaochen Ma Zhenwang Bi Xiaorong Yang Xiuli Zhang Shiqi Zhen Xiaoling Deng Xiumei Liu Yunchang Guo | 2018 | Frontiers of Medicine2018，12，1： | 55 |
| 5 | Polycyclic aromatic hydrocarbon in urban soil from Beijing, China显示文摘Polycyclic aromatic hydrocarbons (EPA-PAHs) in the urban surface soils from Beijing were determined using gas chromatography and mass spectrometry (GC-MS). It is significantly complementary for understanding the PAHs pollution in soil of integrated Beijing city on the basis of the information known in the outskirts. The total concentration of 16 EPA-PAH was from 0.467 to 5.470 ?滋g/g and was described by the contour map. Compound profiles presented that the 4-, 5- and 6-ring PAHs were major compositions. The correlation analysis showed that PAHs have the similar source in the most sampling sites and BaP might be considered as the indicator of PAHs. Characteristic ratios of anthracene (An)/(An+ phenanthrene (Phe)), fluoranthene (Flu)/(Flu+ pyrene (Pyr)) and benzo[a]pyrene (BaP)/benzo[g,h,i]perylene (BghiP) indicated that the PAHs pollutants probably mainly originated from the coal combustion and it was not negligible from vehicular emission. The level of PAHs in our study area was compared with other studies. | LI Xing-hong MA Ling-ling LIU Xiu-fen FU Shan CHENG Hang-xin XU Xiao-bai | 2006 | Journal of Environmental Sciences2006，18，5： | 50 |
| 6 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 7 | Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns显示文摘 | Wei Xiao Qing-Fang Duan Wen-Ya Fu Xin-Zuo Chi Feng-Ying Wang Da-Qing Ma Tian-Long Wang Lei Zhao | 2015 | Chinese Medical Journal2015，，14： | 35 |
| 8 | The effect of land use structure on the distribution of soil nutrients in the hilly area of the Loess Plateau,China显示文摘The irrational land use is one of the main reasons for the soil erosion and nutrient loss in the loess hilly area of China. In this project, 4 types of typical land use structure of sustain ment for about 15 years in the loess hill slope are selected to study the effect of land use structure on the distribution of soil nutrients. From hill bottom to hill top, the patterns of land use types are:, grassland-slope farmland-forest, slope farmland-grassland-forest, terrace-grassland-forest and slope farmland-forest-grassland. By measuring the contents of the total N, total P, available N, available P and organic matter of soils, the results show that the land use structure types of slope farmland-grassland-forest and terrace-grassland-forest have a better capacity to maintain the soil nutrients. | Bojie Fu Keming Ma Huafeng Zhou Liding Chen | 1999 | Chinese Science Bulletin1999，44，8： | 32 |
| 9 | Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-KB pathway显示文摘 | Zong-chao LIU Zhen-long WANG Chen-yi HUANG Zhi-jiang FU Yong LIU Zhang-chao WEI Shi-gui LIU Chuan MA Jie-liang SHEN Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，6： | 29 |
| 10 | Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice显示文摘Perilla frutescens(Perilla leaf), a garnishing vegetable in East Asian countries, as well as a plant-based medicine, has been used for centuries to treat various conditions, including depression. Several studies have demonstrated that the essential oil of P. frutescens(EOPF) attenuated the depressive-like behavior in mice. The present study was designed to test the anti-depressant effects of EOPF and the possible mechanisms in an chronic, unpredictable, mild stress(CUMS)-induced mouse model. With the exposure to stressor once daily for five consecutive weeks, EOPF(3, 6, and 9 mg·kg-1) and a positive control drug fluoxetine(20 mg·kg-1) were administered through gastric intubation to mice once daily for three consecutive weeks from the 3rd week. Open-field test, sucrose consumption test, tail suspension test(TST), and forced swimming test(FST) were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine(5-HT) and its metabolite, 5-hydroxyindoleacetic acid(5-HIAA), in mouse hippocampus were determined by HPLC–ECD. Serum interleukin(IL)-1, IL-6, and tumor necrosis factor(TNF)-α levels were evaluated by enzyme-linked immunosorbent assay(ELISA). The results showed that CUMS significantly decreased the levels of 5-HT and 5-HIAA in the hippocampus, with an increase in plasma IL-6, IL-1β, and TNF-α levels. CUMS also reduced open-field activity, sucrose consumption, as well as increased immobility duration in FST and TST. EOPF administration could effectively reverse the alterations in the concentrations of 5-HT and 5-HIAA; reduce the IL-6, IL-1β, and TNF-α levels. Moreover, EOPF could effectively reverse alterations in immobility duration, sucrose consumption, and open-field activity. However, the effect was not dose-dependent. In conclusion, EOPF administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression. The antidepressant activity of EOPF might be related to the relation between alteration of serotonergic responses and anti-inflammatory effects. | JI Wei-Wei LI Rui-Peng LI Meng WANG Shu-Yuan ZHANG Xian NIU Xing-Xing LI Wei YAN Lu WANG Yang FU Qiang MA Shi-Ping | 2014 | Chinese Journal of Natural Medicines2014，12，10： | 26 |
| 11 | Direct numerical simulation of shock/turbulent boundary layer interaction in a supersonic compression ramp显示文摘A direct numerical simulation of the shock/turbulent boundary layer interaction flow in a supersonic 24-degree compression ramp is conducted with the free stream Mach number 2.9.The blow-and-suction disturbance in the upstream wall boundary is used to trigger the transition.Both the mean wall pressure and the velocity profiles agree with those of the experimental data,which validates the simulation.The turbulent kinetic energy budget in the separation region is analyzed.Results show that the turbulent production term increases fast in the separation region,while the turbulent dissipation term reaches its peak in the near-wall region.The turbulent transport term contributes to the balance of the turbulent conduction and turbulent dissipation.Based on the analysis of instantaneous pressure in the downstream region of the mean shock and that in the separation bubble,the authors suggest that the low frequency oscillation of the shock is not caused by the upstream turbulent disturbance,but rather the instability of separation bubble. | LI XinLiang1,FU DeXun2,MA YanWen2 & LIANG Xian1 1 Key Laboratory of High Temperature Gas Dynamics,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China 2 The State Key Laboratory of Nonlinear Mechanics,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，9： | 24 |
| 12 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 13 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 14 | Concurrent chemoradiotherapy combined with enteral nutrition support:a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant istulae显示文摘Background: Concurrent chemoradiotherapy(CCRT) significantly increases the survival rate of esophageal squa?mous cell carcinoma(ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long?term survival.Methods: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat?sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret?rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening(NRS) before, during, and after treatment. Twenty?two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT.Results: With a median follow?up of 18 months(range, 3–39 months), patients' 1?year overall survival(OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score(P n NRS score(P se to treatment(P < 0.001) were sig= 0.003), increase i= 0.024), fistula closure(P = 0.011), and responnifi?cantly associated with OS. Multivariate analysis showed that tumor response(P = 0.044) and increase in NRS score(P = 0.044) were independent predictors of OS. Grade 3 vomiting was observed in 8 patients(20.0%), grade 3 neutro?penia was observed in 11 patients(27.5%), and grade 3 cough was observed in 13 patients(32.5%); 2 patients(5.0%) died of massive bleeding during treatment.Conclusions: CCRT combined with enteral nutrition support is effective for ESCC patients with malignant fistulae. Patients have an increased potential to be cured, especially those who experience complete response and have an increase in NRS score. Careful observation and nutrition support are required for patients with advanced T?category ESCC who undergo CCRT. | Li Ma Guang-Yu Luo Yu-Feng Ren Bo Qiu Hong Yang Chun-Xia Xie Song-Ran Liu Shi-Liang Liu Zhao-Lin Chen Qun Li Jian-Hua Fu Meng-Zhong Liu Yong-Hong Hu Wen-Feng Ye Hui Liu | 2017 | Chinese Journal of Cancer2017，36，1： | 19 |
| 15 | Infrared thermoimages display of body surface temperature reaction in experimental cholecystitis显示文摘AIM:To display the thermoimages of the body surface inexperimental cholecystitis,to observe the body surfacetemperature reaction in visceral disorders,and to study ifthe theory of body surface-viscera correlation is true and themechanism of temperature changes along the meridians.METHODS:By injecting bacteria suspension into the stricturebile duct and gallbladder,21 rabbits were prepared as acutepyogenic cholangiocholecystitis models,with another 8rabbits prepared by the same process except withoutinjection of bacteria suspension as control.The body surfaceinfrared thermoimagas were continuously observed on thehair shaven rabbit skin with AGA-782 thermovision 24 hbefore,1-11 d after and(2,3 wk)4 wk after the operation witha total of over 10 records of thermoimeges.RESULTS:Twelve cases out of 21 rabbits with cholecystitisrevealed bi-lateml longitudinal high temperature lines in itstrunk;with negative findings in the control group.The high-temperature line appeared on d 1-d 2,first in the right trunk,after the preparation of the model,about 7 d after the modelpreparation,the lines appeared at the left side too,persisting for 4 wk.The hyper-temperature line revealed 1.1-2.7 ℃ higher than before the model preparation,0.7-2.5℃higher than the surrounding skin.The length of the hightemperature line might reach a half length of the body trunk,or as long as the whole body itself.CONCLUSION: The appearance of the longitudinal high temperature lines at the lateral aspects of the trunk in the experimental group is directly bound up with the experimental animals pyogenic cholecystitis, with its running course quite similar to that of the Gallbladder Channel of Foot Shaoyang, but different to the zones of hyperalgesia and site of referred pain in cholecystitis. | Dong Zhang Yuan-Gen Zhu Shu-You Wang Hui-Min Ma Yan Yan Ye Wei-Xing Fu Wei-Guo Hu,Institute of Acupuncture,China Academy of Traditional Chinese Medicine,Beijng 100700,China | 2002 | World Journal of Gastroenterology2002，8，2： | 19 |
| 16 | Global aridification in the second half of the 20th century and its relationship to large-scale climate background显示文摘The variation in surface wetness index (SWI), which was derived from global gridded monthly precipi- tation and monthly mean surface air temperature datasets of Climatic Research Unit (CRU), from 1951― 2002 over global land was analyzed in this paper. The characteristics of the SWI variation in global continents, such as North America, South America, Eurasia, Africa, and Australia, were compared. In addition, the correlation between the SWI variation of each continent (or across the globe) and the large-scale background closely related to SST variations, which affects climate change, was analyzed. The results indicate that the SWI variation shows distinct regional characteristics in the second half of the 20th century under global warming. A drying trend in the last 52 years occurred in Africa, Eurasia, Australia and South America, most obviously in Africa and Eurasia. North America shows a wetting trend after 1976. A 30-year period of dry-wet oscillation is found in South America and Australia; the latest is in a drying period in two regions. The results also revealed that global warming has changed the dry-wet pattern of the global land. South America and Australia have a drying trend despite in- creases in precipitation. This indicates that increases in surface air temperature cannot be ignored in aridification studies. Global dry-wet variation is closely related to large-scale SST variations: the drying trend in Africa and Eurasia and the wetting trend in North America are correlated with Pacific Decadal Oscillation (PDO); the interdecadal oscillation of SWI in South America and Australia is consistent with the interdecadal variation in Southern Oscillation Index (SOI). | MA ZhuGuo FU CongBin | 2007 | Science China Earth Sciences2007，50，5： | 17 |
| 17 | Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo显示文摘瞄准:骨头形态基因的蛋白质(BMP4 ) 4 是在在骨折愈合的早阶段的胼胝形成的主要本地作出贡献因素之一。Adipose-derivedstromal 房间(ADSC ) 是多有势力房间。当暴露了到包含 BMP4 cDNA (Ad-BMP4 ) 的侵入人体气管粘膜的病菌时,现在的学习被进行调查 ADSC 的 theosteogenic 潜力。方法: ADSC 从 Sprague-Dawley 老鼠被收获。在到 Ad-BMP4 的暴露以后, ADSC 被碱的磷酸酶活动(高山) 估计染色的试金, RT-PCR 和 von Kossa。BMP4 表示被 RT-PCR,免疫荧光和西方的污点分析估计。有 Ad-BMP4 的 ADSC transduced 直接被注入 athymic 老鼠的后部的手足肌肉。ADSC Ad-EGFP (提高的绿荧光蛋白质) 用作控制。所有动物被 X 光检查电影和组织学的分析检验。结果:BMP4 的表示在 mRNA 和蛋白质层次被证实。染色的 osteoblastic 基因,高山活动和 von Kossa 的 Theexpression 证实有 Ad-BMP4 的 ADSCtransduced 经历了快速、显著的造骨细胞区别,而有 Ad-EGFP 和房间的 ADSCtransduced 没让 osteogenic 区别独自显示了。X 光检查和组织学的检查在与 Ad-BMP4 与 ADSCtransduced 移植的 athymic 老鼠证实了新骨头形成。结论:我们的数据在 vitro 并且在 vivo 与 Ad-BMP4 表明了成功的 osteogenic 区别 ofADSC transduced。ADSC 可以是为基因治疗和织物工程的间充组织系干细胞的理想的来源。 | Lin LIN Xin FU Xin ZHANG Lian-xu CHEN Ji-ying ZHANG Chang-long YU Kang-tao MA Chun-yan ZHOU | 2006 | Acta Pharmacologica Sinica2006，27，12： | 16 |
| 18 | Direct numerical simulation of compressible turbulent flows显示文摘This paper reviews the authors' recent studies on compressible turbulence by using direct numerical simulation (DNS),including DNS of isotropic(decaying) turbulence, turbulent mixing-layer,turbulent boundary-layer and shock/boundary-layer interaction.Turbulence statistics, compressibility effects,turbulent kinetic energy budget and coherent structures are studied based on the DNS data.The mechanism of sound source in turbulent flows is also analyzed. It shows that DNS is a powerful tool for the mechanistic study of compressible turbulence. | Xin-Liang Li De-Xun Fu Yan-Wen Ma Xian Liang | 2010 | Acta Mechanica Sinica2010，26，6： | 16 |
| 19 | Surgical strategy for presacral tumors: analysis of 33 cases显示文摘背景 Presacral 肿瘤是位于因为在那里的 presacral 或 retrorectal space.Although 是在有恶意的 presacral 肿瘤的病人的预后的实质的改进,知道的空间的高度很少发生的肿瘤,更新的外科的策略的发展是可能的进一步改进这篇文章的 tumors.The 目的是在 33 种情况中报导我们的经验,并且考察外科的策略,病理学的特征和复杂并发症的预防的恶意的 presacral 的 oncologic 结果复发在外科以后在 18 个月内发生在 teratoma 的一种情况中,由 trans 骶的切除治好;本地复发和肺转移手术后地在 6 个月内在 angiosarcoma 的一种情况中同时发生了,病人一个月以后死于大多数 presacral 肿瘤的主要治疗是的呼吸 failure.Conclusions 外科的途径的外科的 resection.Selection 为 presacral tumors.The 地点的完全的切除术是很重要的,肿瘤,皮的条件和软纸巾和病人的尺寸和怪癖是体型都是限定词 factors. | LI Guo-dong CHEN Kai FU Dong MA Xiao-jun SUN Meng-xiong SUN Wei CAI Zheng-dong | 2011 | Chinese Medical Journal2011，，23： | 16 |
| 20 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
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