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| 1 | Post-Translational Derepression of Invertase Activity in Source Leaves via Down-Regulation of Invertase Inhibitor Expression Is Part of the Plant Defense Response显示文摘正在增加病原体做的证据不仅得到直接防卫回答,而且在主要糖类新陈代谢引起显著变化。Cell-wall-bound 转化酶属于糖类划分和来源水池关系的关键管理者。而研究到目前为止响应病原体感染仅仅集中了于转化酶基因的 transcriptional 正式就职,转化酶活动的 translational 以后规定的角色被忽视了并且是现在的学习的焦点。表示分析表明高 mRNA 在 Arabidopsis thaliana 的来源叶子从三个 proteinaceous 转化酶禁止者一个铺平被 Pseudomonas syringae pv 的剧毒的紧张强烈在感染之上镇压。西红柿 DC3000。这压抑是由在转化酶禁止者活动的减少的 paralleled。这规章的机制的生理的角色被发现那在由 P 的感染之上仅仅在 situ 转化酶活动是可检测的揭示。syringae。相反,一项高转化酶活动能在 vitro 被测量在粗略并且准备从的房间墙摘录感染并且非感染的叶子。差异在之间在里面 situ 并且在在 situ 的控制叶子和高度的 vitro 转化酶活动,在感染的叶子的转化酶活动能被转化酶禁止者表示和伴随物减小的病原体依赖者压抑在转化酶禁止者活动解释。从为防卫反应的 translational 以后抑制的转化酶的版本的功能的重要性被竞争化学转化酶禁止者 acarbose 的申请证实。由在叶子的 acarbose 的渗入的细胞外的转化酶活动的 translational 以后抑制被显示增加危险性到 P。syringae。光合作用的压抑和细菌的生长的提升的空间、时间的动力学上的转化酶抑制的影响在植物防卫为细胞外的转化酶在病原体感染期间支持一个角色。危险性的调停 acarbose 的增加在 sid2 和 cpr6 异种也是可检测的并且导致了水杨酸酸的稍微提高的层次,证明效果独立于水杨酸调整酸的防卫小径。这些调查结果为在来源叶子发现被使蛋白质被在转化酶和转化酶禁止者之间的 translational 以后相互作用在 situ 禁止了的高可引出的转化酶活动提供解释。在病原体感染之上,转化酶活动被转化酶禁止者表示的压抑释放,因此连接水池力量的本地正式就职到植物防卫反应。 | Katharina B. Bonfig Andrea Gabler Uwe K. Simon Nora Luschin-Ebengreuth Martina Hatz Susanne Berger Naseem Muhammad Jurgen Zeier Alok K. Sinha Thomas Roitsch | 2010 | Molecular Plant2010，3，6： | 14 |
| 2 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 3 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 4 | Sludge thickening in a wastewater treatment plant using a modified hydrocyclone显示文摘The main application of hydrocyclones in most industry sectors is the separation of particles from liquids.For thickening,however,the separation properties of the cyclone should be adjustable,which requires a different operating mode.Therefore,we investigated an add-on thickening module,consisting of a conical plug and a secondary vortex finder in the underflow of the hydrocyclone.Laboratory scale experiments are carried out to investigate the function of the concept of annular gap modification by the use of the thickening module.In the second step,we transferred this concept to industrial scale for field tests at a municipal wastewater treatment plant.In the field tests,geometrical properties(annular gap modification)and operational parameters(volume flow rate,sludge type)were investigated.The results show that thickening in terms of increasing the total solids content of sludge is possible with the modified hydrocyclone.In the field tests,a thickening factor(total solids content of thickened sludge related to feed sludge)of 1.31(average)was reached for digested sludge.Hence,a hydrocyclone could be a promising addition in wastewater treatment plants for dewatering of sludge. | Thomas Senfter Lukas Fritsch Manuel Berger Tobias Kofler Christian Mayerl Martin Pillei Michael Kraxner | 2021 | Carbon Resources Conversion2021，4，1： | 3 |
| 5 | Estimation of Time to Maximum Rate Under Adiabatic Conditions(TMR_(ad)) Using Kinetic Parameters Derived From DSC-Investigation of Thermal Behavior of 3-Methyl-4-Nitrophenol显示文摘Kinetic parameters of the decomposition of hazardous chemicals can be applied for the estimation of their thermal behavior under any temperature profile.Presented paper describes the application of the advanced kinetic approach for the determination of the thermal behavior also under adiabatic conditions occurring e.g.in batch reactors in case of cooling failure.The kinetics of the decomposition of different samples(different manufacturers and batches) of 3-methyl-4-nitrophenol were investigated by conventional DSC in non-isothermal(few heating rates varying from 0.25 to 8.0K/min) and isothermal(range of 200~260℃) modes.The kinetic parameters obtained with AKTS-Thermokinetics Software were applied for calculating reaction rate and progress under different heating rates and temperatures and verified by comparing simulated and experimental signals.After application of the heat balance to compare the amount of heat generated during reaction and its removal from the system,the knowledge of reaction rate at any temperature profiles allowed the determination of the temperature increase due to the self-heating in adiabatic and pseudo-adiabatic conditions.Applied advanced kinetic approach allowed simulation the course of the Heat-Wait-Search(HWS) mode of operation of adiabatic calorimeters.The thermal safety diagram depicting dependence of Time to Maximum Rate(TMR) on the initial temperature was calculated and compared with the results of HWS experiments carried out in the system with Ф-factor amounting to 3.2.The influence of the Ф-factor and reaction progress reached at the end of the HWS monitoring on the TMR is discussed.Presented calculations clearly indicate that even very minor reaction progress reduces the TMRad of 24h characteristic for a sample with initial reaction progress amounting to zero.Described estimation method can be verified by just one HWS-ARC,or by one correctly chosen ISO-ARC run of reasonable duration by knowing in advance the dependence of the TMR on the initial temperature for any Ф-factor.Proposed procedure results in significant shortening of the measuring time compared to a safety hazard approach based on series of ARC experiments carried out at the beginning of a process safety evaluation. | Bertrand Roduit Patrick Folly Alexandre Sarbach Beat Berger Franz Brogli Francesco Mascarello Mischa Schwaninger Thomas Glarner Eberhard Irle Fritz Tobler Jacques Wiss Markus Luginbühl Craig Williams Pierre Reuse Francis Stoessel | 2011 | 化学推进剂与高分子材料2011，9，1： | 3 |
| 6 | Predictors of Comprehension during Surgical Informed Consent显示文摘 | Aaron S. Fink Allan V. Prochazka William G. Henderson Debra Bartenfeld Carsie Nyirenda Alexandra Webb David H. Berger Kamal Itani Thomas Whitehill James Edwards Mark Wilson Cynthia Karsonovich Patricia Parmelee | 2010 | Journal of the American College of Surgeons2010，，6： | 1 |
| 7 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 8 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 9 | A disease‐specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: Results of a randomized, controlled, multicenter trial显示文摘 | Rainer Fietkau Victor Lewitzki Thomas Kuhnt Tobias H?lscher Clemens‐F. Hess Bernhard Berger Thomas Wiegel Claus R?del Marcus Niewald Robert M. Hermann Dorota Lubgan | 2013 | Cancer2013，，18： | 1 |
| 10 | Hyponatremia in a pediatric stroke patient: Syndrome of inappro- priate antidiuretie hormone secretion or cerebral salt wasting? 显示文摘 | Berger Thomas MMD Kistler Walter MD Berendes Elmar MD | 2002 | Critical Care Medicine2002，30，： | 1 |
| 11 | Charge transfer reductive doping ofnanostructured TiO2 thin films as a way to improve their photoelectrocatalytic performance 显示文摘 | Thomas Berger Teresa Lana-Villarreal Darnian Monllor-Satoca | 2006 | Electrochemistry Communications2006，8，11： | 1 |
| 12 | Competitiveness and the bench- marking of nations-a critical reflection显示文摘 | Thomas Berger Gillian Bristow | 2009 | International Advances in Economic Research2009，，4： | 1 |
| 13 | Applications,complications,and outcomesof transvenous pacemaker implantation in 105 dogs (1997-2002)显示文摘 | Wess G Thomas WP Berger DM | 2006 | J Vet Intern Med2006，20，4： | 1 |
| 14 | Challenges and Recommendations for Early Identification of Metastatic Disease in Prostate Cancer显示文摘 | E. David Crawford Nelson N. Stone Evan Y. Yu Phillip J. Koo Stephen J. Freedland Susan F. Slovin Leonard G. Gomella E. Roy Berger Thomas E. Keane Paul Sieber Neal D. Shore Daniel P. Petrylak | 2013 | Urology2013，，： | 1 |
| 15 | Predictors of aneurysmal formation after surgical correction of aortic coarctation显示文摘 | Yskert von Kodolitsch Muhammet A Aydin Dietmar H Koschyk Roger Loose Ilka Schalwat Matthias Karck Jochen Cremer Axel Haverich Jürgen Berger Thomas Meinertz Christoph A Nienaber | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 16 | Infection with virulent and avirulent P. syringae strains differentially affects photosynthesis and sink metabolism in Arabidopsis leaves显示文摘 | Katharina B. Bonfig Ulrich Schreiber Andrea Gabler Thomas Roitsch Susanne Berger | 2006 | Planta2006，，1： | 1 |
| 17 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals显示文摘 | Harry Olson Graham Betton Denise Robinson Karluss Thomas Alastair Monro Gerald Kolaja Patrick Lilly James Sanders Glenn Sipes William Bracken Michael Dorato Koen Van Deun Peter Smith Bruce Berger Allen Heller | 2000 | Regulatory Toxicology and Pharmacology2000，，1： | 1 |
| 18 | Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells显示文摘 | Thomas W. Grunt Renate Wagner Michael Grusch Walter Berger Christian F. Singer Brigitte Marian Christoph C. Zielinski Ruth Lupu | 2009 | Biochemical and Biophysical Research Communications2009，，3： | 1 |
| 19 | Genome RNAi : a database for cell - based RNAi phenotypes 显示文摘 | Thomas Horn Zeynep Arziman Juerg Berger | 2006 | Nucleic Acids Research2006，32，： | 1 |
| 20 | Impact of Left Ventricular Dysfunction on Hospital Mortality Among Patients Undergoing Elective Percutaneous Coronary Intervention显示文摘 | Thomas W. Wallace Jeffrey S. Berger Andrew Wang Eric J. Velazquez David L. Brown | 2009 | The American Journal of Cardiology2009，，3： | 1 |
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