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| 1 | Liver transplantation for hilar cholangiocarcinoma显示文摘The most appropriate treatment for Klatskin tumor(KT)with a curative intention is multimodal therapy based on achieving resection with tumour-free margins(R0resections)combined with other types of neoadjuvant or adjuvant treatment(the most important factor affecting KT survival is the possibility of R0 resections,achieving 5-year survival rate of 40%-50%).Thirty to forty percent of patients with KT are inoperable and present a 5-year survival rate of 0%.In irresectable non-disseminated KT patients,using liver transplantation without neoadjuvant treatment,the 5-year survival rate increase to 38%,reaching 50%survival in early stage.In selected cases,with liver transplantation and neoadjuvant treatment(chemotherapy and radiotherapy),the actuarial survival rate is 65%at 5 years and 59%at 10 years.In conclusion,correct staging,neoadjuvant treatment,living donor and priority on the liver transplant waiting list may lead to improved results. | Ricardo Robles Francisco Sánchez-Bueno Pablo Ramírez Roberto Brusadin Pascual Parrilla | 2013 | World Journal of Gastroenterology2013，19，48： | 17 |
| 2 | Tolerance in liver transplantation: Biomarkers and clinical relevance显示文摘Transplantation is the optimal treatment for end-stage organ failure,and modern immunosuppression has allowed important progress in short-term outcomes. However,immunosuppression poorly influences chronic rejection and elicits chronic toxicity in current clinical practice. Thus,a major goal in transplantation is to understand and induce tolerance. It is well established that human regulatory T cells expressing the transcription factor Fox P3 play important roles in the maintenance of immunological self-tolerance and immune homeostasis. The major regulatory T cell subsets and mechanisms of expansion that are critical for induction and long-term maintenance of graft tolerance and survival are being actively investigated. Likewise,other immune cells,such as dendritic cells,monocyte/macrophages or natural killer cells,have been described as part of the process known as 'operational tolerance'. However,translation of these results towards clinical practice needs solid tools to identify accurately and reliably patients who are going to be tolerant. In this way,a plethora of genetic and cellular biomarkers is raising and being validated worldwide in large multicenter clinical trials. Few of the studies performed so far have provided a detailed analysis of the impact of immunosuppression withdrawal on pre-existing complications derived from the long-term administration of immunosuppressive drugs and the side effects associated with them. The future of liver transplantation is aimed to develop new therapies which increase the actual low tolerant vs non-tolerant recipients ratio. | Alberto Baroja-Mazo Beatriz Revilla-Nuin Pascual Parrilla Laura Martínez-Alarcón Pablo Ramírez José Antonio Pons | 2016 | World Journal of Gastroenterology2016，22，34： | 4 |
| 3 | Randomized Prospective Study to Compare Laparoscopic Appendectomy Versus Umbilical Single-Incision Appendectomy显示文摘 | Ma Dolores Frutos Jesus Abrisqueta Juan Lujan Israel Abellan Pascual Parrilla | 2013 | Annals of Surgery2013，，3： | 3 |
| 4 | Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients显示文摘 | Martínez-Llordella Marc Lozano Juan José Puig-Pey Isabel Orlando Giuseppe Tisone Giuseppe Lerut Jan Benítez Carlos Pons Jose Antonio Parrilla Pascual Ramírez Pablo Bruguera Miquel Rimola Antoni Sánchez-Fueyo Alberto | 2008 | Journal of Clinical Investigation2008，，8： | 3 |
| 5 | Laparoscopic versus open surgery for rectal cancer: results of a prospective multicentre analysis of 4,970 patients显示文摘 | J. Lujan G. Valero S. Biondo E. Espin P. Parrilla H. Ortiz | 2013 | Surgical Endoscopy2013，，1： | 3 |
| 6 | Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging显示文摘 | F. Guzmán-Aroca M. D. Frutos-Bernal A. Bas J. A. Luján-Mompeán M. Reus Juan Dios Berná-Serna P. Parrilla | 2012 | European Radiology2012，，11： | 2 |
| 7 | Digital Signal Processing Techniques for High Accuracy Ultrasonic Range Measurements显示文摘 | Parrilla M Anaya J J Fritsch C | 1991 | IEEE Transactions on Instrumentation and Measurement1991，40，4： | 1 |
| 8 | Improving the efficiency of insemination with sex-sorted spermatozoa显示文摘 | Vazquez JM Parrilla I Gil MA | 2008 | Reprod Domest Anita2008，43，4： | 1 |
| 9 | Mechanisms involved in the selective transfer of long chain polyunsaturated Fatty acids to the fetus显示文摘 | GIL-SáNCHEZ A DEMMELMAIR H PARRILLA J J | 2011 | Front Genet2011，2，1： | 1 |
| 10 | 3D beamforming with ultrasonic divided ring arrays显示文摘 | ULLATE L G MARTINEZ O PARRILLA M | 2002 | Ultrasoincs2002，40，1： | 1 |
| 11 | Electrocardiographic diagnosis of acute myocardial infarction:Current concepts for the clinician显示文摘 | Birnbaum Y Parrilla JE | 2001 | Am Heart J2001，141，4： | 1 |
| 12 | Analysis of the complications of the piggy-back technique in 1112 liver transplants显示文摘 | Parrilla P Sanchez-Bueno F Figueras J | 1999 | Transplant1999，67，9： | 1 |
| 13 | Pharyngocutaneous fistula onset after total laryngectomy: scintigraphic analysis 显示文摘 | Galli J Valenza V Parrilla C | 2009 | Acta Otorhino- laryngol Ital2009，29，5： | 1 |
| 14 | Suitability and effectiveness of single layer centrifugation using Androcoll-P in the cryopreservation protocol for boar spermatozoa显示文摘 | Maria J. Martinez-Alborcia Jane M. Morrell Maria A. Gil Isabel Barranco Carolina Maside Diego V. Alkmin Inmaculada Parrilla Emilio A. Martinez Jordi Roca | 2013 | Animal Reproduction Science2013，，： | 1 |
| 15 | Analysis of the complications of the piggyback technique in 1112 liver transplants显示文摘 | Parrilla P Sanchez-Bueno Figueras J | 1999 | Transplantation1999，31，6： | 1 |
| 16 | The role of septal surgery in cosmetic rhinoplasty显示文摘 | Parrilla C Artuso A Gallus R | 2013 | Acta Otorhinolaryngol Ital2013，33，3： | 1 |
| 17 | Attitude of Ancillary Personnel Faced With Living Kidney Donation in a Hospital With a Living Donor Kidney Transplant Program显示文摘 | Antonio Ríos Pablo Ramírez María del Mar Rodríguez Lewa Martínez Mariano Jeime Montoya Dolores Lucas Jesús Alcaraz Pascual Parrilla | 2007 | Transplantation2007，，3： | 1 |
| 18 | Improving the Efficiency of Insemination with Sex-sorted Spermatozoa显示文摘 | Vazquez J M Parrilla I Gil M | 2008 | Reproduction in Domestic Animals2008，43，4： | 1 |
| 19 | Tourniquet modifieation of the associating liver partition and portal ligation for staged hepalectomy procedure 显示文摘 | Robles R Parrilla P Lopez-Conesa A | 2014 | Br J Surg2014，101，9： | 1 |
| 20 | Sex-sorting sperm by flow cytometry in pigs:issues and perspectives显示文摘 | Vazquez J M Parrilla I Roca J | 2009 | Theriogenology2009，，1： | 1 |
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