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| 1 | 长江三角洲地区大气污染过程分析显示文摘针对2015年和2016年12月2个月的4次污染过程,利用中分辨率成像光谱仪(MODIS)Terra卫星的气溶胶光学厚度(AOD),Angstrom波长指数(AE)气溶胶数据,并结合PM_(2.5)和PM_(10)的浓度以及比值变化分析,发现以PM_(2.5)为代表的人为因素产生的细颗粒物是造成研究地区污染发生的重要因素.并且利用MODIS火点数据以及美国海军气溶胶分析与预测系统(NAAPS)模拟分析污染物成分,发现2015年12月12~16日和19~27日2次污染都以人为因素产生的细粒子污染物为主,沙尘以及生物质燃烧产生的烟粒对研究地区影响较小.2016年12月6~10日和15~18日2次污染过程产生的原因不同,利用潜在源贡献因子分析法(PSCF)分析发现6~10日污染天气的产生主要是由西北方向含有大量沙尘粒子气流以及南方生物质燃烧产生的大量烟粒共同输送到研究地区,加之研究地区大量人为污染细粒子的产生,导致了此次混合型污染天气发生.15~18日污染过程与2015年2次污染过程相似,主要原因都在于人为因素产生的细颗粒污染物的影响,沙尘以及烟粒对污染过程起到了加剧的作用. | 邓发荣 康娜 Kanike Raghavendra Kumar 胡康 蒋永成 于兴娜 | 2018 | 中国环境科学2018，38，2： | 23 |
| 2 | Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic(type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease显示文摘AIM: To study clinical and histopathological features of nonalcoholic fatty liver disease(NAFLD) in patients with and without type 2 diabetes mellitus(T2DM) using updated nonalcoholic steatohepatitis clinical research network(NASH-CRN) grading system.METHODS: We retrospectively analyzed data of 235 patients with biopsy proven NAFLD with and without T2 DM.This database was utilized in the previously published study comparing ethnicity outcomes in NAFLD by the same corresponding author.The pathology database from University of Chicago was utilized for enrolling consecutive patients who met the criteria for NAFLD and their detailed clinical and histopathology findings were obtained for comparison.The relevant clinical profile of patients was collected from the Electronic Medical Records around the time of liver biopsy and the histology was read by a single well-trained histopathologist.The updated criteria for type 2 diabetes have been utilized for analysis.Background data of patients with NASH and NAFLD has been included.The mean differences were compared using χ2 and t-test along with regression analysis to evaluate the predictors of NASH and advanced fibrosis.RESULTS: Patients with NAFLD and T2 DM were significantly older(49.9 vs 43.0,P < 0.01),predominantly female(71.4 vs 56.3,P < 0.02),had higher rate of metabolic syndrome(88.7 vs 36.4,P < 0.01),had significantly higher aspartate transaminase(AST)/alanine transaminase(ALT) ratio(0.94 vs 0.78,P < 0.01) and Fib-4 index(1.65 vs 1.06,P < 0.01) as markers of NASH,showed higher mean NAFLD activity score(3.5 vs 3.0,P = 0.03) and higher mean fibrosis score(1.2 vs 0.52,P < 0.01) compared to patients with NAFLD without T2 DM.Furthermore,advanced fibrosis(32.5 vs 12.0,P < 0.01) and ballooning(27.3 vs 13.3,P < 0.01) was significantly higher among patients with NAFLD and T2 DM compared to patients with NAFLD without T2 DM.On multivariate analysis,T2 DM was independently associated with NASH(OR = 3.27,95%CI: 1.43-7.50,P < 0.01) and advanced fibrosis(OR = 3.45,95%CI: 1.53-7.77,P < 0.01) in all patients with NAFLD.There was a higher rate of T2DM(38.1 vs 19.4,P < 0.01) and cirrhosis(8.3 vs 0.0,P = 0.01) along with significantly higher mean Bilirubin(0.71 vs 0.56,P = 0.01) and AST(54.2 vs 38.3,P < 0.01) and ALT(78.7 vs 57.0,P = 0.01) level among patients with NASH when compared to patients with steatosis alone.The mean platelet count(247 vs 283,P < 0.01) and high-density lipoprotein cholesterol level(42.7 vs 48.1,P = 0.01) was lower among patients with NASH compared to patients with steatosis.CONCLUSION: Patients with NAFLD and T2 DM tend to have more advanced stages of NAFLD,particularly advanced fibrosis and higher rate of ballooning than patients with NAFLD without T2 DM. | Bharat K Puchakayala Siddharth Verma Pushpjeet Kanwar John Hart Raghavendra R Sanivarapu Smruti R Mohanty | 2015 | World Journal of Hepatology2015，7，25： | 10 |
| 3 | 2015年10月南京霾污染过程分析显示文摘为探讨南京秋季霾污染过程发生的主要影响因素,利用南京信息工程大学太阳光度计观测霾污染发生天气下AOD(aerosol optical depth,气溶胶光学厚度)数据,计算AE440-1020(ngstr9m Exponent,波长指数)以及a2(光谱曲率),结合CALIPSO(Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations)卫星气溶胶组分分析以及MODIS(Moderate Resolution Imaging Spectroradiometer)火点数据,对2015年10月南京霾污染过程进行分析.结果表明:2015年10月出现的两次霾污染过程期间南京地区AE440-1020均高于1.0并且a2呈负值,其中10月16日AQI达到峰值(201),AOD500达1.51,AE440-1020达1.37,a2达-0.77;这两次较为严重的霾污染过程均主要由人为因素(工业污染、城市建设、生物质燃烧、汽车尾气排放等)产生的细粒子所致.后向轨迹分析发现,2015年10月16日南京地区霾污染天气发生的主要原因是区域型污染,同时受长距离输送影响,大量携带人为因素产生的细粒子以及少量沙尘等污染物的空气团途经内蒙古、山东等地到达南京,加剧了当日的污染程度;2015年10月23日南京地区霾污染天气的发生则主要受长距离输送影响,同时也受到区域型污染影响,加剧了当日的污染程度.研究显示,在稳定的气象条件下,较高的相对湿度、较低的地表风速、低混合层高度以及贴地逆温的出现是诱发霾污染天气产生的有利气象条件. | 康娜 胡康 Kanike Raghavendra Kumar 曹晓云 邓发荣 | 2017 | 环境科学研究2017，30，12： | 9 |
| 4 | Induction of the AOX1D Isoform of Alternative Oxidase in A. thaliana T-DNA Insertion Lines Lacking Isoform AOX1A Is Insufficient to Optimize Photosynthesis when Treated with Antimycin A显示文摘植物呼吸被二条小径为电子转移描绘到 O2,也就是被连接到 ATP 生产的细胞色素小径(CP ) ,和其他的小径(AP ) ,没有伴随物 ATP,从 ubiquinol 的电子在哪儿,直接经由其他的 oxidase (AOX ) 转到 O2 生产。这条后者小径很好被适合在光过量电子处理,导致优化光合的性能。我们描绘了不表示主要 isoform 的 Arabidopsis thaliana 的 T-DNA-insertion 变异的线, AOX1A。处于标准生长条件,这些植物没由抗霉素 A 通过 CP 显示出电子流动的任何显型,而是限制,它导致 AOX1A 表示在野类型,在 aox1a 大美人异种的叶子导致了 AOX1D 的增加的表情。尽管有在异种的 AOX1D isoform 的增加的存在,抗霉素 A 引起了光合作用的抑制,增加了 ROS,并且当时,最终导致了放大的膜漏和坏死与相比野类型,它被禁止者仅仅在边际地影响。经由 CP 的电子流动什么时候被限制,因此出现 AOX1D 是不能的充分补偿 AOX1A 的损失。抑制的联合学习,联合了到代谢物介绍并且指向了 glycine decarboxylase 建筑群(GDC ) 的 P 蛋白质的表示分析,建议 aox1a 异种试图为 photorespiration 增加他们的能力。然而,给他们的缺乏,在当与抗霉素 A 对待时,任何一个 AOX1D 都不能充分补偿让 AOX1A 的缺乏优化光合作用的表示增加,是吸引人的。我们建议 aox1a 异种能进一步被用来有关对光合的性能和基因表示的 mitochondrial 氧化还原作用的影响证实当前的模型。 | Inga Strodtkotter Kollipara Padmasree Challabathula Dinakar Birgit Speth Pamela S. Niazi Joanna Wojtera Ingo Voss Phuc Thi Do Adriano Nunes-Nesi Alisdair R. Fernie Vera Linke Agepati S. Raghavendra Renate Scheibe | 2009 | Molecular Plant2009，2，2： | 5 |
| 5 | 南京秋冬季2次霾污染天气过程分析显示文摘针对2013年12月和2014年12月南京地区秋冬季的2次典型霾污染过程,利用地面观测资料和常规气象资料,对这2次霾发生前后以及发生期间的天气环境、天气条件进行观测、分析。该文还通过HYSPLIT-4观察2次污染气团的来源,并利用CALIPSO分析2次污染期间气溶胶组分,发现由南京及周边地区形成、并在局地停留发展壮大的污染气团容易形成重大霾污染事件,污染物主要来源于当地的工厂、交通、建筑等;由北方携带大量污染物的气团入侵到南京地区,容易造成南京的霾污染天气,并且污染物组分以灰尘、污染性灰尘为主。由于天气条件的不同,2次污染发生期间的污染程度存在着巨大的差异。通过文章研究,发现稳定的气象条件容易发生霾天气,特别是当近地层风速较弱、混合层高度低、出现强逆温以及产生弱上升运动时,容易发生严重性霾污染天气。研究还发现各气象要素的共同作用导致了霾污染程度的变化。 | 胡康 康娜 Kanike Raghavendra Kumar | 2017 | 环境科学与技术2017，40，5： | 5 |
| 6 | Tunneling, propping, and expropriation: evidence from connected party transactions in Hong Kong显示文摘 | Yan-Leung Cheung P. Raghavendra Rau Aris Stouraitis | 2006 | Journal of Financial Economics2006，，2： | 5 |
| 7 | 南京市两次秋季污染过程及成因分析显示文摘为探究南京秋季污染过程的特征和影响因素,利用MODIS(Moderate Resolution Imaging Spectroradiometer)传感器获得的气溶胶光学厚度(Aerosol Optical Depth)、波长指数(Angstrom Exponent)、火点数据及CALIPSO(Cloud-Aerosol Lidar And Infrared Pathfinder Satellite Observations)卫星数据和来自NECP、MICAPS的温度、相对湿度、风向风速等常规气象要素数据,对南京2015年10月、2016年9月两次污染过程进行分析.研究结果表明:两次污染过程的AE412-470值(埃斯特朗波长指数α)均高于1,由此判断两次污染均以人为排放产生的细粒子为主.但2015年10月的AE412-470值明显低于2016年9月,说明在2015年10月污染过程中粗粒子所占比重高于2016年9月.结合对后向轨迹的分析发现,南京地区2015年10月污染天气的发生还受长距离输送的影响,污染源主要为来自内蒙古、山西等地的污染型沙尘粒子.研究还发现,较高的相对湿度、较低的地表风速、低混合层高度及贴地逆温等气象条件会导致污染物难以扩散稀释而累积在南京地区,造成该区域在秋季出现较严重的污染天气. | 黄晶 卜令兵 胡康 Kanike Raghavendra Kumar | 2018 | 环境科学学报2018，38，9： | 4 |
| 8 | Predictors of Surgery in Patients With Severe Acute Pancreatitis Managed by the Step-Up Approach显示文摘 | Raghavendra Yalakanti Babu Rajesh Gupta Mandeep Kang Deepak Kumar Bhasin Surinder Singh Rana Rajinder Singh | 2013 | Annals of Surgery2013，，4： | 4 |
| 9 | SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity显示文摘Chondrocytes and osteoblasts differentiate from a common mesenchymal precursor, the osteochondroprogenitor(OCP), and help build the vertebrate skeleton. The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-tyrosine phosphatase SHP2(encoded by Ptpn11) affects skeletal lineage commitment by conditionally deleting Ptpn11 in mouse limb and head mesenchyme using 'Cre-lox P'-mediated gene excision.SHP2-deficient mice have increased cartilage mass and deficient ossification, suggesting that SHP2-deficient OCPs become chondrocytes and not osteoblasts. Consistent with these observations, the expression of the master chondrogenic transcription factor SOX9 and its target genes Acan, Col2a1, and Col10a1 were increased in SHP2-deficient chondrocytes, as revealed by gene expression arrays, q RT-PCR, in situ hybridization, and immunostaining. Mechanistic studies demonstrate that SHP2 regulates OCP fate determination via the phosphorylation and SUMOylation of SOX9, mediated at least in part via the PKA signaling pathway. Our data indicate that SHP2 is critical for skeletal cell lineage differentiation and could thus be a pharmacologic target for bone and cartilage regeneration. | Chunlin Zuo Lijun Wang Raghavendra M.Kamalesh Margot E.Bowen Douglas C.Moore Mark S.Dooner Anthony M.Reginato Qian Wu Christoph Schorl Yueming Song Matthew L.Warman Benjamin G.Neel Michael G.Ehrlich Wentian Yang | 2018 | Bone Research2018，6，2： | 3 |
| 10 | Hepatic Artery Pseudoaneurysms: A Single-Center Experience显示文摘 | Raghavendra Nagaraja Mahendran Govindasamy Vibha Varma Amitabh Yadav Naimish Mehta Vinay Kumaran Arun Gupta Samiran Nundy | 2013 | Annals of Vascular Surgery2013，，6： | 2 |
| 11 | Differentiating adenomas from hyperplastic colorectal polyps: narrow-band imaging can be learned in 20 minutes显示文摘 | Meghana Raghavendra David G. Hewett Douglas K. Rex | 2010 | Gastrointestinal Endoscopy2010，，： | 2 |
| 12 | Data gathering algorithms in sensor networks using energy metrics 显示文摘 | Lindsey S Raghavendra C Slvalingam K M | 2002 | IEEE Transactions on Parallel and Distributed Systems2002，13，9： | 1 |
| 13 | Tunneling,propping and expropriation:evidence from connected party transactions in Hong Kong显示文摘 | Cheung Y L Raghavendra R P Stouraitis A | 2006 | Journal of Financial Economics2006，82，： | 1 |
| 14 | Pegasis: Power-Efficient Gathering in Sensor Information Systems显示文摘 | Lindsey S Raghavendra C | 2002 | IEEE Transactions on Parallel and Distributed Systems2002，13，9： | 1 |
| 15 | ABAperception and signalling显示文摘 | Raghavendra A S Gonugunta V K Christmann A | 2010 | Trends Plant Sci2010，15，7： | 1 |
| 16 | Inhibition of micro- glial activation attenuates the development but not exist- ing hypersensitivity in a rat model of neuropathyl 显示文摘 | Raghavendra V Tanga F Deleo JA | 2003 | J Pharmacol Exp Ther2003，306，： | 1 |
| 17 | Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proin-flammatory cytokine expression in the CNS显示文摘 | Raghavendra V Tanga FY DeLeo JA | 2004 | Eur J Neurosci2004，20，2： | 1 |
| 18 | A hybrid Taguchi-Immune approach to optimize an integrated sup- ply chain design problem with multiple shipping显示文摘 | Tiwari M K Raghavendra N Goyal S K | 2010 | European Journal of Operational Research2010，203，1： | 1 |
| 19 | HCV-Core Region: Its Significance in HCV-Genotyping and Type Dependent Genomic Expression显示文摘 | Mohammad Ansari Raghavendra Lingaiah Mohammad Irshad | 2012 | Macedonian Journal of Medical Sciences2012，，1： | 1 |
| 20 | PEGASIS:Power Efficient Gathering in Sensor Information Systems显示文摘 | Stephanie Lindsey Cauligi S Raghavendra | 2002 | IEEE Aerospace Conference Proceedings2002，3，3： | 1 |
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