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| 1 | Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry显示文摘Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the brain.The reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their lifetime.Due to small numbers,a descriptive analysis is presented.Results:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were female.Where the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain radiotherapy.The median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 years.Conclusions:Brain metastasis is a rare outcome in advanced CRC.Patients within the registry tended to be female,young in age,and harbored with higher rates of KRAS mutations.Whether routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease. | Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers David Roder Amanda R. Townsend | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 2 | Epidemiology of neuroendocrine cancers in an Australian population显示文摘 | Colin Luke Timothy Price Amanda Townsend Christos Karapetis Dusan Kotasek Nimit Singhal Elizabeth Tracey David Roder | 2010 | Cancer Causes & Control2010，，6： | 2 |
| 3 | The epidemiology of gastric cancer显示文摘 | David M. Roder | 2002 | Gastric Cancer2002，，1： | 2 |
| 4 | The epidemiology of gastric cancer显示文摘 | David M. Roder | 2002 | Gastric Cancer2002，，1： | 1 |
| 5 | Brain uptake of thiamine-coated nanoparticles显示文摘 | Paul R Lockman Moses O Oyewumi Joanna M Koziara Karen E Roder Russell J Mumper David D Allen | 2003 | Journal of Controlled Release2003，，3： | 1 |
| 6 | Rising incidence of early‐onset colorectal cancer in A ustralia over two decades: Report and review显示文摘 | Joanne P Young Aung Ko Win Christophe Rosty Ingrid Flight David Roder Graeme P Young Oliver Frank Graeme K Suthers Peter J Hewett Andrew Ruszkiewicz Ehud Hauben Barbara‐Ann Adelstein Susan Parry Amanda Townsend Jennifer E Hardingham Timothy J Price | 2015 | J Gastroenterol Hepatol2015，，： | 1 |
| 7 | Extent and predictors of grade upgrading and downgrading in an Australian cohort according to the new prostate cancer grade groupings显示文摘Object:To determine the extent and impact of upgrading and downgrading among men who underwent radical prostatectomy(RP)according to new grade groupings and to identify predictors of upgrading from biopsy grade Group Ⅰ and Ⅱ,and downgrading to grade Group I,in a community setting.Methods:Study participants included 2279 men with non-metastatic prostate cancer diagnosed 2006-2015 who underwent prostatectomy,from the multi-institutional South Australia Prostate Cancer Clinical Outcomes Collaborative registry.Extent of up-or down-grading was assessed by comparing biopsy and prostatectomy grade groupings.Risk of biochemical recurrence(BCR)with upgrading was assessed using multivariable competing risk regression.Binomial logistic regression was used to identify pre-treatment predictors of upgrading from grade Groups Ⅰ and Ⅱ,and risk group reclassification among men with low risk disease.Results:Upgrading occurred in 35%of cases,while downgrading occurred in 13%of cases.Sixty percent with grade Group I disease were upgraded following prostatectomy.Upgrading from grade Group I was associated with greater risk of BCR compared with concordant grading(Hazard ratio:3.1,95%confidence interval:1.7-6.0).Older age,higher prostate-specific antigen levels(PSA),fewer biopsy cores,higher number of positive cores and more recent diagnosis predicted upgrading from grade Group Ⅰ,while higher PSA and clinical stage predicted upgrading from grade Group Ⅱ.No clinical risk factors for reclassification were identified.Conclusion:Biopsy sampling errors may play an important role in upgrading from grade Group I.Improved clinical assessment of grade is needed to encourage greater uptake of active surveillance. | Kerri Beckmann Michael O’Callaghan Andrew Vincent Penelope Cohen Martin Borg David Roder Sue Evans Jeremy Millar Kim Moretti | 2019 | Asian Journal of Urology2019，6，4： | 1 |
| 8 | Schoolchildren from disadvantaged backgrounds present a loss of lean tissue mass and significant increase of body fat mass during the COVID-19 lockdown in Germany:results from the MEDdirect study显示文摘Children from socio-economically disadvantaged backgrounds receive unequal opportunities to succeed in school,which will lead to a decreased health literacy as adults[U].This is not only directly associated with an impaired eco-nomic and mental health and wellbeing of young people,but above all with an in creased adult mortality[1-4].While this problem is well known and described,only few and even fewer pediatric studies suggest how to interrupt this downward spiral consistently[5,6]. | David Muhmann Marvin Droste Jorn Schulz Frederike Linge Lea Ladewig Ursula Eisenberg Susanne Roder Rainer Buscher | 2022 | World Journal of Pediatrics2022，18，5： | 0 |
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