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| 1 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 2 | 土壤磷酸盐吸持作用的研究显示文摘 | 朱荫湄 G. Pardini P. Sequi | 1985 | 土壤学报1985，22，2： | 4 |
| 3 | Waterborne polyurethane/acrylate: Comparison of hybrid and blend systems显示文摘 | Pablo J. Peruzzo Pablo S. Anbinder Oscar R. Pardini Jorge Vega Carlos A. Costa Fernando Galembeck Javier I. Amalvy | 2011 | Progress in Organic Coatings2011，，3： | 2 |
| 4 | Discovery of a high molecular weight complex of calcium,phosphate,fetuin and matrix gamma-carboxyglutamic acid protein in the serum of etidronatetreated rats显示文摘 | Price PA Thomas GR Pardini AW | 2002 | J Biol Chem2002，277，6： | 1 |
| 5 | Docosahexaenoic acid (DHA), a primary tumor suppressive omega - 3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status 显示文摘 | Kato T Kolenic N Pardini RS | 2007 | Nutr Cancer2007，58，： | 1 |
| 6 | Relative influence of wildfire on soil properties and erosion processes in different Mediteranean environment in NE Spain显示文摘 | Pardini G Gispert M Dunjo G | 2004 | Science of the Total Environment2004，328，： | 1 |
| 7 | Relative influence of wildfire on soil properties and erosion processes in different Mediterranean environments in NE Spain 显示文摘 | Pardini G Gispert M Dunjo G | 2004 | Science of the Total Environment2004，328，： | 1 |
| 8 | Synthesis of copper chromite catalyst 显示文摘 | Kawamoto A M Pardini L C Rezende L C | 2004 | Aerospace Science and Technology2004，8，7： | 1 |
| 9 | Protective Effect of HLA‐DRB1*11 and Predisposition of HLA‐C*04 in the Development of Severe Liver Damage in Brazilian Patients with Chronic Hepatitis C Virus Infection显示文摘 | A. V. Marangon G. F. Silva C. F. V. de Moraes R. M. T. Grotto M. I. M. C. Pardini D. S. de Pauli J. E. L. Visentainer A. M. Sell R. A. Moliterno | 2012 | Scandinavian Journal of Immunology2012，，4： | 1 |
| 10 | The survivability of space tether sys-tems in orbit around the earth 显示文摘 | ANSELMO L PARDINI C | 2005 | Acta Astronautica2005，56，3： | 1 |
| 11 | Improved results with mitral valve repair using new surgical techniques显示文摘 | FucciC Sandrelli L Pardini A | 1995 | Eur J Cardiothorac Surg1995，9，： | 1 |
| 12 | Antibodies to bovine serum albumin inBrazilian children and young adults with IDDM显示文摘 | Pardini V C Vieira J G Miranda W | 1996 | Diabetes Care1996，19，： | 1 |
| 13 | The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury显示文摘 | Krueger F Pardini M Huey ED | | 0，，： | 1 |
| 14 | Improved results with mitral valve repair using new surgical techniques显示文摘 | FUCCI C SANDRELLI L PARDINI A | 1995 | EurJ Cardiothorac Surg1995，9，11： | 1 |
| 15 | Thyroid function differ- ently affects serum cystatin C and creatinine concentrations 显示文摘 | Manetti L Pardini E Genovesi M | 2005 | J Endocrinol Invest2005，28，4： | 1 |
| 16 | Glossy topcoat exterior paint formulations using water-based polyurethane/ acrylic hybrid binders显示文摘 | AZNAR A C PARDINI O R AMALVYA J I | 2006 | Progress in Organic Coatings2006，55，1： | 1 |
| 17 | Interpersonal and affeetive features of psy- chopathy in ehildren and adolescents: Advancing a developmen- tal perspeetive introduction to special section显示文摘 | Pardini DA Loeber R | 2007 | J Clin Child Ad- olesc2007，36，3： | 1 |
| 18 | The survivability of space tether systems in orbit around the earth显示文摘 | Anselmo L Pardini G | | 0，，06： | 1 |
| 19 | Could polymorphisms inATP-binding cassette C3/multidrug resistance associated protein 3(ABCC3/MRP3)modify colorectal cancer risk?显示文摘 | Campa D Vodicka P Pardini B | 2008 | Eur J Cancer2008，44，6： | 1 |
| 20 | The role of landuse- land cover on runoff generation and sediment yield at a micro plot scale, in a small Mediterranean catchment显示文摘 | DUNJO G PARDINI G GISPERT M | 2004 | Journal of Arid Environments2004，57，2： | 1 |
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