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| 1 | Advances in diagnosis,treatment and palliation of cholangiocarcinoma:1990-2009显示文摘Several advances in diagnosis,treatment and palliation of cholangiocarcinoma(CC)have occurred in the last decades.A multidisciplinary approach to this disease is therefore recommended.CC is a relatively rare tumor and the main risk factors are:chronic inflammation, genetic predisposition and congenital abnormalities of the biliary tree.While the incidence of intra-hepatic CC is increasing,the incidence of extra-hepatic CC is trending down.The only curative treatment for CC is surgical resection with negative margins.Liver transplantation has been proposed only for selected patients with hilar CC that cannot be resected who have no metastatic disease after a period of neoadjuvant chemo-radiation therapy.Magnetic resonance imaging/magnetic resonance cholangiopancreatography,positron emission tomography scan,endoscopic ultrasound and computed tomography scans are the most frequently used modalities for diagnosis and tumor staging.Adjuvant therapy,palliative chemotherapy and radiotherapy have been relatively ineffective for inoperable CC.For most of these patients biliary stenting provides effective palliation.Photodynamic therapy is an emerging palliative treatment that seems to provide pain relief,improve biliary patency and increase survival. The clinical utility of other emerging therapies such as transarterial chemoembolization,hepatic arterial chemoinfusion and high intensity intraductal ultrasound needs further study. | Murad Aljiffry Mark J Walsh Michele Molinari | 2009 | World Journal of Gastroenterology2009，15，34： | 82 |
| 2 | Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010显示文摘Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic. | Chakshu Sharma Karim M Eltawil Paul D Renfrew Mark J Walsh Michele Molinari | 2011 | World Journal of Gastroenterology2011，17，7： | 28 |
| 3 | 成人隐匿阴茎治疗的综述显示文摘背景与目的导致隐匿阴茎的原因很多,最常见的是肥胖、包皮环切术后或阴囊水肿。随着肥胖病日益增多,这种病症的发病率也必然增多。儿童先天性隐匿阴茎极为罕见,其结果也是转变成为成人隐匿阴茎。本文的目的旨在综述目前对于此类身心疾患的治疗策略。方法对有关隐匿阴茎治疗的文献进行综述,文献主要来源是1977年至2007年PubMed中刊登的整形外科和泌尿外科文献。结果病态肥胖症和糖尿病是成人隐匿阴茎的危险因素。文献中介绍了多种复位和重建的手术方法,如原位缝合、Z成形、植皮修复等,修复过程中均可能进行脂肪切除。最近的文献更多关注采用断层皮片和负压技术进行治疗,该技术有利于皮片成活,远期美观效果良好。结论隐匿阴茎临床少见,治疗困难,对于整形科和泌尿外科医师具有挑战性。潜在因素如病态肥胖和糖尿病的增加,提示这种疾病的发生率也将不断上升。没有某一特定的技术适用于所有患者,治疗时可以采用几种技术的联合。对于疑难重症患者,可以进行阴茎体断层皮片移植术、阴囊缩小术,并可辅助负压吸脂术或脂肪切除术。个体化治疗方法可以获得更高的修复成功率,并且达到满意的美观效果。 | Ivo A. Pestana Jason M. Greenfield Mark Walsh Craig F. Donatucci Detlev Erdmann 冯爱娜 陶凯 魏峰 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，5： | 5 |
| 4 | SuperDARN CUTLASS Finland radar observations of high-latitude magnetic reconnections under northward interplanetary magnetic field (IMF) conditions显示文摘A number of backscatter power enhancement events with 'equatorward-moving radar auroral forms' in the high-latitude ionosphere were observed by SuperDARN CUTLASS Finland radar when the IMF was northward during 09:00 -10:00 UT on 26 March 2004. These events were also associated with sunward flow enhancements at each location in the Northern Hemisphere which were shown in ionospheric convections measured by the SuperDARN radars. These are typical features of high-latitude (lobe) magnetic reconnections. The durations of the velocity enhancements imply that the evolution time of the lobe reconnections is about 8-16 min from their origin at the reconnection site to their addition to the magnetotail lobe again. In additional, the Double Star TC-1 spacecraft was moving from magnetosheath into magnetosphere, and crossing the magnetopause near the subsolar region during this interval, and observed typical low-latitude magnetic reconnection signatures. This infers that the dayside high- and low-latitude reconnections may occur simultaneously. | ZHANG QingHe LIU RuiYuan YANG HuiGen HU HongQiao ZHANG BeiChen DUNLOP Malcolm LESTER Mark BOGDANOVA Yulia WALSH Andrew | 2012 | Science China(Technological Sciences)2012，55，5： | 5 |
| 5 | High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy显示文摘 | Kevin J. Spring Zhen Zhen Zhao Rozemary Karamatic Michael D. Walsh Vicki L.J. Whitehall Tanya Pike Lisa A. Simms Joanne Young Michael James Grant W. Montgomery Mark Appleyard David Hewett Kazutomo Togashi Jeremy R. Jass Barbara A. Leggett | 2006 | Gastroenterology2006，，5： | 3 |
| 6 | 外科医生和病理医生对胸腺恶性肿瘤切除标本的处理方法和程序显示文摘胸腺恶性肿瘤发病率低,临床病例分散,需要结合多中心经验才能进行良好的研究,但由于在诸多方面没有统一标准,使得研究与研究之间的可比性差。其中外科医生和病理医生对胸腺恶性肿瘤切除标本的处理是统一标准中至关重要的部分。针对目前胸腺瘤的常用手术方式胸骨劈开根治性R0切除术的标本处理作如下规定,包括切除胸腺瘤及周围的受累结构说明如何处理手术切除标本。活检或细胞学标本的处理另文描述[1]。本文首先由国际胸腺肿瘤协作组织(International hTymic Malignacy Interest Group, ITMIG)中病理医生和外科医生组成的小组回顾相关文献形成初步建议[2,3],交扩展组审议提炼后分发给ITMIG成员进讨论,再将ITMIG成员回馈的建议和几个大中心试点的情况进行提炼,最终形成的建议经ITMIG批准并被采用。因此,既强调证据又代表ITMIG成员的广泛共识。 | 付浩 中国胸腺瘤协作组全体成员 Frank C.Detterbeck Cesar Moran James Huang Saul Suster Garrett Walsh Lawrence Kaiser Mark Wick | 2014 | 中国肺癌杂志2014，17，2： | 3 |
| 7 | Evidence-Based Approach to Cholangiocarcinoma: A Systematic Review of the Current Literature显示文摘 | Murad Aljiffry Alhawsawi Abdulelah Mark Walsh Kevork Peltekian Ian Alwayn Michele Molinari | 2008 | Journal of the American College of Surgeons2008，，1： | 3 |
| 8 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 9 | Reduced tumorigenicity of B16-F10 mouse melanoma cells transfected withmycobacterial antigen 85A显示文摘 | Jillian Tarrant Mark Walsh Mark Blanchard Timothy Lee David Hoskin Carman Giacomantonio | 2004 | International Journal of Oncology2004，，6： | 1 |
| 10 | Candidatus “Scalindua brodae”, sp. nov., Candidatus “Scalindua wagneri”, sp. nov., Two New Species of Anaerobic Ammonium Oxidizing Bacteria显示文摘 | Markus Schmid Kerry Walsh Rick Webb W. Irene Rijpstra Katinka van de Pas-Schoonen Mark Jan Verbruggen Thomas Hill Bruce Moffett John Fuerst Stefan Schouten Jaap S. Sinninghe Damsté James Harris Phil Shaw Mike Jetten Marc Strous | 2003 | Systematic and Applied Microbiology2003，，4： | 1 |
| 11 | Efficacy of atrial antitachycardia pacing using the Medtronic AT500 pacemaker in patients with congenital heart disease显示文摘 | Elizabeth A. Stephenson David Casavant Joann Tuzi Mark E. Alexander Ian Law Gerald Serwer Margaret Strieper Edward P. Walsh Charles I. Berul | 2003 | The American Journal of Cardiology2003，，7： | 1 |
| 12 | Multiaxial Pedicle Screw Designs: Static and Dynamic Mechanical Testing显示文摘 | Ralph Edward Stanford Andreas Herman Loefler Philip Mark Stanford William R. Walsh | 2004 | Spine2004，，4： | 1 |
| 13 | Liposomal Amphotericin B (L-AMB) Is Superior to Amphotericin B Deoxycholate (AmB-d) in Preventing Breakthrough Fungal Infections in Patients with Prolonged Neutropenia and Fever:Results of a Sub-Group Analysis of an Empirical Antifungal Therapy Trial显示文摘 | Catherine Cordonnier Thomas J Walsh Mark Bresnik | 2004 | Blood (ASH Annual Meeting Abstracts)2004，104，11： | 1 |
| 14 | Molecular and cell biology of the gingiva显示文摘 | Mark BP Laurence J Walsh | 2000 | Periodontology2000，24，1： | 1 |
| 15 | Emergence of a New AntibioticResistance Mechanism in India, Pakistan, and the UK: A Molecular, Biological,and Epidemiological Study 显示文摘 | KARTHIKEYAN K KUMARASAMY MARK A TOLEMAN TIMOTHY R WALSH | 2010 | Lancet InfectDis2010，10，： | 1 |
| 16 | Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells显示文摘 | Ivanov Andrei Beers Stephen A Walshe Claire A Honeychurch Jamie Alduaij Waleed Cox Kerry L Potter Kathleen N Murray Stephen Chan Claude H T Klymenko Tetyana Erenpreisa Jekaterina Glennie Martin J Illidge Tim M Cragg Mark S | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 17 | Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression显示文摘 | Daniele Torella Marcello Rota Daria Nurzynska Ezio Musso Alyssa Monsen Isao Shiraishi Elias Zias Kenneth Walsh Anthony Rosenzweig Mark A. Sussman Konrad Urbanek Bernardo Nadal-Ginard Jan Kajstura Piero Anversa Annarosa Leri | 2004 | Circulation Research: Journal of the American Heart Association2004，，4： | 1 |
| 18 | Early results of stent-grafting to treat diffuse aortoiliac occlusive disease显示文摘 | Eva M Rzucidlo Richard J Powell Robert M Zwolak Mark F Fillinger Daniel B Walsh Marc L Schermerhorn Jack L Cronenwett | 2003 | Journal of Vascular Surgery2003，，6： | 1 |
| 19 | Effect of Distraction Rate on Biomechanical, Mineralization, and Histologic Properties of an Ovine Mandible Model显示文摘 | Ross D. Farhadieh Mark P. Gianoutsos R. Dickinson William R. Walsh | 2000 | Plastic & Reconstructive Surgery2000，，3： | 1 |
| 20 | Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study显示文摘 | Timothy R Walsh Janis Weeks David M Livermore Mark A Toleman | 2011 | The Lancet Infectious Diseases2011，，5： | 1 |
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