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| 1 | Role of surgery in colorectal cancer liver metastases显示文摘Colorectal carcinoma(CRC)is the third most common cancer,and approximately 35%-55%of patients with CRC will develop hepatic metastases during the course of their disease.Surgical resection represents the only chance of long-term survival.The goal of surgery should be to resect all metastases with negative histological margins while preserving sufficient functional hepatic parenchyma.Although resection remains the only chance of long-term survival,management strategies should be tailored for each case.For patients with extensive metastatic disease who would otherwise be unresectable,the combination of advances in medical therapy,such as systemic chemotherapy(CTX),and the improvement in surgical techniques for metastatic disease,have enhanced prognosis with prolongation of the median survival rate and cure.The use of portal vein embolization and preoperative CTX may also increase the number of patients suitable for surgical treatment.Despite current treatment options,many patients still experience a recurrence after hepatic resection.More active systemic CTX agents are beingused increasingly as adjuvant therapy either before or after surgery.Local tumor ablative therapies,such as microwave coagulation therapy and radiofrequency ablation therapy,should be considered as an adjunct to hepatic resection,in which resection cannot deal with all of the tumor lesions.Formulation of an individualized plan,which combines surgery with systemic CTX,is a necessary task of the multidisciplinary team.The aim of this paper is to discuss different approaches for patients that are treated due to CRC liver metastasis. | ?zgür Akgül Erdin? ?etinkaya ?iyar Ers?z Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，20： | 40 |
| 2 | Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis显示文摘AIM: To evaluate the accuracy of red cell distribution width(RDW) to platelet ratio(RPR) to predict in-hospital mortality in acute pancreatitis(AP).METHODS: Between January 2010 and June 2012, 102 patients with AP were recruited to the study. In this retrospective cohort study, for all subjects, demographic data on hospital admission, AP etiology, comorbid diseases, organ failure assessment, laboratory parameters and length of hospital stay were examined. Additionally, we used a non-invasive prediction method in addition to the RPR to evaluate the disease severity. Multivariate logistic regression analyses were used to evaluate the impact of RPR on hospital admission to predict mortality.RESULTS:The male-female ratio(59/43)was 1.37with a median age of 56.5 years(17-89 years).In both univariate and multivariate analyses,RDW and RPR were presented as independent and significant variables on admission to predict mortality.The RPR obtained on hospital admission was persistently higher amongnon-survivors than among survivors(P<0.0001).The median RPR was 0.000087 in the non-survivor group and 0.000058 in the survivor group.RPR with a cutoff value of 0.000067 presented an area under the curve of 0.783(95%CI:0.688-0.878)in receiver operating characteristic curves and could predict the mortality of approximately 80%of the patients. | Erdin etinkaya Kazim Senol Baris Saylam Mesut Tez | 2014 | World Journal of Gastroenterology2014，20，39： | 38 |
| 3 | Gastric carcinogenesis显示文摘Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in chemotherapy and radiotherapy, there are still 700 000 gastric cancer-related deaths per year worldwide and more than 80% of patients with advanced gastric cancer die of the disease or recurrent disease within 1 year after diagnosis. None of the treatment modalities we have been applying today can influence the overall survival rates:at present, the overall 5-year relative survival rate for gastric cancer is about 28%. Cellular metaplasia due to chronic inflammation, injury and repair are the most documented processes for neoplasia. It appears that chronic inflammation stimulates tumor development and plays a critical role in initiating, sustaining and advancing tumor growth. It is also evident that not all inflammation is tumorigenic. Additional mutations can be acquired, and this leads to the cancer cell gaining a further growth advantage and acquiring a more malignant phenotype. Intestinalization of gastric units, which is called 'intestinal metaplasia'; phenotypic antralization of fundic units, which is called 'spasmolytic polypeptide-expressing metaplasia'; and the development directly from the stem/progenitor cellzone are three pathways that have been described for gastric carcinogenesis. Also, an important factor for the development of gastrointestinal cancers is peritumoral stroma. However, the initiating cellular event in gastric metaplasia is still controversial. Understanding gastric carcinogenesis and its precursor lesions has been under intense investigation, and our paper attempts to highlight recent progress in this field of cancer research. | Ismail Gomceli Baris Demiriz Mesut Tez | 2012 | World Journal of Gastroenterology2012，18，37： | 25 |
| 4 | Removal of heavy metals from aqueous solution by sawdust adsorption显示文摘从由锯屑 ofwalnut 的水的答案的铅,镉和 nicel 的吸附是接触时间,起始的金属离子集中和 temperatureon 金属离子移动的 investigated.The 效果是平衡时间被发现具有 .Kinetics 适合的 60min 的顺序的 studied.The 假一阶,秒顺序和 intraparticle 散开模型,因此 adsorptionrate 常数是在 25,45 的温度的金属离子的 calculated.The 吸附数据, 60deg C 被 Freundlich | BULUT Yasemin TEZ Zeki | 2007 | Journal of Environmental Sciences2007，19，2： | 17 |
| 5 | Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection显示文摘AIM To evaluate the prognostic significance of neutrophilto-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), lymphocyte-to-monocyte ratio(LMR), and prognostic nutritional index(PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer.METHODS183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels(CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival(months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database. The primary outcome measure was overall survival.RESULTS Regarding overall survival, on univariate analysis the following variables were significantly associated with poor outcome following resection: T-stage(P = 0.037), lymph node invasion(P = 0.037), cancer stage(P = 0.034), CEA(P = 0.042), CA19-9(P = 0.004), and PNI(P = 0.001). To evaluate the independent prognostic value, multivariate Cox proportional hazard analysis to control for other prognostic factors was used. Using cancer-specific death as an end point for NLR, PLR, LMR, PNI and CA19-9 the optimal cut off values were calculated by ROC analysis. Regarding overall survival, on multivariate analysis high CA19-9(HR = 1.001, 95%CI: 1.00-1.002, P = 0.012) and low PNI(HR = 0.938, 95%CI: 0.891-0.987, P = 0.014) were the only variables independently associated with shortened overall survival. Patients with a PNI < 35 had a median OS of 52.25 mo. In contrast, patients with an PNI > 35 had a median OS of 66 mo. Patients with a CA 19-9 < 17 had a median OS of 66 mo and in patients with a CA19-9 > 17 had a median OS of 53.76 mo.CONCLUSION This study shows that decrease in the PNI and increase in CA 19-9 is associated with poor survival in patients with resectable colon cancer. | özgür Akgül Erdinc Cetinkaya Metin Yalaza Sabri özden Mesut Tez | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 11 |
| 6 | Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1 vs University of Wisconsin appraisal显示文摘AIM To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin(UW) and Institut Georges Lopez-1(IGL-1)solutions.METHODS Fatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 ℃and subjected to 'ex vivo ' normo-thermic perfusion(2 h; 37 ℃). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography. Total free amino acid release was correlated with the activation of the ubiquitin proteasome system(UPS: measured as chymotryptic-like activity and 20 S and 19 S proteasome), the prevention of liver injury(transaminases), mitochondrial injury(confocal microscopy) and inflammation markers(TNF 1 alpha, high mobility group box-1(HGMB-1) and PPAR gamma), and liver apoptosis(TUNEL assay, cytochrome c and caspase 3).RESULTS Profiles of free AA(alanine, proline, leucine, isoleucine, methionine, lysine, ornithine, and threonine, among others) were similar for tissue and reperfusion effluent. In all cases, the IGL-1 solution showed a significantly higher prevention of proteolysis than UW(P < 0.05) after cold ischemia reperfusion. Livers conserved in IGL-1 presented more effective prevention of ATP-breakdown and more inhibition of UPS activity(measured as chymotryptic-like activity). In addition, the prevention of liver proteolysis and UPS activation correlated with the prevention of liver injury(AST/ALT) and mitochondrial damage(revealed by confocal microscopy findings) as well as with the prevention of inflammatory markers(TNF1alpha and HMGB) after reperfusion. In addition, the liver grafts preserved in IGL-1 showed a significant decrease in liver apoptosis, as shown by TUNEL assay and the reduction of cytochrome c, caspase 3 and P62 levels. CONCLUSION Our comparison of these two preservation solutions suggests that IGL-1 helps to prevent ATP breakdown more effectively than UW and subsequently achieves a higher UPS inhibition and reduced liver proteolysis. | Mohamed Amine Zaouali Arnau Panisello-Roselló Alexandre Lopez Carlos Castro Benítez Emma Folch-Puy Agustín García-Gil Teresa Carbonell RenéAdam Joan Roselló-Catafau | 2017 | World Journal of Gastroenterology2017，23，23： | 3 |
| 7 | Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients显示文摘 | Martínez-Llordella Marc Lozano Juan José Puig-Pey Isabel Orlando Giuseppe Tisone Giuseppe Lerut Jan Benítez Carlos Pons Jose Antonio Parrilla Pascual Ramírez Pablo Bruguera Miquel Rimola Antoni Sánchez-Fueyo Alberto | 2008 | Journal of Clinical Investigation2008，，8： | 3 |
| 8 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 9 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 10 | Polyethylene glycols: An effective strategy for limiting liver ischemia reperfusion injury显示文摘Liver ischemia-reperfusion injury(IRI) is an inherent feature of liver surgery and liver transplantation in which damage to a hypoxic organ(ischemia) is exacerbated following the return of oxygen delivery(reperfusion). IRI is a major cause of primary nonfunction after transplantation and may lead to graft rejection, regardless of immunological considerations. The immediate response involves the disruption of cellular mitochondrial oxidative phosphorylation and the accumulation of metabolic intermediates during the ischemic period, and oxidative stress during blood flow restoration. Moreover, a complex cascade of inflammatory mediators is generated during reperfusion, contributing to the extension of the damage and finally to organ failure. A variety of pharmacological interventions(antioxidants, anticytokines, etc.) have been proposed to alleviate graft injury but their usefulness is limited by the local and specific action of the drugs and by their potential undesirable toxic effects. Polyethylene glycols(PEGs), which are non-toxic water-soluble compounds approved by the FDA, have been widely used as a vehicle or a base in food, cosmetics and pharmaceuticals, and also as adjuvants for ameliorating drug pharmacokinetics. Some PEGs are also currently used as additives in organ preservation solutions prior to transplantation in order to limit the damage associated with cold ischemia reperfusion. More recently, the administration of PEGs of different molecular weights by intravenous injection has emerged as a new therapeutic tool to protect liver grafts from IRI. In this review, we summarize the current knowledge concerning the use of PEGs as a useful target for limiting liver IRI. | Gianfranco Pasut Arnau Panisello Emma Folch-Puy Alexandre Lopez Carlos Castro-Benítez Maria Calvo Teresa Carbonell Agustín García-Gil RenéAdam Joan Roselló-Catafau | 2016 | World Journal of Gastroenterology2016，22，28： | 3 |
| 11 | Can biliary-cyst communication be predicted before surgery for hepatic hydatid disease: does size matter?显示文摘 | Mehmet Kilic Omer Yoldas Mahmut Koc Mehmet Keskek Nazile Karakose Tamer Ertan Erdal Gocmen Mesut Tez | 2008 | The American Journal of Surgery2008，，5： | 2 |
| 12 | 混凝土路面砖抗折强度试验方法的验证试验研究显示文摘本文介绍阿根廷国家标准IRAM11656中,有关混凝土路面砖力学强度检测方法的演变过程。在该标准的1998年版本中,曾对强度试验方法和指标进行过修改,将原来从路面砖上取样进行轴向抗压强度试验,修改为用垫压板法对整砖进行抗压强度试验,压板大小取决于路面砖的厚度。2006年对该标准再次进行修订,修订过程在取得大量试验研究数据的基础上,阿根廷波特兰水泥协会提议参照哥伦比亚NTC2017标准,将对路面砖进行抗压强度检测,改变为对其进行抗折强度检测;并认为抗折强度值更能代表混凝土路面砖在路面使用中的受力情况。我们研究了抗折强度试验方法的一些影响因素,例如:NTC2017标准中所用抗折试验装置的适用性、在抗折支座和路面砖样品之间是否需垫橡胶条、是否需对路面砖先进行干燥,以及混凝土抗压强度、吸水率、密度与路面砖抗折强度之间的相互关系,等等。协调安排多家试验室进行比对试验,以验证其它实验室所取得的混凝土路面砖抗折强度的试验结果。对验证试验的方法、数据等进行分析,建立路面砖抗折试验结果再现性和复验性的数据库。这些实验室研究工作,加快了IRAM11656标准的修订过程。正式批准之后,这项标准已被用于混凝土路面砖产品的自愿认定程序,纳入建筑材料质量保证体系。 | Benítez Alexandra Bertone John Civitillo Paul 崔玉忠 | 2010 | 建筑砌块与砌块建筑2010，，5： | 2 |
| 13 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 14 | Few-mode fibre-optic microwave photonic links显示文摘The fibre-optic microwave photonic link has become one of the basic building blocks for microwave photonics.Increasing the optical power at the receiver is the best way to improve all link performance metrics including gain,noise figure and dynamic range.Even though lasers can produce and photodetectors can receive optical powers on the order of a Watt or more,the power-handling capability of optical fibres is orders-of-magnitude lower.In this paper,we propose and demonstrate the use of few-mode fibres to bridge this power-handling gap,exploiting their unique features of small acousto-optic effective area,large effective areas of optical modes,as well as orthogonality and walk-off among spatial modes.Using specially designed few-mode fibres,we demonstrate order-of-magnitude improvements in link performances for single-channel and multiplexed transmission.This work represents the first step in few-mode microwave photonics.The spatial degrees of freedom can also offer other functionalities such as large,tunable delays based on modal dispersion and wavelength-independent lossless signal combining,which are indispensable in microwave photonics. | He Wen Hongjun Zheng Qi Mo Amado Manuel Velázquez-Benítez Cen Xia Bin Huang Huiyuan Liu Huang Yu Pierre Sillard Jose Enrique Antonio Lopez Rodrigo Amezcua Correa Guifang Li | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 15 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015，，2： | 2 |
| 16 | Atypical teratoid/rhabdoid tumors : imaging findings of two cases and review of the literature 显示文摘 | Tez S Koktener A Guler G | 2008 | Turk Neurosurg2008，18，1： | 1 |
| 17 | Increased antifungal activity of Tfichoderma harzianum transformants that overexpress a 33-kDa chitinase显示文摘 | Limon M C Pintor-Toro J A Benítez T | 1999 | Phytopathol1999，89，： | 1 |
| 18 | High-efficiency LED backlight optics designed with the flow-line method显示文摘 | MINANO J C BEN(I)TEZ P CHAVES J | | 0，，： | 1 |
| 19 | Serum VEGF levels in gastric cancer patients:correlation with clinicopathological parameters显示文摘 | Bilgic CI Tez M | 2015 | Turk J Med Sci2015，45，1： | 1 |
| 20 | Secondary Forests as Tem- porary Carbon Sinks?The Economic Impact of Accounting Methods on Reforestation Projects in the Tropics显示文摘 | OLSCHEWSKI R BEN~TEZ P C | 2005 | Ecolog- ical Economics2005，55，3： | 1 |
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