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| 1 | Non-invasive diagnosis of advanced fibrosis and cirrhosis显示文摘Liver cirrhosis is a common and growing public health problem globally.The diagnosis of cirrhosis portends an increased risk of morbidity and mortality.Liver biopsy is considered the gold standard for diagnosis of cirrhosis and staging of fibrosis.However,despite its universal use,liver biopsy is an invasive and inaccurate gold standard with numerous drawbacks.In order to overcome the limitations of liver biopsy,a number of non-invasive techniques have been investigated for the assessment of cirrhosis.This review will focus on currently available non-invasive markers of cirrhosis.The evidence behind the use of these markers will be highlighted,along with an assessment of diagnostic accuracy and performance characteristics of each test.Non-invasive markers of cirrhosis can be radiologic or serum-based.Radiologic techniques based on ultrasound,magnetic resonance imaging and elastography have been used to assess liver fibrosis.Serum-based biomarkers of cirrhosis have also been developed.These are broadly classified into indirect and direct markers.Indirect biomarkers reflect liver function,which may decline with the onset of cirrhosis.Direct biomarkers,reflect extracellular matrix turnover,and include molecules involved in hepatic fibrogenesis.On the whole,radiologic and serum markers of fibrosis correlate well with biopsy scores,especially when excluding cirrhosis or excluding fibrosis.This feature is certainly clinically useful,and avoids liver biopsy in many cases. | Suraj Sharma Korosh Khalili Geoffrey Christopher Nguyen | 2014 | World Journal of Gastroenterology2014，20，45： | 28 |
| 2 | Investigating the potential of essential oils as penetration enhancer for transdermal losartan delivery: Effectiveness and mechanism of action显示文摘The effect of tea tree oil(TTO),cumin oil(CO),rose oil(RO)and aloe vera oil(AVO)on the skin permeation of losartan potassium(LP)was investigated.In vitro skin permeation studies were carried out using rat skin.The mechanism of skin permeation enhancement of LP by essential oils treatment was evaluated by FTIR,DSC,activation energy measurement and histopathological examination.Both concurrent ethanol/enhancer treatment and neat enhancer pretreatment of rat SC with all the oils produced significance increase in the LP flux over the control.The effectiveness of the oils as the penetration enhancers was found to be in the following descending order:AVO>RO>CO>TTO.However,only AVO was the only enhancer to provide target flux required to deliver the therapeutic transdermal dose of LP.FTIR and DSC spectra of the enhancer treated SC indicated that TTO,CO,RO and AVO increased the LP permeation by extraction of SC lipids.The results of thermodynamic studies and histopathological examination of AVO treated SC suggested additional mechanisms for AVO facilitated permeation i.e.transient reduction in barrier resistance of SC and intracellular transport by dekeratinization of corneocytes which may be attributed to the presence of triglycerides as constituents of AVO.It is feasible to deliver therapeutically effective dose of LP via transdermal route using AVO as penetration enhancer. | Indu Vashisth Abdul Ahad Mohd.Aqil Suraj P.Agarwal | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，5： | 7 |
| 3 | Community Responses to Mountain Tourism:A Case in Bhyundar Valley,Indian Himalaya显示文摘Tourism industry has become an important part of Indian economy,and tourism development has been,however,concentrated to a few areas. Accumulation of tourism activities has reached the critical stage in most of the tourism centers,which pose serious threats to the natural environment. The Bhyundar Valley of Nanda Devi Biosphere Reserve (NDBR) in Uttarakhand State of the Indian Himalaya is a burning example of such problems. Land use/cover changes,deforestation and accumulation of garbage are some of the negative impacts of unregulated tourism in the valley. Unsustainable activities of tourists and villagers in the valley make such problems very severe. To deal with the ongoing problems and ensure community involvement in tourism management and environmental conservation,the Biosphere Reserve Authority introduced ecotourism in the form of Eco Development Committees (EDCs) in the Bhyundar Valley. Study reveals that many problems associated with tourism have been minimized to some extent with the help of EDCs but few are still prevailing in valley. However,the existing attempts to conserve the valley from the negative effects of tourism are inadequate and modifications are needed in the current initiatives. | Ram Babu Singh Suraj Mal Chandra Prakash Kala | 2009 | Journal of Mountain Science2009，6，4： | 6 |
| 4 | Rock fragmentation control in opencast blasting显示文摘The blasting operation plays a pivotal role in the overall economics of opencast mines.The blasting subsystem affects all the other associated sub-systems,i.e.loading,transport,crushing and milling operations.Fragmentation control through effective blast design and its effect on productivity are the challenging tasks for practicing blasting engineer due to inadequate knowledge of actual explosive energy released in the borehole,varying initiation practice in blast design and its effect on explosive energy release characteristic.This paper describes the result of a systematic study on the impact of blast design parameters on rock fragmentation at three mines in India.The mines use draglines and shoveledumper combination for removal of overburden.Despite its pivotal role in controlling the overall economics of a mining operation,the expected blasting performance is often judged almost exclusively on the basis of poorly defined parameters such as powder factor and is often qualitative which results in very subjective assessment of blasting performance.Such an approach is very poor substitutes for accurate assessment of explosive and blasting performance.Ninety one blasts were conducted with varying blast designs and charging patterns,and their impacts on the rock fragmentation were documented.A high-speed camera was deployed to record the detonation sequences of the blasts.The efficiency of the loading machines was also correlated with the mean fragment size obtained from the fragmentation analyses. | P.K.Singh M.P.Roy R.K.Paswan Md.Sarim Suraj Kumar Rakesh Ranjan Jha | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，2： | 5 |
| 5 | Modal analysis of prestressed draft pad of freight wagons using finite element method显示文摘The present work intends to investigate dynamic behaviour of draft gear using finite element method. The longitudinal force that the draft gear absorbs usually leads to the failure of its components, especially, the load bearing draft pads. Dynamic behaviour of an individual draft pad and a draft gear is determined and characterized with exciting frequencies and corresponding mode shapes. The effect of compressive prestress load on the dynamic behaviour of an individual draft pad is also determined as the draft pads in assembled state are under constant axial compressive force in the draft gear. The vibration characteristics of individual draft pad are compared with draft pads that are part of draft gear. The modal analysis gives us a basis for subjecting a draft pad to higher frequency loading for determining its fatigue behaviour. | Sachin Sudhakar Harak Satish Chand Sharma Suraj Prakash Harsha | 2015 | Journal of Modern Transportation2015，23，1： | 4 |
| 6 | Prediction-Adaptation-Resilience(PAR)approach-A new pathway towards future resilience and sustainable development of urban landscape显示文摘Urban land-use planning,especially in the peripheral region,has become an issue in contemporary urban stud-ies.Simultaneously,urban resilience is very indispensable for future urban land use planning and management.Therefore,consistent urban proliferation can be coped through Prediction-Adaptation-Resilience(PAR),to accom-plish future urban land use and sustainable development of any growing up urban areas worldwide.Therefore,different dynamic simulation models,e.g.Cellular automata-Markov model,artificial neural network,are used to project and predict any urban areas’spatial growth.Then,the adaptation strategies are taken to assess the urban land use transformation in the past and present context.Those strategies help to strengthen urban land use planning using an integrated supply and demand chain.Finally,this study checks the resilience of how much it will be threatened or saved for future sustainable urban developmental goals and urban resilience.Therefore,it is important to establish a conceptual framework to achieve Sustainable Development Goals(SDGs)based on principles of the PAR approach.Advocating the on-going adaptation of sustainability,resilience,and rapid urban transformation in the developing cities requires clear and explicit definitions that are embedded with the recent and particular context.Thus,government and policy makers should draw their attention to make proper urban landscape planning and adaptation strategies for the future urban expansion in a holistic way by maintaining appropriate urban resilience. | Suraj Kumar Mallick | 2021 | Geography and Sustainability2021，2，2： | 3 |
| 7 | Mild Encephalopathy/Encephalitis with a Reversible Splenial Lesion(MERS):A Report of Five Neonatal Cases显示文摘Mild encephalopathy/encephalitis with a reversible splenial(MERS) lesion is a clinic-radiological entity. The clinical features of MERS in neonates are still not systemically reported. This paper presents five cases of MERS, and the up-to-date reviews of previously reported cases were collected and analyzed in the literature. Here we describe five cases clinically diagnosed with MERS. All of them were neonates and the average age was about 4 days. They were admitted for the common neurological symptoms such as hyperspasmia, poor reactivity and delirium. Auxiliary examinations during hospitalization also exhibited features in common. In this report, we reached following conclusions. Firstly, magnetic resonance imaging revealed solitary or comprehensive lesions in the splenium of corpus callosum, some of them extending to almost the whole corpus callosum. The lesions showed low intensity signal on T1-weighted images, homogeneously hyperintense signal on T2-weighted images, fluid-attenuated inversion recovery and diffusion-weighted images, and exhibited an obvious reduced diffusion on apparent diffusion coefficient map. Moreover, the lesions in the magnetic resonance imaging disappeared very quickly even prior to the clinical recovery. Secondly, all the cases depicted here suffered electrolyte disturbances especially hyponatremia which could be easily corrected. Lastly, all of the cases recovered quickly over one week to one month and majority of them exhibited signs of infections and normal electroencephalography. | 孙丹 陈文红 suraj baralc 王娟 刘智胜 夏远鹏 陈磊 | 2017 | Journal of Huazhong University of Science and Technology(Medical Sciences)2017，37，3： | 3 |
| 8 | Effect of pioglitazone on nerve conduction velocity of the median nerve in the carpal tunnel in type 2 diabetes patients显示文摘AIM To evaluate the impact of pioglitazone pharmacotherapy in median nerve electrophysiology in the carpal tunnel among type 2 diabetes patients.METHODS The study was executed in patients with type 2 diabetes, treated with oral drugs, categorized under pioglitazone or non-pioglitazone group(14 in each group), and who received electrophysiological evaluation by nerve conduction velocity at baseline and 3 mo.RESULTS At 3 mo, pioglitazone-category had inferior amplitude in sensory median nerve [8.5 interquartile range(IQR) = 6.5 to 11.5) vs non-pioglitazone 14.5(IQR 10.5 to 18.75)](P = 0.002). Non-pioglitazone category displayed amelioration in amplitude in the sensory median nerve [baseline 13(IQR = 9 to 16.25) vs 3 mo 8.5(IQR = 6.5 to 11.5)](P = 0.01) and amplitude in motor median nerve [baseline 9(IQR = 4.75 to 11) vs 3 mo 6.75(IQR = 4.75 to 10.25)](P = 0.049); and deterioration of terminal latency of in motor ulnar nerve [baseline 2.07(IQR = 1.92 to 2.25) vs 3 mo 2.16(IQR = 1.97 to 2.325)](P = 0.043). There was amelioration of terminal latency in sensory ulnar nerve [baseline 2.45(IQR = 2.315 to 2.88) vs 3 mo 2.37(IQR = 2.275 to 2.445) for pioglitazone group(P = 0.038).CONCLUSION Treatment with pioglitazone accentuates probability of compressive neuropathy. In spite of comparable glycemic control over 3 mo, patients treated with pioglitazone showed superior electrophysiological parameters for the ulnar nerve. Pioglitazone has favourable outcome in nerve electrophysiology which was repealed when the nerve was subjected to compressive neuropathy. | Sudip Chatterjee Debmalya Sanyal Sourav Das Choudhury Mili Bandyopadhyay Suraj Chakraborty Arabinda Mukherjee | 2016 | World Journal of Diabetes2016，7，19： | 3 |
| 9 | Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores显示文摘The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging.In this work,we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors.C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most nearinfrared dyes.We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+and Fe^(3+)ions in aqueous media. | Fabio de Moliner Ina Biazruchka Karolina Konsewicz Sam Benson Suraj Singh Jun-Seok Lee Marc Vendrell | 2022 | Frontiers of Chemical Science and Engineering2022，16，1： | 2 |
| 10 | 生物陶瓷人工听骨在开放式鼓室成形术中的应用显示文摘目的:探讨生物陶瓷人工听骨在开放式鼓室成形术中应用的效果。方法:2010年1月至2014年12月间慢性化脓性中耳乳突炎的患者96例98耳,行开放式乳突根治鼓室成形术中应用生物陶瓷人工听骨作听骨链重建术,经1年以上随访,分析疾病康复和听力提高的效果。结果:鼓膜修补一次成功97耳,1耳术后鼓膜出现小穿孔。术后中耳乳突腔2个月干耳的85耳、3个月干耳10耳、〉3个月干耳3耳;术后迟发性面瘫1例,治疗康复。术后换药眩晕2例、耳廓软骨膜炎1例。术后12个月,98耳听力保存了术前相同或高于术前的听力水平。听力测试:语言频率平均气导听阈在30dBHL内有4例5耳,听力提高20-30dBHL 32耳,10-20dBHL26耳,0~10dBHL35耳。以听力提高10dBHL以上为有效,听力提高有效率为64.3%(63/98)。结论:生物陶瓷人工听骨生物相容性好,疗效确切,无不良反应, | Chandra Sharma Suraj 田兴德 强笔 李彦 张云龙 | 2016 | 长江大学学报(自科版)(下旬)2016，13，6： | 2 |
| 11 | A Rare Presentation of Subacute Progressive Ascending Myelopathy Secondary to Cement Leakage in Percutaneous Vertebroplasty显示文摘 | Rohit Prakash Bhide Apurba Barman Shiela Mary Varghese Ahana Chatterjee Suraj Mammen Jacob George Raji Thomas | 2014 | American Journal of Physical Medicine & Rehabilitation2014，，5： | 2 |
| 12 | Literal Approximations to Aircraft Dynamic Modes显示文摘 | Ananthkrishnan N Suraj Unnikrishnan | 2001 | Journal of Guidance Control and Dynamics2001，24，6： | 1 |
| 13 | Effect of flow rate and subcooling on spray heat transfer on microporous copper surfaces 显示文摘 | SURAJ J T SREEKANT N RONGGUI Y | 2014 | International Journal of Heat and Mass Transfer2014，69，： | 1 |
| 14 | A Petri net system: An overview显示文摘 | Suraj Z Fryc B Matusiewicz Z | 2006 | Fundamenta Informaticae2006，71，1： | 1 |
| 15 | Assessment of surface and subsurface waterlogging, water level fluctuations, and lithological variations for evaluating groundwater resources in Ganga Plains显示文摘In the present study,the multi-temporal satellite images of IRS P6 LISS III were used to map waterlogging dynamics over different seasons.An area of 594.36 km2(6.75%)and 4.17 km^(2)(0.04%)was affected by surface waterlogging during pre and postmonsoon season,respectively.The average annual groundwater level fluctuations were calculated using 18 years(1990-2007)pre and postmonsoon groundwater level data to identify the areas which are under groundwater induced waterlogging conditions.The soil map clearly indicates that salinity and sodicity exhibit the highest severity and occur in areas with shallow groundwater levels.The hydrogeomorphical units mapped using IRS P6 LISS III satellite images are flood plain,alluvial plain,paleochannels,and oxbow lakes.The study revealed that 44.65%areas have very good to excellent groundwater resources.The litholog data clearly indicate an alternating sequence of clay and sand in which deep aquifers made up of coarse sand would be best suited for adequate water supply and good groundwater quality.The integrated study utilizing digital spatial data pertaining to waterlogging,soil salinity,water level fluctuation,and lithological variation proved that planning of any surface and subsurface water resources development activity should be taken up after assessments of said parameters. | Arvind Chandra Pandey Suraj Kumar Singh M.S.Nathawat Dipankar Saha | 2013 | International Journal of Digital Earth2013，6，3： | 1 |
| 16 | MTHFR C677T polymorphism and its homocysteine‐driven effect on blood pressure显示文摘 | K. N. Saraswathy Priyanka Rani Garg Kabita Salam Shipra Joshi Suraj Singh Huidrom Pradeep Kumar Ghosh | 2014 | Int J Stroke2014，，： | 1 |
| 17 | Internal hernias after laparoscopic Roux-en-Y gastric bypass显示文摘 | Ernesto Garza Joseph Kuhn David Arnold William Nicholson Suraj Reddy Todd McCarty | 2004 | The American Journal of Surgery2004，，6： | 1 |
| 18 | The development and comparison of bio-thermoset plastics from epoxidized plant oils 显示文摘 | Joo Ran Kim Suraj Sharma | 2012 | Industrial Crops and Products2012，36，： | 1 |
| 19 | The effect of micronization on kaolinites and their sorption behaviour显示文摘 | Suraj G Iyer C S P Rugmini S | | 0，，1： | 1 |
| 20 | Decadal trends in precipitable water vapor over the Indus River Basin using ERA5 reanalysis data显示文摘Precipitable Water Vapor(PWV)constitutes a pivotal parameter within the domains of atmospheric science,and remote sensing due to its profound influence on Earth’s climate dynamics and weather patterns.It exerts a significant impact on atmospheric stability absorption and emission of radiation,thus engendering alterations in the Earth’s radiative equilibrium.As such,precise quantification of PWV holds the potential to enhance weather prognostication and fortify preparedness against severe meteorological phenomena.This study aimed to elucidate the spatial and temporal changes in seasonal and annual PWV across the Indus River Basin and its sub-basins using ERA5 reanalysis datasets.The present study used ERA5 PWV(entire atmospheric column),air temperature at 2 m(t2m)and 500 hPa(T_500hPa),evapotranspiration,and total cloud cover data from 1960 to 2021.Theil Sen slope estimator and Mann-Kendall test were used for trend analysis.Correlation and multiple regression methods were used to understand the association of PWV with other factors.The findings have unveiled the highest increase in mean PWV during the monsoon(0.40 mm/decade),followed by premonsoon(0.37 mm/decade),post-monsoon(0.27 mm/decade),and winter(0.19 mm/decade)throughout the study period.Additionally,the mean PWV exhibited the most pronounced positive trend in the sub-basin Lower Indus(LI),followed by Panjnad(P),Kabul(K),and Upper Indus(UI)across all seasons,except winter.Annual PWV has also risen in the Indus basin and its sub-basins over the last six decades.PWV exhibits a consistent upward trend up to an elevation of 3500 m within the basin which is most pronounced during the monsoon season,followed by the pre-monsoon.The escalating PWV within the basin is reasonably ascribed to increasing air temperatures,augmented evapotranspiration,and heightened cloud cover.These findings hold potential utility for pertinent authorities engaged in water resource management and planning. | Seema RANI Jyotsna SINGH Subhash SINGH Purushottam TIWARI Suraj MAL | 2023 | Journal of Mountain Science2023，20，10： | 1 |
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