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| 1 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 2 | 新一代电子维护系统的系统框架显示文摘未来的制造工业必须能够适应全球化的企业竞争。对于复杂的设计制造行为 ,需要一种简便的管理集成系统的机制 ,在这方面 ,信息技术将会扮演一个不可或缺的角色。为了售后服务的需要 ,要提高对产品性能的理解 ,这将引起质量维护的电子智能化。随着产品、制造和维护系统中更好的电子智能集成 ,制造商和用户方都会从设备和工艺可靠性的提高中受益。 | Muammer Koc Jay Lee 邓军民 | 2001 | 中国机械工程2001，12，5： | 8 |
| 3 | H pylori:Treatment for the patient only or the whole family?显示文摘AIM:To compare the effects of treatment of H pylori-infected individuals with the effects of treatment of individuals as well as all H pylori-infected family members. METHODS:H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all H pylori-positive family members living together (groupⅠ) or patients only (group Ⅱ). Nine months after treatment, all patients were assessed for H pylori positivity. RESULTS:There were 70 H pylori-positive patients in each group;patients in groupsⅠand Ⅱ lived with 175 and 190 H pylori-positive relatives, respectively. Age, sex and H pylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, H pylori positivity was 7.1% in groupⅠpatients and 38.6% in group Ⅱ patients [P < 0.01, OR = 8.61 95% confidence interval (CI):2.91-22.84]. CONCLUSION:The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pylori-positive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high;they also suggest patients, their spouses and all H pylori-positive family members of H pylori-positive individuals should be treated for H pylori infection. | Yavuz Selim Sari Didem Can Vahit Tunali Orhan Sahin Oguz Koc Omer Bender | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 4 | Fluid Inclusion Studies and Geochemistry of Rare Earth Elements of Hydrothermal Fluorites from Pohrenk,Kirsehir,Central Turkey显示文摘Fluorite mineralization occurs along fractures and cracks of Middle Eocene and Pliocene limestones and marls in the north and northeast of the P?hrenk region (?i?ekdagi, Kirsehir). Tb/Ca ( Tb/La and Y/Ho ratios were obtained from REE contents of fluorites which have revealed that mineralization is of hydrothermal type. Negative Ce anomalies and positive Eu anomalies reflect that hydrothermal solutions once had high oxygen fugacity. Fluid inclusion studies indicate that homogenization temperatures of mineralization varied between 90oC and 200oC, and hydrothermal solutions are composed of NaCl + KCl + MgCl2 + H2O. In addition, salinity measurements show that hydrothermal solutions were mixed with meteoric or rock formation water. Geologic setting, REE geochemistry and fluid inclusion studies suggest that mineralization was deposited from a solution generated by mixing of magmatic and meteoric water under epithermal conditions. | Sükrü KOC Ali RECBER | 2001 | Acta Geologica Sinica(English Edition)2001，75，1： | 5 |
| 5 | Comparison of Densiron 68 and 1 000 cSt silicone oil in the management of rhegmatogenous retinal detachment with inferior breaks显示文摘AIM:To compare success rates and complications of Densiron 68 and 1000cSt silicone oil (SO) in the management of rhegmatogenous retinal detachment (RRD) with inferior breaks (IBs). METHODS:Totally 61 eyes of 61 consecutive patients with RRD with IBs were assigned to pars plana vitrectomy (PPV) with Densiron (n =31) or PPV with SO (n=30) in order of presentation. SO and Densiron removal was performed 3 months after initial surgery. Follow up visits were terminated 6 months after SO removal. ·RESULTS:With a single operation, the Densiron group showed 84% and SO 74% reattachment. With further surgery, both groups showed 90% reattachment. Complications such as cataract, raised intraocular pressure (IOP), inflammatory reaction, macular epiretinal membranes, and emulsification of SO were seen in both groups. CONCLUSION:Densiron and SO are found to have similar success rates and complications. | Ibrahim Kocak Haci Koc | 2013 | International Journal of Ophthalmology(English edition)2013，6，1： | 4 |
| 6 | Unusual complication in patient with Gardner's syndrome: Coexistence of triple gastrointestinal perforation and lower gastrointestinal bleeding: A case report and review of literature显示文摘Gardner's syndrome(GS) is a rare syndrome with autosomal dominant inheritance, which is characterized by multiple intestinal polyps, dental anomalies, desmoid tumors, and soft tissue tumors. All gastrointestinal symptoms seen in GS are associated with the underlying familial adenomatosis polyposis and abdominal desmoid tumors, with the most common symptoms being anemia, lower gastrointestinal bleeding, abdominal pain, diarrhea, obstruction, and mucous defecation. To our best knowledge, no case of GS that has presented with gastrointestinal perforation and bleeding has ever been reported in the English language medical literature. A 37-year-old male who had been diagnosed with GS five years earlier was referred to our clinic for lower gastrointestinal bleeding. Despite the absence of a bleeding focus on conventional angiography, the patient was operated on with laparotomy, due to the persistence of both signs and symptoms of mild peritonitis. On the laparotomy, the patient was noted to have areas of perforation in the duodenum, splenic flexura, and midrectum. The third and fourth part of the duodenum, the proximal 15 cm segment of the jejunum, a 10 cm segment of the terminal ileum, the whole colon, and the upper and middle rectum were resected, and duodenojejunal side-to-side anastomosis and terminal ileostomy were performed. The histopathological analysis of the large mass measuring 30 cm × 20 cm was reported as a desmoid tumor. The pathological examination of the tumor foci detected in the colonic specimen revealed poorly differentiated adenosquamous carcinoma. | Sami Akbulut Cemalettin Koc Abuzer Dirican | 2018 | World Journal of Clinical Cases2018，6，10： | 4 |
| 7 | 一名无精症和开咬合畸形男性体内的额外标记染色体15显示文摘额外标记染色体15(sSMC[15])是最常见的标记染色体,通常认为如果不包含Prader-Willi/Angelman综合症关键区(Prader-Willi/Angelman syndrome critical region,PWACR),这一标记染色体就无关紧要。较大标记的关键区域的临床意义在几乎所有与标记染色体15相关的报告中都被提及,较小的标记仅与轻微畸形、无精症、习惯性流产相关。然而,这些不包含PWACR的小额外标记染色体15也可能决定某一基因表现型。我们在一个遗传学门诊对一名无精症病人进行畸形检查,根据标准的细胞遗传学方法进行外周血淋巴染色体分析,还对Y染色体微缺失进行了核仁组织区(NOR)连接、C-连接、荧光原位杂交(Fluorescence in situ hybridization,FISH)以及分子学研究。临床评估确定为畸形特征伴有无精症及重度“安氏Ⅱ类1分类开咬合畸形”。分子细胞遗传结果显示有小额外标记染色体15存在,此外,Y染色体微缺失分析显示无精症不是Y染色体微缺失的结果。额外标记染色体15和下颌不规则的症状同时出现在这一病例中,这可能只是巧合,但也可能标明了一个不仅只是无精症的特定表现型,其特征包括不育、颧骨发育不全、下颌不规则、瘢痕瘤形成以及轻微畸形特征。 | Altug Koc Odul Onur Mehmet Ali Ergun E. Ferda Pergin | 2009 | Asian Journal of Andrology2009，11，5： | 4 |
| 8 | Optimization of CNC cutting parameters using design of experiment(DOE) and desirability function显示文摘In this study,2~5 (five factors at two-level factorial design) design of experiment was applied to investigate a set of optimal machining parameters to achieve a minimum surface roughness value for Abies nordmanniana.Wood specimens were prepared using different values of spindle speed,feed rate,depth of cut,tool radius,and cutting directions.Average surface roughness (R_z) values were applied using a stylus.The objectives were to:(1)obtain the effective variables of wood surface roughness;(2) analyze which of these factors had an impact on variability in the CNC machining process;(3) evaluate the optimal cutting values within the range of different cutting levels of machining parameters.The results indicate that the design of experiment(DOE) based on the desirability function approach determined the optimal machining parameters successfully,leading to minimum R_a compared to the observed value.Minimum surface roughness values of tangential and radial cutting directions were 3.58 and 3.21 μm,respectively. | Ender Hazir Emine Seda Erdinler Kücük Hüseyin Koc | 2018 | Journal of Forestry Research2018，29，5： | 3 |
| 9 | Skin disorders in peritoneal dialysis patients:An underdiagnosed subject显示文摘AIM: To examine all skin changes in peritoneal dialysis(PD) patients followed up in our unit.METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded. The demographic, clinical and laboratory data including measures of dialysis adequacy of patients were recorded also. Statistical Package for Social Sciences(SPSS) for Windows 16.0 standard version was used for statistical analysis.RESULTS: Among the patients followed up in our PD unit, those without exclusion criteria who gave informed consent, 38 patients were included in the study with male/female ratio and mean age of 26/12 and 50.3 ± 13.7 years, respectively. The duration of CKD was 7.86 ± 4.16 years and the mean PD duration was 47.1 ± 29.6 mo. Primary kidney disease was diabetic nephropathy in 11, nephrosclerosis in six, uropathologies in four, chronic glomerulonephritis in three, chronic pyelonephritis in three, autosomal dominant polycystic kidney disease in three patients while cause was unknown in eight patients. All patients except for one patient had at least one skin lesion. Loss of lunula, onychomycosis and tinea pedis are the most frequent skin disorders recorded in the study group. Diabetic patients had tinea pedis more frequently(P = 0.045). No relationship of skin findings was detected with primary renal diseases, comorbidities and medications that the patients were using.CONCLUSION: Skin abnormalities are common in in PD patients. The most frequent skin pathologies are onychomycosis and tinea pedis which must not be overlooked. | Meltem Gursu Sami Uzun Derya Topcuoglu Leyli Kadriye Koc Lamiye Yucel Abdullah Sumnu Egemen Cebeci Oktay Ozkan Ahmet Behlul Leyla Koc Savas Ozturk Rumeyza Kazancioglu | 2016 | World Journal of Nephrology2016，5，4： | 3 |
| 10 | Results of docetaxel plus oxaliplatin (DOCOX) ± cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomized phase 2 study显示文摘 | Donald Richards Darren M. Kocs Alexander I. Spira A. David McCollum Sami Diab Lanny I. Hecker Allen Cohn Feng Zhan Lina Asmar | 2013 | European Journal of Cancer2013，，： | 3 |
| 11 | Can biliary-cyst communication be predicted before surgery for hepatic hydatid disease: does size matter?显示文摘 | Mehmet Kilic Omer Yoldas Mahmut Koc Mehmet Keskek Nazile Karakose Tamer Ertan Erdal Gocmen Mesut Tez | 2008 | The American Journal of Surgery2008，，5： | 2 |
| 12 | Longitudinal - Bending Mode Micromotor Using Multilayer Piezoelectric Actuator 显示文摘 | Kui Yao Burhanettin Koc Kenji Uchino | 2001 | IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL2001，48，4： | 2 |
| 13 | Ectopic liver tissue (choristoma) on the gallbladder: Acomprehensive literature review显示文摘BACKGROUND Liver tissue situated outside the liver with a hepatic connection is usually calledan accessory liver, and that without a connection to the mother liver, is calledectopic liver tissue.AIM To identify studies in the literature on ectopic liver tissue located on thegallbladder surface or mesentery.METHODS We present two patients and review published articles on ectopic liver tissuelocated on the gallbladder surface accessed via PubMed, MEDLINE, GoogleScholar, and Google databases. Keywords used included accessory liver lobe,aberrant liver tissue, ectopic liver tissue, ectopic liver nodule, heterotopic livertissue, hepatic choristoma, heterotopic liver tissue on the gallbladder, and ectopicliver tissue on the gallbladder. The search included articles published before June2020 with no language restriction. Letters to the editor, case reports, reviewarticles, original articles, and meeting presentations were included in the search.Articles or abstracts containing adequate information on age, sex, history of liverdisease, preliminary diagnosis, radiologic tools, lesion size, surgical indication,surgical procedure, and histopathological features of ectopic liver tissue wereincluded in the study.RESULTS A total of 72 articles involving 91 cases of ectopic liver tissue located on the gallbladder surface or mesentery were analyzed. Of these 91 patients, 62 werefemale and 25 were male (no gender available for 4 patients), and the age rangewas 5 d to 91 years. Forty-nine patients underwent surgery for chroniccholecystitis or cholelithiasis, and 14 patients underwent surgery for acutecholecystitis. The remaining 28 patients underwent laparotomy for other reasons.Cholecystectomy was laparoscopic in 69 patients and open in 11 patients. Theremaining 19 patients underwent various other surgical procedures such asautopsy, liver transplantation, living donor hepatectomy, Whipple procedure, andliver segment V resection. Histopathologically, hepatocellular carcinoma wasdetected in the ectopic liver tissue of one patient.CONCLUSION Ectopic liver tissue is a rare developmental anomaly which is usually detectedincidentally. Although most studies suggest that ectopic liver located outside thegallbladder has a high risk of hepatocellular carcinoma, this is not reflected instatistical analysis. | Sami Akbulut Khaled Demyati Felat Ciftci Cemalettin Koc Adem Tuncer Emrah Sahin Nese Karadag Sezai Yilmaz | 2020 | World Journal of Gastrointestinal Surgery2020，12，12： | 2 |
| 14 | First-principles study of the structural,elastic,electronic,optical,and vibrational properties of intermetallic Pd_2Ga显示文摘The structural,elastic,electronic,optical,and vibrational properties of the orthorhombic Pd2Ga compound are investigated using the norm-conserving pseudopotentials within the local density approximation in the frame of density functional theory.The calculated lattice parameters have been compared with the experimental values and found to be in good agreement with these results.The second-order elastic constants and the other relevant quantities,such as the Young's modulus,shear modulus,Poisson's ratio,anisotropy factor,sound velocity,and Debye temperature,have been calculated.It is shown that this compound is mechanically stable after analysing the calculated elastic constants.Furthermore,the real and imaginary parts of the dielectric function and the optical constants,such as the optical dielectric constant and the effective number of electrons per unit cell,are calculated and presented.The phonon dispersion curves are derived using the direct method.The present results demonstrate that this compound is dynamically stable. | Yildirim A Koc H Deligoz E | 2012 | Chinese Physics B2012，21，3： | 2 |
| 15 | Analyzing and Comparing Montgomery Multiplication Algorithms显示文摘 | Koc C K Acar T Burton S | 1996 | IEEE Micro1996，16，3： | 1 |
| 16 | A piezoelectric motor using two orthogonal bending modes of a hollow cylinder显示文摘 | Koc B Cagatay S Uchino K | 2002 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2002，49，6： | 1 |
| 17 | Kinetics and phase evolution during carbothermal synthesis of titanium carbide from carbon-coated titania powder显示文摘 | Rasit Koc | 1997 | J Eur Ceram Soc1997，17，： | 1 |
| 18 | Doxycycline plus streptomycin versus ciprofloxacin plus rifampicin in spinal brucellosis显示文摘 | Alp E Koc RK Durak AC | 2006 | BMC Infect Dis2006，72，6： | 1 |
| 19 | On the power of simple branch prediction analysis显示文摘 | O Aclicmez C K Koc J P Seifert | 2006 | Cryptology ePrintArchive2006，，： | 1 |
| 20 | β-SiC production by reacting silica gel with hydrocarbon gas显示文摘 | Rasit Koc | 2001 | Journal of Materials Science2001，36，： | 1 |
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