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| 1 | 全结肠巨结肠:十年诊疗经验与随访显示文摘目的对近10年来的全结肠巨结肠患儿进行回顾性研究,并对术前、术后并发症及随访情况进行评估。方法1996~2005年间我院共治疗25例全结肠巨结肠患儿,女8例,男17例。观察指标:年龄、临床表现、诊断方法、手术时年龄、回肠受累程度、全静脉营养时间、手术前后并发症及电话问卷调查随访。结果25例患儿中16例(64.0%)在新生儿期即表现为腹胀、呕吐及胎粪延迟排出。术前腹部平片或钡灌肠检查均不能提供确诊的特异性征象。25例均经手术探查、术中病理检查诊断为全结肠巨结肠,23例行回肠造瘘术,2例行Ⅰ期拖出根治手术。18例接受根治手术治疗(12例为改良Martin术;4例Ikeda-soper术;1例Rehbein,1例Soave拖出术);2例回肠造瘘术后因惊厥和败血症死亡;5例失随访。手术前后并发症包括:小肠结肠炎(术前44.4%,术后61.6%),肛周糜烂(77.8%),电解质失衡(50.0%),吻合口瘘(16.7%)。全静脉营养平均时间术前(17.77±12.54)d;术后(10.27±5.23)d。18例根治手术后10例获随访,平均随访时间(27.60±35.39)个月。7例患儿每天排便1~3次,2例每天5~6次,1例每天大便次数大于10次。所有患儿身高体重发育良好。结论全结肠巨结肠诊断较为困难、并发症多,随着对该病的进一步认识及积极治疗,疗效已有明显改善,长期预后良好。 | Basnet Anupama 赵瑞 郑珊 肖现民 | 2007 | 中华小儿外科杂志2007，28，3： | 13 |
| 2 | Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells显示文摘AIM:To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting cells.METHODS:Cinnamon extract was used to treat murine macrophage cell line(Raw 264.7),mouse primary antigen-presenting cells(APCs,MHCII+) and CD11c+dendritic cells to analyze the effects of cinnamon extract on APC function.The mechanisms of action of cinnamon extract on APCs were investigated by analyzing cytokine production,and expression of MHC antigens and co-stimulatory molecules by quantitative real-time PCR and flow cytometry.In addition,the effect of cinnamon extract on antigen presentation capacity and APC-dependent T-cell differentiation were analyzed by [H3]-thymidine incorporation and cytokine analysis,respectively.To confirm the anti-inflammatory effects of cinnamon extract in vivo,cinnamon or PBS was orally administered to mice for 20 d followed by induction of experimental colitis with 2,4,6 trinitrobenzenesulfonic acid.The protective effects of cinnamon extract against experimental colitis were measured by checking clinical symptoms,histological analysis and cytokine expression prof iles in inflamed tissue.RESULTS:Treatment with cinnamon extract inhibited maturation of MHCII+ APCs or CD11c+ dendritic cells(DCs) by suppressing expression of co-stimulatory molecules(B7.1,B7.2,ICOS-L),MHCII and cyclooxygenase(COX)-2.Cinnamon extract induced regulatory DCs(rDCs) that produce low levels of pro-inflammatory cytokines [interleukin(IL)-1β,IL-6,IL-12,interferon(IFN)-γ and tumor necrosis factor(TNF)-α] while expressing high levels of immunoregulatory cytokines(IL-10 and transforming growth factor-β).In addition,rDCs generated by cinnamon extract inhibited APC-dependent T-cell proliferation,and converted CD4+ T cells into IL-10high CD4+ T cells.Furthermore,oral administration of cinnamon extract inhibited development and progression of intestinal colitis by inhibiting expression of COX-2 and pro-inflammatory cytokines(IL-1β,IFN-γ and TNF-α),while enhancing IL-10 levels.CONCLUSION:Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10+ regulatory T cells. | Ho-Keun Kwon Ji-Sun Hwang Choong-Gu Lee Jae-Seon So Anupama Sahoo Chang-Rok Im Won Kyung Jeon Byoung Seob Ko Sung Haeng Lee Zee Yong Park Sin-Hyeog Im | 2011 | World Journal of Gastroenterology2011，17，8： | 6 |
| 3 | Isolated arterioportal fistula presenting with variceal hemorrhage显示文摘We report a case of life-threatening hematemesis due to portal hypertension caused by an isolated arterioportal fistula (APF). Intrahepatic APFs are extremely rare and are a cause of presinusoidal portal hypertension. Etiologies for APFs are comprised of precipitating trauma, malignancy, and hereditary hemorrhagic telangiectasia, but these were not the case in our patient. Idiopathic APFs are usually due to congenital vascular abnormalities and thus usually present in the pediatric setting. This is one of the first cases of adult-onset isolated APF who presented with portal hypertension and was successfully managed through endoscopic hemostasis and subsequent interventional radiological embolization. | Anupama Nookala Behnam Saberi Ramon Ter-Oganesyan Gary Kanel Phillip Duong Takeshi Saito | 2013 | World Journal of Gastroenterology2013，19，17： | 4 |
| 4 | Nonlinear optical properties of integrated GeSbS chalcogenide waveguides显示文摘In this paper, we report the experimental characterization of highly nonlinear Ge Sb S chalcogenide glass waveguides.We used a single-beam characterization protocol that accounts for the magnitude and sign of the real and imaginary parts of the third-order nonlinear susceptibility of integrated Ge23 Sb7 S70(GeSbS) chalcogenide glass waveguides in the near-infrared wavelength range at λ =1580 nm. We measured a waveguide nonlinear parameter of 7.0±0.7 W^(-1)· m(-1), which corresponds to a nonlinear refractive index of n_2=0.93±0.08 × 10^(-18) m^2∕W,comparable to that of silicon, but with an 80 times lower two-photon absorption coefficient βTPA=0.010± 0.003 cm∕GW, accompanied with linear propagation losses as low as 0.5 dB/cm. The outstanding linear and nonlinear properties of Ge Sb S, with a measured nonlinear figure of merit FOMTPA=6.0 ±1.4 at λ =1580 nm, ultimately make it one of the most promising integrated platforms for the realization of nonlinear functionalities. | SAMUEL SERNA HONGTAO LIN CARLOS ALONSO-RAMOS ANUPAMA YADAV XAVIER LE ROUX KATHLEEN RICHARDSON ERIC CASSAN NICOLAS DUBREUIL JUEJUN HU LAURENT VIVIEN | 2018 | Photonics Research2018，6，5： | 3 |
| 5 | Predictors and consequences of pneumonia in critically ill patients with stroke显示文摘 | Anupama Upadya Natalya Thorevska Kanaga N Sena Constantine Manthous Yaw Amoateng-Adjepong | 2004 | Journal of Critical Care2004，，1： | 3 |
| 6 | Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer显示文摘 | Brandon A. Howard Zhong Zheng Michael J. Campa Michael Z. Wang Anupama Sharma Eric Haura James E. Herndon Michael C. Fitzgerald Gerold Bepler Edward F. Patz | 2004 | Lung Cancer2004，，： | 2 |
| 7 | 尿足细胞相关蛋白检测研究进展显示文摘肾小球是肾脏最重要的功能单位部分,它是由毛细血管内皮细胞、基底膜、脏层上皮细胞(足细胞)、系膜细胞及基质组成。其中前三者构成肾小球滤过膜,肾小球过滤的物质必须通过这3个结构才能从毛细血管腔进入Bowman’s囊。足细胞本身由胞体和足突组成,足突是胞体上大的突出部分,长长的足突黏附在肾小球基底膜上。 | 赵亮 Anupama Kumari Yadav 卢宏柱 | 2015 | 中国实用儿科杂志2015，30，9： | 2 |
| 8 | Automated Segmentation of Left Ventricle Using Local and Global Intensity Based Active Contour and Dynamic Programming显示文摘The aim of this work is to develop an improved region based active contour and dynamic programming based method for accurate segmentation of left ventricle(LV) from multi-slice cine short axis cardiac magnetic resonance(MR) images. Intensity inhomogeneity and weak object boundaries present in MR images hinder the segmentation accuracy. The proposed active contour model driven by a local Gaussian distribution fitting(LGDF) energy and an auxiliary global intensity fitting energy improves the accuracy of endocardial boundary detection. The weightage of the global energy fitting term is dynamically adjusted using a spatially varying weight function. Dynamic programming scheme proposed for the segmentation of epicardium considers the myocardium probability map and a distance weighted edge map in the cost matrix. Radial distance weighted technique and conical geometry are employed for segmenting the basal slices with left ventricle outflow tract(LVOT) and most apical slices. The proposed method is validated on a public dataset comprising 45 subjects from medical image computing and computer assisted interventions(MICCAI) 2009 segmentation challenge.The average percentage of good endocardial and epicardial contours detected is about 99%, average perpendicular distance of the detected good contours from the manual reference contours is 1.95 mm, and the dice similarity coefficient between the detected contours and the reference contours is 0.91. Correlation coefficient and the coefficient of determination between the ejection fraction measurements from manual segmentation and the automated method are respectively 0.978 1 and 0.956 7, for LV mass these values are 0.924 9 and0.855 4. Statistical analysis of the results reveals a good agreement between the clinical parameters determined manually and those estimated using the automated method. | G.Dharanibai Anupama Chandrasekharan Zachariah C.Alex | 2018 | International Journal of Automation and computing2018，15，6： | 2 |
| 9 | Nature:利用CRISPR/Cas9治疗镰状细胞疾病取得重大进展显示文摘在一项新的研究中,来自美国斯坦福大学医学院的研究人员利用一种被称作CRISPR/Cas9的基因编辑工具修复人干细胞中导致镰状细胞疾病的基因。这是开发一种治疗这种疾病的基因疗法的关键一步。相关研究结果在线发表在Nature期刊上。 | Daniel P. Dever, Rasmus O. Bak, Joab Camarena, Gabriel Washington, Carmencita E. Nicolas, Mara Pavel-Dinu, Nivi Saxena, Alec B. Wilkens, Sruthi Mantri, Ayal Hendel, Kenneth I. Weinberg Matthew H. Porteus Andreas Reinisch Ravindra Majeti Nobuko Uchida Anupama Narla | 2016 | 现代生物医学进展2016，16，35： | 2 |
| 10 | Scaled- up production of zero - trans margarine fat using pine nut oil and palm stearin显示文摘 | PRAKASH A ZHU Xuemei ANUPAMA G | 2010 | Food Chemistry2010，119，： | 1 |
| 11 | I- solated cerebellar involvement in posterior reversible encepha opathy syndrome in a child with acute lymphoblastie leuke mia显示文摘 | Narendra Chaudhary Rubeena Majeed Anupama Borker | 2011 | Indian J Med Paediatr Oncol2011，32，4： | 1 |
| 12 | The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells显示文摘 | Scott M. Freeman Rajagopal Ramesh Munish Shastri Anupama Munshi Andrea K. Jensen Aizen J. Marrogi | 1995 | Cancer Letters1995，，2： | 1 |
| 13 | Disseminated peritoneal leiomyosarcomas a~ter laparoscopic 'myomectomy' and morcellation显示文摘 | Anupama R Ahmad SZ Kuriakose S et a l | 2011 | J Minim Invasive Gynecol2011，18，3： | 1 |
| 14 | Modeling and analysis of effects of awareness programs by media on the spread of infectious diseases 显示文摘 | Misra A K Sharma Anupama Shukla J B | 2011 | Mathematical & Computer Modelling2011，53，56： | 1 |
| 15 | Thiamine deficiency induces oxidative stress in brain mitochondria of Mus musculus显示文摘 | Anupama Sharma Renu Bist Parvesh Bubber | 2013 | Journal of Physiology and Biochemistry2013，，3： | 1 |
| 16 | Value-added food: single cell protein显示文摘 | ANUPAMA RAVINDRA P | 2000 | Biotechnol Adv2000，18，6： | 1 |
| 17 | Value-added food:显示文摘 | Anupama P. Ravindra | 2000 | Biotechnology Advances2000，，6： | 1 |
| 18 | Understanding web services显示文摘 | Jaideep Roy Anupama Ramanujan | 2001 | IEEE IT Portal2001，，1112： | 1 |
| 19 | Is basiliximab induction, a novel risk factor for new onset diabetes after transplantation for living donor renal allograft recipients?显示文摘 | Narayan Prasad Desraj Gurjer Dharmender Bhadauria Amit Gupta Aneesh Srivastava Anupama Kaul Akhilesh Jaiswal Brijesh Yadav Subhash Yadav Raj K Sharma | 2014 | Nephrology2014，，4： | 1 |
| 20 | Value-added food:single cellprotein显示文摘 | ANUPAMA RAVINDRA P | 2000 | Biotechnology Advances2000，18，： | 1 |
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