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| 1 | IMbrave150研究:免疫抑制剂治疗首次取得晚期肝细胞癌一线治疗成功显示文摘【据The New England Journal of Medicine 2020年5月报道】题:阿特朱单抗联合贝伐单抗在无法手术切除的晚期肝细胞癌中的疗效(作者Finn RS等)索拉非尼和仑伐替尼是目前晚期肝细胞癌(HCC)的标准一线治疗方案,可适当提高患者总生存率,但不良反应较多。PD-1抑制剂、阿特朱单抗(PD-L1抑制剂)以及贝伐单抗在Ⅰb期和Ⅱ期临床试验中显示出良好的客观缓解率。该研究探索了阿特朱单抗联合贝伐单抗对比单药索拉非尼治疗无法手术切除的晚期HCC的疗效和安全性。 | 刘昊天 钟鉴宏 FINN RS QIN S IKEDA M | 2020 | 临床肝胆病杂志2020，36，9： | 460 |
| 2 | 稻草还田对晚稻稻田甲烷排放的影响显示文摘晚稻稻田的甲烷排放呈现前高后低特点 ,稻田甲烷的日排放速率与日均气温具有良好的正相关。稻草翻施使稻田甲烷排放量上升 5 1 .1 1 % ,而采用稻草表施的方法甲烷排放量仅增加 33.98%。水稻分蘖期是稻田甲烷排放的重要时期 ,其甲烷排放量占水稻全生育期排放总量的 65 .6% ,施用稻草进一步加大水稻分蘖期的甲烷排放比例。与稻草翻施相比 ,稻草表施的甲烷减排突出表现在水稻分蘖期及一天中 1 2∶0 0~ 1 6∶0 0的甲烷排放高峰时段。土壤 5cm处温度的昼夜周期性变化与稻田甲烷排放的昼夜周期性变化具有高度相关性。 | 陈苇 卢婉芳 段彬伍 Wassmann R Lantin RS | 2002 | 土壤学报2002，39，2： | 49 |
| 3 | 舌鳞状细胞癌中lncRNA-miRNA-mRNA ceRNA网络的整合分析显示文摘Zhou RS,Zhang EX,Sun QF,et al.Integrated analysis of IncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue.BMC Cancer,2019 Aug.背景:大量研究证实,长链非编码RNA(lncRNA)可以作为竞争性内源RNA(ceRNA)与microRNA(miRNA)位点结合,从而影响和调节mRNA和靶基因的表达。 | 赵泽亮 Zhou RS Zhang EX Sun QF | 2019 | 中国口腔颌面外科杂志2019，17，5： | 27 |
| 4 | 他汀类药物的抗粥样血栓特性对心血管事件减少的意义显示文摘 | Rose.,RS 胡予 | 1999 | 美国医学会杂志(中文版)1999，18，3： | 20 |
| 5 | 麻醉苏醒恢复期的并发症显示文摘一、持续镇静朦胧状态鉴别全麻后苏醒延迟,应有步骤地进行.先了解术前意识水平并排除脑机能不全,或已用过未被注意的药物以及是否酒精中毒等.术前或术中用了镇静作用或可能产生副作用的药物,就应了解用药时间和剂量,并对手术经过作全面回顾.在麻醉苏醒室内(PACU)检查麻醉后感觉迟钝的病人,如果有自主呼吸。 | Mecca RS 陈辉 林建东 | 1993 | 国外医学(麻醉学与复苏分册)1993，14，1： | 18 |
| 6 | 早期头颅成形术和神经学改善显示文摘在减压的颅骨切除术后,头颅成形术普遍用于美容和对大脑的保护。传统上,外科医生会在头颅成形术前等数月来使最初的创伤恢复。这项系统回顾评估了头颅成形术在神经功能方面的效果,以及进一步确定是否手术的选择时间会影响恢复。进行了一项对1990年1月到2016年4月已发表文献的系统回顾。 | 金丹丹 顾旭东 Malcolm JG Rindler RS Chu JK | 2018 | 中国康复2018，33，3： | 15 |
| 7 | Systematic review of prognostic importance of extramuralvenous invasion in rectal cancer显示文摘AIM: To systematically review the survival outcomes relating to extramural venous invasion in rectal cancer.METHODS: A systematic review was conducted using PRISMA guidelines. An electronic search was carried out using MEDLINE, EMBASE, CINAHL, Cochrane library databases, Google scholar and Pub Med until October 2014. Search terms were used in combination to yield articles on extramural venous invasion in rectal cancer. Outcome measures included prevalence and 5-year survival rates. These were graphically displayed using Forest plots. Statistical analysis of the data was carried out.RESULTS: Fourteen studies reported the prevalence of extramural venous invasion(EMVI) positive patients. Prevalence ranged from 9%-61%. The pooled prevalence of EMVI positivity was 26% [Random effects: Event rate 0.26(0.18, 0.36)]. Most studies showed that EMVI related to worse oncological outcomes. The pooled overall survival was 39.5% [Random effects: Event rate 0.395(0.29, 0.51)].CONCLUSION: Historically, there has been huge variation in the prevalence of EMVI through inconsistent reporting. However the presence of EMVI clearly leads to worse survival outcomes. As detection rates become more consistent, EMVI may be considered as part of risk-stratification in rectal cancer. Standardised histopathological definitions and the use of magnetic resonance imaging to identify EMVI will improve detection rates in the future. | Manish Chand Muhammed RS Siddiqui Ian Swift Gina Brown | 2016 | World Journal of Gastroenterology2016，22，4： | 15 |
| 8 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 9 | 纸的断裂韧性及其与纤维长度的关系显示文摘介绍了用断裂基功的概念测定纸张断裂韧性的新方法。并用此法研究了纤维长度对断裂韧性的影响,表明纸的断裂韧性与纤维长度几乎成直线关系;断裂韧性对纤维长度的依赖性比撕裂和抗张强度大。 | 彭毓秀 Seth,RS | 1994 | 中国造纸1994，13，4： | 10 |
| 10 | Effects of raster resolution on landslide susceptibility mapping:A case study of Shenzhen显示文摘Resolution has been playing a significant role in landslide susceptibility mapping and hazard assessment.Based on geographical information system(GIS) and information model,the effects of raster resolution on landslide susceptibility mapping are studied in a central area of Shenzhen,China.Eight factors are selected to calculate landslide susceptibility with eleven groups of different resolutions(5 to 190 m).It has been found that a finer resolution does not necessarily lead to a higher accuracy of landslide susceptibility mappings,while the result of 90 m-resolution has the best accuracy and the 150 m-resolution has the worst one.The accuracy curve is in a shape of 'W' along with resolution decreasing:1) The accuracy decreases from 5 to 70 m;2) and then the best accuracy appears at 90 m,which is almost the same as the mean size of landslides in study area;3) the accuracy decreases again from 110 to 150 m;4) and finally the accuracy increases from 150 to 190 m.The sensitivity analysis indicates that the effects of raster resolution are mainly caused by the resolution impact on landform parameter derivation,while factors like geology and human activity are very insensitive to resolutions.A further study shows that in flat,ridge,and slope foot terrains,the susceptibility mapping result is sensitive to resolution,but in the sloping surface area the sensitivity is much less sensitive to resolution.At last,by choosing study areas with different sizes,it has also been found that the optimal resolutions are variable due to size of study area.But the study area is larger than a threshold,which is 135 km2 in this study,and the optimal resolution is almost fixed. | TIAN Yuan,XIAO ChenChao,LIU Yu & WU Lun Institute of RS and GIS,Peking University,Beijing 100871,China | 2008 | Science China(Technological Sciences)2008，51，S2： | 8 |
| 11 | Systematic review of emergent laparoscopic colorectal surgery for benign and malignant disease显示文摘Laparoscopic surgery has become well established in the management of both and malignant colorectal disease.The last decade has seen increasing numbers of surgeons trained to a high standard in minimallyinvasive surgery.However there has not been the same enthusiasm for the use of laparoscopy in emergency colorectal surgery.There is a perception that emergent surgery is technically more difficult and may lead to worse outcomes.The present review aims to provide a comprehensive and critical appraisal of the available literature on the use of laparoscopic colorectal surgery(LCS)in the emergency setting.The literature is broadly divided by the underlying pathology;that is,inflammatory bowel disease,diverticulitis and malignant obstruction.There were no randomized trials and the majority of the studies were case-matched series or comparative studies.The overall trend was that LCS is associated with shorter hospital stay,par or fewer complications but an increased operating time.Emergency LCS can be safely undertaken for both benign and malignant disease providing there is appropriate patient selection,the surgeon is adequately experienced and there are sufficient resources to allow for a potentially more complex operation. | Manish Chand Muhammed RS Siddiqui Ashish Gupta Shahnawaz Rasheed Paris Tekkis Amjad Parvaiz Alex H Mirnezami Tahseen Qureshi | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 12 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S Brown EJ Banerjee RR Wright CM Patel HR Ahima RS Lazar MA | | 0，，： | 6 |
| 13 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 14 | Investigating spatial distribution of tourist attractions’inlinks: A case study of three mountains显示文摘In hyperlink analysis,most researchers focus on interpreting hyperlink counts,they seldom concern themselves enough about the significance of spatial distribution of hyperlinks.In this paper,we argue that not only can the inlink count to a tourist attraction’s official website reflect its attractiveness,but also the spatial distribution of its inlinks can reflect the distribution of its tourist source markets.Three mountains in Anhui Province,China,are chosen for the case study.Firstly,the correlation between the spatial distributions of an attraction’s tourist source markets and its official website’s inlinks is investigated.Secondly,the tourism indexes such as the spatial concentration index(SCI)and the attraction radius(AR),which are calculated by inlinks,are compared to the real indexes based on tourist sources.Last,the detailed discussion and analysis are presented and an improved model,which is used to calculate the distribution of inlinks,is proposed. | ZHANG Yi 1,QI LiNa 2,YANG AnRan 1,SHI Lei 1 & XU Li 1 1 Institute of RS and GIS,Peking University,Beijing 100871,China 2 Center for Recreation and Tourism Research,Peking University,Beijing 100871,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 5 |
| 15 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 16 | Integral ear elimination and virtual point-based updating algorithms for constrained Delaunay TIN显示文摘Constrained Delaunay Triangular Irregular Networks (CD-TIN),a kind of special data structure,have many practical applications in Geoinformatics,especially in the representation of linear constrained triangulation for DTM and DSM,such as in digital city and digital mine. Past researches on D-TIN mainly focused on point in-sertion and deletion without consideration of constraint,and that on CD-TIN usu-ally paid more attention to the insertion algorithms for points and edges,but little to the deletion algorithms. The presented algorithms are far insufficient for the dy-namic updating of CD-TIN. In this paper,the constraint edge in CD-TIN is consid-ered to be any set of broken lines,i.e.,polygon edges,broken lines and simple segments. The constraint edge may be composed of one or more constraint seg-ments,and it is allowed to be in any form: Open or close,intersection or self-in-tersection. By improving to present insertion and deletion algorithms for D-TIN,two new algorithms for CD-TIN updating are presented. According to the polymorphism of the constraints in CD-TIN,virtual point is adopted to represent the crossing node between constraint edges when a constraint edge is inserted in CD-TIN. Two new algorithms named as Integral Ear Elimination (IEE) and Influence Domain Retrian-gulation for Virtual Point (IDRVP) are presented,the former is for constraint point deletion,while the later is for the insertion and deletion of constraint edge. The principle of IDRVP is that to divide the influence domain of a virtual point into some parts by the constraint-keeping edges,and to retriangulate each part of the influ-ence domain individually referring to the constraint visible property and constraint empty circle (CEC) criterion. Finally,a prototype system is developed with VC++,one case on the integration of 3D terrain and buildings is demonstrated to test the correctness of new algorithms. It shows that the new algorithms are effective for the updating of CD-TIN. | WU LiXin1,2,WANG YanBing2,3 & SHI WenZhong2,4 1 Institute for Geo-informatics & Digital Mine Research,Northeastern University,Shenyang 110004,China 2 Institute for GIS/RS/GPS & Subsidence Engineering Research,China University of Mining & Technology,Beijing 100085,China 3 Laboratory of 3D Information Acquisition & Application,Capital Normal University,Beijing 100037,China 4 Center for Advanced GIS Research,LSGI,Polytechnic University Hong Kong,Hong Kong,China | 2008 | Science China(Technological Sciences)2008，51，S1： | 5 |
| 17 | A method of quantitatively calculating amount of allochthonous organic carbon in lake sediments显示文摘TOTAL organic matter(TOM) or total organic carbon(TOC) is often treated as an importantindicator of lake environment. As a matter of fact, TOC is of multi-origin, and can simply bedivided into two parts: autochthonous and allochthonous organic carbon. The autochthonousorganic carbon is mainly controlled by the production of the plankton of lake itse1f; and the al-lochthonous one by climate and environment in the catchment area, e. g. more precipitationand runoff and densely developed vegetation will give rise to more allochthonous organic com- | Qian, JL Wang, SM Xue, B Chen, RS Ke, SZ | 1997 | Chinese Science Bulletin1997，42，21： | 5 |
| 18 | 中年成人平均动脉压的体位改变与动脉硬度的关系:Framingham心脏研究显示文摘Torjesen A, Cooper LL, Rong J, Larson MG, Hamburg NM, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Relations of arterial stiffness with postural change in mean arterial pressure in middle-aged adults:the Framingham heart study. Hyperten- sion,2017,69(4) :685-690.站立位血压稳定调节受损可导致不良结果,包括跌倒、晕厥和定向障碍。平均动脉压(meanarterialpressure,MAP)通常在站立位时增加,然而,站立位MAP增加不足或减少可能导致脑灌注减少。已有研究报道,在动脉硬度增加的老年人中存在体位性低血压,年轻至中年人MAP的体位性改变与动脉硬度的相关性尚未阐明。该研究分析了Framingham心脏研究第3代队列中的受试者3205人(女性1693人,占53%)的直立性血压反应和全面血液动力学数据。 | Torjesen A Cooper LL Rong J Larson MG Hamburg NM Levy D Benjamin EJ Vasan RS Mitchell GF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，3： | 5 |
| 19 | 乙型肝炎疫苗和HBV感染诱导HBV特异性NK细胞记忆功能显示文摘【据Gut 2021年2月报道】题:乙型肝炎疫苗和HBV感染诱导HBV特异性NK细胞记忆功能(作者Wijaya RS等)接种乙型肝炎疫苗可通过免疫记忆保护机体免受后续感染(传统上被认为是适应性免疫系统的领域)。但在小鼠和非人类灵长类动物中发现了抗原特异性记忆自然杀伤细胞(mNK)后,这一观点受到了挑战。 | WIJAYA RS READ SA TRUONG NR 程俊雅 李海军 | 2021 | 临床肝胆病杂志2021，37，12： | 4 |
| 20 | 鬼臼毒及其有关化合物的合成显示文摘关于鬼臼毒及其有关化合物的合成已有40多篇论文散见于各种刊物。人们对这一小类化合物之所以感兴趣是因为其中某些,如4′去甲基表鬼臼毒可用于肿瘤的化疗。纵观已报道的合成方法,初看起来似乎有许多不同的途径,但细致归纳,却可以分为三条或最多四条路线。其中有用γ氧酯或二羟基羧酸为主要起始原料的;也有以串连共轭加成或 D-A 反应作为关键步骤。 | Ward RS 史玉俊 | 1993 | 国外医药(植物药分册)1993，8，5： | 4 |
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