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| 1 | Oxylipin Pathway in Rice and Arabidopsis显示文摘植物发展了复杂发信号的小径协调回答到发展、环境的信息。oxylipin 小径是一个枢轴的 lipid-basedsignaling 网络,几竞争分支小径镇静,那决定植物“适应各种各样的刺激的 sability。oxylipin 小径的激活导致称为“ oxylipins ”的生物学上活跃的代谢物的 de novosynthesis。这些代谢物的相对层次是每植物硬币沙的不同指示物决定植物的能力适应不同刺激。oxylipin 小径, allene 氧化物 syn-thase (AOS ) 和水疗院过氧化物 lyase (HPL ) 的二个主要分支分别地为发信号的混合物, jasmonates 和醛的生产负责。这里,我们作为单子叶植物的模型和双子叶的系统在米饭和 Arabidopsis 比较并且形成对照 AOS 和 HPLbranch 小径的规定。Theseanalyses 提供新卓见进在单音的简易窄床和 dicots 表明小径,和为压力改编负责的过程的复杂网络的 JA 和醛的进化。 | E. Wassim Chehab John V. Perea Banu Gopalan Steve Theg Katayoon Dehesh | 2007 | Journal of Integrative Plant Biology2007，49，1： | 12 |
| 2 | Multiple primary colorectal cancer: Individual or familial predisposition?显示文摘Colorectal carcinoma(CRC) is one of the most frequent cancers. Along the surface of the large bowel, several foci of CRC may appear simultaneously or over the time. The development of at least two different tumours has been defined as multiple primary CRC(MPCRC):When more than one tumour is diagnosed at the same time, it is known as synchronous CRC(SCRC), while when a second neoplasm is diagnosed some time after the resection and/or diagnosis of the first lesion, it is called metachronous CRC(MCRC). Multiple issues can promote the development of MPCRC, ranging from different personal factors, such as environmental exposure, to familial predisposition due to hereditary factors. However, most studies do not distinguish this dichotomy. High- and low-pentrance genetic variants are involved in MPCRC. An increased risk for MPCRC has been described in Lynch syndrome, familial adenomatous polyposis, and serrated polyposis. Non-syndromic familial CRCs should also be considered as risk factors for MPCRC. Environmental factors can promote damage to colon mucosae that enable the concurrence of MPCRC. Epigenetics are thought to play a major role in the carcinogenesis of sporadic MPCRC. The methylation state of the DNA depends on multiple environmental factors(e.g., smoking and eating foods cooked at high temperatures), and this can contribute to increasing the MPCRC rate. Certain clinical features may also suggest individual predisposition for MPCRC. Different etiopathogenic factors are suspected to be involved in SCRC and MCRC, and different familial vs individual factors may be implicated. MCRC seems to follow a familial pattern, whereas individual factors are more important in SCRC. Further studies must be carried out to know the molecular basis of risks for MPCRC in order to modify, if necessary, its clinical management, especially from a preventive point of view. | José A Pajares José Perea | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 7 |
| 3 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 4 | Approach to early-onset colorectal cancer:Clinicopathological,familial,molecular and immunohistochemical characteristics显示文摘AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the study.Clinical information,a three-generation family history,and tumor samples were obtained.MSI status was analyzed and mismatch repair genes were examined in the MSI families.Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.RESULTS:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of polyps.Hereditary forms represent at least 21% of cases.Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of tumors.CONCLUSION:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite stable.Cyclin E might be a poor prognosis factor. | Jose Perea Edurne Alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 5 | Prevalence and risk factors of Campylobacter infection in broiler flocks from southern Spain显示文摘 | Alicia Torralbo Carmen Borge Alberto Allepuz Ignacio García-Bocanegra Samuel K. Sheppard Anselmo Perea Alfonso Carbonero | 2014 | Preventive Veterinary Medicine2014，，： | 2 |
| 6 | Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis显示文摘Colorectal cancer incidence and mortality in patients younger than 50 years are increasing, but screening before the age of 50 is not offered in Europe. Advancedstage diagnosis and mortality from colorectal cancer before 50 years of age are increasing. This is not a detection-bias effect;it is a real issue affecting the entire population. Three independent computational models indicate that screening from 45 years of age would yield a better balance of benefits and risks than the current start at 50 years of age. Experimental data support these predictions in a sex- and race-independent manner. Earlier screening is seemingly affordable, with minimal impediments to providing younger adults with colonoscopy. Indeed, the American Cancer Society has already started to recommend screening from 45 years of age in the United States. Implementing early screening is a societal and public health problem. The three independent computational models that suggested earlier screening were criticized for assuming perfect compliance. Guidelines and recommendations should be derived from well-collected and reproducible data, and not from mathematical predictions. In the era of personalized medicine, screening decisions might not be based solely on age, and sophisticated prediction software may better guide screening. Moreover, early screening might divert resources away from older individuals with greater biological risks. Finally, it is still unknown whether early colorectal cancer is part of a continuum of disease or a biologically distinct disease and, as such, it might not benefit from screening at all. The increase in early-onset colorectal cancer incidence and mortality demonstrates an obligation to take actions. Earlier screening would save lives, and starting at the age of 45 years may be a robust screening option. | Alessandro Mannucci Raffaella Alessia Zuppardo Riccardo Rosati Milena Di Leo José Perea Giulia Martina Cavestro | 2019 | World Journal of Gastroenterology2019，25，21： | 2 |
| 7 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 8 | Climate,female traits and population features as drivers of breeding timing in Mediterranean red deer populations显示文摘Understanding the factors that lead to variation in the timing of breeding in widespread species such as red deer(Cervus elaphus)is crucial to predict possible responses of wild populations to different climate scenarios.Here,we sought to further understand the causes of inter-annual variation in the reproduction timing of female deer in Mediterranean environments.An integrative approach was used to identify the relative importance of individual,population and climate traits in the date of conception of free-ranging deer,based on a dataset of 829 hinds culled during 12 years.We found that a population trait,density,was the most important factor explaining the variation in conception dates,with greater densities causing later conception dates.Body mass was the second in importance,with heavier females conceiving earlier than lighter ones.Almost equally important was the spring real bioclimatic index,a measure of plant productivity,causing later conception dates in the least productive springs(drier and hotter).Another climatic component,the end of summer drought,showed that the sooner the autumn arrives(greater rainfalls and cooler temperatures)the earlier the conception dates.Interestingly,age class was found to be a minor factor in determining conception date.Only older females(≥10 years old)conceived significantly later,suggesting reproductive senescence.This study highlights not only the importance of population and individual traits but also the influence of climatic parameters on the deer reproductive cycle in Mediterranean environments,giving valuable insight into how reproductive phenology may respond to seasonality and global climate changes. | Marta PELÁEZ Alfonso SAN MIGUEL Carlos RODRÍGUEZ-VIGAL Ramón PEREA | 2017 | Integrative Zoology2017，12，5： | 2 |
| 9 | Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics显示文摘Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global optimum.Herein,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box optimization.Our Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical solvers.With the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the experimentalist.As a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods. | Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi | 2020 | npj Computational Materials2020，，1： | 2 |
| 10 | Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicana strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients显示文摘 | Perea S Lopez-Ribot JL Kirkpatrick WR | 2001 | Antimicrob Agents Chemother2001，45，10： | 1 |
| 11 | Border strip fertigation: effect of injection strategies on the distribution of bromide显示文摘 | Adamsen F J Hunsaker D J Perea H | 2005 | Transactions of the ASAE2005，48，2： | 1 |
| 12 | Mass vaccination campaign with a two - dose oral cholera vaccine in a refugee camp显示文摘 | Legros D Paquet C Perea W | 1999 | Bull of WHO1999，77，10： | 1 |
| 13 | Molecular and genetic damage from environmental pollution in Poland 显示文摘 | Perea FP K-hemminki E Grzybowska G | 1992 | Nature1992，360，： | 1 |
| 14 | Dynamic modeling and classical control theory for supply chain management显示文摘 | PEREA E GROSSMANN I | 2000 | Computers and Chemical Engineering2000，24，27： | 1 |
| 15 | Progressive age -related changes in pulmonary tuberculosis images and the effect of diabetes显示文摘 | Perea GC Torres CS Villarreal VH | 2000 | Am J Res Crit Med2000，62，5： | 1 |
| 16 | Continuous hydrolysis of whey proteins in a membrane recycle reactor显示文摘 | Perea Aide Ugalde Unai | 1996 | Enzyme and Microbial Technology Volume:18 Issue:1 January1996，1996，： | 1 |
| 17 | Muhiple r- oles of the gene zinc finger homeodomain-2 in the development of the drosophila wing 显示文摘 | PEREA D MOLOHON K EDWARDS K | 2013 | Mech Dev2013，130，910： | 1 |
| 18 | Azole resistance in Candida albicans 显示文摘 | Perea S | 2000 | Rev Esp Quimioter2000，13，3： | 1 |
| 19 | Region filling and object removal by exemplar-based image inpainting 显示文摘 | CRIMINISI A PEREA P TOYAMA K | 2004 | IEEE Transactions on Image Processing2004，13，9： | 1 |
| 20 | Communication between astrocytes and neurons:a complex language显示文摘 | Perea G Araque A | 2002 | J Physiol(Paris)2002，96，34： | 1 |
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