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| 1 | Chronic Obstructive Pulmonary Disease:Evidence for an Autoimmune Component显示文摘Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible limitation on pulmonary airflow associated with chronic inflammation and mucous hypersecretion (chronic bronchitis) and/or the pathological destruction of alveolar airspaces leading to emphysema. COPD, predominantly as a result of tobacco smoke exposure, represents the fourth leading cause of mortality worldwide and its prevalence is increasing. Despite this, much of the basic mechanisms which contribute to disease progression remain to be elucidated and current therapeutic approaches are, for the most part, based upon alleviating patient symptoms (bronchodilators) as opposed to treating the underlying pathological mechanisms triggered in response to cigarette smoke exposure. The classic disease paradigm suggests that an imbalance of pulmonary matrix proteases versus anti-proteases underlies the tissue destruction and inflammation associated with COPD. However, there is a growing appreciation of the complex and multifaceted nature of the pathological mechanisms associated with disease progression. Recently, there has been mounting evidence indicating that COPD patients exhibit many of the characteristics of a classical autoimmune response. We will discuss current evidence in support of this paradigm and outline how future therapeutic approaches may be tailored to address this. | Anna M. Stefanska Patrick T. Walsh | 2009 | Cellular & Molecular Immunology2009，6，2： | 24 |
| 2 | 微创牙科学:文献回顾与最新进展(英文)显示文摘微创牙科学是指采用生物学方法而不是传统的牙体手术处理龋病,以最大限度地减少对牙体结构的破坏。这种新的龋病处理方法,将过去强调的视龋损为“洞”而反复充填的理念,转变为视龋损为口腔生态失衡而促使生物膜产生生物学变化。微创牙科学的目的在于阻止龋病进程,然后修复缺失的牙体结构和功能,最大限度地发挥牙体的愈合潜能。微创牙科学的处理方法可概括为3个步骤:(1)判定患者的患龋风险;(2)再矿化,即防止龋损形成并逆转未形成“洞”的浅龋;(3)修复,即控制龋活性,使愈合潜能最大化并修复龋损。龋病并非仅仅是牙体脱矿,而是一个因生物膜与牙界面生态和化学平衡失衡而致的反复的脱矿过程(生态菌斑学说)。饮食和生活方式(尤其是碳水化合物的摄入频次)、饮水、吸烟是导致生物膜生态和致病性的重要因素。椅旁评价菌斑和唾液的方法的问世,使得龋病危险评估和监测患者的顺从性成为可能。唾液的再矿化特性,可以通过使用能够释放Ca2+、P5+、F1-的再矿化剂(CPP-ACPandCPP-ACFP)而予强化。使用某些化学制剂(氟、氯已定和木糖醇),可改变菌斑的致病性。采用微创治疗方案,可修复早期龋损,增进患者的理解力和顺从性。本文从3个方面,详细论述了微创牙科学的概念、理论基础和操作方法。 | Andrew M. Brostek Andrew J. Bochenek Laurence J. Walsh | 2006 | 上海口腔医学2006，15，3： | 12 |
| 3 | Driver mutations of cancer epigenomes显示文摘Epigenetic 改变与癌症的所有方面被联系,从肿瘤开始到癌症前进和转移。DNA methylation 以及改变的染色质组织的损失和获得显著地作出贡献到联系癌症的显型,这现在很好被理解。更最近,新定序技术在 epigenetic 管理者允许司机变化的鉴定,提供在癌症 epigenome 和基因改变之间的一个机械学的连接。激活变化的 Oncogenic 现在被知道发生在很多个 epigenetic 修饰词(即 IDH1/2, EZH2, DNMT3A ) ,指出涉及 tumorigenesis 的 epigenetic 小径。同样,调查进在染色质修饰词使变化失去活性的角色(即 KDM6A, CREBBP/EP300, SMARCB1 ) 含有许多这些基因作为肿瘤 suppressors。有趣地,很多个瘤被变化的过多在 epigenetic 管理者定义,包括肾,膀胱,和 adenoid 膀胱的癌。特别地罢工是在小儿科的 glioma 的经常的 histone H3.3 变化的发现,长糟糕留下了的一个特别地好攻击的瘤理解。癌症 epigenetics 是有为改进癌症结果的许多潜力的相对新的、有希望的边疆。已经,象 5-azacytidine 和 decitabine 那样的治疗证明了在癌症指向 epigenetic 改变能导致有形的好处。理解基因改变怎么产生癌症 epigenome 将为开发更好预示、治疗学的策略提供新可能性。 | David M. Roy Logan A. Walsh Timothy A. Chan | 2014 | Protein & Cell2014，5，4： | 7 |
| 4 | 成人隐匿阴茎治疗的综述显示文摘背景与目的导致隐匿阴茎的原因很多,最常见的是肥胖、包皮环切术后或阴囊水肿。随着肥胖病日益增多,这种病症的发病率也必然增多。儿童先天性隐匿阴茎极为罕见,其结果也是转变成为成人隐匿阴茎。本文的目的旨在综述目前对于此类身心疾患的治疗策略。方法对有关隐匿阴茎治疗的文献进行综述,文献主要来源是1977年至2007年PubMed中刊登的整形外科和泌尿外科文献。结果病态肥胖症和糖尿病是成人隐匿阴茎的危险因素。文献中介绍了多种复位和重建的手术方法,如原位缝合、Z成形、植皮修复等,修复过程中均可能进行脂肪切除。最近的文献更多关注采用断层皮片和负压技术进行治疗,该技术有利于皮片成活,远期美观效果良好。结论隐匿阴茎临床少见,治疗困难,对于整形科和泌尿外科医师具有挑战性。潜在因素如病态肥胖和糖尿病的增加,提示这种疾病的发生率也将不断上升。没有某一特定的技术适用于所有患者,治疗时可以采用几种技术的联合。对于疑难重症患者,可以进行阴茎体断层皮片移植术、阴囊缩小术,并可辅助负压吸脂术或脂肪切除术。个体化治疗方法可以获得更高的修复成功率,并且达到满意的美观效果。 | Ivo A. Pestana Jason M. Greenfield Mark Walsh Craig F. Donatucci Detlev Erdmann 冯爱娜 陶凯 魏峰 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，5： | 5 |
| 5 | Adaptive base-isolation of civil structures using variable amplification显示文摘半活跃的水坝 pers 被使用在对还原剂基础隔离土木工程学结构的地震反应。在现在的学习,用可变扩大的一个新半活跃的抑制系统将被调查为适应基础隔离。它使用在系列连接与的一台新奇可变扩大设备(VAD ) 一被动更潮湿。VAD 能够生产多重扩大因素,各相应于一个不同扩大状态。力量从更潮湿根据当前的扩大状态被放大到结构,它经由明确地定制到系统的一个半活跃的控制算法被选择“ s 唯一的抑制特征。为 adaptivebase 隔离表明 VAD 潮湿系统的有效性,数字模拟为三被进行,易于远、近地的地面的七故事的 base-isolatedbuildings 打手势。结果显示系统能与孤立底的大楼相比在反应完成重要减小没有更潮湿。建议系统也被发现表现很好与相比一典型半活跃更潮湿。 | Kenneth K. Walsh Makola M. Abdullah | 2006 | Earthquake Engineering and Engineering Vibration2006，5，2： | 3 |
| 6 | Keeping in constant touch: The predictors of young Australians’ mobile phone involvement显示文摘 | Shari P. Walsh Katherine M. White Stephen Cox Ross McD. Young | 2010 | Computers in Human Behavior2010，，1： | 2 |
| 7 | VEGF-Induced Vascular Permeability Is Mediated by FAK显示文摘 | Xiao Lei Chen Ju-Ock Nam Christine Jean Christine Lawson Colin T. Walsh Erik Goka Ssang-Taek Lim Alok Tomar Isabelle Tancioni Sean Uryu Jun-Lin Guan Lisette M. Acevedo Sara M. Weis David A. Cheresh David D. Schlaepfer | 2012 | Developmental Cell2012，，： | 1 |
| 8 | Clostridium difficile colitis in the critically Ill显示文摘 | S. Grundfest-Broniatowski M.D. M. Quader M.D. F. Alexander M.D. R. M. Walsh M.D. I. Lavery M.D. J. Milsom M.D | 1996 | Diseases of the Colon & Rectum1996，，6： | 1 |
| 9 | Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites显示文摘 | David W. Green Benjamin J.R.F. Bolland Janos M. Kanczler Stuart A. Lanham Dominic Walsh Stephen Mann Richard O.C. Oreffo | 2008 | Biomaterials2008，，10： | 1 |
| 10 | Outcomes of salvage therapy for steroid‐refractory acute severe ulcerative colitis: ciclosporin vs. infliximab显示文摘 | A. Croft A. Walsh J. Doecke R. Cooley M. Howlett G. Radford‐Smith | 2013 | Aliment Pharmacol Ther2013，，： | 1 |
| 11 | Prognostic G leason grade grouping: data based on the modified G leason scoring system显示文摘 | Phillip M. Pierorazio Patrick C. Walsh Alan W. Partin Jonathan I. Epstein | 2013 | BJU Int2013，，5： | 1 |
| 12 | A Prospective Study of Hepatitis B Vaccination – A Comparison of Responders versus Nonresponders显示文摘 | Catherine M. Brown Sheila Donlon Patrick O’Kelly Anne Marie Casey Cathal Collier Peter J. Conlon John J. Walshe | 2011 | Renal Failure2011，，3： | 1 |
| 13 | Biological markers of amyloid β-related mechanisms in Alzheimer’s disease显示文摘 | Harald Hampel Yong Shen Dominic M. Walsh Paul Aisen Les M. Shaw Henrik Zetterberg John Q. Trojanowski Kaj Blennow | 2009 | Experimental Neurology2009，，2： | 1 |
| 14 | Effects of nutrition and temperature on metabolic enzyme activities in larval and juvenile red drum, Sciaenops ocellatus , and lane snapper, Lutjanus synagris显示文摘 | M. E. Clarke C. Calvi M. Domeier M. Edmonds P. J. Walsh | 1992 | Marine Biology1992，，1： | 1 |
| 15 | A prospective randomized trial of cannulation technique in ERCP: effects on technical success and post-ERCP pancreatitis显示文摘 | A. Bailey M. Bourke S. Williams P. Walsh M. Murray E. Lee V. Kwan P. Lynch | 2008 | Endoscopy2008，，04： | 1 |
| 16 | Response to Corticosteroids in Severe Ulcerative Colitis: A Systematic Review of the Literature and a Meta-Regression显示文摘 | Dan Turner Catharine M. Walsh A. Hillary Steinhart Anne M. Griffiths | 2007 | Clinical Gastroenterology and Hepatology2007，，： | 1 |
| 17 | <ce:link locator='fx1'/> Response to Corticosteroids in Severe Ulcerative Colitis: A Systematic Review of the Literature and a Meta-Regression显示文摘 | Dan Turner Catharine M. Walsh A. Hillary Steinhart Anne M. Griffiths | 2007 | Clinical Gastroenterology and Hepatology2007，，1： | 1 |
| 18 | Natural History of the Early Repolarization Pattern in a Biracial Cohort显示文摘 | Joseph A. Walsh Leonard Ilkhanoff Elsayed Z. Soliman Ronald Prineas Kiang Liu Hongyan Ning Donald M. Lloyd-Jones | 2013 | Journal of the American College of Cardiology2013，，8： | 1 |
| 19 | Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis显示文摘 | Sallie B. Cosgrove Jody A. Wren Dawn M. Cleaver David D. Martin Kelly F. Walsh Jessica A. Harfst Stacey L. Follis Vickie L. King Joseph F. Boucher Michael R. Stegemann | 2013 | Vet Dermatol2013，，5： | 1 |
| 20 | Over-connected? A qualitative exploration of the relationship between Australian youth and their mobile phones显示文摘 | Shari P. Walsh Katherine M. White Ross M. Young | 2007 | Journal of Adolescence2007，，1： | 1 |
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