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| 1 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 2 | 对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究显示文摘目的 对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。 设计 观察性队列研究。 设置 利用来自加拿大安大略2000年4月17日~2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。 对象 年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。 衡量结局的主要指标 每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。 结果 与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95%,可信区间为2.3~6.9,)、双氯芬酸加米索前列醇(3.0,1.7~5.6)以及罗非昔布(1.9,1.3~2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7~1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3~8.5)、双氯芬酸加 米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2~2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0~3.5)。 结论 选择性COX | Muhammad Mamdani Paula A Rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie Peter C Austin Andreas Laupacis 邓瑞雪 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 3 | BuhrNa^+/K^+ ATPase as a Signaling Molecule During Bovine Sperm Capacitation显示文摘 | Jacob C T Muhammad A Mary M | 2006 | Biology of reproduction2006，75，： | 1 |
| 4 | A Fuzzy Controller for Lower Limb Exoskeletons during Sit-to- Stand and Stand-to-Sit Movement Using Wearable Sensors 显示文摘 | Sharif Muhammad Taslim R Norhafizan A Imtiaz Ahmed C | 2014 | Sensors ( 14248220)2014，14，3： | 1 |
| 5 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel显示文摘 | Juurlink David N Gomes Tara Ko Dennis T Szmitko Paul E Austin Peter C Tu Jack V Henry David A Kopp Alex Mamdani Muhammad M | 2009 | Canadian Medical Association. Journal2009，，7： | 1 |
| 6 | Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung显示文摘 | Ziady A G Gedeon C R Muhammad O | 2003 | Mol Therapy2003，8，6： | 1 |
| 7 | Formulation and evaluation of natural gum-based sustained release matrix tablets of flurbiprofen using response surface methodology显示文摘 | Syed N H S Sajid A Muhammad A C | 2009 | Drug Development and Industrial Pharmacy2009，35，12： | 1 |
| 8 | Formulation and evaluation of natural gum-based sustained release matrix tab lets of flurbiprofen using response surface methodology 显示文摘 | Syed N H S Sajid A Muhammad A C | 2009 | Drug Development and Industrial Pharmacy2009，35，12： | 1 |
| 9 | Egrets as monitors of tracemetal contamination in wetland of Pakistan显示文摘 | Boncompagni E Muhammad A Jabeen R Orvini E Gandini C Sanpera C Ruiz X Fasola M | | 0，，： | 1 |
| 10 | Modeling of the thermomechanical behavior of porous shape memory alloys显示文摘 | PAVLIN B E DIMITRIS C L | 2001 | International Journal of Solids and Structures2001，38，： | 1 |
| 11 | Effect of grazing systems on range condition in Pabbi Hills Reserve Forest,Kharian,Punjab,Pakistan显示文摘 | Muhammad S H Angus M Amjad A C | 2011 | Chilean Journal of Agricultural Research2011，71，4： | 1 |
| 12 | Adsorption of fl-carotene onto mesoporous carbon coated monolith in isopropylalcohol and n-hexane solution: equilibrium and thermodynamic study显示文摘 | Muhammad A C Thomas S Y Choong A | 2010 | Chemical Engineering Journal2010，164，： | 1 |
| 13 | Swarm intelligence based routing protocol for wireless sensor networks:Survey and future directions显示文摘 | Muhammad S Gianni A D C Muddassar F | | 0，，： | 1 |
| 14 | Swarm intelligence based routing protocol for wireless sensor networks: Survey and future di- rections显示文摘 | Muhammad S Gianni A D C Muddassar F | 2011 | Information Sciences2011，181，： | 1 |
| 15 | An- tidiabetic compounds from Sarracenia purpurea used traditionally by the EeyouIstchee Cree First Nation显示文摘 | Muhammad A Guerrero-Analco J A Martineau L C | 2012 | J Nat Prod2012，75，7： | 1 |
| 16 | Mixed acceptance sampling plans for product inspection using process capability index显示文摘 | Muhammad A Wu C Muhammad A | 2014 | Qual Eng2014，26，450： | 1 |
| 17 | A Generalized Analytical Compliance Model for Transversely Symmetric Three Segment Flexure Hinges显示文摘 | NICOLAE L MATT C MUHAMMAD A | 2011 | Review of Scientific Instruments2011，82，10： | 1 |
| 18 | Goto-kakizaki rats:its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus显示文摘 | Muhammad Sajid A Kanwal R Shuqing C | 2013 | Current Diabetes Reviews2013，9，5： | 1 |
| 19 | Treatment of weight regain fol- lowing Roux-en-Y gastric bypass : revision of pouch, creation of new gastrojejunostomy and placement of proximal pericardial patch ring显示文摘 | Rena C Andre F Muhammad A | 2014 | Obes Surg2014，24，6： | 1 |
| 20 | Application of geostatisticsto evaluate partiai weather station networks 显示文摘 | Muhammad Ashraf a Jim C Loftis a Hubbard K G | 1997 | Agricultural and Forest Meteorology1997，84，： | 1 |
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