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| 1 | Knights in Action: Lectin Receptor-Like Kinases in Plant Development and Stress Responses显示文摘像受体的 Kinase (RLK ) 是有在 Arabidopsis 的超过 600 基因的一个广阔蛋白质家庭并且 1100 在米饭。Lectin RLK (LecRLK ) 家庭被相信在糖类发信号以及压力感觉起关键作用。所有 LecRLKs 拥有三个领域:一个 N 终端 lectin 领域,一个中间的 transmembrane 领域,和一个 C 终端 kinase 领域。根据 lectin 域可变性, LecRLKs 是进三个子类的 subgrouped:L- , G- ,和 C 类型 LecRLKs。当 LecRLKs 上的以前的研究被基于倡导者的研究奉献给分类,比较结构的分析和表示分析时,大多数 LecRLKs 上的最近的研究在在植物调整关於生命/不能生活的应力和发展小径在这个基因家庭的潜力上放了特殊强调,因此做学习特别答应的 调停LecRLK 的规章的机制的前景。在这评论,我们详细关于一个历史、进化、结构的观点描述了 LecRLK 基因家庭。而且,我们在开发,压力条件,和神经质的反应在 LecRLKs 角色上放了强调。我们也讨论了前景在 LecRLK 基因家庭上由当前的知识提供了的令人激动的研究。LecRLK 基因家庭成员和他们的功能的差异的数量作为进一步的分析的有趣、相称的候选人标记这些基因,特别在庄稼改进的领域里。 | Neha Vaid Anca Macovei Narendra Tuteja | 2013 | Molecular Plant2013，6，5： | 18 |
| 2 | Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy显示文摘AIM:To analyze the prevalence of gastroesophageal reflux disease (GERD) related symptoms in patients with diabetes mellitus (DM) and to find out the relationship between diabetic neuropathy and the prevalence of GERD symptoms. METHODS:In this prospective questionnaire study, 150 consecutive type 2 diabetic patients attending the endocrine clinic were enrolled. A junior physician helped the patients to understand the questions. Patients were asked about the presence of five most frequent symptoms of GERD that included heartburn (at least 1/wk), regurgitation, chest pain, hoarseness of voice and chronic cough. Patients with past medical history of angina, COPD, asthma, cough due to ACEI or preexisting GERD prior to onset of diabetes and apparent psychiatric disorders were excluded from the survey. We further divided the patients into two groups based on presence or absence of peripheral neuropathy. Out of 150 patients, 46 had neuropathy, whereas 104 patients did not have neuropathy. Data are expressed as mean ± SD, and number of patients in each category and percentage of total patients in that group. Normal distributions between groups were compared with Student t test and the prevalence rates between groups were compared with Chi-square tests for significance. RESULTS:The average duration of diabetes were 12 ± 9.2 years and the average HbA1c level of this group was 7.7% ± 2.0%. The mean weight and BMI were 198 ± 54 lbs. and 32 ± 7.2 kg/m2. Forty percent (61/150) patients reported having at least one of the symptoms of GERD and thirty percent (45/150) reported having heartburn at least once a week. The prevalence of GERD symptoms is higher in patients with neuropathy than patients without neuropathy (58.7% vs 32.7%, P < 0.01). The prevalence of heartburn, chest pain and chronic cough are also higher in patients with neuropathy than in patients without neuropathy (43.5% vs 24%;10.9% vs 4.8% and 17.8% vs 6.7% respectively, P < 0.05).CONCLUSION:The prevalence of GERD symptoms in type 2 DM is higher than in the general population. Our data suggest that DM neuropathy may be an important associated factor for developing GERD symptoms. | Xiangbing Wang CS Pitchumoni Khushbu Chandrarana Neha Shah | 2008 | World Journal of Gastroenterology2008，14，5： | 13 |
| 3 | 广西南宁市5岁儿童乳牙龋患病率及其影响因素分析显示文摘目的:调查广西南宁市5岁儿童乳牙龋的患病率,并分析其影响因素。方法:于2016年10月至2017年10月整群随机抽取广西南宁市5岁的儿童进行调查。收集调查对象的社会人口学、口腔健康行为等资料,并调查乳牙患龋情况。患龋状况通过患龋率及龋、失、补牙面(dmfs)指数来评估。根据乳牙患龋的等级强度将调查样本分为无龋组(dmfs=0)、早期低龄儿童龋(ECC)组(0 | 姚君钰 莫丹 Malla Manisha Dhakal Neha 黄华 林焕彩 邱荣敏 | 2018 | 广西医科大学学报2018，35，12： | 10 |
| 4 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 5 | 内质网应激在慢性间歇低氧幼鼠脑损害中的作用显示文摘目的:探讨内质网应激在慢性间歇低氧幼鼠脑损害中的作用机制及salubrinal的干预作用。方法:取SPF级健康雄性SD幼鼠64只,随机分为8组:间歇低氧(intermittent hypoxia,IH)2、4周组(2IH、4IH),对照(control,C)2、4周组(2C、4C),Salubrinal(SAL)干预2、4周组(2SAL、4SAL),二甲基亚砜(DMSO)溶剂对照2、4周组(2DMSO、4DMSO),每组8只。八臂迷宫测试各组幼鼠参考记忆错误(RME)、工作记忆错误(WME)及总错误(TE)次数,观察海马神经元凋亡变化,测定超氧化物歧化酶(SOD)活性,及内质网应激标志物C/EBP同源蛋白(CHOP)、磷酸化真核翻译起始因子2α(p-e IF2α)和磷酸化蛋白激酶R样内质网激酶(p-PERK)的蛋白水平。结果:与相应对照2C、4C组比较,间歇低氧2IH、4IH组幼鼠的RME、WME和TE升高(P<0.01),海马神经元凋亡指数(AI)升高(P<0.01),SOD活性下降(P<0.01),p-PERK和CHOP蛋白水平升高(P<0.01),p-e IF2α蛋白水平下降(P<0.05),4周组最明显;与对应间歇性低氧2IH、4IH组比较,药物干预组2SAL、4SAL组RME、WME和TE次数下降(P<0.05),AI下降(P<0.01),SOD活性升高(P<0.01),p-e IF2α的蛋白水平升高(P<0.01),CHOP表达下降(P<0.01)。结论:慢性间歇低氧可上调记忆相关脑区p-PERK表达,启动内质网应激,从而诱导CHOP所介导的细胞凋亡,可能在慢性间歇低氧所致脑损伤中起重要作用。Salubrinal选择性抑制e IF2α去磷酸化,下调CHOP蛋白的水平,提高SOD活性,从而缓解内质网应激,减轻氧化应激,减少细胞凋亡。 | 李秀翠 方励 李志洁 POONIT Neha Devi 陈帆 蔡晓红 | 2016 | 中国病理生理杂志2016，32，8： | 6 |
| 6 | Estimation of lung cancer burden in Australia,the Philippines,and Singapore:an evaluation of disability adjusted life years显示文摘Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and Singapore.Methods: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for 2015.Results: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these countries.Conclusions: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality. | Suman Morampudi Neha Das Arun Gowda Anand Patil | 2017 | Cancer Biology & Medicine2017，14，1： | 5 |
| 7 | Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis显示文摘Periodontitis 是 periodontium 的煽动性的疾病。在 neutrophils 和织物禁止者分泌的矩阵 metalloproteinases (MMP ) 之间的任何不平衡在口香糖织物开始骨胶原的破坏,导致长期的 periodontitis。这研究瞄准了 MMP-8 的唾液的层次和长期的 periodontitis 的牙齿周围的参数到相互关联为长期的 periodontitis 的早诊断作为一个 noninvasive 标记建立 MMP-8。学习包含了访问扎乌丁·阿赫马德博士的 periodontic OPD 的 40 个题目牙齿的学院和医院,在 Aligarh 定位了, U.P,印度,从 2011 ~ 2012。这些题目被划分成二个组:组当组 II 与长期的 periodontitis 由 20 个病人组成了时,我由 20 个牙齿周围地健康的题目(控制) 组成了。长期的 periodontitis 根据几个牙齿周围的参数被估计,包括探查深度(PPD ) 的衣袋,临床的附件水平(CAL ) ,齿龈的索引(官方补给) ,并且匾索引(PI ) 。为由用 Quantikine 人总数 MMP-8 免疫分析工具包的 ELISA 的 MMP-8 评价在 unstimulated 和整个吐的口水的 3ml 附近是镇定的。数据用 STATISTICA (Windows 版本 6 ) 软件被分析。组的唾液的 MMP-8 层次我和 II 是 190.91?? | Namita Gupta N.D. Gupta Akash Gupta Saif Khan Neha Bansa | 2015 | Frontiers of Medicine2015，9，1： | 5 |
| 8 | Nanodiamonds with powerful ability for drug delivery and biomedical applications:Recent updates on in vivo study and patents显示文摘Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.These are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical era.Alongside,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with nanodiamonds.Surface modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface chemistry.To take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological environment.This review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of nanodiamonds.For the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces. | Swati Chauhan Neha Jain Upendra Nagaich | 2020 | Journal of Pharmaceutical Analysis2020，10，1： | 5 |
| 9 | A comprehensive review from sequential association computing to Hadoop-MapReduce parallel computing in a retail scenario显示文摘Today,the customer’s requirements are entirely transformed.Many big retail organizations are facing sudden decline in the sales and revenues caused due to indecisive and erratic purchasing habits of recent generation of users,as they get abundant preferred information such as cheaper rates,amazing offers,discounts,comparison of similar products,etc.over their smartphones or laptops hence they straightaway place order instead of walking down to showroom.As a result,large companies such as Tesco,Wal-Mart,Target,etc.have realized that it is requisite to shake hands with startup firms which already supports platform to retain customers either via deep exploration of transactional data or by offering lucrative offers in the benefit of customer and to promote market basket.The data which are generated from consumer purchase pattern,Big Data is a concern for companies as a result various big retail organizations are applying advanced and scalable data mining algorithms to precisely store and evaluate data in real-time manner to boost market basket analysis.This research work discusses various improved association rule mining(ARM)algorithms.The objective of this study is to identify gaps,providing opportunities for new research,to recognize expansion of Big Data analytics with retail environment and its future directions.This paper assimilates various aspects of parallel ARM algorithm for market basket analysis against sequential and distributed nature which are further escalated to Hadoop and MapReduce computing platform.Further various use cases highlighting the need of‘Big Data Retail Analytics’are discussed for emerging trends to promote sales and revenues,to keep check on competitor’s websites,comparison of various brands,enticing new customers. | Neha Verma Jatinder Singh | 2017 | Journal of Management Analytics2017，4，4： | 4 |
| 10 | Perovskite Solar Cells Yielding Reproducible Photovoltage of 1.20 V显示文摘High photovoltages and power conversion efciencies of perovskite solar cells(PSCs)can be realized by controlling the undesired nonradiative charge carrier recombination.Here,we introduce a judicious amount of guanidinium iodide into mixed-cation and mixed-halide perovskite flms to suppress the parasitic charge carrier recombination,which enabled the fabrication of>20%efcient and operationally stable PSCs yielding reproducible photovoltageas high as 1.20 V.By introducing guanidinium iodide into the perovskite precursor solution,the bandgap of the resulting absorber material changed minimally;however,the nonradiative recombination diminished considerably as revealed by time-resolved photoluminescence and electroluminescence studies.Furthermore,using capacitance-frequency measurements,we were able to correlate the hysteresis features exhibited by the PSCs with interfacial charge accumulation.Tis study opens up a path to realize new record efciencies for PSCs based on guanidinium iodide doped perovskite flms. | Essa A.Alharbi M.Ibrahim Dar Neha Arora Mohammad Hayal Alotaibi Yahya A.Alzhrani Pankaj Yadav Wolfgang Tress Ahmed Alyamani Abdulrahman Albadri Shaik M.Zakeeruddin Michael Grätzel | 2019 | Research2019，，1： | 4 |
| 11 | Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review显示文摘Glioblastoma(GBM)is the most common primary malignant brain tumor in adults and has an exceedingly low median overall survival of only 15 months.Current standard-of-care for GBM consists of gross total surgical resection followed by radiation with concurrent and adjuvant chemotherapy.Temozolomide(TMZ)is the first-choice chemotherapeutic agent in GBM;however,the development of resistance to TMZ often becomes the limiting factor in effective treatment.While O6-methylguanine-DNA methyltransferase repair activity and uniquely resistant populations of glioma stem cells are the most well-known contributors to TMZ resistance,many other molecular mechanisms have come to light in recent years.Key emerging mechanisms include the involvement of other DNA repair systems,aberrant signaling pathways,autophagy,epigenetic modifications,microRNAs,and extracellular vesicle production.This review aims to provide a comprehensive overview of the clinically relevant molecular mechanisms and their extensive interconnections to better inform efforts to combat TMZ resistance. | Neha Singh Alexandra Miner Lauren Hennis Sandeep Mittal | 2021 | Cancer Drug Resistance2021，4，1： | 4 |
| 12 | Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity,recapitulating key features of FUS proteinopathy显示文摘Mutations in the fused in sarcoma/translocated in liposarcoma(FUS/TLS)gene have been associated with amyotrophic lateral sclerosis(ALS).FUS-positive neuropathology is reported in a range of neurodegenerative diseases,including ALS and fronto-temporal lobar degeneration with ubiquitin-positive pathology(FTLDU).To examine protein aggregation and cytotoxicity,we expressed human FUS protein in yeast.Expression of either wild type or ALS-associated R524S or P525L mutant FUS in yeast cells led to formation of aggregates and cytotoxicity,with the two ALS mutants showing increased cytotoxicity.Therefore,yeast cells expressing human FUS protein recapitulate key features of FUSpositive neurodegenerative diseases.Interestingly,a significant fraction of FUS expressing yeast cells stained by propidium iodide were without detectable protein aggregates,suggesting that membrane impairment and cellular damage caused by FUS expression may occur before protein aggregates become microscopically detectable and that aggregate formation might protect cells from FUS-mediated cytotoxicity.The N-terminus of FUS,containing the QGSY and G rich regions,is sufficient for the formation of aggregates but not cytotoxicity.The C-terminal domain,which contains a cluster of mutations,did not show aggregation or cytotoxicity.Similar to TDP-43 when expressed in yeast,FUS protein has the intrinsic property of forming aggregates in the absence of other human proteins.On the other hand,the aggregates formed by FUS are thioflavin T-positive and resistant to 0.5%sarkosyl,unlike TDP-43 when expressed in yeast cells.Furthermore,TDP-43 and FUS display distinct domain requirements in aggregate formation and cytotoxicity. | Kazuo Fushimi Charles Long Neha Jayaram Xiaoping Chen Liming Li Jane Y.Wu | 2011 | Protein & Cell2011，2，2： | 4 |
| 13 | Exploring the efficacy of natural products in alleviating Alzheimer’s disease显示文摘Alzheimer's disease (hereafter AD) is a progressive neurodegenerative disorder that affects the central nervous system. There are multiple factors that cause AD, viz., accumulation of extracellular Amyloid-beta 42 plaques, intracellular hyper-phosphorylated Tau tangles, generation of reactive oxygen species due to mitochondrial dysfunction and genetic mutations. The plaques and tau tangles trigger aberrant signaling, which eventually cause cell death of the neurons. As a result, there is shrinkage of brain, cogrdtive defects, behavioral and psychological problems. To date, there is no direct cure for AD. Thus, scientists have been testing various strategies like screening for the small inhibitor molecule library or natural products that may block or prevent onset of AD. Historically, natural products have been used in many cultures for the treatment of various diseases. The research on natural products have gained importance as the active compounds extracted from them have medicinal values with reduced side effects, and they are bioavailable. The natural products may target the proteins or members of signaling pathways that get altered in specific diseases. Many natural products are being tested in various animal model systems for their role as a potential therapeutic target for AD, and to address questions about how these natural products can rescue AD or other neurodegenerative disorders. Some of these products are in clinical trials and results are promising because of their neuroprotective, anti-inflammatory, antioxidant, anti-amyloidogenic, anticholinesterase activities and easy availability. This review summarizes the use of animal model systems to identify natural products, which may serve as potential therapeutic targets for AD. | Prajakta Deshpande Neha Gogia Amit Singh | 2019 | Neural Regeneration Research2019，14，8： | 4 |
| 14 | 精神病学与电影:从神奇的画面中我们可以学到什么?(英文)显示文摘概述:电影是一种社会形态的载体,它可展示精神疾病的各个不同方面。由于电影的戏剧性和污蔑性的描述,它有时会传播有关精神疾病的消极影响,给病人带来痛苦。与消极影响相比,虽然它也会有一些正面和鼓舞人心的故事,但却是少之又少。在此,我们将描述电影对精神病学的双重影响。 | Soumitra DAS Nimisha DOVAL Shabna MOHAMMED Neha DUA Seshadri Sekhar CHATTERJEE | 2017 | 上海精神医学2017，29，5： | 3 |
| 15 | Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants显示文摘Epidermal growth factor receptor(EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non-small cell lung cancer(NSCLC) patients that harbor EGFR kinase domain mutations exhibit oncogene addiction to mutant EGFR, which confers high sensitivity to tyrosine kinase inhibitors(TKIs). As patients invariably develop resistance to TKIs, it is important to delineate the cell biological basis of mutant EGFR-induced cellular transformation since components of these pathways can serve as alternate therapeutic targets to preempt or overcome resistance. NSCLC-associated EGFR mutants are constitutively-active and induce ligandindependent transformation in nonmalignant cell lines. Emerging data suggest that a number of factors are critical for the mutant EGFR-dependent tumorigenicity, and bypassing the effects of TKIs on these pathways promotes drug resistance. For example, activation of downstream pathways such as Akt, Erk, STAT3 and Src is critical for mutant EGFR-mediated biological processes. It is now well-established that the potency and spatiotemporal features of cellular signaling by receptor tyrosine kinases such as EGFR, as well as the specific pathways activated, is determined by the nature of endocytic traffic pathways through which the active receptors traverse. Recent evidence indicates that NSCLCassociated mutant EGFRs exhibit altered endocytic trafficking and they exhibit reduced Cbl ubiquitin ligasemediated lysosomal downregulation. More recent work has shown that mutant EGFRs undergo ligand-independent traffic into the endocytic recycling compartment, a behavior that plays a key role in Src pathway activation and oncogenesis. These studies are beginning to delineate the close nexus between signaling and endocytic traffic of EGFR mutants as a key driver of oncogenicprocesses. Therefore, in this review, we will discuss the links between mutant EGFR signaling and endocytic properties, and introduce potential mechanisms by which altered endocytic properties of mutant EGFRs may alter signaling and vice versa as well as their implications for NSCLC therapy. | Byung Min Chung Eric Tom Neha Zutshi Timothy Alan Bielecki Vimla Band Hamid Band | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 16 | Whole-blood sorting,enrichment and in situ immunolabeling of cellular subsets using acoustic microstreaming显示文摘Analyzing undiluted whole human blood is a challenge due to its complex composition of hematopoietic cellular populations,nucleic acids,metabolites,and proteins.We present a novel multi-functional microfluidic acoustic streaming platform that enables sorting,enrichment and in situ identification of cellular subsets from whole blood.This single device platform,based on lateral cavity acoustic transducers(LCAT),enables(1)the sorting of undiluted donor whole blood into its cellular subsets(platelets,RBCs,and WBCs),(2)the enrichment and retrieval of breast cancer cells(MCF-7)spiked in donor whole blood at rare cell relevant concentrations(10 mL^(−1)),and(3)on-chip immunofluorescent labeling for the detection of specific target cellular populations by their known marker expression patterns.Our approach thus demonstrates a compact system that integrates upstream sample processing with downstream separation/enrichment,to carry out multi-parametric cell analysis for blood-based diagnosis and liquid biopsy blood sampling. | Neha Garg Trisha M.Westerhof Vick Liu Robin Liu Edward L.Nelson Abraham P.Lee | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 17 | Label-free SARS-CoV-2 detection and classification using phase imaging with computational specificity显示文摘Efforts to mitigate the COVID-19 crisis revealed that fast,accurate,and scalable testing is crucial for curbing the current impact and that of future pandemics.We propose an optical method for directly imaging unlabeled viral particles and using deep learning for detection and classification.An ultrasensitive interferometric method was used to image four virus types with nanoscale optical path-length sensitivity.Pairing these data with fluorescence images for ground truth,we trained semantic segmentation models based on U-Net,a particular type of convolutional neural network.The trained network was applied to classify the viruses from the interferometric images only,containing simultaneously SARS-CoV-2,H1N1(influenza-A virus),HAdV(adenovirus),and ZIKV(Zika virus).Remarkably,due to the nanoscale sensitivity in the input data,the neural network was able to identify SARS-CoV-2 vs.the other viruses with 96%accuracy.The inference time for each image is 60 ms,on a common graphic-processing unit.This approach of directly imaging unlabeled viral particles may provide an extremely fast test,of less than a minute per patient.As the imaging instrument operates on regular glass slides,we envision this method as potentially testing on patient breath condensates.The necessary high throughput can be achieved by translating concepts from digital pathology,where a microscope can scan hundreds of slides automatically. | Neha Goswami Yuchen R.He Yu-Heng Deng Chamteut Oh Nahil Sobh Enrique Valera Rashid Bashir Nahed Ismail Hyunjoon Kong Thanh H.Nguyen Catherine Best-Popescu Gabriel Popescu | 2021 | Light(Science & Applications)2021，10，9： | 3 |
| 18 | Overview of extended release tacrolimus in solid organ transplantation显示文摘Tacrolimus(Prograf?, Astellas Pharma Europe Ltd, Staines, United Kingdom; referred to as tacrolimusBID) is an immunosuppressive agent to prevent and treat allograft rejection in kidney transplant recipients in combination with mycophenolate mofetil, corticosteroids,with or without basiliximab induction. The drug has also been studied in liver, heart and lung transplant; however, these are currently off-label indications. An extended release tacrolimus formulation(Advagraf?, Astagraf XL?) allows for once-daily dosing, with the potential to improve adherence. Extended release tacrolimus has similar absorption, distribution, metabolism and excretion to tacrolimus-BID. Phase Ⅰ pharmacokinetic trials comparing extended release tacrolimus and tacrolimus-BID have demonstrated a decreased maximum concentration(C max) and delayed time to maximum concentration(t max) with the extended release formulation; however, AUC0-24 was comparable between formulations. Overall extended release tacrolimus has a very similar safety and efficacy profile to tacrolimus-BID. It is not recommended in the use of liver transplant patient's due to the increased risk of mortality in female recipients. There has been minimal data regarding the use of extended release tacrolimus in heart and lung transplant recipients. With the current data available for all organ groups the extended release tacrolimus should be dosed in a 1:1 fashion, the exception may be the cystic fibrosis population where their initial dose may need to be higher. | Neha Patel Abigail Cook Elizabeth Greenhalgh Megan A Rech Joshua Rusinak Lynley Heinrich | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 19 | A review on current status of municipal solid waste management in India显示文摘Municipal solid waste management is a major environmental issue in India. Due to rapid increase in urbanization, industrialization and population, the generation rate of municipal solid waste in Indian cities and towns is also increased. Mismanagement of municipal solid waste can cause adverse environmental impacts, public health risk and other socio-economic problem. This paper presents an overview of current status of solid waste management in India which can help the competent authorities responsible for municipal solid waste management and researchers to prepare more efficient plans. | Neha Gupta Krishna Kumar Yadav Vinit Kumar | 2015 | Journal of Environmental Sciences2015，27，11： | 3 |
| 20 | Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. | Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，1： | 2 |
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