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| 1 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 2 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 3 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 4 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 5 | Theoretical bases of communicative approaches to second language teaching and testing显示文摘 | Canale M Swain M | | 0，，： | 8 |
| 6 | Assessment of rock slope stability by probabilistic-based Slope Stability Probability Classification method along highway cut slopes in Adilcevaz-Bitlis(Turkey)显示文摘Rock slope stability is of great concern along highway routes as stability problems on cut slopes may cause fatal events as well as loss of property.In rock slope engineering,stability evaluations are commonly performed by means of analytical or numerical analyses,principally considering the factor of safety concept.As a matter of fact,the probabilistic assessment of slope stability is progressively getting popularity due to difficulties in assigning the most appropriate values to design parameters in analytical or numerical methods.Additionally,the effect of heterogeneities in rock masses and discontinuities on the analysis results is minimized through the probabilistic concept.In this study,slope stability of high and steep sedimentary rock cut slopes along a state highway in AdilcevazBitlis(Turkey) was evaluated on the basis of probabilistic approach using the Slope Stability Probability Classification(SSPC) system.The probabilistic assessment indicates major slope stability problems because of discontinuity controlled and discontinuity orientation independent mass movements.Almost all studied cut slopes suffer from orientation-independent stability problems with very low stability probabilities.Additionally,the probability of planar and toppling failures issignificantly high with respect to the SSPC system.The stability problems along the investigated rock slopes were also verified by field reconnaissance.Remedial measures such as slope re-design and reinforcement at the studied locations should be taken to prevent hazardous events along the highway.On the other hand,the probabilistic approach may be a useful tool during rock slope engineering to overcome numerous uncertainties when probabilistic and analytic results are compared. | Akgun CANAL Mutluhan AKIN | 2016 | Journal of Mountain Science2016，13，11： | 4 |
| 7 | Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief review显示文摘Reactive oxygen and nitrogen species (RONS) are among the key factors in plasma medicine. They are generated by atmospheric plasmas in biological fluids, living tissues and in a variety of liquids. This ability of plasmas to create a delicate mix of RONS in liquids has been used to design remote or indirect treatments for oncological therapy by treating biological fluids by plasmas and putting them in contact with the tumour;Documented effects include selective cancer cell toxicity, even though the exact mechanisms involved are still under investigation. However, the 'right' dose for suitable therapeutical activity is crucial and still under debate. The wide variety of plasma sources hampers comparisons. This review focuses on atmospheric pressure plasma jets as the most studied plasma devices in plasma medicine and compiles the conditions employed to generate RONS in relevant liquids and the concentration ranges obtained. The concentrations of H2O2, NO2^-, NO3^- and short-lived oxygen species are compared critically to provide a useful overview for the reader. | Anna Khlyustova Cédric Labay Zdenko Machala Maria-Pau Ginebra Cristina Canal | 2019 | Frontiers of Chemical Science and Engineering2019，13，2： | 4 |
| 8 | Field-effect passivation on silicon nanowire solar cells显示文摘表面再结合为高效率的太阳能电池代表一个缺陷。这为 nanowire 数组太阳能电池是特别重要的,在 surface-to-volume 比率极大地被提高的地方。这里,有效再结合上并且在设备表演上的不同钝化材料的效果试验性地被分析。我们的太阳能电池是自顶向下的轴的 n-p 连接硅 nanowires 借助于近地的阶段移动平版印刷术(NF-PSL ) 制作了的大区域。我们为最好的房间报导 9.9% 的效率,与 SiO 使钝化 < 潜水艇 class= “ a-plus-plus ” > 2 /SiN x 栈。表面的存在的影响在硅 / 氧化物接口修理了费用密度被学习。 | Anna Dalmau Mallorqui Esther Alarcon-Llado Ignasi Canales Mundet Amirreza Kiani Benedicte Demaurex Stefaan De Wolf Andreas Menzel Margrit Zacharias Anna Fontcuberta i Morra | 2015 | Nano Research2015，8，2： | 3 |
| 9 | Reduction of acute anterior dislocations of the shoulder without anaesthesia in the position of maximum muscular relaxation显示文摘 | V. Canales Cortés L. García-Dihinx Checa J. Rodriguez Vela | 1989 | International Orthopaedics1989，，4： | 2 |
| 10 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 11 | Singing on the wings! Male wing fanning performances affect female willingness to copulate in the aphid parasitoid Lysiphlebus testaceipes (Hymenoptera: Braconidae: Aphidiinae)显示文摘Lysiphlebus testaceipes (Hymenoptera:Braconidae:Aphidiinae ) 是攻击超过 100 aphid 种类的通晓各方面知识经验丰富的人 endoparasitoid。在 L。testaceipes,翅膀扇是忍受女性的性 pheromone 唤起的主要男求爱显示。然而,没有信息在特征和在这 parasitoid 的在求爱期间的男性扇的行为的角色上是可得到的。这里, L 的野紧张的求爱行为。testaceipes 被确定,扇表演的男翅膀通过高速度的录像记录被分析并且在与交配成功的关系检验了。野 L 的求爱顺序。testaceipes 实质地没不同于那以前为质量在蚜虫上饲养了的另外的人口报导了。我们观察到男求爱持续时间没假装交配成功。然而,录像分析表明生产高周波的扇的信号的男性更高完成了在显示低频率的扇的那些上交配成功。翅膀在成功、失败的求爱前扇向配偶在翅膀运动和排列的振幅不同,断然加亮那正面的求爱影响交配决定的女性。这研究在蚜虫的关键 parasitoid 在性行为上增加知识,强调翅膀在在 L 的性通讯使用的感觉形式的范围之中扇的重要性。testaceipes。从一个实际观点,这个信息在 L 是有用的。基于 testaceipes 的 biocontrol 策略,后来,它能帮助为随着时间的过去的饲养团的黄蜂的优秀检查建立参数。 | Giovanni Benelli Nickolas G. Kavallieratos Elisa Donati Giulia Giunti Cesare Stefanini Angelo Canale | 2016 | Insect Science2016，23，4： | 2 |
| 12 | 地震波数据揭示Casadia俯冲带“干”的Juan De Fuca板片显示文摘俯冲板片中的水(包括孔隙水和含水矿物中的结构水)对地球圈层之间的水循环、岛弧岩浆作用和地震活动等都有至关重要的影响。但是至今尚未综合研究过一个单一板片中水的含量、储存方式(孔隙水和结构水的相对比例)和分布(在沉积物、俯冲板片上地壳、下地壳和地幔中的分配)。 | Canales J P Carbotte S M Nedimovic M R Carton H 夏群科 | 2017 | 矿物岩石地球化学通报2017，36，6： | 2 |
| 13 | The metabolism of cyclic-3′-5′-adenosine monophosphate (cAMP) in diseased muscle显示文摘 | N. Canal L. Frattola S. Smirne | 1975 | Journal of Neurology1975，，4： | 2 |
| 14 | Theoretical Bases of Communicative Approaches to Second Language Teaching and Testing显示文摘 | Canale M Swain M | | 0，，： | 2 |
| 15 | Is bigger better? Male body size affects wing-borne courtship signals and mating success in the olive fruit fly, Bactrocera oleae (Diptera: Tephritidae)显示文摘在男身体尺寸的变化被知道影响内部 -- 并且在大量动物的 intrasexual 选择结果。在交配包含在交配前的性发信号的系统,身体尺寸经常充当影响信号力量和配偶选择的一个关键因素。我们在求爱显示和橄榄水果苍蝇的交配成功上评估了男尺寸的效果, Bactrocera oleae (双翅目:Tephritidae ) 。大、小的男性在成功、失败的求爱期间执行的翅膀颤动被高速度的录像记录并且通过 frame-by-frame 分析了分析。交配大、小的男性的成功被调查。交配成功上的男性男性的竞争的效果被评估。男身体尺寸影响了两个男求爱信号和交配结果。成功的男性与高频率和短 interpulse 间隔显示出忍受翅膀的信号。成功的大男性在交媾期间显示的翅膀颤动在更小的男性和失败的大男性上尝试有的更高的频率。处于没有比赛条件,大男性更高完成了关于更小的交配成功。允许大、小的男性为女性,竞争大男性超过更小的获得更多的交配成功。由女性的配偶选择可以基于更大的男性,的选择能生产高周波的翅膀颤动。如此的特点可能 “good 基因是指示的, ”它在性选择下面能意味着好社会相互作用的基因,或 conspecifics 的一个好竞争操纵者。 | Giovanni Benelli Elisa Donati Donato Romano Giacomo Ragni Gabriella Bonsignori Cesare Stefanini Angelo Canale | 2016 | Insect Science2016，23，6： | 2 |
| 16 | Directly addressable GaN-based nano-LED arrays: fabrication and electro-optical characterization显示文摘The rapid development of display technologies has raised interest in arrays of self-emitting,individually controlled light sources atthe microscale.Gallium nitride(GaN)micro-light-emitting diode(LED)technology meets this demand.However,the current technology is not suitable for the fabrication of arrays of submicron light sources that can be controlled individually.Our approach is based on nanoLED arrays that can directly address each array element and a self-pitch with dimensions below the wavelength of light.The design and fabrication processes are explained in detail and possess two geometries:a 6×6 array with 400 nm LEDs and a 2×32 line array with 200 nm LEDs.These nanoLEDs are developed as core elements of a novel on-chip super-resolution microscope.GaN technology,based on its physical properties,is an ideal platform for such nanoLEDs. | Daria D.Bezshlyakh Hendrik Spende Thomas Weimann Peter Hinze Steffen Bornemann Jan Gulink Joan Canals Joan Daniel Prades Angel Dieguez Andreas Waag | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 17 | Development of Junction Elements from Study of the Bionics显示文摘The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated. These elements favor the application of Ecodesign in reference to the effec-tiveness of product dismount aiming the reduction of ambient impact in all its phases of use. The creation,the development and the confection of new junction elements were described,and case studies of new products developed specifically with this purpose were presented. | Wilson Kindlein Junior Luis Henrique Alves Cndido André Canal Marques Sandra Souza dos Santos Maurício da Silva Viegas | 2007 | Journal of Bionic Engineering2007，4，1： | 2 |
| 18 | TiO2 - B nanowires as negative electrodea for rechargeable lithium batteries显示文摘 | Armstrong A R Armstrong G Canales J | 2005 | J Power Sources2005，146，12： | 1 |
| 19 | Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model 显示文摘 | Canales BK Thompson MG | 2006 | Urol Oncol2006，24，2： | 1 |
| 20 | Breakpoint of a Y chrom osome pericentric inversion in the DAZ gene area A case report 显示文摘 | Causio F Canale D Schonauer L C | 2000 | J Reprod Med2000，45，： | 1 |
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