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| 1 | 关岭及相关生物群沉积与生态环境的探讨显示文摘根据近年来对黔东南至滇东关岭、兴义、贞丰和罗平等地中-晚三叠世含海生爬行动物骨架和(或)深水海百合黑色岩系(通常所称黑色页岩)化石库的研究,现将该区岩石地层单位划分,以及这些黑色岩系化石库生物组合特征、时代、分布、沉积和古地理环境概括如下:1)在关岭—兴义地区中-晚三叠世(安尼期、拉丁期和早卡尼期)地层中,至少夹有3层、甚至4层含海生爬行动物的黑色岩系化石库(或黑色'页岩'化石库),自下而上产盘县生物群、兴义生物群和关岭生物群。云南罗平地区中三叠统关岭组中新发现的'罗平生物群'与盘县生物群层位大致相当。贞丰龙场赖石科组上部新挖掘出的30m厚产创口海百合、双壳类及菊石的黑色岩系,应该是研究地区最高层位的海相三叠纪黑色岩系,时代似属晚三叠世早卡尼期晚期;2)推测这些含海生爬行动物骨架的黑色岩系化石库是在印支造山运动影响下,伴随南盘江前陆盆地隆升和闭合,在扬子克拉通台地边缘所形成的一个或几个边缘凹陷、或边缘盆地之中形成的,这些凹陷或盆地形成之初,表层水充氧,且具有很好的食物链结构,有利于各类海生生物生活;后来的海平面上升至最大海泛期,以及由此引起缺氧和含硫化氢水位的上升,导致这些凹陷逐渐变成安静、滞流的死亡之海和黑色岩系化石库;3)关岭生物群产于晚三叠世卡尼期早期小凹组下段上部黑色岩系之中,是一个典型的在滞流、缺氧且海底没有食腐动物边缘局限盆地中所形成的黑色页岩化石库,以产大量海生爬行动物和深水假浮游海百合为特征,此外还有个别的两栖类和原始龟类发现;4)产于竹杆坡组近底部黑色岩系中的兴义生物群,以产大量肿肋龙类为特点,尤以个体较小的贵州龙最为常见,共生的还有多种鱼类化石,在生物组合和产出层位上,可与阿尔卑斯南部Meride灰岩所夹黑色含沥青页岩化石库对比,时代似应归属拉丁期早或中期;大量米虾在竹杆坡组近底部含贵州龙层的发现,推测兴义生物群可能形成于台地边缘早期并不缺氧,且具有理想食物链结构的浅水、超盐的凹陷或盆地之中。由于存在浮游生物—虾—贵州龙—欧龙—虾—浮游生物所组成的生态组合和食物链结构,从而为解释以肿肋龙类为代表的兴义生物群的繁衍和多生提供了依据;接踵而来的沉积速率下降和缺氧水位的上升,以及间歇性火山作用,导致该特有生态体系的崩溃和化石库的形成。根据对贞丰挽澜竹杆坡组底部首次发现的棘皮动物的化石库的研究,指出该化石库系由海星、细小蛇尾、底栖海百合茎、海胆和海参等5类棘皮动物化石和含贵州龙骨架碎片组成,其下为8m厚夹有薄层的骨层的凝缩层沉积,后者位于硬底之上。此种沉积和埋藏模式与德国上壳灰岩早拉丁期的棘皮动物化石库类似,是在近岸海水不太浅的内陆棚的环境下,由于风暴潮作用所形成的化石库,他们与在滞流、缺氧海底、通过化石聚集所形成的化石库是不同的;5)产盘县生物群的黑色岩系化石库主要见于盘县羊件和普安青山中三叠世(安尼期)关岭组中,与云南罗平地区的'罗平生物群'在层位及生物组合上大致相当,均以含大量混鱼龙、幻龙和欧龙,以及鱼类为特点,共生的还有大量节肢动物。所不同的是后者由于靠近滨岸,故而出现大量幼年期的鱼类以及虾类和鲎类化石,推测他们形成于靠近古陆或滨岸的台缘浅水表层充氧的正常、且有时超盐的凹陷之中,时代上早于阿尔卑斯南部安尼期/拉丁期比塞娄组;其集群死亡除因后期盆地滞流、缺氧外,可能还与风暴和火山作用有关。 | 汪啸风 陈孝红 程龙 王传尚 Bachmann G H Sander M Hagdorn H | 2009 | 古生物学报2009，48，3： | 24 |
| 2 | 局部和全身给药后泼尼松龙在外淋巴液中的浓度分析显示文摘目的 :比较局部和全身给药后 2 1 氢化琥珀酸 泼尼松龙在外淋巴液中的药物动力学。方法 :将实验豚鼠分组 ,局部用药 (局部组 ) :将 0 .5 %的 2 1 氢化琥珀酸 泼尼松龙液在直视下置于圆窗龛 ;全身用药 (全身组 ) :按 6 0mg/kg腹腔内注药 ;两组均以生理盐水作为对照。分别于给药后不同时间段采集外淋巴液标本 ,采用高压液相色谱法 (HPLC)测定药物浓度。结果 :局部组药物最高浓度出现在给药后 180min ,为 (95 2 .3± 382 .7)mg/L ,并在 96 0min后维持在 (18.72± 16 .97)mg/L。全身组药物最高峰时间在给药后 15 0min ,为 (14 .71± 7.0 5 )mg/L。结论 :局部给予 2 1 氢化琥珀酸 泼尼松龙 ,可以获得长时间、高浓度的药物水平。 | 苏纪平 Bachmann G 唐安洲 Zumegen C Michel O Wittekindt C | 2003 | 临床耳鼻咽喉科杂志2003，17，10： | 16 |
| 3 | Transcutaneous perianal sonography:A sensitive method for the detection of perianal inflammatory lesions in Crohn's disease显示文摘AIM: Pelvic magnetic resonance imaging (MRI) and endoanalultrasound which are established imaging methods forperianal inflammatory lesions in patients with Crohn'sdisease require expensive specialized equipments andexpertise. We investigated the feasibility and sensitivity oftranscutaneous perianal ultrasound (PAUS) using regularultrasound probes in the imaging of perianal inflammatorylesions. The sonographic findings were correlated to pelvicMRI-scans.METHODS: We performed PAUS in 25 patients with Crohn'sdisease and clinical signs of perianal inflammatory disease.VCChin a median of 10 d (range 0-75) these patients underwentMRI of the pelvis. Regular convex and linear high resolutionprobes were used for PAUS. The sonographic findings werecorrelated to the MRI findings by blinded investigators.RESULTS: The sonographic investigations were welltolerated by all patients. Fistulae typically presented ashypoechoic tracks. Twenty-nine fistulae were detected in22 patients. Abscesses were detected in 7 patients andpresented as hypo- or anechoic formations. Twenty-six of29 fistulae and 6 of 7 abscesses could be confirmed byMRI. Kappa statistics showed an excellent agreement(kappa>0.83) between the two imaging methods.CONCLUSION: PAUS is a simple, painless, feasible, real-time method that can be performed without specific patientpreparation which is comparable in its sensitivity to pelvicMRI in the detection of perianal fistulae and/or abscesses.PAUS can especially be recommended as a screening toolin acute perianal disorders such as perianal abscess andfor follow-up studies of perianal inflammatory disease. | Jochen Wedemeyer Timm Kirchhoff Gernot Sellge Oliver Bachmann Joachim Lotz Michael Galanski Michael P.Manns Michael J.Gebel Jrg S.Bleck | 2004 | World Journal of Gastroenterology2004，10，19： | 8 |
| 4 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 5 | Environmental analysis of innovative sustainable composites with potential use in aviation sector -A life cycle assessment review显示文摘The forecast of growing air transport in the upcoming decades faces the challenge of an increasing environmental impact.Aviation industry is working on promising technologies to mitigate this environmental impact.Lightweight design is a strong lever to lower the fuel consumption and,consequently,with it the emissions of aviation.High performance composites are a key technology to help achieve these aims thanks to their favourable combination of mechanical properties and low weight in primary structures.However,mainly synthetic materials such as petrol based carbon fibres and epoxy resins are used nowadays to produce composite in aviation.Renewable materials like bio-based fibres and resin systems offer potential environmental advantages.However,they have not found their way into aviation,yet.The reasons are reduced mechanical properties and,especially for the use of natural fibres,their flammability.Improvements of these shortcomings are under investigation.Therefore the application of bio-based and recycled materials in certain areas of the aircraft could be possible in the future.Good examples for applications are furnishings and secondary structures.The motivation for this paper is to give an overview of potential environmental properties by using such eco-materials in aviation.Life cycle assessment(LCA) is a tool to calculate environmental impacts during all life stages of a product.The main focus is laid on the bio-fibres flax and ramie,recycled carbon fibres and bio-based thermoset resin systems.Furthermore an overview of environmental aspects of existing composite materials used in aviation is given.Generally,a lack of LCA results for the substitution of synthetic materials by bio-based/recycled composite materials in aviation applications has been identified.Therefore,available information from other transport areas,such as automotive,has been summarized.More detailed LCA data for eco-composite materials and technologies to improve their properties is important to understand potential environmental effects in aviation. | BACHMANN Jens HIDALGO Carme RICOUT Stephanie | 2017 | Science China(Technological Sciences)2017，60，9： | 4 |
| 6 | Cachexia and pancreatic cancer: Are there treatment options?显示文摘Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma(PDAC)and is associated with reduced survival and quality of life.Unfortunately,the therapeutic options of this multi-factorial and complex syndrome are limited.This is due to the fact that,despite extensive preclinical and clinical research,the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood.Furthermore,there is still a lack of consensus on the definition of cachexia,which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature.In order to provide an efficient therapy for cachexia,an early and reliable diagnosis and consistent monitoring is required,which can be challenging especially in obese patients.Although many substances have been tested in clinical and preclinical settings,so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia.However,recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancerassociated cachexia and ultimately improve patients’outcome.In this current review,we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients.This strategy consists of nutritional,dietary,pharmacological,physical and psychological methods. | Tara C Mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 7 | Fluid Flow Simulation of the Influence of a Steady Magnetic Field on the Weld Pool Dynamics in Deep Penetration Laser Beam Welding of Aluminum显示文摘A multi-physics numerical model was developed to investigate the influence of a steady magnetic field during partial penetration keyhole laser beam welding of an aluminum plate in flat position.Three-dimensional heat transfer,fluid dynamics including phase transition and electromagnetic field partial differential equations were solved with the finite element differential equation solver COMSOL Multiphysics.The magnetic field was aligned perpendicularly to the welding direction.The main objective of these simulations was to estimate the critical value of the magnetic field needed to suppress convective flows in the weld pool during high-power(up to 20 kW)laser beam welding of aluminum alloys with up to 20 mm deep weld pool.It reveals that steady magnetic fields with corresponding Hartmann numbers Ha2-10~4based on the half-width of the weld pool can effectively suppress convective flows in the weld pool.Moreover,the typically occurring wineglass-shape of the weld cross section caused by thermo-capillary flow is weakened. | BACHMANN Marcel AVILOV Vjaceslav GUMENYUK Andrey RETHMEIER Michael | 2012 | Journal of Iron and Steel Research(International)2012，19，S1： | 3 |
| 8 | Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases显示文摘 | J?rg Kleeff Markus K. Diener Kaspar Z?graggen Ulf Hinz Markus Wagner Jeannine Bachmann J?rg Zehetner Michael W. Müller Helmut Friess Markus W. Büchler | 2007 | Annals of Surgery2007，，4： | 3 |
| 9 | The impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis显示文摘 | Constantin J. C. Trepte Kai A. Bachmann Jan H. Stork Till J. Friedheim Andrea Hinsch Matthias S. Goepfert Olliver Mann Jakob R. Izbicki Alwin E. Goetz Daniel A. Reuter | 2013 | Intensive Care Medicine2013，，4： | 2 |
| 10 | Purification and cooperative activity of enzymes constituting the xylan-degrading system of Thermomonospora fuscs显示文摘 | Bachmann SL McCauthy AJ | 1991 | Appl Environ Microbiol1991，57，： | 2 |
| 11 | Numerical simulation of full-penetration laser beam welding of thick aluminium plates with inductive support显示文摘 | Marcel Bachmann Vjaceslav Avilov Andrey Gumenyuk Michael Rethmeier | 2012 | Journal of Physics D: Applied Physics2012，，3： | 2 |
| 12 | Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death: a closed cohort study显示文摘 | Christine N. Manser Lucas M. Bachmann Jakob Brunner Fritz Hunold Peter Bauerfeind Urs A. Marbet | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 13 | Experimental study and modeling of particle drying in a continuously-operated horizontal fluidized bed显示文摘 | Kaicheng Chen Philipp Bachmann Andreas Buck Michael Jacob Evangelos Tsotsas | 2017 | Particuology2017，15，5： | 2 |
| 14 | The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): Update 2011 on non-hepatic applications显示文摘 | F. Piscaglia C. Nols?e C. Dietrich D. Cosgrove O. Gilja M. Bachmann Nielsen T. Albrecht L. Barozzi M. Bertolotto O. Catalano M. Claudon D. Clevert J. Correas M. D'Onofrio F. Drudi J. Eyding M. Giovannini M. Hocke A. Ignee E. Jung A. Klauser N. Lassau E. L | 2012 | Ultraschall in Med2012，，01： | 2 |
| 15 | Time dependence of the expression of ICAM-1 (CD54)in human skin wounds 显示文摘 | Drebler J Bachmann L Mvller E | 1997 | Int J Legal Med1997，110，6： | 1 |
| 16 | Impact of Improved Survival of Very Low-Birth-Weight Infants on Incidence and Serverity of Bronchopulmonary Dysplasia 显示文摘 | Berger TM Bachmann II AdamsM | 2004 | Biol Neonate2004，86，2： | 1 |
| 17 | Development and application of a new sessile drop contact angle method to assess soil water repellency 显示文摘 | Bachmann J Ellies A Hartge K H | 2000 | J Hydrol2000，23，： | 1 |
| 18 | SYFPEITHI:database for MHC ligands and peptide motifs显示文摘 | Rammensee H Bachmann J Emmerich N P | 1999 | Immunogenetics1999，50，34： | 1 |
| 19 | Lowest effective trasdermal 17β-estradiol dose for relief of hot flushes in postmenopausal women: a randomized controlled trial 显示文摘 | Bachmann GA Schaefers M Uddin A | 2007 | Obstet Gynecol2007，110，： | 1 |
| 20 | An infrared study of phase ]I显示文摘 | M A Bachmann W L Gordon | 1979 | J Appl Phys1979，50，61： | 1 |
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