|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression显示文摘AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents. | Valeska Portela Lima Marcos Antonio Pereira de Lima Angela Rosa André Márcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst | 2008 | World Journal of Gastroenterology2008，14，6： | 17 |
| 2 | Differences in standing balance between patients with diplegic and hemiplegic cerebral palsy显示文摘Maintaining standing postural balance is important for walking and handling abilities in patients with cerebral palsy.This study included 23 patients with cerebral palsy(seven with spastic diplegia and16 with spastic hemiplegia),aged from 7 to 16 years of age.Standing posture balance measurements were performed using an AMTI model OR6-7 force platform with the eyes open and closed.Patients with diplegic cerebral palsy exhibited greater center of pressure displacement areas with the eyes open and greater center of pressure sway in the medial-lateral direction with the eyes open and closed compared with hemiplegic patients.Thus,diplegic patients exhibited weaker postural balance control ability and less standing stability compared with hemiplegic cerebral palsy patients. | Valeska Gatica Rojas Guillermo Méndez Rebolledo Eduardo Guzman Muoz Natalia Ibarra Cortés Caterine Berrios Gaete Carlos Manterola Delgado | 2013 | Neural Regeneration Research2013，8，26： | 6 |
| 3 | Hierarchical Metal-Organic Frameworks with Macroporosity:Synthesis, Achievements,and Challenges显示文摘Introduction of multiple pore size regimes into metalorganic frameworks(MOFs)to form hierarchical porous structures can lead to improved performance of the material in various applications.In many cases,where interactions with bulky molecules are involved,enlarging the pore size of typically microporous MOF adsorbents or MOF catalysts is crucial for enhancing both mass transfer and molecular accessibility.In this review,we examine the range of synthetic strategies which have been reported thus far to prepare hierarchical MOFs or MOF composites with added macroporosity.These fabrication techniques can be either pre-or post-synthetic and include using hard or soft structural template agents,defect formation,routes involving supercritical CO2,and 3D printing.We also discuss potential applications and some of the challenges involved with current techniques,which must be addressed if any of these approaches are to be taken forward for industrial applications. | Huan VDoan Harina Amer Hamzah Prasanth Karikkethu Prabhakaran Chiara Petrillo Valeska PTing | 2019 | Nano-Micro Letters2019，11，3： | 6 |
| 4 | Virtual reality interface devices in the reorganization of neural networks in the brain of patients with neurological diseases显示文摘Two key characteristics of all virtual reality applications are interaction and immersion. Systemic interaction is achieved through a variety of multisensory channels(hearing, sight, touch, and smell), permitting the user to interact with the virtual world in real time. Immersion is the degree to which a person can feel wrapped in the virtual world through a defined interface. Virtual reality interface devices such as the Nintendo? Wii and its peripheral nunchuks-balance board, head mounted displays and joystick allow interaction and immersion in unreal environments created from computer software. Virtual environments are highly interactive, generating great activation of visual, vestibular and proprioceptive systems during the execution of a video game. In addition, they are entertaining and safe for the user. Recently, incorporating therapeutic purposes in virtual reality interface devices has allowed them to be used for the rehabilitation of neurological patients, e.g., balance training in older adults and dynamic stability in healthy participants. The improvements observed in neurological diseases(chronic stroke and cerebral palsy) have been shown by changes in the reorganization of neural networks in patients' brain, along with better hand function and other skills, contributing to their quality of life. The data generated by such studies could substantially contribute to physical rehabilitation strategies. | Valeska Gatica-Rojas Guillermo Méndez-Rebolledo | 2014 | Neural Regeneration Research2014，9，8： | 5 |
| 5 | 氨基酮戊酸光动力疗法抑制成纤维细胞生长因子10诱导的HaCaT细胞过度角化及增殖的机制研究显示文摘目的 探讨氨基酮戊酸光动力疗法(ALA-PDT)对成纤维细胞生长因子10(FGF-10)诱导的HaCaT细胞过度角化及增殖的作用及其机制。 方法 将培养的HaCaT细胞分为4组:空白对照组(无任何处理),FGF-10组(加入FGF-10孵育24 h),ALA-PDT组(ALA孵育24 h后红光照射),FGF-10 + ALA-PDT组(FGF-10孵育24 h后,再加ALA孵育24 h,红光照射)。用CCK-8法检测各组细胞增殖活性,Western印迹法检测K1、K6、K16及角质形成细胞生长因子受体(KGFR)的含量,ELISA法检测各组细胞上清液中白细胞介素1α(IL-1α)蛋白表达,免疫荧光检测各组细胞KGFR和K6蛋白表达水平。统计学分析采用析因设计的方差分析和单因素方差分析。结果 析因分析显示,ALA-PDT和FGF-10对HaCaT细胞增殖无交互作用(F交互 = 1.369,P = 0.276),FGF-10对HaCaT细胞增殖有促进作用(FFGF-10 = 20.853,P 〈 0.05),而ALA-PDT有抑制作用(FALA-PDT = 24.822,P 〈 0.05)。与空白对照组细胞增殖活性(A值为0.924 ± 0.024)比较,FGF-10组(1.233 ± 0.099)显著升高(P 〈 0.05),而ALA-PDT组(0.718 ± 0.107)显著降低(P 〈 0.05),FGF-10 + ALA-PDT组(0.901 ± 0.014)较FGF-10组显著降低(P 〈 0.05)。Western印迹法显示,FGF-10可促进K1、K6、K16蛋白和KGFR的表达(均P 〈 0.05),而ALA-PDT抑制这些蛋白的表达(均P 〈 0.05),FGF-10 + ALA-PDT组K1、K6、K16和KGFR的相对表达量与FGF-10组比较均显著降低(均P 〈 0.05)。ELISA法显示,FGF-10会增加HaCaT细胞IL-1α蛋白分泌(P 〈 0.05),但ALA-PDT对其没有影响(P = 0.467)。此外,免疫荧光检测显示,FGF-10增加HaCaT细胞K6和KGFR免疫荧光强度(P 〈 0.05),而ALA-PDT降低K6和KGFR免疫荧光强度(P 〈 0.05),FGF-10 + ALA-PDT组K6和KGFR免疫荧光强度显著低于FGF-10组(P 〈 0.05)。 结论 ALA-PDT能抑制FGF-10诱导的HaCaT细胞过度角化及增殖,其机制与下调K1、K6、K16、KGFR及IL-1α有关。 | 易飞 Maya Valeska Gozali 张家安 周炳荣 骆丹 张丽超 王申 刘娟 吴红巾 | 2015 | 中华皮肤科杂志2015，48，11： | 4 |
| 6 | ALA-PDT对UVB诱导的早衰成纤维细胞形态及增殖活性的影响显示文摘目的研究5-氨基酮戊酸光动力疗法(ALA-PDT)对中波紫外线诱导的提前衰老(UVB-SIPS)成纤维细胞形态及增殖活性的影响。方法将不同浓度5-氨基酮戊酸(5-aminolevulinicacid,ALA)孵育UVB-SIPS成纤维细胞,不同时间点检测细胞内原卟啉IX(ProtoporphyrinIX,PpⅨ)荧光强度;1mmol/LALA孵育正常及UVB.SIPS成纤维细胞2h,6h,采用635nm红光以不同照光剂量处理后,倒置显微镜观察细胞形态、CellCountingKit-8(CCK-8)法检测细胞活性。结果1.00mm01/LALA孵育6h内,UVB-SIPS成纤维细胞内PpIX荧光强度逐渐增强,6~24h荧光强度逐渐减弱。ALA-PDT可诱导UVB-SIPS成纤维细胞形态改变、增殖减缓,与照光剂量及ALA孵育时间呈量效依赖关系,使用抗氧化剂NAC预处理可以减轻上述改变。结论ALA-PDT对UVB-SIPS成纤维细胞的增殖和生长有一定的抑制作用,其机制可能与ALA.PDT对细胞的氧化损伤有关。 | 张丽超 周炳荣 骆丹 马立文 易飞 王申 Maya Valeska Gozali 吴红巾 栗丹 | 2015 | 中国皮肤性病学杂志2015，29，3： | 2 |
| 7 | 氨基酮戊酸光动力疗法诱导中波紫外线应激性衰老成纤维细胞发生凋亡显示文摘目的 研究氨基酮戊酸光动力疗法(ALA-PDT)对中波紫外线(UVB)应激性衰老成纤维细胞(UVB-SIPS-FB)的氧化损伤和凋亡作用.方法 正常成纤维细胞及UVB-SIPS-FB均分为2h和6h孵育组,每组内再分为7组:对照组、ALA组、100 J/cm2照光组、3组不同红光照射剂量ALA-PDT处理组(25 J/cm2组、50 J/cm2组、100 J/cm2组)及抗氧化剂NAC+ 50 J/cm2红光照射ALA-PDT处理组.采用635 nm红光(能量密度50 mW/cm2)照射处理后,使用荧光显微镜、流式细胞仪检测各组细胞中活性氧及线粒体膜电位水平;Hoechst染色、流式细胞仪检测细胞凋亡率.数据用SPSS 13.0软件分析,多组间均数行单因素方差分析,结合q检验.结果 孵育2h,25、50、100 J/cm2 ALA-PDT组UVB-SIPS-FB凋亡率(分别为7.34%±0.87%、8.39%±1.16%、17.03%±1.29%)较对照组(3.81%±0.59%)上升(F=102.70,均P<0.05),NAC+ 50 J/cm2 ALA-PDT组凋亡率(5.35%±0.58%)下降(P<0.05);孵育6h,25、50、100 J/cm2 ALA-PDT组UVB-SIPS-FB凋亡率(分别为13.85%±1.71%、23.40%±2.14%、41.02%±2.73%)较对照组(5.09%±1.64%)显著上升(F=106.00,均P<0.05),NAC+50 J/cm2 ALA-PDT组凋亡率(9.97%±3.23%)显著下降(P<0.05).单纯ALA组或照光组UVB-SIPS-FB凋亡率与对照组差异均无统计学意义.ALA-PDT处理组细胞活性氧荧光强度显著上升,线粒体去极化增强,这些现象与ALA孵育时间及红光照射剂量均呈量效依赖性关系.使用抗氧化剂NAC预处理可以减少ALA-PDT诱导的活性氧增多及线粒体去极化增强,与凋亡率变化一致.结论 ALA-PDT可诱导UVB-SIPS-FB出现明显的细胞凋亡,其作用机制可能与ALA-PDT对细胞的氧化损伤有关. | 张丽超 张海荣 周炳荣 骆丹 马立文 张家安 王申 易飞 Maya Valeska Gozali 刘娟 | 2015 | 中华皮肤科杂志2015，48，4： | 1 |
| 8 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 9 | 显示文摘 | Heinz W Meike M Valeska H | 2002 | J Immunol2002，168，9： | 1 |
| 10 | CDKN2A promoter methylation is related to the tumor location and histological subtype and associated with Helicobacter pylori flaA (+) strains in gastric adenocarcinomas显示文摘 | MARKENIA K S A VALESKA P L ADRIANA C F | | 0，，04： | 1 |
| 11 | Inactivation of COX-2, HMLH1 and CDKN2A Gene by Promoter Methylation in Gastric Cancer: Relationship with Histological Subtype, Tumor Location and Helicobacter pylori Genotype显示文摘 | Alves Markênia Kélia Santos Ferrasi Adriana Camargo Lima Valeska Portela Ferreira Márcia Valéria Pitombeira De Moura Campos Pardini Maria Inês Rabenhorst Silvia Helena Barem | 2011 | EN2011，，5： | 1 |
| 12 | Intrahepatic response markersin chronic hepatitis B patients treated with peginterferon alpha -2a and adefovir 显示文摘 | Bart T Valeska T Hans Z | 2011 | J Gastroenterol Hepatol2011，26，10： | 1 |
| 13 | Gas sensing using porous materials for automotive applications显示文摘 | Dominic J Wales Julien Grand Valeska P Ting | 2015 | Chem Soc Rev2015，44，： | 1 |
| 14 | Inactivation of COX-2,HMLH1 and CDKN2A gene by promoter methylation in gastric cancer:relationship with histological subtype,tumor location and Helicobacter pylori genotype显示文摘 | MARK(E)NIA K ADRIANA C F VALESKA P L | | 0，，： | 1 |
| 15 | 淋巴瘤经自体干细胞移植后发生白癜风及普秃一例显示文摘患者女,27岁,因头发脱落2月余,左下肢皮肤白斑t年余于2015年9月就诊。两年前患者在血液科确诊为霍奇金淋巴瘤(结节硬化型)。2013年10月至2014年4月先后予ABVD(阿柔比星+博来霉素+达卡巴嗪+长春地辛)方案化疗2个周期,IGVE(异环磷酰胺+吉西他滨+酒石酸长春瑞滨胶丸+地塞米松)方案化疗5个周期。每次化疗期间均有头发脱落现象,但化疗结束后,头发能恢复生长, | 易飞 李锦 Maya Valeska Gozali 卢瑞南 骆丹 | 2017 | 中华皮肤科杂志2017，50，1： | 1 |
| 16 | Combined NGS Approaches Identify Mutations in the Intraflagellar Transport Gene IFT140 in Skeletal Ciliopathies with Early Progressive Kidney Disease显示文摘 | Miriam Schmidts Valeska Frank Tobias Eisenberger Saeed al Turki Albane A. Bizet Dinu Antony Suzanne Rix Christian Decker Nadine Bachmann Martin Bald Tobias Vinke Burkhard Toenshoff Natalia Di Donato Theresa Neuhann Jane L. Hartley Eamonn R. Maher Radovan | 2013 | Human Mutation2013，，5： | 1 |
| 17 | Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C显示文摘 | Anneloes E. Bohte Annikki Niet Louis Jansen Shandra Bipat Aart J. Nederveen Joanne Verheij Valeska Terpstra Ralph Sinkus Karin M. J. Nieuwkerk Rob J. Knegt Bert C. Baak Peter L. M. Jansen Henk W. Reesink Jaap Stoker | 2014 | European Radiology2014，，3： | 1 |
| 18 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 19 | Skin disorders and disease profile of poverty: analysis of medical records in Tigray, northern Ethiopia, 2005–2007显示文摘 | Sandro Accorsi Gebre Ab Barnabas Pasquale Farese Valeska Padovese Margherita Terranova Vincenzo Racalbuto Aldo Morrone | 2008 | Transactions of the Royal Society of Tropical Medicine and Hygiene2008，，5： | 1 |
| 20 | Prevalence of helicobacter pylori genotypes(vacA,cagA,cagE and virB 11 ) in gastric cancer in brazilian's patients:an association with histopathological parameters 显示文摘 | Valeska P L Isabelle J L Markenia K S | 2011 | Cancer Epidemiol2011，35，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员