|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | A transparent aqueous-saturated sand surrogate for use in physical modeling显示文摘 | Ivan L. Guzman Magued Iskander Eduardo Suescun-Florez Mehdi Omidvar | 2014 | Acta Geotechnica2014，，2： | 3 |
| 3 | Prognostic utility of myocardial viability assessment显示文摘 | ISKANDER S ISKANDRIAN A E | 1999 | Am J Cardiology1999，83，5： | 2 |
| 4 | 癌症筛查之未来显示文摘1引言癌症已成为美国的第二大致死病因,52%的人死于肺癌、支气管癌、女性乳腺癌、宫颈癌、结直肠癌、口腔及咽喉癌、前列腺癌和皮肤癌(黑色素瘤)。19世纪30年代,包括宫颈癌在内的子宫癌,位居美国女性癌症死亡第一位。50年代,随着巴氏涂片技术(Pap test)的应用,可以在细胞水平检测宫颈的变化,宫颈癌死亡率显著降低,这是第一个癌症筛查检测技术。此后,已有多种影像学检查(例如乳腺癌钼靶X线、内窥镜检查和计算机体层扫描)和实验室检测方法(粪便隐血试验)用于癌症筛检。 | Cheryll C.Thomas Thomas B.Richards Marcus Plescia Faye L.Wong Rachel Ballard Theodore R.Levin Bruce N.Calonge Otis W.Brawley John Iskander 徐海燕(翻译) 陆仁敏(审校) 蔡颖(审校) | 2017 | 上海预防医学2017，29，3： | 2 |
| 5 | Accuracy of Orbscan pachymetry measurements and DHG ultrasound pachymetry in primary laser in situ keratomileusis and LASIK enhancement procedures显示文摘 | Nader G Iskander Ellen Anderson Penno N.Timothy Peters Howard V Gimbel Maria Ferensowicz | 2001 | Journal of Cataract & Refractive Surgery2001，，5： | 2 |
| 6 | Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubiuemia显示文摘 | Gamaleldin R Iskander I Seoud I | 2011 | Pediatrics2011，128，4： | 1 |
| 7 | Surveillance for safety after immunization: Vaccine Adverse Event Reporting System (VAERS)- United States, 1991-2001显示文摘 | Zhou W Pool V Iskander JK | 2003 | MMWR Surveill Suture2003，52，1： | 1 |
| 8 | Surveillance for safety af- ter immunization: vaccine adverse event reporting system-Unit- ed States 1991-2001显示文摘 | Zhou W Pool V Iskander J K | 2002 | Pediatrics2002，110，6： | 1 |
| 9 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 10 | Investigation of structural requirements of anticancer activity at the paclitaxel/tubulinbinding site using CoMFA and CoMSIA显示文摘 | Islam MN Song Y Iskander MN | 2003 | J Mol Graph Model2003，21，4： | 1 |
| 11 | Metallothionein induction in human CNS in vitro: neuroprotection from ionizing radiation 显示文摘 | Cai L Cherian MG Iskander S | 2000 | Radiat Biol2000，76，7： | 1 |
| 12 | Intravenous administrationof human umbilical cord blood-derived AC133+ endothelial progenitorcells in rat stroke model reduces infarct volume: magnetic resonanceimaging and histological findings 显示文摘 | Iskander A Knight RA Zhang ZG | 2013 | Stem Cells Transl Med2013，2，9： | 1 |
| 13 | Analytical level crossing rates and average fade durations for diversity techniques in Nakagami fading channels显示文摘 | MATHIOPOULOS P | 2002 | IEEE Transaction on Communications2002，50，8： | 1 |
| 14 | A survey of scheduling rules显示文摘 | PANWALKAR S S ISKANDER W | 1977 | Operations Research1977，25，1： | 1 |
| 15 | Coordination compounds of hydrazine derivatives with transition metals III: The reaction of aroyl hydrazones with Ni( Ⅲ ) and Cu ( Ⅱ ) salts显示文摘 | Sayed L E Iskander M F | 1971 | J Inorg Nucl Chem1971，33，2： | 1 |
| 16 | Long-term filtration and visual field outcomes after primary glaucoma triple procedure with and without mitomycin-C显示文摘 | Shin DH Iskander NG Ahee JA | 2002 | Ophthalmology2002，109，9： | 1 |
| 17 | State of the practice review in FRP composite piling 显示文摘 | ISKANDER M G HASSAN M | 1998 | Journal of Composites for Construction1998，2，3： | 1 |
| 18 | 显示文摘 | ISLAM M N SONG Y ISKANDER M N | 2003 | Journal of Molecular Graphics and Modelling2003，21，4： | 1 |
| 19 | Coordination compounds of hydrazine derivatives with transition metals. Part 27. Coordination chemistry of 4-amino-3-alkyl-5-thio-1,2,4-triazolines and 4-amino-5-oxo-3-thioxo-6-alkyl-2,3,4,5-tetrahydro-1,2,4-triazines显示文摘 | Magdi F. Iskander Josefe Stephanos Nagwa El Kady Mohyi El Essawi Ahmed El Toukhy Laila El Sayed | 1989 | Transition Metal Chemistry1989，，1： | 1 |
| 20 | Root causes for late presentation of severe neonatal hyperbilirubinaemia in Egypt显示文摘 | Iskander I Gamaleldin R Kabbani M | 2012 | East Mediterr Health J2012，18，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员