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| 1 | 2010年世界胃肠病学组织关于炎症性肠病诊断和治疗的实践指南显示文摘炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和治疗方面提出的独特议题在当前的文献和指南中几乎从未被提及。由于各地区的IBD临床特点差异较大,因此根据患者的主诉诊断IBD或评估疾病活动度需随地区的变化而变化。同样,治疗亦应根据疾病的分类和当地医疗资源进行调整。世界胃肠病学组织根据世界各国医疗资源的差异,采用级联方法制订了IBD的诊疗指南。 | Charles N.Bernstein Michael Fried J.H.Krabshuis Henry Cohen R.Eliakim Suleiman Fedail Richard Gearry K.L.Goh Saheed Hamid Aamir Ghafor Khan A.W.LeMair Malfertheiner Qin Ouyang J.F.Rey Ajit Sood Flavio Steinwurz Ole O.Thomsen Alan Thomson Gillian Watermeyer 杨钊斌 杨川华 钱本余 | 2010 | 胃肠病学2010，15，9： | 101 |
| 2 | Management of complex and redo cases of pelvic fracture urethral injuries显示文摘Objectives:Pelvic fracture urethral injuries(PFUI)result from traumatic disruption of the urethra.A significant proportion of cases are complex rendering their management challenging.We described management strategies for eight different complex PFUI scenarios.Methods:Our centre is a tertiary referral centre for complex PFUI cases.We maintain a prospective database(1995e2016),which we retrospectively analysed.All patients with PFUI managed at our institute were included.Results:Over two decades 1062 cases of PFUI were managed at our institute(521 primary and 541 redo cases).Most redo cases were referred to us from other centres.Redo cases had up to five prior attempts at urethroplasty.We managed complex cases,which included bulbar ischemia,young boys and girls with PFUI,PFUI with double block,concomitant PFUI and iatrogenic anterior urethral strictures.Bulbar ischemia merits substitution urethroplasty,most commonly,using pedicled preputial tube.PFUI in young girls is usually associated with urethrovaginal fistula.Young boys with PFUI commonly have a long gap necessitating trans-abdominal approach.Our success rate with individualised management is 85.60%in primary cases,79.13%in redo cases and 82.40%in cases of bulbar ischemia.Conclusion:The definition of complex PFUI is ever expanding.The best chance of success is at the first attempt.Anastomotic urethroplasty for PFUI should be performed in experienced hands at high volume centres. | Sanjay BKulkarni Sandesh Surana Devang JDesai Hazem Orabi Subramanian Iyer Jyotsna Kulkarni Ajit Dumawat Pankaj M.Joshi | 2018 | Asian Journal of Urology2018，5，2： | 13 |
| 3 | The most important questions in cancer research and clinical oncology Question 2-5.Obesity-related cancers:more questions than answers显示文摘Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is 'malignant'? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition. | Ajit Venniyoor | 2017 | Chinese Journal of Cancer2017，36，2： | 10 |
| 4 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 5 | A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment显示文摘 | Ajit K. Sarmah Michael T. Meyer Alistair B.A. Boxall | 2006 | Chemosphere2006，，5： | 10 |
| 6 | A prospective longitudinal study for latent tuberculosis infection in hospital in Beijing evaluating a T-cell-based assay health-care workers in a general显示文摘 | ZHANG Li-fan LIU Xiao-qing ZHANG Yao DENG Guo-hua Manish Pareek Ajit Lalvani | 2013 | Chinese Medical Journal2013，，11： | 10 |
| 7 | Effect of climate change on seasonal monsoon in Asia and its impact on the variability of monsoon rainfall in Southeast Asia显示文摘Global warming and climate change is one of the most extensively researched and discussed topical issues affecting the environment.Although there are enough historical evidence to support the theory that climate change is a natural phenomenon,many research scientists are widely in agreement that the increase in temperature in the 20 th century is anthropologically related.The associated effects are the variability of rainfall and cyclonic patterns that are being observed globally.In Southeast Asia the link between global warming and the seasonal atmospheric flow during the monsoon seasons shows varying degree of fuzziness.This study investigates the impact of climate change on the seasonality of monsoon Asia and its effect on the variability of monsoon rainfall in Southeast Asia.The comparison of decadal variation of precipitation and temperature anomalies before the 1970 s found general increases which were mostly varying.But beyond the 1970 s,global precipitation anomalous showed increases that almost corresponded with increases in global temperature anomalies for the same period.There are frequent changes and a shift westward of the Indian summer monsoon.Although precipitation is observed to be 70%below normal levels,in some areas the topography affects the intensity of rainfall.These shifting phenomenon of other monsoon season in the region are impacting on the variability of rainfall and the onset of monsoons in Southeast Asia and is predicted to delay for 15 days the onset of the monsoon in the future.The variability of monsoon rainfall in the SEA region is observed to be decadal and the frequency and intensity of intermittent flooding of some areas during the monsoon season have serious consequences on the human,financial,infrastructure and food security of the region. | Yen Yi Loo Lawal Billa Ajit Singh | 2015 | Geoscience Frontiers2015，6，6： | 8 |
| 8 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 9 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 10 | 超声生物显微镜在硅油填充眼中的应用显示文摘目的 探索眼玻璃体腔内长期硅油填充眼(>3月)的超声生物显微镜影像特征并探讨它在硅油填充眼中的临床应用。方法 对23例患者的23只硅油填充眼(平均10.5月,从3-18月)进行超声生物显微镜检查并进行图像分析。结果 观察到的超声生物显微镜影像有:高反射颗粒(硅油乳化颗粒),角膜鬼影,硅油在眼内的不完全填充,硅油颗粒在眼前部软组织镶嵌的高反射影像以及硅油周边组织的增生。结论 眼内硅油有着非常清晰的超声生物显微镜影像。它对充分了解硅油在眼内的分布状态及硅油填充术后眼前节的各种增殖性变化及硅油与这些增殖的关系起着重要的作用。 | 李文化 Zazimul Hussian Taratrasad Das Ajit B Majji Subhadra Jalali | 2003 | 国际眼科杂志2003，3，2： | 5 |
| 11 | Filling Simulation of Three-dimension Braided Composite in Resin Transfer Molding显示文摘This paper measured permeability of three-dimension braided preform by radial technology. The results show that principal permeability tensor coincided with their braiding axial direction. The software of one dimensional flow filling mold was designed using Visual C++ language. Filling time is predicted and validated. The result showed that the filling time of the mold centerline agrees with the prediction value. The filling time of the mould edge is shorter than that of the prediction. An actual plate of 3D braided preform/ modified polyarylacetylene composite is produced according to prediction value and validation analysis. | 吴晓青 李嘉禄 R Ajit Shenoi 汪日伟 | 2005 | Journal of Donghua University(English Edition)2005，22，4： | 4 |
| 12 | Science and prediction of monsoon heavy rainfall显示文摘With the increasing incidence of heavy rainfall events,particularly over the monsoon regions,the highly dense populations are more vulnerable[1].Research initiatives on observation,modeling,and prediction of monsoon heavy rainfall have been promoted actively by World Weather Research Programme's(WWRP)Working Group on Tropical Meteorology Research(WGTMR)of the World Meteorological Organization(WMO)since 2010.Series of monsoon-heavy-rainfall workshops were held in Beijing(2011),Petaling Jaya(2012),and New Delhi(2015)to benefit scientists worldwide and forecasters from the National Meteorological and Hydrological Services.An international Research and Development Project,namely,the Southern China Monsoon Rainfall Experiment(SCMREX)[2]was established in 2013 to coordinate field campaign experiments and to conduct scientific research on presummer(April-June)heavy rainfall processes in southern China. | Yali Luo Liye Li Richard HJohnson Chih-Pei Chang Lianshou Chen Wai-Kin Wong Jing Chen Kalli Furtado John LMcBride Ajit Tyagi Nanette Lomarda Thierry Lefort Esperanza O.Cayanan | 2019 | Science Bulletin2019，64，21： | 4 |
| 13 | Graphene-induced Pd nanodendrites: A high performance hybrid nanoelectrocatalyst显示文摘一条灵巧、绿的途径被开发了为在里面基于塑造树突的 Pd, nanostructures 在 graphene (RG ) 上支持了的混合 nanomaterials 的 situ 合成。同样综合的混合 nanomaterials (RG-PdnDs ) 被高分辨率传播电子显微镜学, X 光检查光电子光谱学,原子力量显微镜学,拉曼光谱学和电气化学的技术彻底地描绘了。graphene 支持上的如此的塑造树突的 Pd nanostructures 的形成的机制用 TEM 大小被阐明了。RG 导致形成,并且在塑造起一个明确的作用,它的表面上的 Pd nanostructures 的树突形态学。周期的 voltammetry 和 chronoamperometry 技术被采用了向甲醇的氧化评估 RG-PdnDs 的电气化学的表演。电气化学(EC ) RG-PdnDs 的活动与支持 graphene 的球形形状的 Pd nanostructures,独自一个的 Pd nanodendrites 和商业可得到的 Pd/C 相比对应物。graphene 支持的联合效果和 RG-PdnDs 的树突形态学触发高 electrocatalytic 活动并且导致柔韧的忍耐到毒害的公司。 | Subash Chandra Sahu Aneeya K. Samantarat Ajit Dash R. R. Juluri Ranjan K. Sahu B. K. Mishra Bikash Kumar Jena (1~3) | 2013 | Nano Research2013，6，9： | 4 |
| 14 | Mapping of dwarfing gene Rht14 in durum wheat and its effect on seedling vigor, internode length and plant height显示文摘Short coleoptiles associated with GA-insensitive Rht-1 alleles in wheat reduces yield due to poor seedling establishment under dry, or stubble-retained conditions. Hence there is a need for alternative dwarfing genes for wheat improvement programs. GA-sensitive dwarfing gene Rht14 confers semidwarf stature in wheat while retaining longer coleoptiles and early seedling vigor. Two RIL populations were used to identify the map position of Rht14 and to estimate its effect on plant height, coleoptile length, seedling shoot length,spike length and internode length. Rht14 on chromosome 6 A was mapped in the genomic region 383–422 Mbp flanked by GA2oxA9 and wmc753 in a Bijaga Yellow/Castelporziano RIL population. Recombination events between Rht14 and GA2oxA9 in the RIL population indicated that Rht14 might not be allelic to GA2oxA9. The conserved DNA sequence of GA2oxA9 and its flanking region in Castelporziano also suggested that the point of mutation responsible for the Rht14 allele must be a few Mbp away from GA2oxA9. The dwarfing effects of Rht14 on plant height, internode length and seedling vigor were compared with those of Rht-B1 b in an HI 8498/Castelporziano RIL population. Both genes significantly reduced plant height and internode length. Rht-B1 b conferred a significant reduction in coleoptile length and seedling shoot length, whereas Rht14 reduced plant height, but not coleoptile and seedling shoot length. Therefore, Rht14 can be a used as an alternative to Rht-B1 b for development of cultivars suitable for deeper sowing in dry environments and in conditions of conservation agriculture where crop residues are retained. | Parimal Vikhe Suhasini Venkatesan Ajit Chavan Shubhada Tamhankar Ravindra Patil | 2019 | The Crop Journal2019，7，2： | 4 |
| 15 | Graphene-based flexible and wearable electronics显示文摘Graphene with an exceptional combination of electronic, optical and outstanding mechanical features has been proved to lead a completely different kind of 2-D electronics. The most exciting feature of graphene is its ultra-thin thickness, that can be conformally contacted to any kind of rough surface without losing much of its transparency and conductivity. Graphene has been explored demonstrating various prototype flexible electronic applications, however, its potentiality has been proven wherever transparent conductive electrodes(TCEs) are needed in a flexible, stretchable format. Graphene-based TCEs in flexible electronic applications showed greatly superior performance over their conventionally available competitor indium tin oxide(ITO). Moreover, enormous applications have been emerging, especially in wearable devices that can be potentially used in our daily life as well as in biomedical areas. However, the production of high-quality, defect-free large area graphene is still a challenge and the main hurdle in the commercialization of flexible and wearable products. The objective of the present review paper is to summarize the progress made so far in graphene-based flexible and wearable applications. The current developments including challenges and future perspectives arc also highlighted. | Tanmoy Das Bhupendra K.Sharma Ajit K.Katiyar Jong-Hyun Ahn | 2018 | Journal of Semiconductors2018，39，1： | 4 |
| 16 | A Systemic Approach to Integrated E-maintenance of Large Engineering Plants显示文摘Large engineering plants (LEPs) have certain unique features that necessitate a maintenance strategy that is a combination of both time and condition based maintenance. Although this requirement is appreciated to varying degrees by asset owners, applied research leading to a systematic development of such a maintenance strategy is the need of the day. Such a strategy should also adopt a wholesome 'systemic' approach so that the realization of the overall objectives of maintenance is maximized. E-maintenance has several potential benefits for large engineering plants. In this paper, a three pronged strategy is suggested for the successful implementation of e-maintenance for LEPs. Firstly, an integrated condition and time based maintenance framework is proposed for LEPs. Secondly, reference is drawn to models for condition and time based maintenance at systemic levels. As a part of the ab initio development of a condition monitoring system for a LEP, one of the characteristics of the condition monitoring system, namely, predictability, is discussed in detail as a sample for a systemic study. Thirdly, emphasis is laid on the information and expertise available in the domain of plant design, operation and maintenance and the same is tapped for incorporation in maintenance decision making. | Ajit Kumar Verma A.Srividya P.G.Ramesh | 2010 | International Journal of Automation and computing2010，7，2： | 3 |
| 17 | Corrosion Study of Base Material and Welds of a Ni-Cr-Mo-W Alloy显示文摘Alloys containing chromium(Cr) and molybdenum(Mo),as the major alloying elements,are widely used in various industries where the material experiences corrosive environments.Chromium(Cr),when added in an optimum amount,forms a Cr_2O_3 passive film which protects the underlying metal in aggressive solutions.Molybdenum(Mo) forms its oxides in the low pH solutions,thus,enhances the uniform corrosion resistance of an alloy in reducing acids and assists in inhibition to localized corrosion.Minor alloying elements,like tungsten(W) and copper(Cu),also improve the overall corrosion resistance of an alloy in specific solutions.In the present study,corrosion resistance behavior of commercial ironbased alloys(316L SS,254 SMO and 20Cb3) and nickel-based alloys(Monel 400,Alloy 625 and C-276) was studied in the acidic solutions.While the corrosion behavior of wrought alloys has been widely studied,there is little to no information on the corrosion performance of their welds,typically being the weak regions for corrosion initiation and propagation.Therefore,an attempt was undertaken to investigate the uniform and localized corrosion performance of base metal,simulated heat-affected zone and all-weld-metal samples of a Ni-Cr-Mo-W alloy,C-276.The study was conducted in aggressive acidic solutions.Various corrosion and surface analytical techniques were utilized to analyze the results. | Ajit Mishra | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，4： | 3 |
| 18 | DEM simulation of polydisperse systems of particles in a fluidized bed显示文摘Numerical simulations based on three-dimensional discrete element model (DEM) are conducted for mono-disperse, binary and ternary systems of particles in a fluidized bed. Fluid drag force acting on each particle depending on its size and relative velocity is assigned. The drag coefficient corresponding to Ergun’s correlation is applied to the system of fluidized bed with particle size ratios of 1:1 for the mono-disperse system, 1:1.2, 1:1.4 and 1:2 for the binary system and 1:1.33:2 for the ternary system by keeping total volume and surface area of the particles constant. Results indicated that a reasonable estimation of drag force based on individual particle diameters as compared to that of the mean diameter of the particles is achieved in the fluid cells. The total translational kinetic energy of the particles is found to increase as the particle size ratio increases, suggesting an enhanced momentum transfer in polydisperse particle systems. Systems with wide particle size distribution exhibited higher particle velocities around bubbles, resulting in faster bubble growth and its subsequent rise through the fluidized bed. | Nobuyuki Tagami Ajit Mujumdar Masayuki Horio | 2009 | Particuology2009，7，1： | 3 |
| 19 | Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars显示文摘New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly.Mycobacteria have a unique cell wall.Deletion of the gene for arylamine N-acetyltransferase(NAT)decreases mycobacterial cell wall lipids,particularly the distinctive mycolates,and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis BCG.The nat gene and its associated gene cluster are almost identical in sequence in M.bovis BCG and M.tuberculosis.The gene cluster is essential for intracellular survival of mycobacteria.We have therefore used pure NAT protein for high-throughput screening to identify several classes of small molecules that inhibit NAT activity.Here,we characterize one class of such molecules—triazoles—in relation to its effects on the target enzyme and on both M.bovis BCG and M.tuberculosis.The most potent triazole mimics the effects of deletion of the nat gene on growth,lipid disruption and intracellular survival.We also present the structure-activity relationship between NAT inhibition and effects on mycobacterial growth,and use ligand-protein analysis to give further insight into the structure-activity relationships.We conclude that screening a chemical library with NAT protein yields compounds that have high potential as anti-tubercular agents and that the inhibitors will allow further exploration of the biochemical pathway in which NAT is involved. | Isaac M.Westwood Sanjib Bhakta Angela J.Russell Elizabeth Fullam Matthew C.Anderton Akane Kawamura Andrew W.Mulvaney Richard J.Vickers Veemal Bhowruth Gurdyal S.Besra Ajit Lalvani Stephen G.Davies Edith Sim | 2010 | Protein & Cell2010，1，1： | 3 |
| 20 | Composition, structure and diversity characterization of dry tropical forest of Chhattisgarh using satellite data显示文摘The purpose of this study was to characterize the land use, vegetation structure, and diversity in the Barnowpara Sanctuary, Raipur district, Chhattisgarh, India through the use of satellite remote sensing and GIS. Land cover and vegetation were spatially analyzed by digitally classifying IRS 1D LISS III satellite data using a maximum likelihood algorithm. Later, the variations in structure and diversity in different forest types and classes were quantified by adopting quadratic sampling procedures. Nine land-cover types were delineated: teak forest, dense mixed forest, degraded mixed forest, Sal mixed forest, open mixed forest, young teak plantation, grasslands, agriculture, habitation, and water bodies. The classification accuracy for different land-use classes ranged from 71.23% to 100%. The highest accuracy was observed in water bodies and grassland, followed by habitation and agriculture, teak forest, degraded mixed forest, and dense mixed forest. The accuracy was lower in open mixed forest, and sal mixed forest. Results revealed that density of different forest types varied from 324 to 733 trees ha-1, basal area from 8.13 to 28.87 m2·ha-1 and number of species from 20 to 40. Similarly, the diversity ranged from 1.36 to 2.98, concentration of dominance from 0.06 to 0.49, species richness from 3.88 to 6.86, and beta diversity from 1.29 to 2.21. The sal mixed forest type recorded the highest basal area, diversity was highest in the dense mixed forest, and the teak forest recorded maximum density, which was poor in degraded mixed forests. The study also showed that Normalized Difference Vegetation Index(NDVI) was strongly correlated to with the Shannon Index and species richness. | Tarun Thakur S.L. Swamy Ajit Singh Nain | 2014 | Journal of Forestry Research2014，25，4： | 3 |
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