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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Post‐stroke depression: mechanisms, translation and therapy显示文摘 | Isabelle Loubinoux Golo Kronenberg Matthias Endres Pascale Schumann‐Bard Thomas Freret Robert K. Filipkowski Leszek Kaczmarek Aurel Popa‐Wagner | 2012 | J. Cell. Mol. Med2012，，9： | 3 |
| 3 | Pharmacogenetics of anticancer monoclonal antibodies显示文摘Pharmacogenetics is the study of therapeutic and adverse responses to drugs based on an individual’s genetic background.Monoclonal antibodies(mAbs)are a rapidly evolving field in cancer therapy,however a number of newly developed and highly effective mAbs(e.g.,anti-CTLA-4 and anti-PD-1)possess pharmacogenomic profiles that remain largely undefined.Since the first chemotherapeutic mAb Rituximab was approved in 1997 by the US Food and Drug Administration for cancer treatment,a broad number of other mAbs have been successfully developed and implemented into oncological practice.Nowadays,mAbs are considered as one of the most promising new approaches for cancer treatment.The efficacy of mAb treatment can however be significantly affected by genetic background,where genes responsible for antibody presentation and metabolism,for example,can seriously affect patient outcome.This review will focus on current anticancer mAb treatments,patient genetics that shape their efficacy,and the molecular pathways that bridge the two. | Dmitrii Shek Scott ARead Golo Ahlenstiel Irina Piatkov | 2019 | Cancer Drug Resistance2019，2，1： | 2 |
| 4 | Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection显示文摘Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)infection.Further,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in CHC.The emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin resistance.This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression. | Mohammed Eslam David R Booth Jacob George Golo Ahlenstiel | 2013 | World Journal of Gastroenterology2013，19，41： | 2 |
| 5 | Trade-offs between ecosystem service provision and the predisposition to disturbances: a NFI-based scenario analysis显示文摘Background: Scenario analyses that evaluate management effects on the long-term provision and sustainability of forest ecosystem services and biodiversity(ESB) also need to account for disturbances. The objectives of this study were to reveal potential trade-offs and synergies between ESB provision and disturbance predisposition at the scale of a whole country.Methods: The empirical scenario model MASSIMO was used to simulate forest development and management from years 2016 to 2106 on 5086 sample plots of the Swiss National Forest Inventory(NFI). We included a businessas-usual(BAU) scenario and four scenarios of increased timber harvesting. Model output was evaluated with indicators for 1) ESB provision including a) timber production, b) old-growth forest characteristics as biodiversity proxies and c) protection against rockfall and avalanches and 2) for a) storm and b) bark beetle predisposition.Results: The predisposition indicators corresponded well(AUC: 0.71–0.86) to storm and insect(mostly bark beetle)damage observations in logistic regression models. Increased timber production was generally accompanied with decreased predisposition(storm: >-11%, beetle: >-37%, depending on region and scenario), except for a scenario that promoted conifers where beetle predisposition increased(e.g. + 61% in the Southern Alps). Decreased disturbance predisposition and decreases in old-growth forest indicators in scenarios of increased timber production revealed a trade-off situation. In contrast, growing stock increased under BAU management along with a reduction in conifer proportions, resulting in a reduction of beetle predisposition that in turn was accompanied by increasing old-growth forest indicators. Disturbance predisposition was elevated in NFI plots with high avalanche and rockfall protection value.Conclusions: By evaluating ESB and disturbance predisposition based on single-tree data at a national scale we bridged a gap between detailed, stand-scale assessments and broader inventory-based approaches at the national scale. We discuss the limitations of the indicator framework and advocate for future amendments that include climate-sensitive forest development and disturbance modelling to strengthen decision making in national forest policy making. | Christian Temperli Clemens Blattert Golo Stadelmann Urs-Beat Brändli Esther Thürig | 2020 | Forest Ecosystems2020，7，3： | 2 |
| 6 | Milestones of neuronal development in the adult hippocampus显示文摘 | Gerd Kempermann Sebastian Jessberger Barbara Steiner Golo Kronenberg | 2004 | Trends in Neurosciences2004，，： | 2 |
| 7 | Isolation of a primate embryonic stem cell显示文摘 | KALISHMAN T G GOLOS M | 1995 | Proc Natl Ccad Sci1995，92，17： | 1 |
| 8 | Isolation of a primate embryonic stem cell line 显示文摘 | Thomson JA Kalishman J Golos TG | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 9 | Pluripotent cell lines derived from common marmoset(callithrix jacchus) blastocysts显示文摘 | Thomson J A Kalishman J Golos T G | 1996 | Biol Reprod1996，55，2： | 1 |
| 10 | Isolation of a primate embryonic stem cell line显示文摘 | Thomson J A Kalishman J Golos T G | 1995 | Proc Natl Acad Sci1995，92，： | 1 |
| 11 | Multiaxial fatigue damage criterion显示文摘 | ELLYIN F GOLOS K | 1988 | J Eng Mater Technol ASME1988，110，1： | 1 |
| 12 | Molecular cloning of three nonhuman primate follicle stimulating hormone betasubunit cDNAs 显示文摘 | Wolfgang M J Grendell RL Golos TG | 2001 | J Med Primatol2001，30，6： | 1 |
| 13 | Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus 显示文摘 | Golo Kronenberg Anika Bick-Sander Eva Bunk | 2006 | Neurobiology of Aging2006，27，： | 1 |
| 14 | Uterine and ovarian aryl hydrocarbon receptor(AHR)and aryl hydrocarbon receptor nuclear transloeator(ARNT)mRNA expression in benign and malignant gynaecological conditions显示文摘 | Khorram O Gart hwaite M Golos T | 2002 | Mol Hum Rep rod2002，8，1： | 1 |
| 15 | Isolation of a primate embryonic stem cell line显示文摘 | Thomson J A Kaalishman J Golos T G | 1995 | Proc Natl Acad Sci USA1995，92，17： | 1 |
| 16 | Isolation of a primate embryonic stem cell line显示文摘 | Thomson JA Kalishman J Golos TG | 1995 | Proc Natl Acad Sci USA1995，92，17： | 1 |
| 17 | Synergistic effects of vascular en- dothelial growth factor and basic fibroblast growth factor on Ihe pro- liferation and cord Jbrmation of bovine capillary endothelial cells within collagen gels 显示文摘 | Golo F Gnto K Weindel K | 1993 | Lab Invest1993，69，5： | 1 |
| 18 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 19 | Isloation of a primate embrtyonic stem cell line显示文摘 | Kalishman Golos T G | 1995 | proc Natl Acad Sci USA1995，，92： | 1 |
| 20 | Uterine ahd ovarian arylhydrocarbon recptor(AHR) and arylhydrocarbon receptor nuclear translocator(ARNT) mRNAexpression in benigh and malignant gynaecological conditions 显示文摘 | Khonam O Garthwaite M Golos T | 2004 | Mol Hum Reprod2004，8，1： | 1 |
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