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| 1 | 人类血压测量方法:美国心脏协会科学声明显示文摘准确的血压测量对高血压诊断与治疗至关重要。该文是美国心脏协会关于人类血压测量的最新科学声明。业已证实,在诊室许多电子血压计可以准确测量血压,同时减少与听诊法有关的人为误差。即使没有一个观察者在场,全自动电子血压计也可以通过多次测量提供较听诊法更准确的血压测量值。研究表明诊室外所测血压与诊室血压比较存在实质性差别。目前认为动态血压监测是诊室外血压评估的参考标准,当动态血压监测不可行或患者不能耐受时,家庭血压监测则是一个替代方法。 | 赵狄(摘译) 练桂丽(审校) Muntner P Shimbo D Carey RM Charleston JB Gaillard T Misra S Myers MG Ogedegbe G Schwartz JE Townsend RR Urbina EM Viera AJ White WB Wright JT Jr | 2019 | 中华高血压杂志2019，27，6： | 16 |
| 2 | Boceprevir,GC-376,and calpain inhibitors Ⅱ,Ⅻ inhibit SARS-CoV-2 viral replication by targeting the viral main protease显示文摘A new coronavirus SARS-CoV-2,also called novel coronavirus 2019(2019-nCoV),started to circulate among humans around December 2019,and it is now widespread as a global pandemic.The disease caused by SARS-CoV-2 virus is called COVID-19,which is highly contagious and has an overall mortality rate of 6.35%as of May 26,2020.There is no vaccine or antiviral available for SARS-CoV-2.In this study,we report our discovery of inhibitors targeting the SARS-CoV-2 main protease(Mpro).Using the FRET-based enzymatic assay,several inhibitors including boceprevir,GC-376,and calpain inhibitorsⅡ,andⅫwere identified to have potent activity with single-digit to submicromolar ICs0 values in the enzymatic assay.The mechanism of action of the hits was further characterized using enzyme kinetic studies,thermal shift binding assays,and native mass spectrometry.Significantly,four compounds(boceprevir,GC-376,calpain inhibitorsⅡandⅫ)inhibit SARS-CoV-2 viral replication in cell culture with EC50 values ranging from 0.49 to 3.37μM.Notably,boceprevir,calpain inhibitorsⅡandⅫrepresent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors.A complex crystal structure of SARS-CoV-2 Mpro with GC-376,determined at 2.15(A)resolution with three protomers per asymmetric unit,revealed two unique binding configurations,shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro.Overall,the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | Chunlong Ma Michael Dominic Sacco Brett Hurst Julia Alma Townsend Yanmei Hu Tommy Szeto Xiujun Zhang Bart Tarbet Michael Thomas Marty Yu Chen Jun Wang | 2020 | Cell Research2020，30，8： | 13 |
| 3 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 4 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012显示文摘 | R. Phillip Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell | 2013 | Critical Care Medicine2013，，2： | 12 |
| 5 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012显示文摘 | R. P. Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell Derek | 2013 | Intensive Care Medicine2013，，2： | 7 |
| 6 | 苏州文博中心项目结构设计显示文摘苏州文博中心项目包含吴江博览中心(南区)和苏州大剧院(北区)两大建筑,两建筑造型新颖独特,建筑使用功能要求繁多,且建筑空间关系相对复杂。高、低位两条飘带更是本项目亮点,其体型复杂,为扭曲的空间桁架结构,通过变换角度最终与南北区两栋建筑连为一体。对飘带进行了风荷载、温度作用、地震作用分析,提出了飘带结构整体稳定及上人舒适度问题的解决方案,并简要介绍了飘带下部两大建筑的结构体系、超长悬挑的解决方案和一个新型桁架端部节点。 | 孔启明 赵俊钊 来少平 Chris Townsend 丁剑豪 朱立刚 梁金桐 | 2015 | 建筑结构2015，45，24： | 7 |
| 7 | 竞技运动教育模式的教学赛季计划显示文摘竞技运动教育模式已经赢得业内文献的大量支持,成为美国学校身体教育环境中竞技运动教学的重要途径.随着竞技运动教育模式的日益风靡,身体教育领域中的理论学者应同实践教师协同建立合适的指导模式.介绍了美国中学身体教育实践中,一个帮助体育教师有效筹划竞技运动教育的教学赛季计划的体系,希望对中国的学校体育教育有所帮助. | Mohr D J Townsend J S Bulger S M 陈森林 | 2010 | 西南师范大学学报(自然科学版)2010，35，6： | 7 |
| 8 | 澳大利亚欧泊矿床地质显示文摘 | Townsend I.J. 杨梅珍 | 2000 | 宝石和宝石学杂志2000，2，4： | 4 |
| 9 | Nitrogen Cycles: Past, Present, and Future显示文摘 | J. N. Galloway F. J. Dentener D. G. Capone E. W. Boyer R. W. Howarth S. P. Seitzinger G. P. Asner C. C. Cleveland P. A. Green E. A. Holland D. M. Karl A. F. Michaels J. H. Porter A. R. Townsend C. J. V?osmarty | 2004 | Biogeochemistry2004，，2： | 4 |
| 10 | Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry显示文摘Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the brain.The reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their lifetime.Due to small numbers,a descriptive analysis is presented.Results:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were female.Where the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain radiotherapy.The median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 years.Conclusions:Brain metastasis is a rare outcome in advanced CRC.Patients within the registry tended to be female,young in age,and harbored with higher rates of KRAS mutations.Whether routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease. | Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers David Roder Amanda R. Townsend | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 11 | 中美垃圾场渗滤液中的金属成分变化的调研显示文摘主要对2000~2004年美国佛罗里达州中部的5个垃圾场中垃圾渗滤液的金属离子成分进行统计分析,从中发现锑(Sb)、砷(As)、铬(Cr)、铁(Fe)、镍(Ni)、钠(Na)、钒(V)、硒(Se)等8种金属在渗滤液中的质量浓度超过EPA地表及饮用水标准,其中比较严重的是As,Fe和Na,每年都超EPA标准。推测该地区地表或地下水体被As,Fe,Na污染的可能性很大。对其他还未列入监控标准的金属也做了来源及危害分析。同时与国内某垃圾场渗滤液中的金属成份进行了比较,结果显示该垃圾场渗滤液只有汞(Hg)超国家Ⅴ类水体标准,但还在美国EPA容许范围内。 | 刘芳 徐期勇 TOWNSEND T G | 2010 | 环境科技2010，23，5： | 3 |
| 12 | 香港九龙大坑东地下蓄水方案数值研究显示文摘香港九龙大坑东地下蓄水方案(Tai Hang Tung Storage Scheme-THTSS)是香港西九龙渠道改善二期计划的一个重要组成部分,其目标是解决香港九龙繁华拥挤、人口稠密的商业中心旺角一带的洪水淹没问题。THTSS即是在经常洪水淹没区域(大坑东和界限街水渠交接处)上游足球场下面建立一个100 000 m3的地下蓄水池。本文建立了一个能处理明渠缓流和急流、封闭管道有压流、侧流堰和渠道汇合处过渡流于一体的一维水力数学模型,用1∶22正态物理模型恒定流下的结果进行验证。数值模型计算了在50年一遇暴雨下,非恒定洪水在不同的侧流堰方案下的流动过程。结合物理模型试验结果,选择最佳的地下蓄水方案。计算结果表明,大坑东地下蓄水方案确实能加强旺角地区地洪水控制能力,并能通过50年一遇暴雨的洪水。 | 匡翠萍 李行伟 陈孝章 Peter Clark Nick Townsend Raymond Siu | 2006 | 水科学进展2006，17，3： | 3 |
| 13 | Regional nitrogen budgets and riverine N & P fluxes for the drainages to the North Atlantic Ocean: Natural and human influences显示文摘 | R. W. Howarth G. Billen D. Swaney A. Townsend N. Jaworski K. Lajtha J. A. Downing R. Elmgren N. Caraco T. Jordan F. Berendse J. Freney V. Kudeyarov P. Murdoch Zhu Zhao-Liang | 1996 | Biogeochemistry1996，，1： | 3 |
| 14 | 光通信网络关键技术及其发展趋势显示文摘文章讨论了现代光通信系统中关键技术,特别是数字信号处理(DSP)技术在其中的应用,主要针对光纤通信系统中不同的干扰与损伤效应以及先进的DSP信号调制与补偿方法进行分析讨论;介绍了一种用于光纤通信系统的新型DSP调制技术——正交啁啾复用(OCDM)技术。由于OCDM具有优良的抗干扰能力并可以有效地利用简单的单抽头频域均衡器,相比于其他系统,基于OCDM的光纤通信系统表现出优良的传输性能并保持类似的系统复杂度。文章展示了该OCDM技术分别应用在基于相干光系统的长距传输与基于光强调制直接检测系统的短距传输的研究进展,以及在相应条件下与正交频分复用技术(OFDM)的实验对比。 | 欧阳兴 陈高华 Paul Townsend | 2019 | 控制与信息技术2019，，1： | 2 |
| 15 | Nitrogen Cycles: Past, Present, and Future显示文摘 | J. N. Galloway F. J. Dentener D. G. Capone E. W. Boyer R. W. Howarth S. P. Seitzinger G. P. Asner C. C. Cleveland P. A. Green E. A. Holland D. M. Karl A. F. Michaels J. H. Porter A. R. Townsend C. J. V?osmarty | 2004 | Biogeochemistry2004，，2： | 2 |
| 16 | Global Invasive Potential of 10 Parasitic Witchweeds and Related Orobanchaceae显示文摘列当科植物包括许多寄生性杂草,它们也是令人印象深刻的入侵植物和侵害作物的有害植物,它们还具有一些特殊的特点(例如细微的种子、寄生习性)。虽然它们已经引发了几次大规模的根除和控制工作,但是还没有人对它们的全球入侵潜力进行过评价。我们采用生态位模型技术与干燥标本的分布记录相结合来估计这10个物种的全球入侵潜力,这10种植物代表了最严重的几种全球入侵植物。所有的热带和亚热带国家以及大部分的温带国家容易受到这些物种中的一种或几种的巨大入侵潜力的威胁。 | Kamal I. Mohamed Monica Papes Richard Williams Brett W. Benz A. Townsend Peterson 丁莉(译) | 2006 | AMBIO-人类环境杂志2006，35，6： | 2 |
| 17 | Epidemiology of neuroendocrine cancers in an Australian population显示文摘 | Colin Luke Timothy Price Amanda Townsend Christos Karapetis Dusan Kotasek Nimit Singhal Elizabeth Tracey David Roder | 2010 | Cancer Causes & Control2010，，6： | 2 |
| 18 | Video thoracoscopy in the treatment of early empyema: an initial experience显示文摘 | Hornik P Clark D Townsend E | 1996 | Ann R Coll Surg Engl1996，78，： | 2 |
| 19 | The antioxidant role of selenium and seleno-compounds显示文摘 | H Tapiero D.M Townsend K.D Tew | 2003 | Biomedicine & Pharmacotherapy2003，，3： | 2 |
| 20 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis显示文摘 | Mitchell M. Levy R. Phillip Dellinger Sean R. Townsend Walter T. Linde-Zwirble John C. Marshall Julian Bion Christa Schorr Antonio Artigas Graham Ramsay Richard Beale Margaret M. Parker Herwig Gerlach Konrad Reinhart Eliezer Silva Maurene Harvey Susan Reg | 2010 | Intensive Care Medicine2010，，2： | 2 |
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