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| 1 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 2 | Role of community-based active case finding in screening tuberculosis in Yunnan province of China显示文摘Background:The barriers to access diagnosis and receive treatment,in addition to insufficient case identification and reporting,lead to tuberculosis(TB)spreads in communities,especially among hard-to-reach populations.This study evaluated a community-based active case finding(ACF)strategy for the detection of tuberculosis cases among high-risk groups and general population in China between 2013 and 2015.Methods:This retrospective cohort study conducted an ACF in ten communities of Dongchuan County,located in northeast Yunnan Province between 2013 and 2015;and compared to 136 communities that had passive case finding(PCF).The algorithm for ACF was:1)screen for TB symptoms among community enrolled residents by home visits,2)those with positive symptoms along with defined high-risk groups underwent chest X-ray(CXR),followed by sputum microscopy confirmation.TB incidence proportion and the number needed to screen(NNS)to detect one case were calculated to evaluate the ACF strategy compared to PCF,chi-square test was applied to compare the incidence proportion of TB cases'demography and the characteristics for detected cases under different strategies.Thereafter,the incidence rate ratio(IRR)and multiple Fisher's exact test were applied to compare the incidence proportion between general population and high-risk groups.Patient and diagnostic delays for ACF and PCF were compared by Wilcoxon rank sum test.Results:A total of 97521 enrolled residents were visited with the ACF cumulatively,12.3%were defined as highrisk groups or had TB symptoms.Sixty-six new TB patients were detected by ACF.There was no significant difference between the cumulative TB incidence proportion for ACF(67.7/100000 population)and the prevalence for PCF(62.6/100000 population)during 2013 to 2015,though the incidence proportion in ACF communities decreased after three rounds active screening,concurrent with the remained stable prevalence in PCF communities.The cumulative NNS were 34,39 and 29 in HIV/AIDS infected individuals,people with positive TB symptoms and history of previous TB,respectively,compared to 1478 in the general population.The median patient delay under ACF was 1 day(Interquartile range,IQR:0-27)compared to PCF with 30 days(IQR:14-61).Conclusions:This study confirmed that massive ACF was not effective in general population in a moderate TB prevalence setting.The priority should be the definition and targeting of high-risk groups in the community before the screening process is launched.The shorter time interval of ACF between TB symptoms onset and linkage to healthcare service may decrease the risk of TB community transmission.Furthermore,integrated ACF strategy in the National Project of Basic Public Health Service may have long term public health impact. | Jin-Ou Chen Yu-Bing Qiu Zulma Vanessa Rueda Jing-Long Hou Kun-Yun Lu Liu-Ping Chen Wei-Wei Su Li Huang Fei Zhao Tao Li Lin Xu | 2019 | Infectious Diseases of Poverty2019，8，5： | 4 |
| 3 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 4 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 5 | Analysis of MIF,FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population显示文摘In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor(MIF),Fcg receptors CD16A(FCGR3A) and CD32A(FCGR2A) genes on susceptibility to pulmonary tuberculosis(PTB) in the Moroccan population,we analyzed 123 patients with PTB and 154 healthy controls.The genotyping for MIF-173(G/C)(rs755622),FCGR2A-131H/R(rs1801274) and FCGR3A-158V/F(rs396991) was carried out using TaqMan SNP Genotyping Assay method.We found a statistically significant increase of the MIF-173CC homozygote genotype and MIF-173C allele frequencies in PTB patients compared with healthy controls(17.07% versus 5.84%,P=0.003;and 35.37% versus 26.30%,P=0.02;respectively).In contrast,no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease.Our finding suggests that MIF-173C variant may play an important role in the development of active tuberculosis. | Khalid Sadki Hoda Lamsyah Blanca Rueda ELmahfoud Akil Abderrahim Sadak Javier Martin Rajae El Aouad | 2010 | Journal of Genetics and Genomics2010，37，4： | 2 |
| 6 | Large scale production and downstream processing of a recombinant porcine parvovirus vaccine显示文摘 | MARANGA L RUEDA P ANTONIS AFG | 2002 | Appl Microbiol Biotechnol2002，59，： | 1 |
| 7 | Detection of complex gangliosides in human amniotic fluid显示文摘 | Rueda R Tabsh K Ladisch S | 1993 | FEBS Lett1993，328，： | 1 |
| 8 | Stem cell contribution to ovarian development, function and disease显示文摘 | Tilly JL Rueda BR | 2008 | Endocrinology2008，149，9： | 1 |
| 9 | Associati on between functional haplotypes of vascular endothelial growth factor and renal comp lications in Henoch-Schonlein purpura显示文摘 | Rueda B Perez-Ar mengol C Lopez-Lopez S | | 0，，1： | 1 |
| 10 | Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis显示文摘 | RUEDA B REDDY MV GONZALEZ-GAY MA | 2006 | Arthritis Rheum2006，54，38： | 1 |
| 11 | Effect ofdietary carbohydrate - to - lipid ratios on growth,lipid deposition and metabolic hepatic enzymes injuvenile Senegalese sole ( Solea senegalensis, Kaup)显示文摘 | Dias J Rueda - Jasso R Panserat S | 2004 | Aquaculture Research2004，35，12： | 1 |
| 12 | Laser in situkeratomileusis for mixed and simple myopic astigma- tism withthe Nidek EC-5000 laser 显示文摘 | RUEDA L PINEDA-FERNANDEZ A HUANG D NUR J | 2002 | J Refract Surg2002，18，3： | 1 |
| 13 | Fetal immune response to chodoamnionitis显示文摘 | KaUapur SG Presicce P Rueda CM | 2014 | Semin Reprod Med2014，32，1： | 1 |
| 14 | Infectious spondylitis in the Balearic Islands:An analysis of 51cases显示文摘 | Raya Cruza M Vilchez Rueda HH Marinescu CI | 2015 | Rev Clin Esp2015，215，5： | 1 |
| 15 | Thermo -mechanical prop- erties of candelilla wax and dotriacontane organogels in saf- flower oil 显示文摘 | MORALES - RUEDA J A DIBILDOX - ALVARADO E CHAR- ALONSO M A | 2009 | Eur J Lipid Sci Tech2009，111，2： | 1 |
| 16 | Azo dye decolorization by optimized cross linked enzyme aggregates (CLEAs) of a royal palm (Roystonea regia) peroxidase 显示文摘 | GRATERON C BARBOSA O RUEDA N | | J Biotechnol0，131，2： | 1 |
| 17 | Endometrial cancer in women 40 years old or younger显示文摘 | Duska LR Garrett A Rueda BR | 2001 | Gynecol Oncol2001，83，2： | 1 |
| 18 | A Prussian blue-based flow-through renewable surface opt sensor for analysis of ascorbic acid显示文摘 | RUEDAS RAMA M J RUIZ MEDINA A MOLINA DIAZ A | 2004 | Microchemical Journal2004，78，： | 1 |
| 19 | Temperature-dependent development of the fungal pathogen Lagenidium giganteum (Oomycetes: Lagenidiales) in larvae d Culex quinquefasciatus (Diptera: Culicidae) 显示文摘 | Patel KJ Rueda LM Axtell RC | 1991 | J Med Entomol1991，28，1： | 1 |
| 20 | Endoscopic axillary dissection: a systematic review of the literature显示文摘 | Aponte Rueda ME Saade Cardenas RA Saade Aure MJ | 2009 | Breast2009，18，3： | 1 |
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