|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 2 | 植物来源的磷脂酰胆碱可介导抗肺纤维化小RNA(HJT-sRNA-m7)进入哺乳动物细胞显示文摘肺纤维化是慢性进行性疾病,死亡率高,临床上除肺移植之外尚无其他明显有效治疗手段.本研究发现,来源于中药大花红景天(Rhodiola crenulata)的小RNA,HJT-sRNA-m7,可以显著降低纤维化因子的表达,在细胞和动物水平上均可改善纤维化症状.此外,本研究组在红景天熬制的汤汁中提取鉴定了一百多种脂质,其中大部分脂质也同时存在于中药蒲公英(Taraxacum mongolicum)、穿心莲(Andrographis paniculata)和金银花(lonicera japonica)中.选取其中两种磷脂酰胆碱PC(18:0/18:2)和PC(16:0/18:2),使之与植物小RNA形成脂质体,发现其可促进HJT-s RNA-m7等小RNA进入人肺和胃肠道细胞,降低纤维化靶基因的表达.实验结果揭示了植物来源小RNA通过脂质复合物进入人体的可能途径,为si RNA的临床应用提供了新的口服递送途径. | 杜涧超 梁竹 许剑涛 赵妍 李晓芸 张艳丽 赵丹丹 陈茹萱 刘洋 Trupti Joshi 常佳慧 王志清 张延旭 朱锦东 刘强 许东 蒋澄宇 | 2018 | 中国科学:生命科学2018，48，4： | 4 |
| 3 | Catharanthus roseus:a natural source for the synthesis of silver nanoparticles显示文摘Objective:To develop a simple rapid procedure for bioreduction of silver nanoparticles(AgNPs)using aqueous leaves extracts of Catharanthus roseus(C.roseus).Methods:Characterization were determined by using UV-Vis spectrophotometry,scanning electron microscopy(SEM),energy dispersive X-ray and X-ray diffraction.Results:SEM showed the formation of silver nanoparticles with an average size of 67 nm to 48 nm.X-ray diffraction analysis showed that the particles were crystalline in nature with face centered cubic geometry.Conclusions:C.roseus demonstrates strong potential for synthesis of silver nanoparticles by rapid reduction of silver ions(Ag^+ to Ag^0).This study provides evidence for developing large scale commercial production of value-added products for biomedical/nanotechnology-based industries. | Mukunthan KS Elumalai EK Trupti N Patel V Ramachandra Murty | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 4 |
| 4 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 5 | Eu(Ⅲ) Indirect Probe to Investigate Interaction of DOPA (3,4,Di-Hydroxyphenylalanine) and Dopamine (3,4-Dihydroxy Phenyl Ethyl Amine) Using Electrochemical Methods显示文摘Eu(Ⅲ) can be utilized as an indirect electrochemical probe to investigate the interaction of bio-molecules such as DOPA and Dopamine with Ca(Ⅱ) in vitro. The interaction of DOPA and Dopamine with Eu(Ⅲ)-Eu(Ⅱ) redox pair was investigated by electrochemical techniques. Both the neurotransmitters are structurally related and undergo interaction with Eu(Ⅲ). Eu(Ⅲ) coordinates with DOPA and Dopamine through five-member chelate rings via carboxylic oxygen and amino nitrogen. The electrode kinetic parameters viz, transfer coefficient (α_ na ), diffusion coefficient (D), forward heterogeneous rate constant (k^0_ fh ) were evaluated for Eu(Ⅲ)-DOPA/Eu(Ⅲ)-Dopamine. The results obtained were used to investigate the nature of interaction of Eu(Ⅲ) with multi-donor biomolecules. The possible mechanism was also proposed. [BT(4+1] | Prashant N Bhatt Trupti V Pathak Jignasu P Mehta G.Ramchandraiha | 2006 | Journal of Rare Earths2006，24，6： | 3 |
| 6 | Lung cancer metastasis to the gastrointestinal system:An enigmatic occurrence显示文摘Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made. | Kanthi Rekha Badipatla Niharika Yadavalli Trupti Vakde Masooma Niazi Harish K Patel | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
| 7 | Application of electrochemically prepared carbon nanofibers in supercapacitors显示文摘 | ADHYAPAK P V TRUPTI MADDANIMATH SUSHAMA PETHKAR | 2002 | J Power Sources2002，109，1： | 2 |
| 8 | Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies显示文摘Development is a sophisticated process maintained by various signal transduction pathways,including the Hedgehog(Hh)pathway.Several important functions are executed by the Hh signaling cascade such as organogenesis,tissue regeneration,and tissue homeostasis,among various others.Considering the multiple functions carried out by this pathway,any mutation causing aberrant Hh signaling may lead to myriad developmental abnormalities besides cancers.In the present review article,we explored a wide range of diseases caused by aberrant Hh signaling,including developmental defects and cancers.Finally,we concluded this mini-review with various treatment strategies for Hh-induced diseases. | Trupti N.Patel Pavan Kumar Dhanyamraju | 2022 | The Journal of Biomedical Research2022，36，1： | 2 |
| 9 | A yurveda – The Science of Healing显示文摘 | Trupti Gokani | 2014 | Headache: The Journal of Head and Face Pain2014，，： | 1 |
| 10 | Fine-tuning immune surveillance by fever-range thermal stress显示文摘 | Daniel T. Fisher Trupti D. Vardam Jason B. Muhitch Sharon S. Evans | 2010 | Immunologic Research2010，，1： | 1 |
| 11 | HIV/ AIDS Knowledge Among Female Migrant Farm Workers in the Midwest显示文摘 | Keri Fitzgerald Joana Chakraborty Trupti Shah | 2003 | Journal of Immigrant Health2003，5，1： | 1 |
| 12 | Unusual Case of Adrenal and Renal Metastases From Papillary Carcinoma of Thyroid显示文摘 | Gaurav Malhotra Trupti S. Upadhye Epari Sridhar Ramesh V. Asopa Parul S. Garde Sachin Gawde Venkatesh Rangarajan | 2010 | Clinical Nuclear Medicine2010，，9： | 1 |
| 13 | Thread-based multiplexed sensor patch for real-time sweat monitoring显示文摘Sensor platforms that exploit the fibrous textile threads as substrates offer great promise since they can be directly sewn,woven or stitched on to any clothing.They can also be placed directly in intimate contact with the skin.In this work,we present a thread-based sensing platform in the form of a multiplexed sensing patch for continuous simultaneous on-skin monitoring of sweat.The patch performs real-time,on-body measurements of important biomarkers present in sweat such as electrolytes(sodium and ammonium ions),metabolites(lactate)and acidity(pH).Flexible threads coated with conductive inks were used as sensing electrodes.Selective potentiometric detection of electrolytes and pH was made possible through ion-selective membrane deposition and pH-sensitive polyaniline coating on threads,respectively.An amperometric enzymatic sensing scheme with lactate oxidase was used for the detection of lactate.An array of the thread sensors is integrated onto a patch with connectivity to a miniaturized circuit module containing a potentiostat,microprocessor and wireless circuitry for wireless smartphone readout.Extensive in vitro validation and an in vivo human pilot study involving a maximal exertion test show the promise of this platform for real-time physiological monitoring of human performance/fitness under stress,as well as diagnostic monitoring through sweat analysis. | Trupti Terse-Thakoor Meera Punjiya Zimple Matharu Boyang Lyu Meraj Ahmad Grace E.Giles Rachel Owyeung Francesco Alaimo Maryam Shojaei Baghini Tad TBrunyé Sameer Sonkusale | 2020 | npj Flexible Electronics2020，4，1： | 1 |
| 14 | Design, Synthesis and Pharmacological Screening of Novel Antihypertensive Agents Using Hybrid Approach显示文摘 | Shashikant V. Bhandari Kailash G. Bothara Ajit A. Patil Trupti S. Chitre Aniket P. Sarkate Suraj T. Gore Sudarshan C. Dangre Chetan V. Khachane | 2008 | Bioorganic & Medicinal Chemistry2008，，1： | 1 |
| 15 | Overexpression of CD44: A useful independent predictor of prognosis in patients with colorectal carcinomas显示文摘 | Jyotsna M. Bhatavdekar PhD Devendra D. Patel MS Priya R. Chikhlikar MSc Trupti I. Trivedi MSc Neha M. Gosalia MSc Nandita Ghosh PhD Neelam G. Shah PhD Hemangini H. Vora PhD Tejal P. Suthar MSc | 1998 | Annals of Surgical Oncology1998，，6： | 1 |
| 16 | Separation of glycyrrhizic acid fTomlicorice root extract using macroporous resin显示文摘 | TRUPTI W C VIRENDRA K R | 2015 | Food Bioprod Process2015，93，1： | 1 |
| 17 | Molecular markers are predictors of recurrence and survival in patients with Dukes B and Dukes C colorectal adenocarcinoma显示文摘 | Jyotsna M. Bhatavdekar Ph.D. Devendra D. Patel M.S. Priya R. Chikhlikar Ph.D. Dr. Neelam G. Shah Ph.D. Hemangini H. Vora Ph.D. Nandita Ghosh Ph.D. Trupti I. Trivedi M.Sc | 2001 | Diseases of the Colon & Rectum2001，，4： | 1 |
| 18 | Penicillin G acylase from Achromobacter sp. CCM 4824显示文摘 | Stanislav Be?ka Václav ?těpánek Rajasekar W. Vyasarayani Michal Grulich Jaroslav Mar?álek Kamila Plhá?ková Marie Dobi?ová Helena Mare?ová Martina Pla?ková Renáta Vale?ová Andrea Palyzová Anupama Datla Trupti K. Ashar Pavel Kyslík | 2014 | Applied Microbiology and Biotechnology2014，，3： | 1 |
| 19 | Novel magnetic cross-linked enzyme aggregates (magnetic CLEAs) of alpha amylase显示文摘 | Sachin Talekar Vishal Ghodake Trupti Ghotage Pavan Rathod Priyant Deshmukh Shamraja Nadar Mosin Mulla Mayur Ladole | 2012 | Bioresource Technology2012，，： | 1 |
| 20 | HIV/AIDS Knowledge Among Female No-local Farm Workers inthe Midwest显示文摘 | KERI FITZGERALD JOANA CHAKRABORTY TRUPTI SHAH et a1 | 2003 | Journal of Imno-local Health2003，5，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员