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| 1 | Proteoglycans in liver cancer显示文摘Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,such as a heparan,dermatan,chondroitin,or keratan sulfate,covalently attached to the protein core.These molecules arecategorized based on their structure,localization,and function,and can be found in the extracellular matrix,on the cell surface,and in the cytoplasm.Cell-surface heparan sulfate proteoglycans,such as syndecans,are the primary type present in healthy liver tissue.However,deterioration of the liver results in overproduction of other proteoglycan types.The purpose of this article is to provide a current summary of the most relevant data implicating proteoglycans in the development and progression of human and experimental liver cancer.A review of our work and other studies in the literature indicate that deterioration of liver function is accompanied by an increase in the amount of chondroitin sulfate proteoglycans.The alteration of proteoglycan composition interferes with the physiologic function of the liver on several levels.This article details and discusses the roles of syndecan-1,glypicans,agrin,perlecan,collagen XVIII/endostatin,endocan,serglycin,decorin,biglycan,asporin,fibromodulin,lumican,and versican in liver function.Specifically,glypicans,agrin,and versican play significant roles in the development of liver cancer.Conversely,the presence of decorin could potentially provide protective effects. | Kornélia Baghy Péter Tátrai Eszter Regős Ilona Kovalszky | 2016 | World Journal of Gastroenterology2016，22，1： | 8 |
| 2 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 3 | 全球捕捞船队的燃料问题显示文摘20世纪,化石燃料逐渐成为世界大多数渔场的主要能源输入。尽管各种分析报告确定了对个别渔场的燃料输入数量,但迄今为止,还没有对全球范围的燃料输入进行量化,及绘制渔业所消耗燃料分布图的尝试。通过用2000年空间分解渔获量统计数据综合了代表世界各地250多个渔场的数据,我们认为,在全球范围内,在8000万t海洋鱼类和无脊椎动物上市的过程中,渔船烧掉了近500亿L燃料,平均为620L/t。因此,渔船约占全球油耗的1.2%,相当于全球第18位油耗国——荷兰的数量,并直接向大气排入1.3亿tCO_2。从效能角度看,全球渔船所烧掉的燃料的能量含量是所产生的渔获量可食用蛋白质能量含量的12.5倍。 | Peter H.Tyedmers Reg Watson Daniel Pauly 林宝法(译) 胡恩和(校) | 2005 | AMBIO-人类环境杂志2005，34，B12： | 3 |
| 4 | Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy显示文摘AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 software.The Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal injury.Arthropathy patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were screened.Patients with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the study.During this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d omeprazole.At the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS results.The primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine treatment.RESULTS:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one month.Eight patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS < 135) in five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two patients.Ten patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was performed.When comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-treatment mean total LIS was detected in 7 patients who had moderate-tosevere enteropathy gradings at the inclusion CE (mean LIS:1615 ± 672vs 1064 ± 424,P=0.033).CONCLUSION:According to the small bowel CE evaluation mesalazine granules significantly attenuated mucosal injuries in patients with moderate-to-severe enteropathies induced by naproxen. | István Rácz Milán Szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth | 2013 | World Journal of Gastroenterology2013，19，6： | 2 |
| 5 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis显示文摘 | Mitchell M. Levy R. Phillip Dellinger Sean R. Townsend Walter T. Linde-Zwirble John C. Marshall Julian Bion Christa Schorr Antonio Artigas Graham Ramsay Richard Beale Margaret M. Parker Herwig Gerlach Konrad Reinhart Eliezer Silva Maurene Harvey Susan Reg | 2010 | Intensive Care Medicine2010，，2： | 2 |
| 6 | Reinventing residual reserves in the sea: are we favouring ease of establishment over need for protection?显示文摘 | Rodolphe Devillers Robert L. Pressey Alana Grech John N. Kittinger Graham J. Edgar Trevor Ward Reg Watson | 2015 | Aquatic Conserv: Mar. Freshw. Ecosyst2015，，4： | 1 |
| 7 | Film Forming and Friction Properties of Overbased Calcium Sulphonate Detergents 显示文摘 | Ksenija Topolovec - Miklozic T Reg Forbus Hugh Spikes | 2008 | Tribology Letters2008，29，： | 1 |
| 8 | Postoperative Complications Following Colectomy for Ulcerative Colitis in Children显示文摘 | Ing Shian Soon Iwona Wrobel Jennifer C.C. deBruyn Reg Sauve David L. Sigalet Belle S. Kaplan Marie-Claude Proulx Gilaad G. Kaplan | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，6： | 1 |
| 9 | Report of the Canadianhypertensive disorders in pregnancy 显示文摘 | Lelorier J Burgess E | 1997 | Can Med Assoc J1997，157，： | 1 |
| 10 | A stochastic competing-species model and ergodicity 显示文摘 | CHEN Z J REG K | 2005 | J Appl Prob2005，42，： | 1 |
| 11 | Design through operation of an image-based velocity estimation system for Mars landing显示文摘 | Andrew J Reg W Yang C | 2007 | International Journal of Computer Vision2007，74，3： | 1 |
| 12 | Changes in abundance of the neon flying squid Ommastrepkes bartramii in relation to climate change in the central North Pacific Ocean显示文摘 | LAURA TREMBLAY-BOYER DIDIEk GASCUEL REG WATSON | 2011 | Mar Ecol Prog Ser2011，，442： | 1 |
| 13 | Aeroballistics of a terminally corrected spinning projectile (TCSP)显示文摘 | Reg F J Smith J | 1975 | Journal of Spacecraft and Rockets1975，12，12： | 1 |
| 14 | Oncoplastic breast-conserving surgery: analysis of quadrantectomy and immediate reconstruction with latissimus dorsi flap 显示文摘 | Hernanz F Reg afio S Redondo-Figuero C | 2007 | World J Surg2007，31，10： | 1 |
| 15 | Development of gene-specific markers for acid soil/aluminium tolerance in barley ( Hordeum vulgare L.)显示文摘 | Miao Bian Irene Waters Sue Broughton Xiao-Qi Zhang Meixue Zhou Reg Lance Dongfa Sun Chengdao Li | 2013 | Molecular Breeding2013，，1： | 1 |
| 16 | Expression of maspin in mammary gland tumors of the dog显示文摘 | Mill n MY Ram reg GA | 2005 | VetPathol2005，42，3： | 1 |
| 17 | Experimental studies on effects at micro-structureing of highly reflecting metals using nano-and picosecond-laser显示文摘 | Reg Y Kageler C Schmidt M | 2010 | Physics P rocedia2010，，5： | 1 |
| 18 | Effects of grapefruit juice ingestion – pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men显示文摘 | J. Lundahl C. G. Reg?rdh B. Edgar G. Johnsson | 1997 | European Journal of Clinical Pharmacology1997，，2： | 1 |
| 19 | HPLC of triglycerides显示文摘 | HERSLF F B PODLAHA O T REG R D B | 1979 | J Am Oil Chem Soc1979，56，9： | 1 |
| 20 | Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects显示文摘 | J. Lundahl C. G. Reg?rdh B. Edgar G. Johnsson | 1995 | European Journal of Clinical Pharmacology (-)1995，，1： | 1 |
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